HIV molecular immunology database
Found 17 matching records:
Download this epitope record as JSON.
HXB2 Location | Gag(429-437) p2p7p1p6(66-74) DNA(2074..2100) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(429-437) | |
Epitope |
RQANFLGKI
|
Epitope Alignment
|
Epitope Name | RI9 | |
Species (MHC/HLA) | human(B*13) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(429-437) p2p7p1p6(66-74) DNA(2074..2100) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
RQANFLGKI
|
Epitope Alignment
|
Epitope Name | RI9 | |
Species (MHC/HLA) | human(B*13) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(429-437) p2p7p1p6(66-74) DNA(2074..2100) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(429-437) | |
Epitope |
RQANFLGKI
|
Epitope Alignment
|
Subtype | B, C | |
Species (MHC/HLA) | human(B*13) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*03:01, A*30:01, B*13:01, B*14:02, C*06:02, C*08:02 | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining | |
Keywords | epitope processing, escape, mutation acquisition, viral fitness and reversion, HLA associated polymorphism |
Honeyborne2007 Isobella Honeyborne, Andrew Prendergast, Florencia Pereyra, Alasdair Leslie, Hayley Crawford, Rebecca Payne, Shabashini Reddy, Karen Bishop, Eshia Moodley, Kriebashnie Nair, Mary van der Stok, Noel McCarthy, Christine M. Rousseau, Marylyn Addo, James I. Mullins, Christian Brander, Photini Kiepiela, Bruce D. Walker, and Philip J. R. Goulder. Control of Human Immunodeficiency Virus Type 1 Is Associated with HLA-B*13 and Targeting of Multiple Gag-Specific CD8+ T-Cell Epitopes. J. Virol., 81(7):3667-3672, Apr 2007. PubMed ID: 17251285. Show all entries for this paper.
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HXB2 Location | Gag(429-437) p2p7p1p6(66-74) DNA(2074..2100) |
Gag Epitope Map |
---|---|---|
Author Location | ( C consensus) | |
Epitope |
RQANFLGKI
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*13) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, optimal epitope |
Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(429-437) p2p7p1p6(66-74) DNA(2074..2100) |
Gag Epitope Map |
---|---|---|
Author Location | p2p7p1p6(429-437) | |
Epitope |
RQANFLGKI
|
Epitope Alignment
|
Epitope Name | RI9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*13) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, Germany, United States | |
Experimental methods | ||
Keywords | HLA associated polymorphism |
Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.
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HXB2 Location | Gag(429-437) p2p7p1p6(66-74) DNA(2074..2100) |
Gag Epitope Map |
---|---|---|
Author Location | p1(429-437) | |
Epitope |
RQANFLGKI
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | RI9 | |
Subtype | C | |
Species (MHC/HLA) | human(B*13) | |
Immunogen | virus | |
Experimental methods | Relative replication capacity assay | |
Keywords | escape |
Prado2009 Julia G. Prado, Isobella Honeyborne, Ian Brierley, Maria Carmen Puertas, Javier Martinez-Picado, and Philip J. R. Goulder. Functional Consequences of Human Immunodeficiency Virus Escape from an HLA-B*13-Restricted CD8+ T-Cell Epitope in p1 Gag Protein. J. Virol., 83(2):1018-1025, Jan 2009. PubMed ID: 18945768. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(429-437) p2p7p1p6(66-74) DNA(2074..2100) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(429-437) | |
Epitope |
RQANFLGKI
|
Epitope Alignment
|
Epitope Name | RI9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*13) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | S00024: A*02, B*13, B*15, C*06, C*07; S00039: A*31, A*32, B*13, B*35, C*04, C*06 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | dynamics, chronic infection |
Balamurugan2017 Arumugam Balamurugan, Deon Claiborne, Hwee L. Ng, and Otto O. Yang. HIV-1 Epitope Variability Is Associated with T Cell Receptor Repertoire Instability and Breadth. J. Virol., 91(16), 15 Aug 2017. PubMed ID: 28592539. Show all entries for this paper.
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HXB2 Location | Gag(429-437) p2p7p1p6(66-74) DNA(2074..2100) |
Gag Epitope Map |
---|---|---|
Author Location | p2p7p1p6 | |
Epitope |
RQANFLGKI
|
Epitope Alignment
|
Epitope Name | RI9(p2p7p1p6) | |
Subtype | B | |
Species (MHC/HLA) | human(B13) | |
Immunogen | HIV-1 infection | |
Country | China | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | chronic infection |
Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.
