HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 27 matching records:

Displaying record number 60224

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location Gag(76-86)
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Epitope Name RY11
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 57300

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location p17(76-86)
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Show epitope variants
Epitope Name RY11
Subtype B
Species (MHC/HLA) human(A*02:01, A*30:02)
Immunogen peptide-HLA interaction
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Other
Keywords epitope processing

Notes

References

Tenzer2009 Stefan Tenzer, Edmund Wee, Anne Burgevin, Guillaume Stewart-Jones, Lone Friis, Kasper Lamberth, Chih-hao Chang, Mikkel Harndahl, Mirjana Weimershaus, Jan Gerstoft, Nadja Akkad, Paul Klenerman, Lars Fugger, E. Yvonne Jones, Andrew J. McMichael, Søren Buus, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. Antigen Processing Influences HIV-Specific Cytotoxic T Lymphocyte Immunodominance. Nat. Immunol., 10(6):636-646, Jun 2009. PubMed ID: 19412183. Show all entries for this paper.


Displaying record number 60227

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location Gag(76-86)
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Epitope Name RY11
Species (MHC/HLA) human(A*29)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 62248

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location Gag(76-86)
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Show epitope variants
Epitope Name Gag-RY11
Subtype C
Species (MHC/HLA) human(A*30)
Immunogen HIV-1 infection
Patient MHC/HLA 517-C: A*30:02, A*68:02, B*15:10, B*42:01, C*03:04, C*17:01; 517-M: A*30:02, A*30:04, B*42:01, B*58:02, C*06:02, C*17:01
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords dynamics, responses in children, mother-to-infant transmission, rate of progression, escape

Notes

References

Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.


Displaying record number 60226

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location Gag(76-86)
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Epitope Name RY11
Species (MHC/HLA) human(A*30)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54525

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location p17(76-86)
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Subtype B
Species (MHC/HLA) human(A30)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity, subtype comparisons, acute/early infection

Notes

References

Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.


Displaying record number 52278

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location p17
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Epitope Name A30-RY11(p17)
Subtype B
Species (MHC/HLA) human(A30)
Immunogen HIV-1 infection
Patient MHC/HLA A30, A32, B18, B27
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Altfeld2002 Marcus Altfeld, Jan van Lunzen, Nicole Frahm, Xu G. Yu, Claus Schneider, Robert L. Eldridge, Margaret E. Feeney, Dirk Meyer-Olson, Hans-Juergen Stellbrink, and Bruce D. Walker. Expansion of Pre-existing, Lymph Node-localized CD8+ T Cells During Supervised Treatment Interruptions in Chronic HIV-1 Infection. J. Clin. Invest., 109(6):837-843, Mar 2002. PubMed ID: 11901192. Show all entries for this paper.


Displaying record number 1534

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location p17(74-86 SF2)
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Species (MHC/HLA) human(A30)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 54884

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location  
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Species (MHC/HLA) human(A30)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, characterizing CD8+ T cells

Vaccine Details

Vaccine type canarypox, canarypox prime with recombinant protein boost
Vaccine strain B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen
Vaccine component Gag, gp120, gp41, Nef, Pol, Protease

Notes

References

Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.


Displaying record number 53062

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location p17
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Epitope Name RY-11
Subtype C
Species (MHC/HLA) human(A30)
Immunogen HIV-1 infection
Experimental methods CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining
Keywords subtype comparisons, epitope processing, immunodominance, HLA cross-presentation

Notes

References

Masemola2004a Agatha M. Masemola, Tumelo N. Mashishi, Greg Khoury, Helba Bredell, Maria Paximadis, Tiyani Mathebula, Debra Barkhan, Adrian Puren, Efthyia Vardas, Mark Colvin, Lynn Zijenah, David Katzenstein, Rosemary Musonda, Susan Allen, Newton Kumwenda, Taha Taha, Glenda Gray, James McIntyre, Salim Abdool Karim, Haynes W. Sheppard, and Clive M. Gray. Novel and Promiscuous CTL Epitopes in Conserved Regions of Gag Targeted by Individuals with Early Subtype C HIV Type 1 Infection from Southern Africa. J. Immunol., 173(7):4607-4617, 1 Oct 2004. PubMed ID: 15383595. Show all entries for this paper.


