HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 29 matching records:

Displaying record number 706

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location gp120(298-307)
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Experimental methods  
Keywords epitope processing, TCR usage

Notes

References

Ferris1999 R. L. Ferris, C. Hall, N. V. Sipsas, J. T. Safrit, A. Trocha, R. A. Koup, R. P. Johnson, and R. F. Siliciano. Processing of HIV-1 Envelope Glycoprotein for Class I-Restricted Recognition: Dependence on TAP1/2 and Mechanisms for Cytosolic Localization. J. Immunol., 162:1324-1332, 1999. PubMed ID: 9973386. Show all entries for this paper.

Hammond1995 S. A. Hammond, R. P. Johnson, S. A. Kalams, B. D. Walker, M. Takiguchi, J. T. Safrit, R. A. Koup, and R. F. Siliciano. An Epitope-Selective Transporter Associated with Antigen Presentation TAP-1/2-Independent Pathway and a More General TAP-1/2-Dependent Antigen-Processing Pathway Allow Recognition of the HIV-1 Envelope Glycoprotein by CD8+ CTL. J. Immunol., 154:6140-6156, 1995. Two peptide-processing pathways are utilized for MHC class I presentation of HIV-1 Env epitopes. The previously characterized TAP-1 and TAP-2 dependent pathway can generate all Env epitopes and uses Env protein mislocalized in the cytosol to produce peptides. The second, novel pathway uses a TAP-1/2 independent pathway, and allows a subset of MHC-restricted epitopes to be processed in the endoplasmic reticulum or a Golgi compartment. PubMed ID: 7538543. Show all entries for this paper.


Displaying record number 62124

HXB2 Location gp160(298-307)
gp120(298-307)
gp160 Epitope Map
Author Location gp120(298-307)
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Show epitope variants
Epitope Name B*07-RI10
Subtype B
Species (MHC/HLA) human(B*07)
Immunogen computer prediction
Experimental methods Other, Relative replication capacity assay
Keywords binding affinity, structure, assay or method development, contact residues

Notes

References

Gaiha2019 Gaurav D. Gaiha, Elizabeth J. Rossin, Jonathan Urbach, Christian Landeros, David R. Collins, Chioma Nwonu, Itai Muzhingi, Melis N. Anahtar, Olivia M. Waring, Alicja Piechocka-Trocha, Michael Waring, Daniel P. Worrall, Musie S. Ghebremichael, Ruchi M. Newman, Karen A. Power, Todd M. Allen, James Chodosh, and Bruce D. Walker. Structural Topology Defines Protective CD8+ T Cell Epitopes in the HIV Proteome. Science, 364(6439):480-484, 3 May 2019. PubMed ID: 31048489. Show all entries for this paper.


Displaying record number 57537

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location gp160(298-307)
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Show epitope variants
Epitope Name R10SI
Species (MHC/HLA) human, transgenic mouse(B*07)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords subtype comparisons, vaccine-induced immune responses, variant cross-reactivity, vaccine antigen design

Vaccine Details

Vaccine type polyepitope
Vaccine strain multiple epitope immunogen
Vaccine component HIV-1

Notes

References

Cardinaud2009 Sylvain Cardinaud, Romain Bouziat, Pierre-Simon Rohrlich, Sophie Tourdot, Laurence Weiss, Pierre Langlade-Demoyen, Anne Burgevin, Susana Fiorentino, Peter van Endert, and François A. Lemonnier. Design of a HIV-1-Derived HLA-B07.02-Restricted Polyepitope Construct. AIDS, 23(15):1945-1954, 24 Sep 2009. PubMed ID: 19644347. Show all entries for this paper.


Displaying record number 59150

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location gp120
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Epitope Name RI10
Subtype B
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords elite controllers

Notes

References

Jessen2014 Heiko Jessen, Todd M. Allen, and Hendrik Streeck. How a Single Patient Influenced HIV Research — 15-Year Follow-Up. N. Engl. J. Med., 370(7):682-683, 13 Feb 2014. PubMed ID: 24521131. Show all entries for this paper.


Displaying record number 60169

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location Env(298-307)
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Epitope Name RI10
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 53117

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location Env(302-311)
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Country Spain
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.


Displaying record number 1784

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location gp120(298-307)
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, acute/early infection

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 59246

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location Env(298-307)
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection
Patient MHC/HLA Subject 8: A*0201, A*2402, B*0702, B*4001, Cw*0304, Cw*0702
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords dynamics, acute/early infection, dendritic cells

Notes

References

Melhem2014 Nada M Melhem, Kellie N. Smith, Xiao-Li Huang, Bonnie A Colleton, Weimin Jiang, Robbie B. Mailliard, James I. Mullins, and Charles R. Rinaldo. The Impact of Viral Evolution and Frequency of Variant Epitopes on Primary and Memory Human Immunodeficiency Virus Type 1-Specific CD8+ T Cell Responses. Virology, 450-451:34-48, Feb 2014. PubMed ID: 24503065. Show all entries for this paper.


