HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 34 matching records:

Displaying record number 60175

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(71-79)
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Epitope Name RM9
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 56480

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Subtype C
Species (MHC/HLA) human(B*07, B*8101)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords viral fitness and reversion, HLA associated polymorphism

Notes

References

Matthews2008 Philippa C. Matthews, Andrew Prendergast, Alasdair Leslie, Hayley Crawford, Rebecca Payne, Christine Rousseau, Morgane Rolland, Isobella Honeyborne, Jonathan Carlson, Carl Kadie, Christian Brander, Karen Bishop, Nonkululeko Mlotshwa, James I. Mullins, Hoosen Coovadia, Thumbi Ndung'u, Bruce D. Walker, David Heckerman, and Philip J. R. Goulder. Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point. J. Virol., 82(17):8548-8559, Sep 2008. PubMed ID: 18596105. Show all entries for this paper.


Displaying record number 57876

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Show epitope variants
Subtype C
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, acute/early infection

Notes

References

Chopera2011 D. R. Chopera, M. Mlotshwa, Z. Woodman, K. Mlisana, D. de Assis Rosa, D. P. Martin, S. Abdool Karim, C. M. Gray, C. Williamson, and CAPRISA 002 Study Team. Virological and Immunological Factors Associated with HIV-1 Differential Disease Progression in HLA-B*58:01-Positive Individuals. J. Virol., 85(14):7070-7080, Jul 2011. PubMed ID: 21613398. Show all entries for this paper.


Displaying record number 59044

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Epitope Name RM9-Nef
Subtype B, C
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection
Country Japan, South Africa, United Kingdom, United States
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, subtype comparisons

Notes

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.


Displaying record number 53261

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef( C consensus)
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Subtype C
Species (MHC/HLA) human(B*0702, B*4201, B*8101, B7, B81)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, HLA cross-presentation

Notes

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.


Displaying record number 56601

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(72-80)
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Epitope Name RM9
Subtype C
Species (MHC/HLA) human(B*0702, B*8101)
Immunogen HIV-1 infection
Country South Africa, Zambia
Experimental methods  
Keywords viral fitness and reversion, HLA associated polymorphism

Notes

References

Goepfert2008 Paul A. Goepfert, Wendy Lumm, Paul Farmer, Philippa Matthews, Andrew Prendergast, Jonathan M. Carlson, Cynthia A. Derdeyn, Jianming Tang, Richard A. Kaslow, Anju Bansal, Karina Yusim, David Heckerman, Joseph Mulenga, Susan Allen, Philip J. R. Goulder, and Eric Hunter. Transmission of HIV-1 Gag Immune Escape Mutations Is Associated with Reduced Viral Load in Linked Recipients. J. Exp. Med., 205(5):1009-1017, 12 May 2008. PubMed ID: 18426987. Show all entries for this paper.


Displaying record number 62132

HXB2 Location Nef(71-79) Nef Epitope Map
Author Location Nef(71-79)
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Show epitope variants
Species (MHC/HLA) human(B*0702, B*8101)
Immunogen HIV-1 infection
Experimental methods Other, Relative replication capacity assay
Keywords escape

Notes

References

Barton2019 John P. Barton, Erasha Rajkoomar, Jaclyn K. Mann, Dariusz K. Murakowski, Mako Toyoda, Macdonald Mahiti, Phillip Mwimanzi, Takamasa Ueno, Arup K. Chakraborty, and Thumbi Ndung'u. Modelling and In Vitro Testing of the HIV-1 Nef Fitness Landscape. Virus Evol., 5(2):vez029, Jul 2019. PubMed ID: 31392033. Show all entries for this paper.


Displaying record number 59270

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Epitope Name RM9
Subtype B
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Country Japan
Experimental methods Flow cytometric T-cell cytokine assay, HLA binding, TCR binding, Tetramer binding
Keywords structure

Notes

References

Motozono2014 Chihiro Motozono, Masaru Yokoyama, Hironori Sato, and Takamasa Ueno. Cross-Reactivity Analysis of T Cell Receptors Specific for Overlapping HIV-1 Nef Epitopes of Different Lengths. Microbes Infect., 16(4):320-327, Apr 2014. PubMed ID: 24380790. Show all entries for this paper.


Displaying record number 60172

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(71-79)
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Epitope Name RM9
Species (MHC/HLA) human(B*3502, B*3503, B*5301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60174

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(71-79)
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Epitope Name RM9
Species (MHC/HLA) human(B*39)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 62239

HXB2 Location Nef(71-79)
DNA(805..834)
Nef Epitope Map
Author Location Nef(71-79)
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Epitope Name Nef-RM9
Subtype C
Species (MHC/HLA) human(B*42)
Immunogen HIV-1 infection
Patient MHC/HLA 517-C: A*3002, A*6802, B*1510, B*4201, Cw*0304, Cw*1701; 517-M: A*3002, A*3004, B*4201, B*5802, Cw*0602, Cw*1701
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords responses in children, mother-to-infant transmission, rate of progression, escape

Notes

References

Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.


