HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 15 matching records:

Displaying record number 53984

HXB2 Location Gag(429-437)
p2p7p1p6(66-74)
DNA(2074..2100)
Gag Epitope Map
Author Location ( C consensus)
Epitope RQANFLGKI Epitope Alignment
RQANFLGKI epitope logo
Subtype C
Species (MHC/HLA) human(B*13)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 54091

HXB2 Location Gag(429-437)
p2p7p1p6(66-74)
DNA(2074..2100)
Gag Epitope Map
Author Location  
Epitope RQANFLGKI Epitope Alignment
RQANFLGKI epitope logo
Epitope Name RI9
Species (MHC/HLA) human(B*13)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 54583

HXB2 Location Gag(429-437)
p2p7p1p6(66-74)
DNA(2074..2100)
Gag Epitope Map
Author Location Gag(429-437)
Epitope RQANFLGKI Epitope Alignment
RQANFLGKI epitope logo
Subtype B, C
Species (MHC/HLA) human(B*13)
Immunogen HIV-1 infection
Patient MHC/HLA A*0301, A*3001, B*1301, B*1402, Cw*0602, Cw*0802
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords epitope processing, escape, mutation acquisition, viral fitness and reversion, HLA associated polymorphism

Notes

References

Honeyborne2007 Isobella Honeyborne, Andrew Prendergast, Florencia Pereyra, Alasdair Leslie, Hayley Crawford, Rebecca Payne, Shabashini Reddy, Karen Bishop, Eshia Moodley, Kriebashnie Nair, Mary van der Stok, Noel McCarthy, Christine M. Rousseau, Marylyn Addo, James I. Mullins, Christian Brander, Photini Kiepiela, Bruce D. Walker, and Philip J. R. Goulder. Control of Human Immunodeficiency Virus Type 1 Is Associated with HLA-B*13 and Targeting of Multiple Gag-Specific CD8+ T-Cell Epitopes. J. Virol., 81(7):3667-3672, Apr 2007. PubMed ID: 17251285. Show all entries for this paper.


Displaying record number 60179

HXB2 Location Gag(429-437)
p2p7p1p6(66-74)
DNA(2074..2100)
Gag Epitope Map
Author Location Gag(429-437)
Epitope RQANFLGKI Epitope Alignment
RQANFLGKI epitope logo
Epitope Name RI9
Species (MHC/HLA) human(B*13)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 56379

HXB2 Location Gag(429-437)
p2p7p1p6(66-74)
DNA(2074..2100)
Gag Epitope Map
Author Location p2p7p1p6(429-437)
Epitope RQANFLGKI Epitope Alignment
RQANFLGKI epitope logo
Epitope Name RI9
Subtype B
Species (MHC/HLA) human(B*13)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 57179

HXB2 Location Gag(429-437)
p2p7p1p6(66-74)
DNA(2074..2100)
Gag Epitope Map
Author Location p1(429-437)
Epitope RQANFLGKI Epitope Alignment
RQANFLGKI epitope logo
Show epitope variants
Epitope Name RI9
Subtype C
Species (MHC/HLA) human(B*13)
Immunogen virus
Experimental methods Relative replication capacity assay
Keywords escape

Notes

References

Prado2009 Julia G. Prado, Isobella Honeyborne, Ian Brierley, Maria Carmen Puertas, Javier Martinez-Picado, and Philip J. R. Goulder. Functional Consequences of Human Immunodeficiency Virus Escape from an HLA-B*13-Restricted CD8+ T-Cell Epitope in p1 Gag Protein. J. Virol., 83(2):1018-1025, Jan 2009. PubMed ID: 18945768. Show all entries for this paper.


Displaying record number 55986

HXB2 Location Gag(429-437)
p2p7p1p6(66-74)
DNA(2074..2100)
Gag Epitope Map
Author Location p2p7p1p6
Epitope RQANFLGKI Epitope Alignment
RQANFLGKI epitope logo
Epitope Name RI9(p2p7p1p6)
Subtype B
Species (MHC/HLA) human(B13)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 61572

HXB2 Location Gag(429-437)
p2p7p1p6(66-74)
DNA(2074..2100)
Gag Epitope Map
Author Location Gag(429-437)
Epitope RQANFLGKI Epitope Alignment
RQANFLGKI epitope logo
Species (MHC/HLA) human(B*1302)
Immunogen vaccine
Experimental methods Other
Keywords review, vaccine-induced immune responses, vaccine antigen design, protective allele

Notes

References

Goulder2008 Philip J. R. Goulder and David I. Watkins. Impact of MHC Class I Diversity on Immune Control of Immunodeficiency Virus Replication. Nat. Rev. Immunol., 8(8):619-630, Aug 2008. PubMed ID: 18617886. Show all entries for this paper.