Displaying record number 702

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location gp120(302-312 HXB2)
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Subtype B
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 60997

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location gp160(298-307)
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Subtype B
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection
Patient MHC/HLA 63794: A*0201, A*0201, B*0701, B*4401, Cw*0702, Cw*0704
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 59050

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location Env
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Epitope Name RI10-Env
Subtype B, C
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection
Country Japan, South Africa, United Kingdom, United States
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, subtype comparisons

Notes

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.


Displaying record number 62225

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(805..834)
gp160 Epitope Map
Author Location Env(298-307)
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Show epitope variants
Epitope Name Env-RI10
Subtype C
Species (MHC/HLA) human(B*42)
Immunogen HIV-1 infection
Patient MHC/HLA 517-C: A*3002, A*6802, B*1510, B*4201, Cw*0304, Cw*1701; 517-M: A*3002, A*3004, B*4201, B*5802, Cw*0602, Cw*1701; 021-C: A*0205, A*2902, B*4201, B*4403, Cw*0210, Cw*1701; 021-M: A*0205, A*3301, B*4201, B*4403, Cw*0210, Cw*1701
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords responses in children, mother-to-infant transmission, rate of progression, escape

Notes

References

Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.


Displaying record number 59441

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location Env(298-307)
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Epitope Name Env-RI10
Subtype C
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Country Botswana, South Africa, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Other, Tetramer binding
Keywords immunodominance, optimal epitope

Notes

References

Kloverpris2015 Henrik N Kløverpris, Reuben McGregor, James E. McLaren, Kristin Ladell, Mikkel Harndahl, Anette Stryhn, Jonathan M. Carlson, Catherine Koofhethile, Bram Gerritsen, Can Keşmir, Fabian Chen, Lynn Riddell, Graz Luzzi, Alasdair Leslie, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, David A. Price, and Philip J. Goulder. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J. Immunol., 194(11):5329-5345, 1 Jun 2015. PubMed ID: 25911754. Show all entries for this paper.


Displaying record number 53333

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location ( C consensus)
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Subtype C
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords characterizing CD8+ T cells

Notes

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.


Displaying record number 58705

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location Env(298-307)
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Epitope Name Env-RI10
Subtype C
Species (MHC/HLA) human(B*4201, B*4202)
Immunogen HIV-1 infection
Patient MHC/HLA A*3001, B*4201, Cw*1701; A*3001, B*4202, Cw*1701
Country Botswana, South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HLA associated polymorphism, novel epitope

Notes

References

Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.


Displaying record number 55031

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location  
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, immunodominance, optimal epitope

Notes

References

Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.


Displaying record number 703

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location gp120(302-312 HXB2)
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Hammond1995 S. A. Hammond, R. P. Johnson, S. A. Kalams, B. D. Walker, M. Takiguchi, J. T. Safrit, R. A. Koup, and R. F. Siliciano. An Epitope-Selective Transporter Associated with Antigen Presentation TAP-1/2-Independent Pathway and a More General TAP-1/2-Dependent Antigen-Processing Pathway Allow Recognition of the HIV-1 Envelope Glycoprotein by CD8+ CTL. J. Immunol., 154:6140-6156, 1995. Two peptide-processing pathways are utilized for MHC class I presentation of HIV-1 Env epitopes. The previously characterized TAP-1 and TAP-2 dependent pathway can generate all Env epitopes and uses Env protein mislocalized in the cytosol to produce peptides. The second, novel pathway uses a TAP-1/2 independent pathway, and allows a subset of MHC-restricted epitopes to be processed in the endoplasmic reticulum or a Golgi compartment. PubMed ID: 7538543. Show all entries for this paper.


Displaying record number 704

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location gp120(302-312 HXB2)
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Wolinsky1996 S. M. Wolinsky, B. T. M. Korber, A. U. Neumann, M. Daniels, K. J. Kuntsman, A. J. Whetsell, M. R. Furtado, Y. Chao, D. D. Ho, J. T. Safrit, and R. A. Koup. Adaptive Evolution of Human Immunodeficiency Virus-Type 1 during the Natural Course of Infection. Science, 272:537-542, 1996. In a longitudinal study of six patients, epitope variation occurred only when there was a notable CTLp frequency and the individual had the appropriate HLA type. PubMed ID: 8614801. Show all entries for this paper.


Displaying record number 707

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location gp120(302-311 subtype B)
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons, immunodominance

Notes

References

Wilson1998b S. E. Wilson, S. L. Pedersen, J. C. Kunich, V. L. Wilkins, D. L. Mann, G. P. Mazzara, J. Tartaglia, C. L. Celum, and H. W. Sheppard. Cross-Clade Envelope Glycoprotein 160-Specific CD8+ Cytotoxic T Lymphocyte Responses in Early HIV Type 1 Clade B Infection. AIDS Res. Hum. Retroviruses, 14:925-937, 1998. PubMed ID: 9686639. Show all entries for this paper.