Displaying record number 62221

HXB2 Location Nef(71-79)
DNA(805..834)
Nef Epitope Map
Author Location Nef(71-79)
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Epitope Name Nef-RM9
Subtype C
Species (MHC/HLA) human(B*42)
Immunogen HIV-1 infection
Patient MHC/HLA 517-C: A*3002, A*6802, B*1510, B*4201, Cw*0304, Cw*1701
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords responses in children, mother-to-infant transmission, rate of progression, escape

Notes

References

Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.


Displaying record number 55160

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location  
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Epitope Name RM9 ?
Species (MHC/HLA) human(B42)
Immunogen HIV-1 infection
Country South Africa, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords memory cells

Notes

References

Wherry2006 E John Wherry, Cheryl L. Day, Rika Draenert, Joseph D. Miller, Photini Kiepiela, Tonia Woodberry, Christian Brander, Marylyn Addo, Paul Klenerman, Rafi Ahmed, and Bruce D. Walker. HIV-Specific CD8 T Cells Express Low Levels of IL-7Ralpha: Implications for HIV-Specific T Cell Memory. Virology, 353(2):366-373, 30 Sep 2006. PubMed ID: 16860834. Show all entries for this paper.


Displaying record number 55172

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location  
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Epitope Name RM9
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Country South Africa
Experimental methods Intracellular cytokine staining, Proliferation, Tetramer binding
Keywords  

Notes

References

Day2006 Cheryl L. Day, Daniel E. Kaufmann, Photini Kiepiela, Julia A. Brown, Eshia S. Moodley, Sharon Reddy, Elizabeth W. Mackey, Joseph D. Miller, Alasdair J. Leslie, Chantal DePierres, Zenele Mncube, Jaikumar Duraiswamy, Baogong Zhu, Quentin Eichbaum, Marcus Altfeld, E. John Wherry, Hoosen M. Coovadia, Philip J. R. Goulder, Paul Klenerman, Rafi Ahmed, Gordon J. Freeman, and Bruce D. Walker. PD-1 Expression on HIV-Specific T Cells Is Associated with T-Cell Exhaustion and Disease Progression. Nature, 443(7109):350-354, 21 Sep 2006. PubMed ID: 16921384. Show all entries for this paper.


Displaying record number 56219

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location  
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Subtype C
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Patient MHC/HLA A*3001, A*3303, B*5301, B*8101, Cw*0401
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords rate of progression

Notes

References

Gray2009 Clive M. Gray, Mandla Mlotshwa, Catherine Riou, Tiyani Mathebula, Debra de Assis Rosa, Tumelo Mashishi, Cathal Seoighe, Nobubelo Ngandu, Francois van Loggerenberg, Lynn Morris, Koleka Mlisana, Carolyn Williamson, Salim Abdool Karim, and CAPRISA 002 Acute Infection Study Team. Human Immunodeficiency Virus-Specific gamma Interferon Enzyme-Linked Immunospot Assay Responses Targeting Specific Regions of the Proteome during Primary Subtype C Infection Are Poor Predictors of the Course of Viremia and Set Point. J. Virol., 83(1):470-478, Jan 2009. PubMed ID: 18945774. Show all entries for this paper.


Displaying record number 54609

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Epitope Name RM9
Subtype C
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Proliferation, Tetramer binding
Keywords rate of progression

Notes

References

Day2007 Cheryl L. Day, Photini Kiepiela, Alasdair J. Leslie, Mary van der Stok, Kriebashne Nair, Nasreen Ismail, Isobella Honeyborne, Hayley Crawford, Hoosen M. Coovadia, Philip J. R. Goulder, Bruce D. Walker, and Paul Klenerman. Proliferative Capacity of Epitope-Specific CD8 T-cell Responses Is Inversely Related to Viral Load in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 81(1):434-438, Jan 2007. PubMed ID: 17050606. Show all entries for this paper.


Displaying record number 59444

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(71-79)
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Epitope Name Nef-RM9
Subtype C
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Country Botswana, South Africa, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Other, Tetramer binding
Keywords immunodominance

Notes

References

Kloverpris2015 Henrik N Kløverpris, Reuben McGregor, James E. McLaren, Kristin Ladell, Mikkel Harndahl, Anette Stryhn, Jonathan M. Carlson, Catherine Koofhethile, Bram Gerritsen, Can Keşmir, Fabian Chen, Lynn Riddell, Graz Luzzi, Alasdair Leslie, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, David A. Price, and Philip J. Goulder. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J. Immunol., 194(11):5329-5345, 1 Jun 2015. PubMed ID: 25911754. Show all entries for this paper.


