HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 37 matching records:

Displaying record number 57845

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location  
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Epitope Name RW8
Subtype B
Species (MHC/HLA) human(A23, A24, B35, B53)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, TCR binding
Keywords rate of progression, TCR usage, optimal epitope

Notes

References

Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.


Displaying record number 60235

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef(134-141)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Epitope Name RW8
Species (MHC/HLA) human(A*23)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 53949

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location ( C consensus)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Subtype C
Species (MHC/HLA) human(A*2301)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords epitope processing, rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 53279

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location ( C consensus)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Subtype C
Species (MHC/HLA) human(A*2301)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords characterizing CD8+ T cells

Notes

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.


Displaying record number 56237

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location  
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Subtype C
Species (MHC/HLA) human(A*2301, A24)
Immunogen HIV-1 infection
Patient MHC/HLA A*2301, A*2902, B*1510, B*4501, Cw*0602, Cw*1601; A*2301, A*2902, B*4101, B*4201, Cw*1701
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords rate of progression, immunodominance

Notes

References

Gray2009 Clive M. Gray, Mandla Mlotshwa, Catherine Riou, Tiyani Mathebula, Debra de Assis Rosa, Tumelo Mashishi, Cathal Seoighe, Nobubelo Ngandu, Francois van Loggerenberg, Lynn Morris, Koleka Mlisana, Carolyn Williamson, Salim Abdool Karim, and CAPRISA 002 Acute Infection Study Team. Human Immunodeficiency Virus-Specific gamma Interferon Enzyme-Linked Immunospot Assay Responses Targeting Specific Regions of the Proteome during Primary Subtype C Infection Are Poor Predictors of the Course of Viremia and Set Point. J. Virol., 83(1):470-478, Jan 2009. PubMed ID: 18945774. Show all entries for this paper.


Displaying record number 56607

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef(134-141)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Epitope Name RW8
Subtype C
Species (MHC/HLA) human(A*2301, A*2402)
Immunogen HIV-1 infection
Country South Africa, Zambia
Experimental methods  
Keywords viral fitness and reversion, HLA associated polymorphism

Notes

References

Goepfert2008 Paul A. Goepfert, Wendy Lumm, Paul Farmer, Philippa Matthews, Andrew Prendergast, Jonathan M. Carlson, Cynthia A. Derdeyn, Jianming Tang, Richard A. Kaslow, Anju Bansal, Karina Yusim, David Heckerman, Joseph Mulenga, Susan Allen, Philip J. R. Goulder, and Eric Hunter. Transmission of HIV-1 Gag Immune Escape Mutations Is Associated with Reduced Viral Load in Linked Recipients. J. Exp. Med., 205(5):1009-1017, 12 May 2008. PubMed ID: 18426987. Show all entries for this paper.


Displaying record number 1543

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef(138-147 SF2)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Species (MHC/HLA) human(A24)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 54261

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Epitope Name A24-WR8(Nef)
Species (MHC/HLA) human(A24)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 52275

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Epitope Name A24-RW8(Nef)
Subtype B
Species (MHC/HLA) human(A24)
Immunogen HIV-1 infection
Patient MHC/HLA A24, B27, B7
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Altfeld2002 Marcus Altfeld, Jan van Lunzen, Nicole Frahm, Xu G. Yu, Claus Schneider, Robert L. Eldridge, Margaret E. Feeney, Dirk Meyer-Olson, Hans-Juergen Stellbrink, and Bruce D. Walker. Expansion of Pre-existing, Lymph Node-localized CD8+ T Cells During Supervised Treatment Interruptions in Chronic HIV-1 Infection. J. Clin. Invest., 109(6):837-843, Mar 2002. PubMed ID: 11901192. Show all entries for this paper.


Displaying record number 55021

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location  
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Species (MHC/HLA) human(A24)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, immunodominance, optimal epitope

Notes

References

Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.


Displaying record number 55193

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location  
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Species (MHC/HLA) human(A24)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supertype, HLA cross-presentation, optimal epitope

Notes

References

Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.