Displaying record number 1546

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location gp120(303-312 SF2)
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 52168

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location gp120(298-307)
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Epitope Name B7-RI10
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA A3, B7, Cw7
Experimental methods  
Keywords dynamics, supervised treatment interruptions (STI), acute/early infection

Notes

References

Yu2002b Xu G. Yu, Marylyn M. Addo, Eric S. Rosenberg, William R. Rodriguez, Paul K. Lee, Cecily A. Fitzpatrick, Mary N. Johnston, Daryld. Strick, Philip J. R. Goulder, Bruce D. Walker, and Marcus Altfeld. Consistent Patterns in the Development and Immunodominance of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T-Cell Responses Following Acute HIV-1 Infection. J. Virol., 76(17):8690-8701, Sep 2002. PubMed ID: 12163589. Show all entries for this paper.


Displaying record number 52361

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location gp120
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A3, B7, Bw6
Experimental methods  
Keywords HAART, ART

Notes

References

Appay2002 Victor Appay, Pokrath Hansasuta, Julian Sutton, Rachel D. Schrier, Joseph K. Wong, Manohar Furtado, Diane V. Havlir, Steven M. Wolinsky, Andrew J. McMichael, Douglas D. Richman, Sarah L. Rowland-Jones, and Celsa A. Spina. Persistent HIV-1-Specific Cellular Responses Despite Prolonged Therapeutic Viral Suppression. AIDS, 16(2):161-170, 25 Jan 2002. PubMed ID: 11807299. Show all entries for this paper.


Displaying record number 53039

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location gp120
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Koning2004 Fransje A. Koning, Christine A. Jansen, Jos Dekker, Richard A. Kaslow, Nicole Dukers, Debbie van Baarle, Maria Prins, and Hanneke Schuitemaker. Correlates of Resistance to HIV-1 Infection in Homosexual Men with High-Risk Sexual Behaviour. AIDS, 18(8):1117-1126, 21 May 2004. PubMed ID: 15166527. Show all entries for this paper.


Displaying record number 701

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location gp120(302-312 HXB2)
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Safrit1994b J. T. Safrit, A. Y. Lee, C. A. Andrews, and R. A. Koup. A Region of the Third Variable Loop of HIV-1 gp120 Is Recognized by HLA-B7-Restricted CTLs from Two Acute Seroconversion Patients. J. Immunol., 153:3822-3830, 1994. HIV-1 envelope-specific CTL clones were isolated from the peripheral blood of two patients within weeks of seroconversion. These clones were CD8+ and restricted by the HLA-B7 molecule. The minimum epitope was defined, RPNNNTRKSI, with anchor residues at the proline and isoleucine; the anchor residues are relatively well conserved. A Serine to Arginine change at position 9 of the epitope abrogated clone recognition in one of the patients. This amino acid change is one factor that has been associated with a change from a nonsyncytium-inducing to a syncytium-inducing phenotype of HIV-1.. PubMed ID: 7523505. Show all entries for this paper.


Displaying record number 56079

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location Env
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Epitope Name Env1146
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

References

DeGroot2008 Anne S. De Groot, Daniel S. Rivera, Julie A. McMurry, Soren Buus, and William Martin. Identification of Immunogenic HLA-B7 ``Achilles' Heel'' Epitopes within Highly Conserved Regions of HIV. Vaccine, 26(24):3059-3071, 6 Jun 2008. PubMed ID: 18206276. Show all entries for this paper.


Displaying record number 56440

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location gp120
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Epitope Name RI10(gp120)
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 60170

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location Env(298-307)
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Epitope Name RI10
Species (MHC/HLA) human(C*17)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 57240

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location Env(298-307)
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA A*300101, A*330301, B*4201, B*530101
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, acute/early infection, elite controllers

Notes

References

OConnell2009 Karen A. O'Connell, Jie Xu, Anna P. Durbin, Linda G. Apuzzo, Hejab Imteyaz, Thomas M. Williams, Stuart C. Ray, Joseph B. Margolick, Robert F. Siliciano, and Joel N. Blankson. HIV-1 Evolution Following Transmission to an HLA-B*5801-Positive Patient. J. Infect. Dis., 200(12):1820-1824, 15 Dec 2009. PubMed ID: 19909081. Show all entries for this paper.


Displaying record number 705

HXB2 Location gp160(298-307)
gp120(298-307)
DNA(7116..7145)
gp160 Epitope Map
Author Location gp120(303-312)
Epitope RPNNNTRKSI Epitope Alignment
RPNNNTRKSI epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords responses in children, mother-to-infant transmission

Notes

References

Walkerpercom1996 C. Wilson, B. Wilkes, D. Ruhl, and B. Walker. Personal communication, 1996. Defined in the context of the Pediatric AIDS Foundation ARIEL Project, a mother-infant HIV transmission study. Personal communication. Show all entries for this paper.


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