HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 18 matching records:

Displaying record number 60153

HXB2 Location Gag(275-282)
p24(143-150)
DNA(1612..1635)
Gag Epitope Map
Author Location Gag(275-282)
Epitope RMYSPTSI Epitope Alignment
RMYSPTSI epitope logo
Epitope Name RI8
Species (MHC/HLA) human(A*24)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 1459

HXB2 Location Gag(275-282)
p24(143-150)
DNA(1612..1635)
Gag Epitope Map
Author Location p24(143-150)
Epitope RMYSPTSI Epitope Alignment
RMYSPTSI epitope logo
Species (MHC/HLA) human(B52)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.


Displaying record number 303

HXB2 Location Gag(275-282)
p24(143-150)
DNA(1612..1635)
Gag Epitope Map
Author Location p24(273-283 IIIB)
Epitope RMYSPTSI Epitope Alignment
RMYSPTSI epitope logo
Epitope Name SL9
Species (MHC/HLA) human(B52)
Immunogen HIV-1 infection
Experimental methods  
Keywords epitope processing, immunodominance, escape

Notes

References

Brander1999a C. Brander, O. O. Yang, N. G. Jones, Y. Lee, P. Goulder, R. P. Johnson, A. Trocha, D. Colbert, C. Hay, S. Buchbinder, C. C. Bergmann, H. J. Zweerink, S. Wolinsky, W. A. Blattner, S. A. Kalams, and B. D. Walker. Efficient Processing of the Immunodominant, HLA-A*0201-Restricted Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitope Despite Multiple Variations in the Epitope Flanking Sequences. J. Virol., 73:10191-10198, 1999. PubMed ID: 10559335. Show all entries for this paper.


Displaying record number 53758

HXB2 Location Gag(275-282)
p24(143-150)
DNA(1612..1635)
Gag Epitope Map
Author Location Gag(275-282)
Epitope RMYSPTSI Epitope Alignment
RMYSPTSI epitope logo
Show epitope variants
Epitope Name RI8
Subtype B
Species (MHC/HLA) human(B52)
Immunogen HIV-1 infection
Patient MHC/HLA A*02, A*68, B*14, B*52, Cw*08, Cw*12
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords escape, optimal epitope

Notes

References

Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.


Displaying record number 54888

HXB2 Location Gag(275-282)
p24(143-150)
DNA(1612..1635)
Gag Epitope Map
Author Location  
Epitope RMYSPTSI Epitope Alignment
RMYSPTSI epitope logo
Species (MHC/HLA) human(B52)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, characterizing CD8+ T cells

Vaccine Details

Vaccine type canarypox, canarypox prime with recombinant protein boost
Vaccine strain B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen
Vaccine component Gag, gp120, gp41, Nef, Pol, Protease

Notes

References

Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.


Displaying record number 55719

HXB2 Location Gag(275-282)
p24(143-150)
DNA(1612..1635)
Gag Epitope Map
Author Location Gag
Epitope RMYSPTSI Epitope Alignment
RMYSPTSI epitope logo
Epitope Name RI8-B*52
Subtype B, F
Species (MHC/HLA) human(B52)
Immunogen HIV-1 infection
Country Argentina
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Dilernia2008 Dario Alberto Dilernia, Leandro Jones, Sabrina Rodriguez, Gabriela Turk, Andrea E Rubio, Sandra Pampuro, Manuel Gomez-Carrillo, Christian Bautista, Gabriel Deluchi, Jorge Benetucci, María Beatriz Lasala, Leonardo Lourtau, Marcelo Horacio Losso, Héctor Perez, Pedro Cahn, and Horacio Salomón. HLA-Driven Convergence of HIV-1 Viral Subtypes B and F Toward the Adaptation to Immune Responses in Human Populations. PLoS ONE, 3(10):e3429, 2008. PubMed ID: 18941505. Show all entries for this paper.