Displaying record number 58545

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Epitope Name A24-RW8
Subtype B
Species (MHC/HLA) human(A*24)
Immunogen HIV-1 infection
Country United States
Experimental methods  
Keywords review, rate of progression, acute/early infection

Notes

References

Streeck2010 Hendrik Streeck and Douglas F. Nixon. T Cell Immunity in Acute HIV-1 Infection. J. Infect. Dis., 202(Suppl 2):S302-8, 15 Oct 2010. PubMed ID: 20846037. Show all entries for this paper.


Displaying record number 56399

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef(134-141)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Epitope Name RW8
Subtype B
Species (MHC/HLA) human(A*24)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords viral fitness and reversion, HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 60236

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef(134-141)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Epitope Name RW8
Species (MHC/HLA) human(A*24)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 61603

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Show epitope variants
Epitope Name A24-RW8 Nef
Species (MHC/HLA) human(A*24)
Immunogen HIV-1 infection
Patient MHC/HLA 9213: A*01, A*24, B*38, B*44, Cw*04
Experimental methods Other
Keywords escape

Notes

References

Pandit2014 Aridaman Pandit and Rob J. de Boer. Reliable Reconstruction of HIV-1 Whole Genome Haplotypes Reveals Clonal Interference and Genetic Hitchhiking among Immune Escape Variants. Retrovirology, 11:56, 4 Jul 2014. PubMed ID: 24996694. Show all entries for this paper.


Displaying record number 62163

HXB2 Location Nef(134-141) Nef Epitope Map
Author Location Nef(134-141)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Epitope Name Nef-RW8
Species (MHC/HLA) human(A*2402)
Immunogen HIV-1 infection
Experimental methods  
Keywords escape, HLA associated polymorphism, review

Notes

References

Avila-Rios2019 Santiago Avila-Rios, Jonathan M. Carlson, Mina John, Simon Mallal, and Zabrina L. Brumme. Clinical and evolutionary consequences of HIV adaptation to HLA: implications for vaccine and cure. Curr Opin HIV AIDS, 14(3):194-204 doi, May 2019. PubMed ID: 30925534 Show all entries for this paper.


Displaying record number 1132

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef(138-147 LAI)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Subtype B
Species (MHC/HLA) human(A*2402)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 54189

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef(169-176)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Subtype C
Species (MHC/HLA) human(A*2402)
Immunogen HIV-1 infection
Experimental methods Other
Keywords HLA associated polymorphism

Notes

References

Boutwell2007 Christian L. Boutwell and M. Essex. Identification of HLA Class I-Associated Amino Acid Polymorphisms in the HIV-1C Proteome. AIDS Res. Hum. Retroviruses, 23(1):165-174, Jan 2007. PubMed ID: 17263647. Show all entries for this paper.


Displaying record number 54755

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Species (MHC/HLA) human(A*2402)
Immunogen peptide-HLA interaction
Experimental methods Tetramer binding
Keywords binding affinity

Notes

References

Gillespie2007 Geraldine M. A. Gillespie, Arman Bashirova, Tao Dong, Daniel W. McVicar, Sarah L. Rowland-Jones, and Mary Carrington. Lack of KIR3DS1 Binding to MHC Class I Bw4 Tetramers in Complex with CD8+ T Cell Epitopes. AIDS Res. Hum. Retroviruses, 23(3):451-455, Mar 2007. PubMed ID: 17411378. Show all entries for this paper.


Displaying record number 57249

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Show epitope variants
Epitope Name RW8
Subtype B
Species (MHC/HLA) human(A*2402)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords acute/early infection

Notes

References

Malhotra2009 U. Malhotra, J. Nolin, H. Horton, F. Li, L. Corey, J. I. Mullins, and M. J. McElrath. Functional Properties and Epitope Characteristics of T-Cells Recognizing Natural HIV-1 Variants. Vaccine, 27(48):6678-6687, 12 Nov 2009. PubMed ID: 19747576. Show all entries for this paper.


