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Found 2 matching records:

Displaying record number 1737

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HXB2 Location	gp160(340-348) gp120(340-348) DNA(7242..7268)	gp160 Epitope Map
Author Location	gp120(346-354 CM243 subtype CRF01)
Epitope	RVLKQVTEK	Epitope Alignment
Subtype	CRF01_AE
Species (MHC/HLA)	human(A*11)
Immunogen	HIV-1 infection
Experimental methods
Keywords	subtype comparisons

Notes

• HLA-A*11 CRF01 (called subtype E in Bond et al.) epitopes were identified that stimulated CTL from HIV+ female sex workers (FSW) from Northern Thailand, of whom more than half were HLA-A*11 positive.
• 77 possible HLA-A*11 epitopes were first defined using EpiMatrix, these were screened for binding to A*11 finding and 26 bound, and 12 of these were epitopes for CTL responses from 8 HLA-A*11 positive FSWs, six were novel, six were previously identified.
• This is one of the new A*11 epitopes identified through the streamlined EpiMatrix method, and 2/8 tested FSWs recognized it.
• This epitope was not conserved in other subtypes, and exact matches were rare.

References

Bond2001 K. B. Bond, B. Sriwanthana, T. W. Hodge, A. S. De Groot, T. D. Mastro, N. L. Young, N. Promadej, J. D. Altman, K. Limpakarnjanarat, and J. M. McNicholl. An HLA-directed molecular and bioinformatics approach identifies new HLA-A11 HIV-1 subtype E cytotoxic T lymphocyte epitopes in HIV-1-infected Thais. AIDS Res. Hum. Retroviruses, 17(8):703-17, 20 May 2001. PubMed ID: 11429111. Show all entries for this paper.

Displaying record number 1717

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HXB2 Location	gp160(340-348) gp120(340-348) DNA(7242..7268)	gp160 Epitope Map
Author Location	gp120(346-354 CM243 subtype CRF01)
Epitope	RVLKQVTEK	Epitope Alignment
Epitope Name	E340-348
Subtype	CRF01_AE
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

• This was a study of HIV-1 exposed persistently seronegative (HEPS) female sex workers in Chiang Mai, northern Thailand.
• HLA-A11 is very common in this population, and was enriched among the HEPS sexworkers -- weak CTL responses were detected in 4/7 HEPS women, and CTL responses were found in 8/8 HIV+ controls, and 0/9 HIV- women that were not exposed.
• This epitope was weakly reactive in HIV+ control study subject 053 who carried HLA-A11.

References

Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.