Displaying record number 56048

HXB2 Location Gag(275-282)
p24(143-150)
DNA(1612..1635)
Gag Epitope Map
Author Location p24
Epitope RMYSPTSI Epitope Alignment
RMYSPTSI epitope logo
Epitope Name RI8(p24)
Subtype B
Species (MHC/HLA) human(B52)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 304

HXB2 Location Gag(275-282)
p24(143-150)
DNA(1612..1635)
Gag Epitope Map
Author Location p24(273-283 IIIB)
Epitope RMYSPTSI Epitope Alignment
RMYSPTSI epitope logo
Species (MHC/HLA) human(B52)
Immunogen HIV-1 infection
Experimental methods  
Keywords responses in children, mother-to-infant transmission, escape

Notes

References

Wilson1999a C. C. Wilson, R. C. Brown, B. T. Korber, B. M. Wilkes, D. J. Ruhl, D. Sakamoto, K. Kunstman, K. Luzuriaga, I. C. Hanson, S. M. Widmayer, A. Wiznia, S. Clapp, A. J. Ammann, R. A. Koup, S. M. Wolinsky, and B. D. Walker. Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: The Ariel Project for the Prevention of Transmission of HIV from Mother to Infant. J. Virol., 73:3975-3985, 1999. PubMed ID: 10196293. Show all entries for this paper.


Displaying record number 56376

HXB2 Location Gag(275-282)
p24(143-150)
DNA(1612..1635)
Gag Epitope Map
Author Location p24(275-282)
Epitope RMYSPTSI Epitope Alignment
RMYSPTSI epitope logo
Epitope Name RI8
Subtype B
Species (MHC/HLA) human(B*52)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 60152

HXB2 Location Gag(275-282)
p24(143-150)
DNA(1612..1635)
Gag Epitope Map
Author Location Gag(275-282)
Epitope RMYSPTSI Epitope Alignment
RMYSPTSI epitope logo
Epitope Name RI8
Species (MHC/HLA) human(B*52)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 61778

HXB2 Location Gag(275-282)
p24(143-150)
DNA(1612..1635)
Gag Epitope Map
Author Location  
Epitope RMYSPTSI Epitope Alignment
RMYSPTSI epitope logo
Epitope Name RI8
Subtype B
Species (MHC/HLA) human(B*5201)
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Intracellular cytokine staining
Keywords vaccine-induced immune responses, variant cross-reactivity

Notes

References

Murakoshi2018 Hayato Murakoshi, Chengcheng Zou, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tomáš Hanke, and Masafumi Takiguchi. CD8+ T Cells Specific for Conserved, Cross-Reactive Gag Epitopes with Strong Ability to Suppress HIV-1 Replication. Retrovirology, 15(1):46, 3 Jul 2018. PubMed ID: 29970102. Show all entries for this paper.


Displaying record number 305

HXB2 Location Gag(275-282)
p24(143-150)
DNA(1612..1635)
Gag Epitope Map
Author Location p24(273-283 IIIB)
Epitope RMYSPTSI Epitope Alignment
RMYSPTSI epitope logo
Species (MHC/HLA) human(B*5201)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 58792

HXB2 Location Gag(275-282)
p24(143-150)
DNA(1612..1635)
Gag Epitope Map
Author Location p24(275-282)
Epitope RMYSPTSI Epitope Alignment
RMYSPTSI epitope logo
Species (MHC/HLA) human(B*5201)
Immunogen  
Experimental methods  
Keywords review

Notes

References

Goulder2012 Philip J. R. Goulder and Bruce D. Walker. HIV and HLA Class I: An Evolving Relationship. Immunity, 37(3):426-440, 21 Sep 2012. PubMed ID: 22999948. Show all entries for this paper.


Displaying record number 61147

HXB2 Location Gag(275-282)
p24(143-150)
DNA(1612..1635)
Gag Epitope Map
Author Location  
Epitope RMYSPTSI Epitope Alignment
RMYSPTSI epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human, mouse(B*5201)
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type DNA, modified vaccinia Ankara (MVA), adenovirus
Vaccine strain B clade

Notes

References

Ondondo2016 Beatrice Ondondo, Hayato Murakoshi, Genevieve Clutton, Sultan Abdul-Jawad, Edmund G.-T. Wee, Hiroyuki Gatanaga, Shinichi Oka, Andrew J. McMichael, Masafumi Takiguchi, Bette Korber, and Tomáš Hanke. Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection. Mol. Ther., 24(4):832-842, Apr 2016. PubMed ID: 26743582. Show all entries for this paper.


