HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 11 matching records:

Displaying record number 53706

HXB2 Location Nef(106-114)
DNA(9112..9138)
Nef Epitope Map
Author Location Nef(106-114)
Epitope RQDILDLWI Epitope Alignment
RQDILDLWI epitope logo
Show epitope variants
Epitope Name RI9
Species (MHC/HLA) human(B13)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, escape, variant cross-reactivity, optimal epitope

Notes

References

Harrer2005b Ellen G. Harrer, Silke Bergmann, Kathrin Eismann, Marion Rittmaier, Andreas Goldwich, Sandra M. Müller, Bernd M. Spriewald, and Thomas Harrer. A Conserved HLA B13-Restricted Cytotoxic T Lymphocyte Epitope in Nef is a Dominant Epitope in HLA B13-Positive HIV-1-Infected Patients. AIDS, 19(7):734-735, 29 Apr 2005. PubMed ID: 15821402. Show all entries for this paper.


Displaying record number 57580

HXB2 Location Nef(106-114)
DNA(9112..9138)
Nef Epitope Map
Author Location Nef(106-114)
Epitope RQDILDLWI Epitope Alignment
RQDILDLWI epitope logo
Epitope Name RI9
Subtype B
Species (MHC/HLA) (B*13)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.


Displaying record number 54122

HXB2 Location Nef(106-114)
DNA(9112..9138)
Nef Epitope Map
Author Location Nef(106-114)
Epitope RQDILDLWI Epitope Alignment
RQDILDLWI epitope logo
Species (MHC/HLA) human(B*13)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 60183

HXB2 Location Nef(106-114)
DNA(9112..9138)
Nef Epitope Map
Author Location Nef(106-114)
Epitope RQDILDLWI Epitope Alignment
RQDILDLWI epitope logo
Epitope Name RI9
Species (MHC/HLA) human(B*13)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 61225

HXB2 Location Nef(106-114)
DNA(9112..9138)
Nef Epitope Map
Author Location Nef(106-114)
Epitope RQDILDLWI Epitope Alignment
RQDILDLWI epitope logo
Show epitope variants
Epitope Name RI9
Subtype B
Species (MHC/HLA) human(B*1302)
Immunogen HIV-1 infection
Experimental methods Relative replication capacity assay
Keywords class I down-regulation by Nef, escape, novel epitope

Notes

References

Shahid2015 Aniqa Shahid, Alex Olvera, Gursev Anmole, Xiaomei T. Kuang, Laura A. Cotton, Montserrat Plana, Christian Brander, Mark A. Brockman, and Zabrina L. Brumme. Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function. J. Virol., 89(22):11557-11571, Nov 2015. PubMed ID: 26355081. Show all entries for this paper.


Displaying record number 60186

HXB2 Location Nef(106-114)
DNA(9112..9138)
Nef Epitope Map
Author Location Nef(106-114)
Epitope RQDILDLWI Epitope Alignment
RQDILDLWI epitope logo
Epitope Name RI9
Species (MHC/HLA) human(B*1524)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60185

HXB2 Location Nef(106-114)
DNA(9112..9138)
Nef Epitope Map
Author Location Nef(106-114)
Epitope RQDILDLWI Epitope Alignment
RQDILDLWI epitope logo
Epitope Name RI9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 56303

HXB2 Location Nef(106-114)
DNA(9112..9138)
Nef Epitope Map
Author Location Nef(106-114 SF2, HXBc2/Bal R5)
Epitope RQDILDLWI Epitope Alignment
RQDILDLWI epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA A24, A25, B18, B7, Cw12, Cw7
Country United States
Experimental methods Cytokine production, Degranulation, CD107a and b cell surface mobilization, Flow cytometric T-cell cytokine assay
Keywords supervised treatment interruptions (STI), immunodominance, variant cross-reactivity, characterizing CD8+ T cells, drug resistance

Notes

References

Daucher2008 Marybeth Daucher, David A. Price, Jason M. Brenchley, Laurie Lamoreaux, Julia A. Metcalf, Catherine Rehm, Elizabeth Nies-Kraske, Elizabeth Urban, Christian Yoder, Diane Rock, Julie Gumkowski, Michael R. Betts, Mark R. Dybul, and Daniel C. Douek. Virological Outcome after Structured Interruption of Antiretroviral Therapy for Human Immunodeficiency Virus Infection Is Associated with the Functional Profile of Virus-Specific CD8+ T Cells. J. Virol., 82(8):4102-4114, Apr 2008. PubMed ID: 18234797. Show all entries for this paper.


Displaying record number 60182

HXB2 Location Nef(106-114)
DNA(9112..9138)
Nef Epitope Map
Author Location Nef(106-114)
Epitope RQDILDLWI Epitope Alignment
RQDILDLWI epitope logo
Epitope Name RI9
Species (MHC/HLA) human(C*01)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60184

HXB2 Location Nef(106-114)
DNA(9112..9138)
Nef Epitope Map
Author Location Nef(106-114)
Epitope RQDILDLWI Epitope Alignment
RQDILDLWI epitope logo
Epitope Name RI9
Species (MHC/HLA) human(C*15)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 53900

HXB2 Location Nef(106-114)
DNA(9112..9138)
Nef Epitope Map
Author Location Nef(106-114)
Epitope RQDILDLWI Epitope Alignment
RQDILDLWI epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country India
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, computational epitope prediction, immunodominance

Notes

References

Thakar2005 Madhuri R. Thakar, Leena S. Bhonge, Samir K. Lakhashe, U. Shankarkumar, Suvarna S. Sane, Smita S. Kulkarni, Bharati A. Mahajan, and Ramesh S. Paranjape. Cytolytic T Lymphocytes (CTLs) from HIV-1 Subtype C-Infected Indian Patients Recognize CTL Epitopes From a Conserved Immunodominant Region of HIV-1 Gag and Nef. J. Infect. Dis., 192(5):749-759, 1 Sep 2005. PubMed ID: 16088824. Show all entries for this paper.


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