Displaying record number 58986

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef(131-141)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Subtype B
Species (MHC/HLA) human(A*2402)
Immunogen HIV-1 infection
Country Australia, Canada, Spain, Switzerland
Experimental methods Other
Keywords mutation acquisition

Notes

References

Bartha2013 István Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. McLaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López-Galíndez, Concepción Casado, Andri Rauch, Huldrych F. Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M. Allen, Viktor Müller, P. Richard Harrigan, David Heckerman, Amalio Telenti, and Jacques Fellay. A Genome-to-Genome Analysis of Associations between Human Genetic Variation, HIV-1 Sequence Diversity, and Viral Control. eLife, 2:e01123, 2013. PubMed ID: 24171102. Show all entries for this paper.


Displaying record number 59313

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef(138-145)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Epitope Name RW8
Subtype B
Species (MHC/HLA) human(A*2402)
Immunogen HIV-1 infection
Country Japan
Experimental methods Chromium-release assay, Relative replication capacity assay, TCR binding, Tetramer binding
Keywords TCR usage, structure

Notes

References

Sun2014 Xiaoming Sun, Mamoru Fujiwara, Yi Shi, Nozomi Kuse, Hiroyuki Gatanaga, Victor Appay, George F. Gao, Shinichi Oka, and Masafumi Takiguchi. Superimposed Epitopes Restricted by the Same HLA Molecule Drive Distinct HIV-Specific CD8+ T Cell Repertoires. J. Immunol., 193(1):77-84, 1 Jul 2014. PubMed ID: 24899498. Show all entries for this paper.


Displaying record number 59375

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location  
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Epitope Name RW8
Species (MHC/HLA) human(A*2402)
Immunogen HIV-1 infection
Patient MHC/HLA P07: A*2402, A*6801, B*1801, B*3501, C*0701, C*0704
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction, optimal epitope

Notes

References

Roider2014 Julia Roider, Tim Meissner, Franziska Kraut, Thomas Vollbrecht, Renate Stirner, Johannes R. Bogner, and Rika Draenert. Comparison of Experimental Fine-Mapping to In Silico Prediction Results of HIV-1 Epitopes Reveals Ongoing Need for Mapping Experiments. Immunology, 143(2):193-201, Oct 2014. PubMed ID: 24724694. Show all entries for this paper.


Displaying record number 60668

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef(134-)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Show epitope variants
Epitope Name RW8, Nef134-8
Subtype B
Species (MHC/HLA) human(A*2402)
Immunogen HIV-1 infection
Country Japan
Experimental methods Other, Tetramer binding
Keywords rate of progression, escape

Notes

References

Katoh2016 Jiro Katoh, Ai Kawana-Tachikawa, Akihisa Shimizu, Dayong Zhu, Chungyong Han, Hitomi Nakamura, Michiko Koga, Tadashi Kikuchi, Eisuke Adachi, Tomohiko Koibuchi, George F. Gao, Zabrina L. Brumme, and Aikichi Iwamoto. Rapid HIV-1 Disease Progression in Individuals Infected with a Virus Adapted to Its Host Population. PLoS One, 11(3):e0150397, 2016. PubMed ID: 26953793. Show all entries for this paper.


Displaying record number 61002

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef(134-141)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Subtype B
Species (MHC/HLA) human(A*2402)
Immunogen HIV-1 infection
Patient MHC/HLA 44091: A*0201, A*2401, B*4401, B*5701, Cw*0501, Cw*6002
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 61180

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef(134-141)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Show epitope variants
Epitope Name RW8
Subtype B
Species (MHC/HLA) human(A*2402)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords acute/early infection, variant cross-reactivity

Notes

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61235

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Show epitope variants
Epitope Name RW8
Species (MHC/HLA) human(A*2402)
Immunogen HIV-1 infection
Experimental methods Other
Keywords review, TCR usage

Notes

References

Lissina2016 Anna Lissina, Lisa A. Chakrabarti, Masafumi Takiguchi, and Victor Appay. TCR Clonotypes: Molecular Determinants of T-Cell Efficacy against HIV. Curr. Opin. Virol., 16:77-85, Feb 2016. PubMed ID: 26874617. Show all entries for this paper.


