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Displaying record number 54590

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HXB2 Location	Gag(22-31) p17(22-31) DNA(853..882)	Gag Epitope Map
Author Location	Gag(22-31)
Epitope	`RPGGKKKYML`	Epitope Alignment
Subtype	A, C, D
Species (MHC/HLA)	human(B07:02, B42:01)
Immunogen	HIV-1 infection
Country	Tanzania
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	rate of progression, immunodominance

Notes

The objectives of this study were to find antiviral epitopic determinants of Gag HIV-specific CTL response and to find 'host HLA-CTL response' correlations. By studying 56 ART-naive subjects including low viral load (LVL) responders, the authors show that subjects expressing the "protective" HLA-B*0702, -B*5801, and -B*8101 have broader Gag epitope recognition which may be abrogated if co-expressed with HLA-B alleles associated with rapid AIDS progression. Also, a negative linear relation was seen between Gag epitope numbers and plasma viral load while a positive relationship was seen with CD4 T-cell count. Finally, LVL subjects recognized specific Gag regions at the N- and C-termini of the protein more often than peptides in the middle of the protein.
Epitope RPGGKKKYML, presented by HLA-B*0702 and B*4201 is strongly associated with LVL. However, the last position RPGGKKKYMl is highly variable.

References

Geldmacher2007a Christof Geldmacher, Jeffrey R. Currier, Eva Herrmann, Antelmo Haule, Ellen Kuta, Francine McCutchan, Lilian Njovu, Steffen Geis, Oliver Hoffmann, Leonard Maboko, Carolyn Williamson, Deborah Birx, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. CD8 T-Cell Recognition of Multiple Epitopes within Specific Gag Regions Is Associated with Maintenance of a Low Steady-State Viremia in Human Immunodeficiency Virus Type 1-Seropositive Patients. J. Virol., 81(5):2440-2248, Mar 2007. PubMed ID: 17182686. Show all entries for this paper.