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Displaying record number 835

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HXB2 Location	gp160(585-592) gp41(74-81) DNA(7977..8000)	gp160 Epitope Map
Author Location	gp41(584-591 SF2)
Epitope	RYLRDQQL	Epitope Alignment
Epitope Name	Env584-8
Subtype	B
Species (MHC/HLA)	human(A*24:02)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods
Keywords

Notes

• Defined using reverse immunogenetics -- 59 HLA-A*2402 binding peptides were predicted by searching for A*2402 anchors in HIV proteins (Tyr at 2, and Phe, Leu or Ile at the C term) -- 53 of the 59 peptides bound A*2402.
• This peptide induced CTL in 2/4 HIV-1+ people tested.
• RYLRDQQL bound to A*2402 weakly, the epitope can be processed in a vaccinia construct and presented -- two specific CTL clones were obtained.

References

IkedaMoore1997 Y. Ikeda-Moore, H. Tomiyama, K. Miwa, S. Oka, A. Iwamoto, Y. Kaneko, and M. Takiguchi. Identification and Characterization of Multiple HLA-A24-Restricted HIV-1 CTL Epitopes: Strong Epitopes Are Derived from V Regions of HIV-1. J. Immunol., 159:6242-6252, 1997. PubMed ID: 9550428. Show all entries for this paper.