Displaying record number 61248

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef(134-141)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Show epitope variants
Epitope Name RW8
Subtype B
Species (MHC/HLA) human(A*2402)
Immunogen HIV-1 infection
Patient MHC/HLA KI-060: A*2402, A*2601, B*4002, B*5201, Cw*0304, Cw*1202; KI-067: A*2402, B*4801, B*5201, Cw*0304, Cw*1202; KI-069: A*2402, B*4006, B*5201, Cw*0304, Cw*1202; KI-087: A*2402, B*4001, B*5502, Cw*0102, Cw*0304; KI-708: A*2402, A*3101, B*0702, B*1501, Cw*0303, Cw*0702; KI-130: A*2402, B*0702, B*5201, Cw*0702, Cw*1202; KI-092: A*0206, A*2402, B*4801, B*5101, Cw*0801, Cw*1402; KI-102: A*0206, A*2402, B*0702, B*3501, Cw*0303, Cw*0702; KI-158: A*2402, A*3303, B*4403, B*5201, Cw*1202, Cw*1403; KI-161: A*2402, A*2601, B*3501, B*5401, Cw*0102, Cw*0303
Country Japan
Experimental methods Chromium-release assay, Other, Relative replication capacity assay, Tetramer binding
Keywords escape, structure, variant cross-reactivity

Notes

References

Sun2016 Xiaoming Sun, Yi Shi, Tomohiro Akahoshi, Mamoru Fujiwara, Hiroyuki Gatanaga, Christian Schönbach, Nozomi Kuse, Victor Appay, George F. Gao, Shinichi Oka, and Masafumi Takiguchi. Effects of a Single Escape Mutation on T Cell and HIV-1 Co-Adaptation. Cell Rep., 15(10):2279-2291, 7 Jun 2016. PubMed ID: 27239036. Show all entries for this paper.


Displaying record number 61669

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef(134-141)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Show epitope variants
Epitope Name RW8
Species (MHC/HLA) human(A*2402)
Immunogen peptide-HLA interaction
Experimental methods Other, Tetramer binding
Keywords structure, NK cells, protective allele

Notes

References

OConnor2015 Geraldine M. O'Connor, Julian P. Vivian, Emma Gostick, Phillip Pymm, Bernard A. P. Lafont, David A. Price, Jamie Rossjohn, Andrew G. Brooks, and Daniel W. McVicar. Peptide-Dependent Recognition of HLA-B*57:01 by KIR3DS1. J. Virol., 89(10):5213-5221, May 2015. PubMed ID: 25740999. Show all entries for this paper.


Displaying record number 60238

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef(134-141)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Epitope Name RW8
Species (MHC/HLA) human(A*29)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 52629

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef(134-141)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Subtype B
Species (MHC/HLA) human(A33)
Immunogen HIV-1 infection
Patient MHC/HLA A3, A33, B14, B35, Cw*0401, Cw*0802
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity, acute/early infection, early-expressed proteins

Notes

References

Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.


Displaying record number 60237

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef(134-141)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Epitope Name RW8
Species (MHC/HLA) human(B*18)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 1064

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef(134-141 LAI)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Subtype B
Species (MHC/HLA) human(B27)
Immunogen  
Experimental methods  
Keywords  

Notes

References

CulmannPerCom B. Culmann. Personal communication, 1998. Show all entries for this paper.


Displaying record number 55619

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Epitope Name RW8
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction

Notes

References

Schellens2008 Ingrid M. M. Schellens, Can Kesmir, Frank Miedema, Debbie van Baarle, and José A. M. Borghans. An Unanticipated Lack of Consensus Cytotoxic T Lymphocyte Epitopes in HIV-1 Databases: The Contribution of Prediction Programs. AIDS, 22(1):33-37, 2 Jan 2008. PubMed ID: 18090389. Show all entries for this paper.


Displaying record number 60240

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef(134-141)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Epitope Name RW8
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60239

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef(134-141)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Epitope Name RW8
Species (MHC/HLA) human(B*3502, B*3503, B*5301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60234

HXB2 Location Nef(134-141)
DNA(9196..9219)
Nef Epitope Map
Author Location Nef(134-141)
Epitope RYPLTFGW Epitope Alignment
RYPLTFGW epitope logo
Epitope Name RW8
Species (MHC/HLA) human(C*04)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


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