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Displaying record number 1115

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HXB2 Location	Gag(22-31) p17(22-31) DNA(853..882)	Gag Epitope Map
Author Location	Gag(22-31)
Epitope	RPGGKKRYKL	Epitope Alignment
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

• This B7 epitope is one of three subdominant CTL responses detected in a long-term non-progressor.
• A dominant B7 epitope was defined using conventional methods, and three additional sub-dominant HLA B7 epitopes were defined by first using a non-anchor based strategy, EpiMatrix, to identify 2078 possible epitopes in the autologous HIV-1, followed by B7 anchor residue prediction to narrow the set to 55 peptides for experimental testing.

References

Jin2000 X. Jin, C. G. Roberts, D. F. Nixon, J. T. Safrit, L. Q. Zhang, Y. X. Huang, N. Bhardwaj, B. Jesdale, A. S. DeGroot, and R. A. Koup. Identification of Subdominant Cytotoxic T Lymphocyte Epitopes Encoded by Autologous HIV Type 1 Sequences, Using Dendritic Cell Stimulation and Computer-Driven Algorithm. AIDS Res. Hum. Retroviruses, 16:67-76, 2000. PubMed ID: 10628818. Show all entries for this paper.