HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 18 matching records:

Displaying record number 967

HXB2 Location Nef(71-81)
DNA(9007..9039)
Nef Epitope Map
Author Location Nef(75-85 SF2)
Epitope RPQVPLRPMTY Epitope Alignment
RPQVPLRPMTY epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Shiga1996 H. Shiga, T. Shioda, H. Tomiyama, Y. Takamiya, S. Oka, S. Kimura, Y. Yamaguchi, T. Gojoubori, H. G. Rammensee, K. Miwa, and M. Takiguchi. Identification of Multiple HIV-1 Cytotoxic T Cell Epitopes Presented by Human Leukocyte Antigen B35 Molecule. AIDS, 10:1075-1083, 1996. PubMed ID: 8874623. Show all entries for this paper.


Displaying record number 971

HXB2 Location Nef(71-81)
DNA(9007..9039)
Nef Epitope Map
Author Location ( SF2)
Epitope RPQVPLRPMTY Epitope Alignment
RPQVPLRPMTY epitope logo
Show epitope variants
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, rate of progression, escape

Notes

References

Kawana1999 A. Kawana, H. Tomiyama, M. Takiguchi, T. Shioda, T. Nakamura, and A. Iwamoto. Accumulation of Specific Amino Acid Substitutions in HLA-B35-Restricted Human Immunodeficiency Virus Type 1 Cytotoxic T Lymphocyte Epitopes. AIDS Res. Hum. Retroviruses, 15:1099-1107, 1999. PubMed ID: 10461830. Show all entries for this paper.


Displaying record number 1420

HXB2 Location Nef(71-81)
DNA(9007..9039)
Nef Epitope Map
Author Location Nef(69-79)
Epitope RPQVPLRPMTY Epitope Alignment
RPQVPLRPMTY epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.


Displaying record number 57333

HXB2 Location Nef(71-81)
DNA(9007..9039)
Nef Epitope Map
Author Location Nef(75-)
Epitope RPQVPLRPMTY Epitope Alignment
RPQVPLRPMTY epitope logo
Show epitope variants
Epitope Name Nef75
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Country Japan
Experimental methods Chromium-release assay, Cytotoxicity assay, Intracellular cytokine staining, Proliferation, Tetramer binding
Keywords binding affinity, escape

Notes

References

Ueno2007 Takamasa Ueno, Yuka Idegami, Chihiro Motozono, Shinichi Oka, and Masafumi Takiguchi. Altering Effects of Antigenic Variations in HIV-1 on Antiviral Effectiveness of HIV-Specific CTLs. J. Immunol., 178(9):5513-5523, 1 May 2007. PubMed ID: 17442933. Show all entries for this paper.


Displaying record number 57338

HXB2 Location Nef(71-81)
DNA(9007..9039)
Nef Epitope Map
Author Location Nef
Epitope RPQVPLRPMTY Epitope Alignment
RPQVPLRPMTY epitope logo
Epitope Name RY11
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Country Japan
Experimental methods Cytokine production, Cytotoxicity assay, Other, Tetramer binding
Keywords binding affinity, TCR usage, optimal epitope

Notes

References

Motozono2009 Chihiro Motozono, Saeko Yanaka, Kouhei Tsumoto, Masafumi Takiguchi, and Takamasa Ueno. Impact of Intrinsic Cooperative Thermodynamics of Peptide-MHC Complexes on Antiviral Activity of HIV-Specific CTL. J. Immunol., 182(9):5528-5536, 1 May 2009. PubMed ID: 19380801. Show all entries for this paper.


Displaying record number 58169

HXB2 Location Nef(71-81)
DNA(9007..9039)
Nef Epitope Map
Author Location Nef(75-85 JRFL-SF2nef)
Epitope RPQVPLRPMTY Epitope Alignment
RPQVPLRPMTY epitope logo
Show epitope variants
Epitope Name RY11
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infected monocyte-derived
Experimental methods Cytotoxicity assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords class I down-regulation by Nef, immunodominance

Notes

References

Mwimanzi2011 Philip Mwimanzi, Zafrul Hasan, Ranya Hassan, Shinya Suzu, Masafumi Takiguchi, and Takamasa Ueno. Effects of Naturally-Arising HIV Nef Mutations on Cytotoxic T Lymphocyte Recognition and Nef's Functionality in Primary Macrophages. Retrovirology, 8:50, 2011. PubMed ID: 21696586. Show all entries for this paper.


