HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 5 matching records:

Displaying record number 1796

HXB2 Location gp160(2-10)
gp120(2-10)
DNA(6228..6254)
gp160 Epitope Map
Author Location gp120(2-10)
Epitope RVKEKYQHL Epitope Alignment
RVKEKYQHL epitope logo
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 621

HXB2 Location gp160(2-10)
gp120(2-10)
DNA(6228..6254)
gp160 Epitope Map
Author Location gp160(2-10 IIIB)
Epitope RVKEKYQHL Epitope Alignment
RVKEKYQHL epitope logo
Species (MHC/HLA) human(B*0801)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy CedeƱo, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 61997

HXB2 Location gp160(2-10)
gp120(2-10)
DNA(6228..6254)
gp160 Epitope Map
Author Location Env(2-10)
Epitope RVKEKYQHL Epitope Alignment
RVKEKYQHL epitope logo
Species (MHC/HLA) human(B*0801)
Immunogen peptide-HLA interaction
Experimental methods Intracellular cytokine staining, Other
Keywords assay or method development, NK cells

Notes

References

Partridge2018 Thomas Partridge, Annalisa Nicastri, Anna E. Kliszczak, Louis-Marie Yindom, Benedikt M. Kessler, Nicola Ternette, and Persephone Borrow. Discrimination Between Human Leukocyte Antigen Class I-Bound and Co-Purified HIV-Derived Peptides in Immunopeptidomics Workflows. Front. Immunol., 9:912, 2018. PubMed ID: 29780384. Show all entries for this paper.


Displaying record number 620

HXB2 Location gp160(2-10)
gp120(2-10)
DNA(6228..6254)
gp160 Epitope Map
Author Location gp160(2-10 IIIB)
Epitope RVKEKYQHL Epitope Alignment
RVKEKYQHL epitope logo
Show epitope variants
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

Sipsas1997 N. V. Sipsas, S. A. Kalams, A. Trocha, S. He, W. A. Blattner, B. D. Walker, and R. P. Johnson. Identification of Type-Specific Cytotoxic T Lymphocyte Responses to Homologous Viral Proteins in Laboratory Workers Accidentally Infected with HIV-1. J. Clin. Invest., 99:752-762, 1997. To examine a situation where the autologous strain and the reference reagents would be the same, the CTL response of three lab workers accidentally infected with HIV IIIB was studied. Both group specific and type specific epitopes were targets for CTL clones. One subject had a broadening of CTL response over time, using a broad range of restricting HLA class I alleles. Characterization of the cytotoxic T lymphocyte (CTL) response against HIV-1 has been limited by the use of target cells expressing viral proteins from laboratory isolates of HIV-1. This approach has favored identification of group-specific CTL responses and precluded assessment of the extent of type-specific CTL responses directed against HIV-1. Using cells expressing viral proteins from the HIV-1 IIIB strain, we performed a detailed characterization of HIV-1-specific CTL response in three laboratory workers accidentally infected with HIV-1 IIIB. Eight of the epitopes identified were group specific, lying in relatively conserved regions of Gag, reverse transcriptase, and envelope. Three type-specific epitopes were identified, two of them in highly variable regions of envelope. In longitudinal studies in one subject, seven different epitopes and five different restricting HLA class I alleles were identified, with a progressive increase in the number of CTL epitopes recognized by this subject over time. Our data demonstrate that type-specific CTL responses make up a significant proportion of the host cellular immune response against HIV-1 and that a broadening of epitope specificity may occur. PubMed ID: 9045880. Show all entries for this paper.


Displaying record number 54811

HXB2 Location gp160(2-10)
gp120(2-10)
DNA(6228..6254)
gp160 Epitope Map
Author Location  
Epitope RVKEKYQHL Epitope Alignment
RVKEKYQHL epitope logo
Species (MHC/HLA) (B8)
Immunogen  
Experimental methods  
Keywords review, immunodominance, escape, vaccine antigen design

Notes

References

Altfeld2006a Marcus Altfeld and Todd M. Allen. Hitting HIV Where It Hurts: An Alternative Approach to HIV Vaccine Design. Trends Immunol., 27(11):504-510, Nov 2006. PubMed ID: 16997629. Show all entries for this paper.


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