HIV molecular immunology database
Found 5 matching records:
Download this epitope record as JSON.
| HXB2 Location | gp160(2-10) gp120(2-10) DNA(6228..6254) |
gp160 Epitope Map |
|---|---|---|
| Author Location | gp120(2-10) | |
| Epitope |
RVKEKYQHL
|
Epitope Alignment
|
| Species (MHC/HLA) | human(B*08) | |
| Immunogen | HIV-1 infection | |
| Experimental methods | ||
| Keywords |
Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.
Download this epitope record as JSON.
| HXB2 Location | gp160(2-10) gp120(2-10) DNA(6228..6254) |
gp160 Epitope Map |
|---|---|---|
| Author Location | gp160(2-10 IIIB) | |
| Epitope |
RVKEKYQHL
|
Epitope Alignment
|
| Species (MHC/HLA) | human(B*08:01) | |
| Immunogen | HIV-1 infection | |
| Experimental methods | ||
| Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
| HXB2 Location | gp160(2-10) gp120(2-10) DNA(6228..6254) |
gp160 Epitope Map |
|---|---|---|
| Author Location | Env(2-10) | |
| Epitope |
RVKEKYQHL
|
Epitope Alignment
|
| Species (MHC/HLA) | human(B*08:01) | |
| Immunogen | peptide-HLA interaction | |
| Experimental methods | Intracellular cytokine staining, Other | |
| Keywords | assay or method development, NK cells |
Partridge2018 Thomas Partridge, Annalisa Nicastri, Anna E. Kliszczak, Louis-Marie Yindom, Benedikt M. Kessler, Nicola Ternette, and Persephone Borrow. Discrimination Between Human Leukocyte Antigen Class I-Bound and Co-Purified HIV-Derived Peptides in Immunopeptidomics Workflows. Front. Immunol., 9:912, 2018. PubMed ID: 29780384. Show all entries for this paper.
Download this epitope record as JSON.
| HXB2 Location | gp160(2-10) gp120(2-10) DNA(6228..6254) |
gp160 Epitope Map |
|---|---|---|
| Author Location | gp160(2-10 IIIB) | |
| Epitope |
RVKEKYQHL
|
Epitope Alignment
|
| Show epitope variants | ||
| Species (MHC/HLA) | human(B8) | |
| Immunogen | HIV-1 infection | |
| Experimental methods | ||
| Keywords | subtype comparisons |
Sipsas1997 N. V. Sipsas, S. A. Kalams, A. Trocha, S. He, W. A. Blattner, B. D. Walker, and R. P. Johnson. Identification of Type-Specific Cytotoxic T Lymphocyte Responses to Homologous Viral Proteins in Laboratory Workers Accidentally Infected with HIV-1. J. Clin. Invest., 99:752-762, 1997. To examine a situation where the autologous strain and the reference reagents would be the same, the CTL response of three lab workers accidentally infected with HIV IIIB was studied. Both group specific and type specific epitopes were targets for CTL clones. One subject had a broadening of CTL response over time, using a broad range of restricting HLA class I alleles. Characterization of the cytotoxic T lymphocyte (CTL) response against HIV-1 has been limited by the use of target cells expressing viral proteins from laboratory isolates of HIV-1. This approach has favored identification of group-specific CTL responses and precluded assessment of the extent of type-specific CTL responses directed against HIV-1. Using cells expressing viral proteins from the HIV-1 IIIB strain, we performed a detailed characterization of HIV-1-specific CTL response in three laboratory workers accidentally infected with HIV-1 IIIB. Eight of the epitopes identified were group specific, lying in relatively conserved regions of Gag, reverse transcriptase, and envelope. Three type-specific epitopes were identified, two of them in highly variable regions of envelope. In longitudinal studies in one subject, seven different epitopes and five different restricting HLA class I alleles were identified, with a progressive increase in the number of CTL epitopes recognized by this subject over time. Our data demonstrate that type-specific CTL responses make up a significant proportion of the host cellular immune response against HIV-1 and that a broadening of epitope specificity may occur. PubMed ID: 9045880. Show all entries for this paper.
Download this epitope record as JSON.
| HXB2 Location | gp160(2-10) gp120(2-10) DNA(6228..6254) |
gp160 Epitope Map |
|---|---|---|
| Author Location | ||
| Epitope |
RVKEKYQHL
|
Epitope Alignment
|
| Species (MHC/HLA) | (B8) | |
| Immunogen | ||
| Experimental methods | ||
| Keywords | review, immunodominance, escape, vaccine antigen design |
Altfeld2006a Marcus Altfeld and Todd M. Allen. Hitting HIV Where It Hurts: An Alternative Approach to HIV Vaccine Design. Trends Immunol., 27(11):504-510, Nov 2006. PubMed ID: 16997629. Show all entries for this paper.