Displaying record number 55711

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location Gag
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Epitope Name RY11-A30
Subtype B, F
Species (MHC/HLA) human(A30)
Immunogen HIV-1 infection
Country Argentina
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Dilernia2008 Dario Alberto Dilernia, Leandro Jones, Sabrina Rodriguez, Gabriela Turk, Andrea E Rubio, Sandra Pampuro, Manuel Gomez-Carrillo, Christian Bautista, Gabriel Deluchi, Jorge Benetucci, María Beatriz Lasala, Leonardo Lourtau, Marcelo Horacio Losso, Héctor Perez, Pedro Cahn, and Horacio Salomón. HLA-Driven Convergence of HIV-1 Viral Subtypes B and F Toward the Adaptation to Immune Responses in Human Populations. PLoS ONE, 3(10):e3429, 2008. PubMed ID: 18941505. Show all entries for this paper.


Displaying record number 57210

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location Gag
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Species (MHC/HLA) (A30)
Immunogen HIV-1 infection
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords mother-to-infant transmission

Notes

References

Lohman-Payne2009 B. Lohman-Payne, J. A. Slyker, B. A. Richardson, C. Farquhar, M. Majiwa, E. Maleche-Obimbo, D. Mbori-Ngacha, J. Overbaugh, S. Rowland-Jones, and G. John-Stewart. Infants with Late Breast Milk Acquisition of HIV-1 Generate Interferon-gamma Responses More Rapidly than Infants with Early Peripartum Acquisition. Clin. Exp. Immunol., 156(3):511-517, Jun 2009. PubMed ID: 19438605. Show all entries for this paper.


Displaying record number 1133

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location p17(74-86 LAI)
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Subtype B
Species (MHC/HLA) human(A*30:02)
Immunogen  
Experimental methods  
Keywords optimal epitope, A-list

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 1171

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location p17( SF2)
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Species (MHC/HLA) human(A*30:02)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons, immunodominance

Notes

References

Goulder2000 P. J. Goulder, C. Brander, K. Annamalai, N. Mngqundaniso, U. Govender, Y. Tang, S. He, K. E. Hartman, C. A. O'Callaghan, G. S. Ogg, M. A. Altfeld, E. S. Rosenberg, H. Cao, S. A. Kalams, M. Hammond, M. Bunce, S. I. Pelton, S. A. Burchett, K. McIntosh, H. M. Coovadia, and B. D. Walker. Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children. J. Virol., 74:5679-90, 2000. PubMed ID: 10823876. Show all entries for this paper.


Displaying record number 1760

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location p17(76-86)
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Epitope Name RY11 (p17)
Species (MHC/HLA) human(A*30:02)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Goulder2001 P. J. Goulder, M. M. Addo, M. A. Altfeld, E. S. Rosenberg, Y. Tang, U. Govender, N. Mngqundaniso, K. Annamalai, T. U. Vogel, M. Hammond, M. Bunce, H. M. Coovadia, and B. D. Walker. Rapid Definition of Five Novel HLA-A*3002-Restricted Human Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Epitopes by Elispot and Intracellular Cytokine Staining Assays. J. Virol., 75(3):1339-1347, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1339. PubMed ID: 11152507. Show all entries for this paper.


Displaying record number 1971

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location p17(76-86)
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Epitope Name Gag-RY11; p17-RY11
Subtype B
Species (MHC/HLA) human(A*30:02)
Immunogen HIV-1 infection
Patient MHC/HLA 00RCH33: A*30:02, A*32:01, B*45:01, B*53:01, C*04:01, C*12:02; A*30:02, A*32:01, B*45:01, B*53:01, C*04:01, C*12:02
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords HAART, ART

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 53283

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location ( C consensus)
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Subtype C
Species (MHC/HLA) human(A*30:02)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords characterizing CD8+ T cells

Notes

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.


Displaying record number 53959

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location ( C consensus)
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Subtype C
Species (MHC/HLA) human(A*30:02)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 55672

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location Gag
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Subtype C
Species (MHC/HLA) human(A*30:02)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Chopera2008 Denis R. Chopera, Zenda Woodman, Koleka Mlisana, Mandla Mlotshwa, Darren P. Martin, Cathal Seoighe, Florette Treurnicht, Debra Assis de Rosa, Winston Hide, Salim Abdool Karim, Clive M. Gray, Carolyn Williamson, and CAPRISA 002 Study Team. Transmission of HIV-1 CTL Escape Variants Provides HLA-Mismatched Recipients with a Survival Advantage. PLoS Pathog, 4(3):e1000033, Mar 2008. PubMed ID: 18369479. Show all entries for this paper.


Displaying record number 57877

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location p17
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Show epitope variants
Subtype C
Species (MHC/HLA) human(A*30:02)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, acute/early infection

Notes

References

Chopera2011 D. R. Chopera, M. Mlotshwa, Z. Woodman, K. Mlisana, D. de Assis Rosa, D. P. Martin, S. Abdool Karim, C. M. Gray, C. Williamson, and CAPRISA 002 Study Team. Virological and Immunological Factors Associated with HIV-1 Differential Disease Progression in HLA-B*58:01-Positive Individuals. J. Virol., 85(14):7070-7080, Jul 2011. PubMed ID: 21613398. Show all entries for this paper.