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HXB2 Location | Gag(429-437) p2p7p1p6(66-74) DNA(2074..2100) |
Gag Epitope Map |
---|---|---|
Author Location | p15(429-437) | |
Epitope |
RQANFLGKI
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*13:02) | |
Immunogen | ||
Experimental methods | ||
Keywords | review |
Goulder2012 Philip J. R. Goulder and Bruce D. Walker. HIV and HLA Class I: An Evolving Relationship. Immunity, 37(3):426-440, 21 Sep 2012. PubMed ID: 22999948. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(429-437) p2p7p1p6(66-74) DNA(2074..2100) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(429-437) | |
Epitope |
RQANFLGKI
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*13:02) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, Spain, Switzerland | |
Experimental methods | Other | |
Keywords | mutation acquisition |
Bartha2013 István Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. McLaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López-Galíndez, Concepción Casado, Andri Rauch, Huldrych F. Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M. Allen, Viktor Müller, P. Richard Harrigan, David Heckerman, Amalio Telenti, and Jacques Fellay. A Genome-to-Genome Analysis of Associations between Human Genetic Variation, HIV-1 Sequence Diversity, and Viral Control. eLife, 2:e01123, 2013. PubMed ID: 24171102. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(429-437) p2p7p1p6(66-74) DNA(2074..2100) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(429-437) | |
Epitope |
RQANFLGKI
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | RI9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*13:02) | |
Immunogen | HIV-1 infection | |
Experimental methods | Relative replication capacity assay | |
Keywords | escape, novel epitope |
Shahid2015 Aniqa Shahid, Alex Olvera, Gursev Anmole, Xiaomei T. Kuang, Laura A. Cotton, Montserrat Plana, Christian Brander, Mark A. Brockman, and Zabrina L. Brumme. Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function. J. Virol., 89(22):11557-11571, Nov 2015. PubMed ID: 26355081. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(429-437) p2p7p1p6(66-74) DNA(2074..2100) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(429-437) | |
Epitope |
RQANFLGKI
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*13:02) | |
Immunogen | vaccine | |
Experimental methods | Other | |
Keywords | review, vaccine-induced immune responses, vaccine antigen design, protective allele |
Goulder2008 Philip J. R. Goulder and David I. Watkins. Impact of MHC Class I Diversity on Immune Control of Immunodeficiency Virus Replication. Nat. Rev. Immunol., 8(8):619-630, Aug 2008. PubMed ID: 18617886. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(429-437) p2p7p1p6(66-74) DNA(2074..2100) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(429-437) | |
Epitope |
RQANFLGKI
|
Epitope Alignment
|
Epitope Name | RI9 | |
Species (MHC/HLA) | human(B*15:24) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(429-437) p2p7p1p6(66-74) DNA(2074..2100) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
RQANFLGKI
|
Epitope Alignment
|
Epitope Name | Gag429-437 | |
Subtype | B | |
Species (MHC/HLA) | human(B*48:01) | |
Immunogen | HIV-1 infection | |
Country | Japan | |
Experimental methods | Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | optimal epitope |
Murakoshi2009 Hayato Murakoshi, Mitsutaka Kitano, Tomohiro Akahoshi, Yuka Kawashima, Sachi Dohki, Shinichi Oka, and Masafumi Takiguchi. Identification and Characterization of 2 HIV-1 Gag Immunodominant Epitopes Restricted by Asian HLA Allele HLA-B*4801. Hum. Immunol., 70(3):170-174, Mar 2009. PubMed ID: 19167445. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(429-437) p2p7p1p6(66-74) DNA(2074..2100) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
RQANFLGKI
|
Epitope Alignment
|
Epitope Name | Gag429-437 | |
Subtype | B | |
Species (MHC/HLA) | human(B*48:01) | |
Immunogen | HIV-1 infection | |
Country | Japan | |
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(429-437) p2p7p1p6(66-74) DNA(2074..2100) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(429-437) | |
Epitope |
RQANFLGKI
|
Epitope Alignment
|
Epitope Name | RI9 | |
Species (MHC/HLA) | human(B*52) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(429-437) p2p7p1p6(66-74) DNA(2074..2100) |
Gag Epitope Map |
---|---|---|
Author Location | p2p7p1p6(429-437) | |
Epitope |
RQANFLGKI
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | engineered | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | assay or method development, protective allele |
Du2017 Yushen Du, Tian-Hao Zhang, Lei Dai, Xiaojuan Zheng, Aleksandr M. Gorin, John Oishi, Ting-Ting Wu, Janice M. Yoshizawa, Xinmin Li, Otto O. Yang, Otoniel Martinez-Maza, Roger Detels, and Ren Sun. Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes. mBio, 8(6), 28 Nov 2017. PubMed ID: 29184023. Show all entries for this paper.