HIV molecular immunology database
Found 18 matching records:
Download this epitope record as JSON.
HXB2 Location | Nef(71-81) DNA(9007..9039) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
RPQVPLRPMTY
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | RY11 | |
Species (MHC/HLA) | human(B*35) | |
Immunogen | ||
Experimental methods | ||
Keywords | review |
Motozono2010 Chihiro Motozono, Philip Mwimanzi, and Takamasa Ueno. Dynamic Interplay between Viral Adaptation and Immune Recognition during HIV-1 Infection. Protein Cell, 1(6):514-519, Jun 2010. PubMed ID: 21204005. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-81) DNA(9007..9039) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
RPQVPLRPMTY
|
Epitope Alignment
|
Epitope Name | RY11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*35) | |
Immunogen | HIV-1 infection | |
Country | Japan | |
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
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HXB2 Location | Nef(71-81) DNA(9007..9039) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(75-85) | |
Epitope |
RPQVPLRPMTY
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | RY11 | |
Species (MHC/HLA) | human(B*35) | |
Immunogen | HIV-1 infection | |
Country | Japan | |
Experimental methods | CTL suppression of replication, Cytokine production, HLA binding, Intracellular cytokine staining, Other, Tetramer binding | |
Keywords | class I down-regulation by Nef, escape |
Ueno2008 Takamasa Ueno, Chihiro Motozono, Sachi Dohki, Philip Mwimanzi, Susanne Rauch, Oliver T. Fackler, Shinichi Oka, and Masafumi Takiguchi. CTL-Mediated Selective Pressure Influences Dynamic Evolution and Pathogenic Functions of HIV-1 Nef. J. Immunol., 180(2):1107-1116, 15 Jan 2008. PubMed ID: 18178851. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-81) DNA(9007..9039) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(75-85 SF2) | |
Epitope |
RPQVPLRPMTY
|
Epitope Alignment
|
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Shiga1996 H. Shiga, T. Shioda, H. Tomiyama, Y. Takamiya, S. Oka, S. Kimura, Y. Yamaguchi, T. Gojoubori, H. G. Rammensee, K. Miwa, and M. Takiguchi. Identification of Multiple HIV-1 Cytotoxic T Cell Epitopes Presented by Human Leukocyte Antigen B35 Molecule. AIDS, 10:1075-1083, 1996. PubMed ID: 8874623. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-81) DNA(9007..9039) |
Nef Epitope Map |
---|---|---|
Author Location | ( SF2) | |
Epitope |
RPQVPLRPMTY
|
Epitope Alignment
|
Show epitope variants | ||
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | binding affinity, rate of progression, escape |
Kawana1999 A. Kawana, H. Tomiyama, M. Takiguchi, T. Shioda, T. Nakamura, and A. Iwamoto. Accumulation of Specific Amino Acid Substitutions in HLA-B35-Restricted Human Immunodeficiency Virus Type 1 Cytotoxic T Lymphocyte Epitopes. AIDS Res. Hum. Retroviruses, 15:1099-1107, 1999. PubMed ID: 10461830. Show all entries for this paper.
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HXB2 Location | Nef(71-81) DNA(9007..9039) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(69-79) | |
Epitope |
RPQVPLRPMTY
|
Epitope Alignment
|
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.
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HXB2 Location | Nef(71-81) DNA(9007..9039) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(75-) | |
Epitope |
RPQVPLRPMTY
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | Nef75 | |
Subtype | B | |
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Country | Japan | |
Experimental methods | Chromium-release assay, Cytotoxicity assay, Intracellular cytokine staining, Proliferation, Tetramer binding | |
Keywords | binding affinity, escape |
Ueno2007 Takamasa Ueno, Yuka Idegami, Chihiro Motozono, Shinichi Oka, and Masafumi Takiguchi. Altering Effects of Antigenic Variations in HIV-1 on Antiviral Effectiveness of HIV-Specific CTLs. J. Immunol., 178(9):5513-5523, 1 May 2007. PubMed ID: 17442933. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-81) DNA(9007..9039) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
RPQVPLRPMTY
|
Epitope Alignment
|
Epitope Name | RY11 | |
Subtype | B | |
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Country | Japan | |
Experimental methods | Cytokine production, Cytotoxicity assay, Other, Tetramer binding | |
Keywords | binding affinity, TCR usage, optimal epitope |
Motozono2009 Chihiro Motozono, Saeko Yanaka, Kouhei Tsumoto, Masafumi Takiguchi, and Takamasa Ueno. Impact of Intrinsic Cooperative Thermodynamics of Peptide-MHC Complexes on Antiviral Activity of HIV-Specific CTL. J. Immunol., 182(9):5528-5536, 1 May 2009. PubMed ID: 19380801. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-81) DNA(9007..9039) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(75-85 JRFL-SF2nef) | |
Epitope |
RPQVPLRPMTY
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | RY11 | |
Subtype | B | |
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infected monocyte-derived | |
Experimental methods | Cytotoxicity assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | class I down-regulation by Nef, immunodominance |
Mwimanzi2011 Philip Mwimanzi, Zafrul Hasan, Ranya Hassan, Shinya Suzu, Masafumi Takiguchi, and Takamasa Ueno. Effects of Naturally-Arising HIV Nef Mutations on Cytotoxic T Lymphocyte Recognition and Nef's Functionality in Primary Macrophages. Retrovirology, 8:50, 2011. PubMed ID: 21696586. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-81) DNA(9007..9039) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(71-81) | |
Epitope |
RPQVPLRPMTY
|
Epitope Alignment
|
Show epitope variants | ||
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | escape |