Displaying record number 62131

HXB2 Location Nef(71-81) Nef Epitope Map
Author Location Nef(71-81)
Epitope RPQVPLRPMTY Epitope Alignment
RPQVPLRPMTY epitope logo
Show epitope variants
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods Other, Relative replication capacity assay
Keywords escape

Notes

References

Barton2019 John P. Barton, Erasha Rajkoomar, Jaclyn K. Mann, Dariusz K. Murakowski, Mako Toyoda, Macdonald Mahiti, Phillip Mwimanzi, Takamasa Ueno, Arup K. Chakraborty, and Thumbi Ndung'u. Modelling and in vitro testing of the HIV-1 Nef fitness landscape. Virus Evol, 5(2):vez029 doi, Jul 2019. PubMed ID: 31392033 Show all entries for this paper.


Displaying record number 57736

HXB2 Location Nef(71-81)
DNA(9007..9039)
Nef Epitope Map
Author Location Nef
Epitope RPQVPLRPMTY Epitope Alignment
RPQVPLRPMTY epitope logo
Show epitope variants
Epitope Name RY11
Species (MHC/HLA) human(B*35)
Immunogen  
Experimental methods  
Keywords review

Notes

References

Motozono2010 Chihiro Motozono, Philip Mwimanzi, and Takamasa Ueno. Dynamic Interplay between Viral Adaptation and Immune Recognition during HIV-1 Infection. Protein Cell, 1(6):514-519, Jun 2010. PubMed ID: 21204005. Show all entries for this paper.


Displaying record number 55694

HXB2 Location Nef(71-81)
DNA(9007..9039)
Nef Epitope Map
Author Location Nef(75-85)
Epitope RPQVPLRPMTY Epitope Alignment
RPQVPLRPMTY epitope logo
Show epitope variants
Epitope Name RY11
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Country Japan
Experimental methods CTL suppression of replication, Cytokine production, HLA binding, Intracellular cytokine staining, Other, Tetramer binding
Keywords class I down-regulation by Nef, escape

Notes

References

Ueno2008 Takamasa Ueno, Chihiro Motozono, Sachi Dohki, Philip Mwimanzi, Susanne Rauch, Oliver T. Fackler, Shinichi Oka, and Masafumi Takiguchi. CTL-Mediated Selective Pressure Influences Dynamic Evolution and Pathogenic Functions of HIV-1 Nef. J. Immunol., 180(2):1107-1116, 15 Jan 2008. PubMed ID: 18178851. Show all entries for this paper.


Displaying record number 58619

HXB2 Location Nef(71-81)
DNA(9007..9039)
Nef Epitope Map
Author Location Nef
Epitope RPQVPLRPMTY Epitope Alignment
RPQVPLRPMTY epitope logo
Epitope Name RY11
Subtype B
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Country Japan
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 57805

HXB2 Location Nef(71-81)
DNA(9007..9039)
Nef Epitope Map
Author Location Nef
Epitope RPQVPLRPMTY Epitope Alignment
RPQVPLRPMTY epitope logo
Subtype B
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction, HLA associated polymorphism

Notes

References

Almeida2011 Coral-Ann M. Almeida, Corine Bronke, Steven G. Roberts, Elizabeth McKinnon, Niamh M. Keane, Abha Chopra, Carl Kadie, Jonathan Carlson, David W. Haas, Sharon A. Riddler, Richard Haubrich, David Heckerman, Simon Mallal, and Mina John. Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts to Inflate CD8 T Cell Responses against Nef and HLA-Adapted Variant Epitopes. J. Immunol., 187(5):2502-2513, 1 Sep 2011. PubMed ID: 21821798. Show all entries for this paper.


Displaying record number 61889

HXB2 Location Nef(71-81)
DNA(9007..9039)
Nef Epitope Map
Author Location Nef(71-81)
Epitope RPQVPLRPMTY Epitope Alignment
RPQVPLRPMTY epitope logo
Show epitope variants
Epitope Name RY11
Subtype B
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Intracellular cytokine staining, Tetramer binding
Keywords escape, HLA associated polymorphism

Notes

References

Murakoshi2018a Hayato Murakoshi, Madoka Koyanagi, Tomohiro Akahoshi, Takayuki Chikata, Nozomi Kuse, Hiroyuki Gatanaga, Sarah L. Rowland-Jones, Shinichi Oka, and Masafumi Takiguchi. Impact of a Single HLA-A*24:02-Associated Escape Mutation on the Detrimental Effect of HLA-B*35:01 in HIV-1 Control. EBioMedicine, 36:103-112, Oct 2018. PubMed ID: 30249546. Show all entries for this paper.


