HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 8 matching records:

Displaying record number 53765

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HXB2 Location Gag(275-283)
p24(143-151)
DNA(1612..1638)
Gag Epitope Map
Author Location Gag(275-283 HXB2)
Epitope RMYSPTSIL Epitope Alignment
RMYSPTSIL epitope logo
Show epitope variants
Subtype B, CRF01_AE
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Viet Nam
Experimental methods HLA binding
Keywords subtype comparisons, computational epitope prediction, escape, variant cross-reactivity, vaccine antigen design

Notes

References

Lazaro2005 Estibaliz Lazaro, Ioannis Theodorou, Elisabeth Legrand, Patricia Recordon-Pinson, Sebastien Boucher, Corinne Capoulade, Thi Hoang Lan, Pham Van Hung, Patrice Debre, and Herve Fleury. Sequences of Clustered Epitopes in Gag and Nef Potentially Presented by Predominant Class I Human Leukocyte Antigen (HLA) Alleles A and B Expressed By Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients in Vietnam. AIDS Res. Hum. Retroviruses, 21(6):586-591, Jun 2005. PubMed ID: 15989466. Show all entries for this paper.


Displaying record number 57192

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HXB2 Location Gag(275-283)
p24(143-151)
DNA(1612..1638)
Gag Epitope Map
Author Location Gag(275-283)
Epitope RMYSPTSIL Epitope Alignment
RMYSPTSIL epitope logo
Epitope Name Gag 275-283
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Patient MHC/HLA A*02, B*57
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, autologous responses, elite controllers

Notes

References

OConnell2010 Karen A. O'Connell, Timothy P. Brennan, Justin R. Bailey, Stuart C. Ray, Robert F. Siliciano, and Joel N. Blankson. Control of HIV-1 in Elite Suppressors Despite Ongoing Replication and Evolution in Plasma Virus. J. Virol., 84(14):7018-7028, Jul 2010. PubMed ID: 20444904. Show all entries for this paper.


Displaying record number 54849

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HXB2 Location Gag(275-283)
p24(143-151)
DNA(1612..1638)
Gag Epitope Map
Author Location Gag( Henan isolate)
Epitope RMYSPTSIL Epitope Alignment
RMYSPTSIL epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Gong2006 Xiaoyan Gong, Xien Gui, Yuxia Zhang, and Po Tien. Screening for CD8 Cytotoxic T Lymphocytes Specific for Gag of Human Immunodeficiency Virus Type 1 Subtype B' Henan Isolate from China and Identification of Novel Epitopes Restricted by the HLA-A2 and HLA-A11 Alleles. J. Gen. Virol., 87(Pt 1):151-158, Jan 2006. PubMed ID: 16361427. Show all entries for this paper.


Displaying record number 52954

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HXB2 Location Gag(275-283)
p24(143-151)
DNA(1612..1638)
Gag Epitope Map
Author Location Gag(275-283)
Epitope RMYSPTSIL Epitope Alignment
RMYSPTSIL epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Proliferation
Keywords vaccine-induced immune responses, variant cross-reactivity

Vaccine Details

Vaccine type lipopeptide
Vaccine strain B clade LAI
Vaccine component Env, Gag, Nef
Adjuvant QS21

Notes

References

Gahery-Segard2003 Hanne Gahéry-Ségard, Gilles Pialoux, Suzanne Figueiredo, Céline Igéa, Mathieu Surenaud, Jessintha Gaston, Helene Gras-Masse, Jean-Paul Lévy, and Jean-Gérard Guillet. Long-Term Specific Immune Responses Induced in Humans by a Human Immunodeficiency Virus Type 1 Lipopeptide Vaccine: Characterization of CD8+-T-Cell Epitopes Recognized. J. Virol., 77(20):11220-11231, Oct 2003. PubMed ID: 14512570. Show all entries for this paper.