Barton2019 John P. Barton, Erasha Rajkoomar, Jaclyn K. Mann, Dariusz K. Murakowski, Mako Toyoda, Macdonald Mahiti, Phillip Mwimanzi, Takamasa Ueno, Arup K. Chakraborty, and Thumbi Ndung'u. Modelling and In Vitro Testing of the HIV-1 Nef Fitness Landscape. Virus Evol., 5(2):vez029, Jul 2019. PubMed ID: 31392033. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-81) DNA(9007..9039) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(75-85) | |
Epitope |
RPQVPLRPMTY
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*35:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Tomiyama2000a H. Tomiyama, S. Oka, G. S. Ogg, S. Ida, A. J. McMichael, and M. Takiguchi. Expansion of HIV-1-specific CD28- CD45RA- CD8+ T cells in chronically HIV-1-infected individuals. AIDS, 14(13):2049-51, 8 Sep 2000. PubMed ID: 10997412. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-81) DNA(9007..9039) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
RPQVPLRPMTY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*35:01) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | computational epitope prediction, HLA associated polymorphism |
Almeida2011 Coral-Ann M. Almeida, Corine Bronke, Steven G. Roberts, Elizabeth McKinnon, Niamh M. Keane, Abha Chopra, Carl Kadie, Jonathan Carlson, David W. Haas, Sharon A. Riddler, Richard Haubrich, David Heckerman, Simon Mallal, and Mina John. Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts to Inflate CD8 T Cell Responses against Nef and HLA-Adapted Variant Epitopes. J. Immunol., 187(5):2502-2513, 1 Sep 2011. PubMed ID: 21821798. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-81) DNA(9007..9039) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(71-81) | |
Epitope |
RPQVPLRPMTY
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | RY11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*35:01) | |
Immunogen | HIV-1 infection | |
Country | Japan | |
Experimental methods | CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Intracellular cytokine staining, Tetramer binding | |
Keywords | escape, HLA associated polymorphism |
Murakoshi2018a Hayato Murakoshi, Madoka Koyanagi, Tomohiro Akahoshi, Takayuki Chikata, Nozomi Kuse, Hiroyuki Gatanaga, Sarah L. Rowland-Jones, Shinichi Oka, and Masafumi Takiguchi. Impact of a Single HLA-A*24:02-Associated Escape Mutation on the Detrimental Effect of HLA-B*35:01 in HIV-1 Control. EBioMedicine, 36:103-112, Oct 2018. PubMed ID: 30249546. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-81) DNA(9007..9039) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(75-85 SF2) | |
Epitope |
RPQVPLRPMTY
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*35:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Tomiyama1997 H. Tomiyama, K. Miwa, H. Shiga, Y. I. Moore, S. Oka, A. Iwamoto, Y. Kaneko, and M. Takiguchi. Evidence of Presentation of Multiple HIV-1 Cytotoxic T Lymphocyte Epitopes by HLA-B*3501 Molecules That Are Associated with the Accelerated Progression of AIDS. J. Immunol., 158:5026-5034, 1997. PubMed ID: 9144523. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-81) DNA(9007..9039) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
RPQVPLRPMTY
|
Epitope Alignment
|
Epitope Name | RY11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*35:01) | |
Immunogen | HIV-1 infection | |
Country | Japan | |
Experimental methods | Flow cytometric T-cell cytokine assay, HLA binding, TCR binding, Tetramer binding | |
Keywords | structure |
Motozono2014 Chihiro Motozono, Masaru Yokoyama, Hironori Sato, and Takamasa Ueno. Cross-Reactivity Analysis of T Cell Receptors Specific for Overlapping HIV-1 Nef Epitopes of Different Lengths. Microbes Infect., 16(4):320-327, Apr 2014. PubMed ID: 24380790. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-81) DNA(9007..9039) |
Nef Epitope Map |
---|---|---|
Author Location | ( SF2) | |
Epitope |
RPQVPLRPMTY
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | RY11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*35:01) | |
Immunogen | HIV-1 infection | |
Country | Japan | |
Experimental methods | Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | class I down-regulation by Nef, superinfection, HLA associated polymorphism |
Mwimanzi2010 Philip Mwimanzi, Zafrul Hasan, Michiyo Tokunaga, Hiroyuki Gatanaga, Shinichi Oka, and Takamasa Ueno. Naturally Arising HIV-1 Nef Variants Conferring Escape from Cytotoxic T Lymphocytes Influence Viral Entry Co-Receptor Expression and Susceptibility to Superinfection. Biochem. Biophys. Res. Commun., 403(3-4):422-427, 17 Dec 2010. PubMed ID: 21093412. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-81) DNA(9007..9039) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
RPQVPLRPMTY
|
Epitope Alignment
|
Subtype | A, B, D | |
Species (MHC/HLA) | human, macaque(B51) | |
Immunogen | HIV-1 infection, vaccine | |
Experimental methods | ||
Keywords | subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance |
Vaccine type | DNA prime with modified vaccinia Ankara (MVA) boost |
---|---|
Vaccine strain | A clade |
Vaccine component | p17 Gag, p24 Gag |
Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.
Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(71-81) DNA(9007..9039) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
RPQVPLRPMTY
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | RY11 | |
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | peptide-HLA interaction | |
Experimental methods | HLA binding, Other | |
Keywords | structure |
Yanaka2014 Saeko Yanaka, Takamasa Ueno, Yi Shi, Jianxun Qi, George F. Gao, Kouhei Tsumoto, and Kenji Sugase. Peptide-Dependent Conformational Fluctuation Determines the Stability of the Human Leukocyte Antigen Class I Complex. J. Biol. Chem., 289(35):24680-24690, 29 Aug 2014. PubMed ID: 25028510. Show all entries for this paper.