Displaying record number 61498

HXB2 Location Gag(275-282)
p24(143-150)
DNA(1612..1635)
Gag Epitope Map
Author Location Gag
Epitope RMYSPTSI Epitope Alignment
RMYSPTSI epitope logo
Epitope Name RI8
Subtype B
Species (MHC/HLA) human(B*5201)
Immunogen HIV-1 infection
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords chronic infection

Notes

References

Chikata2017 Takayuki Chikata, Hayato Murakoshi, Madoka Koyanagi, Kazutaka Honda, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Control of HIV-1 by an HLA-B*52:01-C*12:02 Protective Haplotype. J. Infect. Dis., 216(11):1415-1424, 12 Dec 2017. PubMed ID: 28968792. Show all entries for this paper.


Displaying record number 61505

HXB2 Location Gag(275-282)
p24(143-150)
DNA(1612..1635)
Gag Epitope Map
Author Location Gag(275-282)
Epitope RMYSPTSI Epitope Alignment
RMYSPTSI epitope logo
Show epitope variants
Epitope Name GagRI8
Subtype B
Species (MHC/HLA) human(B*5201)
Immunogen HIV-1 infection
Patient MHC/HLA KI-692: ; KI-829: ; KI-902:
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords optimal epitope, chronic infection

Notes

References

Murakoshi2015 Hayato Murakoshi, Tomohiro Akahoshi, Madoka Koyanagi, Takayuki Chikata, Takuya Naruto, Rie Maruyama, Yoshiko Tamura, Naoki Ishizuka, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved Epitopes. J. Virol., 89(10):5330-5339, May 2015. PubMed ID: 25741000. Show all entries for this paper.


Displaying record number 61538

HXB2 Location Gag(275-282)
p24(143-150)
DNA(1612..1635)
Gag Epitope Map
Author Location p24(143-150)
Epitope RMYSPTSI Epitope Alignment
RMYSPTSI epitope logo
Show epitope variants
Epitope Name Gag RI8
Subtype B
Species (MHC/HLA) human(B*5201)
Immunogen HIV-1 infection
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords subtype comparisons, variant cross-reactivity, optimal epitope, novel epitope, chronic infection

Notes

References

Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.


Displaying record number 61338

HXB2 Location Gag(275-282)
p24(143-150)
DNA(1612..1635)
Gag Epitope Map
Author Location Gag
Epitope RMYSPTSI Epitope Alignment
RMYSPTSI epitope logo
Species (MHC/HLA) human
Immunogen vaccine
Country Australia, Brazil, Canada, Dominican Republic, Haiti, Jamaica, Peru, Puerto Rico, United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses, assay or method development, optimal epitope

Vaccine Details

Vaccine type adenovirus type 5 (Ad5)
Vaccine component Gag, Nef, Pol

Notes

References

Fiore-Gartland2016 Andrew Fiore-Gartland, Bryce A. Manso, David P. Friedrich, Erin E. Gabriel, Greg Finak, Zoe Moodie, Tomer Hertz, Stephen C. De Rosa, Nicole Frahm, Peter B. Gilbert, and M Juliana McElrath. Pooled-Peptide Epitope Mapping Strategies Are Efficient and Highly Sensitive: An Evaluation of Methods for Identifying Human T Cell Epitope Specificities in Large-Scale HIV Vaccine Efficacy Trials. PLoS One, 11(2):e0147812, 2016. PubMed ID: 26863315. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Operated by Los Alamos National Security, LLC, for the U.S. Department of Energy's National Nuclear Security Administration
Copyright © 2006-2017 LANS LLC All rights reserved | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health