HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 13 matching records:

Displaying record number 60156

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HXB2 Location Rev(66-75)
DNA(8498..8527)
Rev Epitope Map
Author Location Rev(66-75)
Epitope RPAEPVPLQL Epitope Alignment
RPAEPVPLQL epitope logo
Epitope Name RL10
Species (MHC/HLA) human(A*80)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54797

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HXB2 Location Rev(66-75)
DNA(8498..8527)
Rev Epitope Map
Author Location Rev(66-75)
Epitope RPAEPVPLQL Epitope Alignment
RPAEPVPLQL epitope logo
Epitope Name RL10
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Experimental methods CTL suppression of replication
Keywords class I down-regulation by Nef

Notes

References

Adnan2006 Sama Adnan, Arumugam Balamurugan, Alicja Trocha, Michael S. Bennett, Hwee L. Ng, Ayub Ali, Christian Brander, and Otto O. Yang. Nef Interference with HIV-1-Specific CTL Antiviral Activity Is Epitope Specific. Blood, 108(10):3414-3419, 15 Nov 2006. PubMed ID: 16882705. Show all entries for this paper.


Displaying record number 55517

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HXB2 Location Rev(66-75)
DNA(8498..8527)
Rev Epitope Map
Author Location Rev
Epitope RPAEPVPLQL Epitope Alignment
RPAEPVPLQL epitope logo
Show epitope variants
Epitope Name RL10
Subtype A, B, C, D, F, G
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Country United States
Experimental methods Chromium-release assay, Other
Keywords subtype comparisons

Notes

References

Bennett2008 Michael S. Bennett, Hwee L. Ng, Ayub Ali, and Otto O. Yang. Cross-Clade Detection of HIV-1-Specific Cytotoxic T Lymphocytes Does Not Reflect Cross-Clade Antiviral Activity. J. Infect. Dis., 197(3):390-397, 1 Feb 2008. PubMed ID: 18184090. Show all entries for this paper.


Displaying record number 62760

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HXB2 Location Rev(66-75)
DNA(8498..8527)
Rev Epitope Map
Author Location Rev(66-75)
Epitope RPAEPVPLQL Epitope Alignment
RPAEPVPLQL epitope logo
Show epitope variants
Epitope Name RL10
Subtype B
Species (MHC/HLA) human(B*07)
Immunogen in vitro stimulation or selection
Experimental methods Chromium-release assay, Cytokine production, Gene expression assay/analyses, Other
Keywords characterizing CD8+ T cells

Notes

References

Grossman2019 Mark A. Grossman, Christian Hofmann, Hwee L. Ng, and Otto O. Yang. Suboptimal Stimulation by Weak Agonist Epitope Variants Does Not Drive Dysfunction of HIV-1-Specific Cytotoxic T Lymphocyte Clones. AIDS, 33(10):1565-1574, 1 Aug 2019. PubMed ID: 31306165. Show all entries for this paper.


Displaying record number 60154

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HXB2 Location Rev(66-75)
DNA(8498..8527)
Rev Epitope Map
Author Location Rev(66-75)
Epitope RPAEPVPLQL Epitope Alignment
RPAEPVPLQL epitope logo
Epitope Name RL10
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54088

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HXB2 Location Rev(66-75)
DNA(8498..8527)
Rev Epitope Map
Author Location  
Epitope RPAEPVPLQL Epitope Alignment
RPAEPVPLQL epitope logo
Epitope Name RL10
Species (MHC/HLA) human(B*07)
Immunogen  
Experimental methods  
Keywords optimal epitope, A-list

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 59048

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HXB2 Location Rev(66-75)
DNA(8498..8527)
Rev Epitope Map
Author Location Rev
Epitope RPAEPVPLQL Epitope Alignment
RPAEPVPLQL epitope logo
Epitope Name RL10-Rev
Subtype B, C
Species (MHC/HLA) human(B*07:02)
Immunogen HIV-1 infection
Country Japan, South Africa, United Kingdom, United States
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, subtype comparisons

Notes

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.


Displaying record number 61162

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HXB2 Location Rev(66-75)
DNA(8498..8527)
Rev Epitope Map
Author Location Rev(66-75)
Epitope RPAEPVPLQL Epitope Alignment
RPAEPVPLQL epitope logo
Show epitope variants
Epitope Name RL10
Subtype B
Species (MHC/HLA) human(B*07:02)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords acute/early infection, variant cross-reactivity

Notes

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 58712

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HXB2 Location Rev(66-75)
DNA(8498..8527)
Rev Epitope Map
Author Location Rev(66-75)
Epitope RPAEPVPLQL Epitope Alignment
RPAEPVPLQL epitope logo
Epitope Name Rev-RL10
Subtype C
Species (MHC/HLA) human(B*42:02)
Immunogen HIV-1 infection
Patient MHC/HLA A*30:01, B*42:02, C*17:01
Country Botswana, South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HLA associated polymorphism, novel epitope

Notes

References

Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.


Displaying record number 54760

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HXB2 Location Rev(66-75)
DNA(8498..8527)
Rev Epitope Map
Author Location Rev(66-75)
Epitope RPAEPVPLQL Epitope Alignment
RPAEPVPLQL epitope logo
Epitope Name RL10
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods Chromium-release assay, Other
Keywords binding affinity

Notes

References

Bennett2007 Michael S. Bennett, Hwee L. Ng, Mirabelle Dagarag, Ayub Ali, and Otto O. Yang. Epitope-Dependent Avidity Thresholds for Cytotoxic T-Lymphocyte Clearance of Virus-Infected Cells. J. Virol., 81(10):4973-4980, May 2007. PubMed ID: 17329324. Show all entries for this paper.


Displaying record number 60995

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HXB2 Location Rev(66-75)
DNA(8498..8527)
Rev Epitope Map
Author Location Rev(66-75)
Epitope RPAEPVPLQL Epitope Alignment
RPAEPVPLQL epitope logo
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA 17543: A*01:01, A*02:02, B*07:02, B*15:03, C*02:10, C*07:02
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 60155

Download this epitope record as JSON.

HXB2 Location Rev(66-75)
DNA(8498..8527)
Rev Epitope Map
Author Location Rev(66-75)
Epitope RPAEPVPLQL Epitope Alignment
RPAEPVPLQL epitope logo
Epitope Name RL10
Species (MHC/HLA) human(C*12)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60157

Download this epitope record as JSON.

HXB2 Location Rev(66-75)
DNA(8498..8527)
Rev Epitope Map
Author Location Rev(66-75)
Epitope RPAEPVPLQL Epitope Alignment
RPAEPVPLQL epitope logo
Epitope Name RL10
Species (MHC/HLA) human(C*17)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


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