Displaying record number 1342

HXB2 Location Nef(71-81)
DNA(9007..9039)
Nef Epitope Map
Author Location Nef(75-85)
Epitope RPQVPLRPMTY Epitope Alignment
RPQVPLRPMTY epitope logo
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tomiyama2000a H. Tomiyama, S. Oka, G. S. Ogg, S. Ida, A. J. McMichael, and M. Takiguchi. Expansion of HIV-1-specific CD28- CD45RA- CD8+ T cells in chronically HIV-1-infected individuals. AIDS, 14(13):2049-51, 8 Sep 2000. PubMed ID: 10997412. Show all entries for this paper.


Displaying record number 968

HXB2 Location Nef(71-81)
DNA(9007..9039)
Nef Epitope Map
Author Location Nef(75-85 SF2)
Epitope RPQVPLRPMTY Epitope Alignment
RPQVPLRPMTY epitope logo
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tomiyama1997 H. Tomiyama, K. Miwa, H. Shiga, Y. I. Moore, S. Oka, A. Iwamoto, Y. Kaneko, and M. Takiguchi. Evidence of Presentation of Multiple HIV-1 Cytotoxic T Lymphocyte Epitopes by HLA-B*3501 Molecules That Are Associated with the Accelerated Progression of AIDS. J. Immunol., 158:5026-5034, 1997. PubMed ID: 9144523. Show all entries for this paper.


Displaying record number 59269

HXB2 Location Nef(71-81)
DNA(9007..9039)
Nef Epitope Map
Author Location Nef
Epitope RPQVPLRPMTY Epitope Alignment
RPQVPLRPMTY epitope logo
Epitope Name RY11
Subtype B
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Country Japan
Experimental methods Flow cytometric T-cell cytokine assay, HLA binding, TCR binding, Tetramer binding
Keywords structure

Notes

References

Motozono2014 Chihiro Motozono, Masaru Yokoyama, Hironori Sato, and Takamasa Ueno. Cross-Reactivity Analysis of T Cell Receptors Specific for Overlapping HIV-1 Nef Epitopes of Different Lengths. Microbes Infect., 16(4):320-327, Apr 2014. PubMed ID: 24380790. Show all entries for this paper.


Displaying record number 57672

HXB2 Location Nef(71-81)
DNA(9007..9039)
Nef Epitope Map
Author Location ( SF2)
Epitope RPQVPLRPMTY Epitope Alignment
RPQVPLRPMTY epitope logo
Show epitope variants
Epitope Name RY11
Subtype B
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Country Japan
Experimental methods Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords class I down-regulation by Nef, superinfection, HLA associated polymorphism

Notes

References

Mwimanzi2010 Philip Mwimanzi, Zafrul Hasan, Michiyo Tokunaga, Hiroyuki Gatanaga, Shinichi Oka, and Takamasa Ueno. Naturally Arising HIV-1 Nef Variants Conferring Escape from Cytotoxic T Lymphocytes Influence Viral Entry Co-Receptor Expression and Susceptibility to Superinfection. Biochem. Biophys. Res. Commun., 403(3-4):422-427, 17 Dec 2010. PubMed ID: 21093412. Show all entries for this paper.


Displaying record number 52433

HXB2 Location Nef(71-81)
DNA(9007..9039)
Nef Epitope Map
Author Location Nef
Epitope RPQVPLRPMTY Epitope Alignment
RPQVPLRPMTY epitope logo
Subtype A, B, D
Species (MHC/HLA) human, macaque(B51)
Immunogen HIV-1 infection, vaccine
Experimental methods  
Keywords subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain A clade
Vaccine component p17 Gag, p24 Gag

Notes

References

Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.

Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.


Displaying record number 59228

HXB2 Location Nef(71-81)
DNA(9007..9039)
Nef Epitope Map
Author Location  
Epitope RPQVPLRPMTY Epitope Alignment
RPQVPLRPMTY epitope logo
Show epitope variants
Epitope Name RY11
Subtype B
Species (MHC/HLA) human
Immunogen peptide-HLA interaction
Experimental methods HLA binding, Other
Keywords structure

Notes

References

Yanaka2014 Saeko Yanaka, Takamasa Ueno, Yi Shi, Jianxun Qi, George F. Gao, Kouhei Tsumoto, and Kenji Sugase. Peptide-Dependent Conformational Fluctuation Determines the Stability of the Human Leukocyte Antigen Class I Complex. J. Biol. Chem., 289(35):24680-24690, 29 Aug 2014. PubMed ID: 25028510. Show all entries for this paper.


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