HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 8 matching records:

Displaying record number 57809

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HXB2 Location Nef(77-85)
DNA(9025..9051)
Nef Epitope Map
Author Location Nef
Epitope RPMTYKGAL Epitope Alignment
RPMTYKGAL epitope logo
Subtype B
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction, HLA associated polymorphism

Notes

References

Almeida2011 Coral-Ann M. Almeida, Corine Bronke, Steven G. Roberts, Elizabeth McKinnon, Niamh M. Keane, Abha Chopra, Carl Kadie, Jonathan Carlson, David W. Haas, Sharon A. Riddler, Richard Haubrich, David Heckerman, Simon Mallal, and Mina John. Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts to Inflate CD8 T Cell Responses against Nef and HLA-Adapted Variant Epitopes. J. Immunol., 187(5):2502-2513, 1 Sep 2011. PubMed ID: 21821798. Show all entries for this paper.


Displaying record number 61136

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HXB2 Location Nef(77-85)
DNA(9025..9051)
Nef Epitope Map
Author Location Nef(77-85)
Epitope RPMTYKGAL Epitope Alignment
RPMTYKGAL epitope logo
Show epitope variants
Epitope Name RL9
Subtype B
Species (MHC/HLA) human(B*07:02)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords acute/early infection, variant cross-reactivity

Notes

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61132

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HXB2 Location Nef(77-85)
DNA(9025..9051)
Nef Epitope Map
Author Location Nef
Epitope RPMTYKGAL Epitope Alignment
RPMTYKGAL epitope logo
Show epitope variants
Epitope Name RL9
Subtype C
Species (MHC/HLA) human(B*07:02)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining, Other
Keywords escape, mutation acquisition, HLA associated polymorphism

Notes

References

Carlson2016 Jonathan M. Carlson, Victor Y. Du, Nico Pfeifer, Anju Bansal, Vincent Y. F. Tan, Karen Power, Chanson J. Brumme, Anat Kreimer, Charles E. DeZiel, Nicolo Fusi, Malinda Schaefer, Mark A. Brockman, Jill Gilmour, Matt A. Price, William Kilembe, Richard Haubrich, Mina John, Simon Mallal, Roger Shapiro, John Frater, P. Richard Harrigan, Thumbi Ndung'u, Susan Allen, David Heckerman, John Sidney, Todd M. Allen, Philip J. R. Goulder, Zabrina L. Brumme, Eric Hunter, and Paul A. Goepfert. Impact of Pre-Adapted HIV Transmission. Nat. Med., 22(6):606-613, Jun 2016. PubMed ID: 27183217. Show all entries for this paper.


Displaying record number 53412

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HXB2 Location Nef(77-85)
DNA(9025..9051)
Nef Epitope Map
Author Location Nef(75-83)
Epitope RPMTYKGAL Epitope Alignment
RPMTYKGAL epitope logo
Show epitope variants
Epitope Name RPM
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A68.1, B*07, B*35:03, C*04:01, C*07:02, DQ2, DQ6, DR15, DR17, DR51, DR52
Experimental methods CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords rate of progression, immunodominance, escape

Notes

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.


Displaying record number 53522

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HXB2 Location Nef(77-85)
DNA(9025..9051)
Nef Epitope Map
Author Location Nef
Epitope RPMTYKGAL Epitope Alignment
RPMTYKGAL epitope logo
Epitope Name RL9
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A3, B57, B7, Cw6, Cw7
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 55976

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HXB2 Location Nef(77-85)
DNA(9025..9051)
Nef Epitope Map
Author Location Nef
Epitope RPMTYKGAL Epitope Alignment
RPMTYKGAL epitope logo
Show epitope variants
Epitope Name RL9(Nef)
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords variant cross-reactivity, chronic infection

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 54544

Download this epitope record as JSON.

HXB2 Location Nef(77-85)
DNA(9025..9051)
Nef Epitope Map
Author Location Nef(77-85)
Epitope RPMTYKGAL Epitope Alignment
RPMTYKGAL epitope logo
Show epitope variants
Epitope Name RL9
Subtype B
Species (MHC/HLA) human(B7 supertype)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, acute/early infection, assay or method development, mutation acquisition

Notes

References

Malhotra2007a Uma Malhotra, Fusheng Li, Jessica Nolin, Megan Allison, Hong Zhao, James I. Mullins, Steve Self, and M. Juliana McElrath. Enhanced Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Nef-Specific T Cells Recognizing Multiple Variants in Early HIV-1 Infection. J. Virol., 81(10):5225-5237, May 2007. PubMed ID: 17329342. Show all entries for this paper.


Displaying record number 57011

Download this epitope record as JSON.

HXB2 Location Nef(77-85)
DNA(9025..9051)
Nef Epitope Map
Author Location Nef
Epitope RPMTYKGAL Epitope Alignment
RPMTYKGAL epitope logo
Subtype B, C
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, computational epitope prediction, vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.


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