Displaying record number 53721

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HXB2 Location Gag(275-283)
p24(143-151)
DNA(1612..1638)
Gag Epitope Map
Author Location Gag(275-283 BRU)
Epitope RMYSPTSIL Epitope Alignment
RMYSPTSIL epitope logo
Subtype B, CRF02_AG
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Cote D'Ivoire
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons

Notes

References

Inwoley2005 André Inwoley, Patricia Recordon-Pinson, Marion Dupuis, Jessintha Gaston, Mathieu Genête, Albert Minga, Franck Letourneur, François Rouet, Jeannine Choppin, Hervé Fleury, Jean-Gérard Guillet, Muriel Andrieu, and ANRS 1220 PRIMO-CI Study Group. Cross-Clade Conservation of HIV Type 1 Nef Immunodominant Regions Recognized by CD8+ T Cells of HIV Type 1 CRF02\_AG-Infected Ivorian (West Africa). AIDS Res. Hum. Retroviruses, 21(7):620-628, Jul 2005. PubMed ID: 16060833. Show all entries for this paper.


Displaying record number 61988

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HXB2 Location Gag(275-283)
p24(143-151)
DNA(1612..1638)
Gag Epitope Map
Author Location  
Epitope RMYSPTSIL Epitope Alignment
RMYSPTSIL epitope logo
Epitope Name RL9
Species (MHC/HLA) human(E*01:03)
Immunogen peptide-HLA interaction
Experimental methods HLA binding, Other, T-cell Elispot
Keywords structure, NK cells

Notes

References

Walters2018 Lucy C. Walters, Karl Harlos, Simon Brackenridge, Daniel Rozbesky, Jordan R. Barrett, Vitul Jain, Thomas S. Walter, Chris A. O'Callaghan, Persephone Borrow, Mireille Toebes, Scott G. Hansen, Jonah B. Sacha, Shaheed Abdulhaqq, Justin M. Greene, Klaus Früh, Emily Marshall, Louis J. Picker, E. Yvonne Jones, Andrew J. McMichael, and Geraldine M. Gillespie. Pathogen-Derived HLA-E Bound Epitopes Reveal Broad Primary Anchor Pocket Tolerability and Conformationally Malleable Peptide Binding. Nat. Commun., 9(1):3137, 7 Aug 2018. PubMed ID: 30087334. Show all entries for this paper.


Displaying record number 59245

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HXB2 Location Gag(275-283)
p24(143-151)
DNA(1612..1638)
Gag Epitope Map
Author Location p24(143-151)
Epitope RMYSPTSIL Epitope Alignment
RMYSPTSIL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA Subject 8: A*02:01, A*24:02, B*07:02, B*40:01, C*03:04, C*07:02
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords dynamics, acute/early infection, dendritic cells

Notes

References

Melhem2014 Nada M Melhem, Kellie N. Smith, Xiao-Li Huang, Bonnie A Colleton, Weimin Jiang, Robbie B. Mailliard, James I. Mullins, and Charles R. Rinaldo. The Impact of Viral Evolution and Frequency of Variant Epitopes on Primary and Memory Human Immunodeficiency Virus Type 1-Specific CD8+ T Cell Responses. Virology, 450-451:34-48, Feb 2014. PubMed ID: 24503065. Show all entries for this paper.


Displaying record number 61066

Download this epitope record as JSON.

HXB2 Location Gag(275-283)
p24(143-151)
DNA(1612..1638)
Gag Epitope Map
Author Location p24(143-151)
Epitope RMYSPTSIL Epitope Alignment
RMYSPTSIL epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA CH077: A*02:05, B*53:01, B*57:01, C*04:01, C*18:01
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords computational epitope prediction, escape, acute/early infection, mutation acquisition

Notes

References

Barton2016 John P. Barton, Nilu Goonetilleke, Thomas C. Butler, Bruce D. Walker, Andrew J. McMichael, and Arup K. Chakraborty. Relative Rate and Location of Intra-Host HIV Evolution to Evade Cellular Immunity Are Predictable. Nat. Commun., 7:11660, 23 May 2016. PubMed ID: 27212475. Show all entries for this paper.


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