Displaying record number 58431

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location Gag(76-86)
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Subtype A1
Species (MHC/HLA) human(A*30:02)
Immunogen HIV-1 infection
Patient MHC/HLA ML1992: A*02:01, A*30:01, B*08:01, B*44:15, C*02:02, C*04:01.
Country Kenya
Experimental methods Other
Keywords assay or method development

Notes

References

Liang2011 Binhua Liang, Ma Luo, Joel Scott-Herridge, Christina Semeniuk, Mark Mendoza, Rupert Capina, Brent Sheardown, Hezhao Ji, Joshua Kimani, Blake T. Ball, Gary Van Domselaar, Morag Graham, Shane Tyler, Steven J. M. Jones, and Francis A. Plummer. A Comparison of Parallel Pyrosequencing and Sanger Clone-Based Sequencing and Its Impact on the Characterization of the Genetic Diversity of HIV-1. PLoS One, 6(10):e26745, 2011. PubMed ID: 22039546. Show all entries for this paper.


Displaying record number 58604

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location  
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Show epitope variants
Epitope Name GagRY11
Species (MHC/HLA) human, macaque(A*30:02)
Immunogen HIV-1 infection
Country Malawi
Experimental methods Cytokine production, Tetramer binding
Keywords mother-to-infant transmission

Notes

References

Mahlokozera2011 Tatenda Mahlokozera, Helen H. Kang, Nilu Goonetilleke, Andrea R. Stacey, Rachel V. Lovingood, Thomas N. Denny, Linda Kalilani, James E. G. Bunn, Steve R. Meshnick, Persephone Borrow, Norman L. Letvin, Sallie R. Permar, and Center for HIV/AIDS Vaccine Immunology. The Magnitude and Kinetics of the Mucosal HIV-Specific CD8+ T Lymphocyte Response and Virus RNA Load in Breast Milk. PLoS One, 6(8):e23735, 2011. PubMed ID: 21886819. Show all entries for this paper.


Displaying record number 53664

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location p17
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Epitope Name RY11
Subtype B, C
Species (MHC/HLA) human(B57, B58, B63)
Immunogen HIV-1 infection
Patient MHC/HLA A*02, A*24, B*15:17, B*58, C*03, C*07
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, HLA cross-presentation, optimal epitope, novel epitope

Notes

References

Frahm2005a Nicole Frahm, Sharon Adams, Photini Kiepiela, Caitlyn H. Linde, Hannah S. Hewitt, Mathias Lichterfeld, Kaori Sango, Nancy V. Brown, Eunice Pae, Alysse G. Wurcel, Marcus Altfeld, Margaret E. Feeney, Todd M. Allen, Timothy Roach, M. Anne St. John, Eric S. Daar, Eric Rosenberg, Bette Korber, Francesco Marincola, Bruce D. Walker, Philip J. R. Goulder, and Christian Brander. HLA-B63 Presents HLA-B57/B58-Restricted Cytotoxic T-Lymphocyte Epitopes and Is Associated with Low Human Immunodeficiency Virus Load. J. Virol., 79(16):10218-10225, Aug 2005. PubMed ID: 16051815. Show all entries for this paper.


Displaying record number 54133

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location  
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Species (MHC/HLA) human(B*58)
Immunogen  
Experimental methods  
Keywords optimal epitope, A-list

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 54135

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HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location  
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Species (MHC/HLA) human(B*63)
Immunogen  
Experimental methods  
Keywords optimal epitope, A-list

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 60225

Download this epitope record as JSON.

HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location Gag(76-86)
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Epitope Name RY11
Species (MHC/HLA) human(C*03)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 62717

Download this epitope record as JSON.

HXB2 Location Gag(76-86)
p17(76-86)
DNA(1015..1047)
Gag Epitope Map
Author Location p17(76-86)
Epitope RSLYNTVATLY Epitope Alignment
RSLYNTVATLY epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen engineered
Experimental methods Other, Relative replication capacity assay
Keywords assay or method development, protective allele

Notes

References

Du2017 Yushen Du, Tian-Hao Zhang, Lei Dai, Xiaojuan Zheng, Aleksandr M. Gorin, John Oishi, Ting-Ting Wu, Janice M. Yoshizawa, Xinmin Li, Otto O. Yang, Otoniel Martinez-Maza, Roger Detels, and Ren Sun. Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes. mBio, 8(6), 28 Nov 2017. PubMed ID: 29184023. Show all entries for this paper.


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