Displaying record number 58785

HXB2 Location Gag(429-437)
p2p7p1p6(66-74)
DNA(2074..2100)
Gag Epitope Map
Author Location p15(429-437)
Epitope RQANFLGKI Epitope Alignment
RQANFLGKI epitope logo
Species (MHC/HLA) human(B*1302)
Immunogen  
Experimental methods  
Keywords review

Notes

References

Goulder2012 Philip J. R. Goulder and Bruce D. Walker. HIV and HLA Class I: An Evolving Relationship. Immunity, 37(3):426-440, 21 Sep 2012. PubMed ID: 22999948. Show all entries for this paper.


Displaying record number 58978

HXB2 Location Gag(429-437)
p2p7p1p6(66-74)
DNA(2074..2100)
Gag Epitope Map
Author Location Gag(429-437)
Epitope RQANFLGKI Epitope Alignment
RQANFLGKI epitope logo
Subtype B
Species (MHC/HLA) human(B*1302)
Immunogen HIV-1 infection
Country Australia, Canada, Spain, Switzerland
Experimental methods Other
Keywords mutation acquisition

Notes

References

Bartha2013 István Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. McLaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López-Galíndez, Concepción Casado, Andri Rauch, Huldrych F. Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M. Allen, Viktor Müller, P. Richard Harrigan, David Heckerman, Amalio Telenti, and Jacques Fellay. A Genome-to-Genome Analysis of Associations between Human Genetic Variation, HIV-1 Sequence Diversity, and Viral Control. eLife, 2:e01123, 2013. PubMed ID: 24171102. Show all entries for this paper.


Displaying record number 61224

HXB2 Location Gag(429-437)
p2p7p1p6(66-74)
DNA(2074..2100)
Gag Epitope Map
Author Location Gag(429-437)
Epitope RQANFLGKI Epitope Alignment
RQANFLGKI epitope logo
Show epitope variants
Epitope Name RI9
Subtype B
Species (MHC/HLA) human(B*1302)
Immunogen HIV-1 infection
Experimental methods Relative replication capacity assay
Keywords escape, novel epitope

Notes

References

Shahid2015 Aniqa Shahid, Alex Olvera, Gursev Anmole, Xiaomei T. Kuang, Laura A. Cotton, Montserrat Plana, Christian Brander, Mark A. Brockman, and Zabrina L. Brumme. Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function. J. Virol., 89(22):11557-11571, Nov 2015. PubMed ID: 26355081. Show all entries for this paper.


Displaying record number 60180

HXB2 Location Gag(429-437)
p2p7p1p6(66-74)
DNA(2074..2100)
Gag Epitope Map
Author Location Gag(429-437)
Epitope RQANFLGKI Epitope Alignment
RQANFLGKI epitope logo
Epitope Name RI9
Species (MHC/HLA) human(B*1524)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 57325

HXB2 Location Gag(429-437)
p2p7p1p6(66-74)
DNA(2074..2100)
Gag Epitope Map
Author Location  
Epitope RQANFLGKI Epitope Alignment
RQANFLGKI epitope logo
Epitope Name Gag429-437
Subtype B
Species (MHC/HLA) human(B*4801)
Immunogen HIV-1 infection
Country Japan
Experimental methods Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords optimal epitope

Notes

References

Murakoshi2009 Hayato Murakoshi, Mitsutaka Kitano, Tomohiro Akahoshi, Yuka Kawashima, Sachi Dohki, Shinichi Oka, and Masafumi Takiguchi. Identification and Characterization of 2 HIV-1 Gag Immunodominant Epitopes Restricted by Asian HLA Allele HLA-B*4801. Hum. Immunol., 70(3):170-174, Mar 2009. PubMed ID: 19167445. Show all entries for this paper.


Displaying record number 58618

HXB2 Location Gag(429-437)
p2p7p1p6(66-74)
DNA(2074..2100)
Gag Epitope Map
Author Location  
Epitope RQANFLGKI Epitope Alignment
RQANFLGKI epitope logo
Epitope Name Gag429-437
Subtype B
Species (MHC/HLA) human(B*4801)
Immunogen HIV-1 infection
Country Japan
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 60181

HXB2 Location Gag(429-437)
p2p7p1p6(66-74)
DNA(2074..2100)
Gag Epitope Map
Author Location Gag(429-437)
Epitope RQANFLGKI Epitope Alignment
RQANFLGKI epitope logo
Epitope Name RI9
Species (MHC/HLA) human(B*52)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


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