Displaying record number 54608

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Epitope Name RM9
Subtype C
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Proliferation, Tetramer binding
Keywords rate of progression

Notes

References

Day2007 Cheryl L. Day, Photini Kiepiela, Alasdair J. Leslie, Mary van der Stok, Kriebashne Nair, Nasreen Ismail, Isobella Honeyborne, Hayley Crawford, Hoosen M. Coovadia, Philip J. R. Goulder, Bruce D. Walker, and Paul Klenerman. Proliferative Capacity of Epitope-Specific CD8 T-cell Responses Is Inversely Related to Viral Load in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 81(1):434-438, Jan 2007. PubMed ID: 17050606. Show all entries for this paper.


Displaying record number 54104

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location  
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Epitope Name RM9
Species (MHC/HLA) human(B*4201)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 54072

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location ( C consensus)
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Subtype C
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 58714

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(70-78)
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Epitope Name Nef-RM9
Subtype C
Species (MHC/HLA) human(B*4201, B*4202)
Immunogen HIV-1 infection
Patient MHC/HLA A*3001, B*4201, Cw*1701; A*3001, B*4202, Cw*1701
Country Botswana, South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Tetramer binding
Keywords HLA associated polymorphism, novel epitope

Notes

References

Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.


Displaying record number 54073

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location ( C consensus)
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Subtype C
Species (MHC/HLA) human(B*4202)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 58629

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location  
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Species (MHC/HLA) (B*4202)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 55975

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Show epitope variants
Epitope Name TM9(Nef)
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords variant cross-reactivity

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 60178

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(71-79)
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Epitope Name RM9
Species (MHC/HLA) human(B*78)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60177

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(71-79)
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Epitope Name RM9
Species (MHC/HLA) human(B*81)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54624

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Show epitope variants
Epitope Name RM9
Subtype C
Species (MHC/HLA) human(B*8101)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, escape, HLA associated polymorphism, elite controllers

Notes

References

Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.


Displaying record number 62218

HXB2 Location Nef(71-79)
DNA(805..834)
Nef Epitope Map
Author Location Nef(71-79)
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Show epitope variants
Epitope Name Nef-RM9
Subtype C
Species (MHC/HLA) human(B*8101)
Immunogen HIV-1 infection
Patient MHC/HLA 133-C: A*6801, A*7401, B*5802, B*8101, Cw*0401, Cw*0602
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords responses in children, mother-to-infant transmission, rate of progression, escape

Notes

References

Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.


Displaying record number 57759

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Subtype C
Species (MHC/HLA) human(B*8101)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, acute/early infection

Notes

References

Mlotshwa2010 Mandla Mlotshwa, Catherine Riou, Denis Chopera, Debra de Assis Rosa, Roman Ntale, Florette Treunicht, Zenda Woodman, Lise Werner, Francois van Loggerenberg, Koleka Mlisana, Salim Abdool Karim, Carolyn Williamson, Clive M Gray, and CAPRISA 002 Study Team. Fluidity of HIV-1-Specific T-Cell Responses during Acute and Early Subtype C HIV-1 Infection and Associations with Early Disease Progression. J. Virol., 84(22):12018-12029, Nov 2010. PubMed ID: 20826686. Show all entries for this paper.


Displaying record number 60176

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(71-79)
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Epitope Name RM9
Species (MHC/HLA) human(B*82)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60171

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(71-79)
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Epitope Name RM9
Species (MHC/HLA) human(C*04)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60173

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(71-79)
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Epitope Name RM9
Species (MHC/HLA) human(C*17)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 57012

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Subtype A1, CRF06_cpx, D
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, computational epitope prediction, vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.


Displaying record number 54193

HXB2 Location Nef(71-79)
DNA(9007..9033)
Nef Epitope Map
Author Location Nef(71-79)
Epitope RPQVPLRPM Epitope Alignment
RPQVPLRPM epitope logo
Show epitope variants
Epitope Name RM9
Subtype C
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Other, Tetramer binding
Keywords supertype, escape, HLA cross-presentation, TCR usage, HLA associated polymorphism

Notes

References

Leslie2006 Alasdair Leslie, David A. Price, Pamela Mkhize, Karen Bishop, Almas Rathod, Cheryl Day, Hayley Crawford, Isobella Honeyborne, Tedi E. Asher, Graz Luzzi, Anne Edwards, Christine M. Rousseau, James I. Mullins, Gareth Tudor-Williams, Vas Novelli, Christian Brander, Daniel C. Douek, Photini Kiepiela, Bruce D. Walker, and Philip J. R. Goulder. Differential Selection Pressure Exerted on HIV by CTL Targeting Identical Epitopes but Restricted by Distinct HLA Alleles from the Same HLA Supertype. J. Immunol., 177(7):4699-4708, 1 Oct 2006. PubMed ID: 16982909. Show all entries for this paper.


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