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Displaying record number 62491

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HXB2 Location	Pol(977-986) Integrase(262-271) DNA(5013..5042)	Pol Epitope Map
Author Location	Pol(978-986)
Epitope	RRKAKIIRDY	Epitope Alignment
Epitope Name	RY10 978-986
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	CH131: A*23:01, A*29:01, B*15:03, B*45:01, C*02:02, C*06:02
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	dynamics, mutation acquisition

Notes

• Some mutations under study in patient CH0131 (4 Gag and 1 Pol) were found to have strong selection pressure despite not being adaptive-immunologically responsive. Alternate, host-driven selection-pressures, are postulated by the authors to drive this selection.
• Pol epitope RRKAKIIRDY contains the A980V mutation that was fixed to 100% in CH0131 by day 670.

References

Liu2017a Donglai Liu, Chu Wang, Bhavna Hora, Tao Zuo, Nilu Goonetilleke, Michael K. P. Liu, Mark Berrong, Guido Ferrari, Andrew J. McMichael, Tanmoy Bhattacharya, Alan S. Perelson, and Feng Gao. A Strongly Selected Mutation in the HIV-1 Genome Is Independent of T Cell Responses and Neutralizing Antibodies. Retrovirology, 14(1):46, 10 Oct 2017. PubMed ID: 29017536. Show all entries for this paper.