Search CTL/CD8+ T-Cell Epitope Database

Found 6 matching records:

Displaying record number 55948

HXB2 Location	Pol(511-520) RT(356-365) DNA(3615..3644)	Pol Epitope Map
Author Location	RT
Epitope	`RMRGAHTNDV`	Epitope Alignment
Epitope Name	RV10(RT)
Subtype	B
Species (MHC/HLA)	human(A30)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-gamma assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
An inverse correlation was found between CTL response and viral load.
Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
Previously described HLA-A30-restricted epitope RMRGAHTNDV elicited an immune response in Chinese HIV-1 positive subjects LKTGKYARMRGAHTNDVK.
1 of the 15 HLA-A30 carriers responded to RMRGAHTNDV-containing peptide with average magnitude of CTL response of 90 SFC/million PBMC (author communication and Fig.1).

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.

Displaying record number 60142

HXB2 Location	Pol(511-520) RT(356-365) DNA(3615..3644)	Pol Epitope Map
Author Location	Pol(511-520)
Epitope	`RMRGAHTNDV`	Epitope Alignment
Epitope Name	RV10
Species (MHC/HLA)	human(A*30)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
RMRGAHTNDV had a significantly positive association with HLA A*30; it was recognized by 9/53 A*30-positive subjects and 13/288 A*30-negative subjects.

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.

Displaying record number 1968

HXB2 Location	Pol(511-520) RT(356-365) DNA(3615..3644)	Pol Epitope Map
Author Location	RT(356-365)
Epitope	`RMRGAHTNDV`	Epitope Alignment
Epitope Name	Pol-RV10; RT-RV10
Subtype	B
Species (MHC/HLA)	human(A*3002)
Immunogen	HIV-1 infection
Patient MHC/HLA	A2904, A3002, B1503, B5802, Cw0202, Cw0602; 01RCH50: A2904, A3002, B1503, B5802, Cw0202, Cw0602
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords	novel epitope

Notes

This study monitored epitope responses in HIV-1 infected minority women living in the United States.
24 epitopes were described -- 8 were novel, 8 used new restricting elements but were previously defined epitopes, and 8 were previously described. This epitope was previously described with A*03 restriction and here it is identified with a novel restriction, A*3002.
Serial peptide truncations were used to define optimal epitopes for CTL cell lines isolated from 12 individuals, assayed by a Cr-release.
Subject 01RCH50 also recognized the epitope WRFDSRLAF, Nef(183-191), B*1503.
Among HIV+ individuals who carried HLA A30, 5/16 (31%) recognized this epitope.

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.

Displaying record number 52538

HXB2 Location	Pol(511-520) RT(356-365) DNA(3615..3644)	Pol Epitope Map
Author Location	RT(356-365)
Epitope	`RMRGAHTNDV`	Epitope Alignment
Species (MHC/HLA)	human(A*3002)
Immunogen	HIV-1 infection
Experimental methods
Keywords	optimal epitope

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.

Displaying record number 60143

HXB2 Location	Pol(511-520) RT(356-365) DNA(3615..3644)	Pol Epitope Map
Author Location	Pol(511-520)
Epitope	`RMRGAHTNDV`	Epitope Alignment
Epitope Name	RV10
Species (MHC/HLA)	human(B3502, B3503, B*5301)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
RMRGAHTNDV had a significantly positive association with HLA B*3502,B*3503,B*5301; it was recognized by 5/27 B*3502,B*3503,B*5301-positive subjects and 8/261 B*3502,B*3503,B*5301-negative subjects.

References

Displaying record number 60144

HXB2 Location	Pol(511-520) RT(356-365) DNA(3615..3644)	Pol Epitope Map
Author Location	Pol(511-520)
Epitope	`RMRGAHTNDV`	Epitope Alignment
Epitope Name	RV10
Species (MHC/HLA)	human(C*16)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
RMRGAHTNDV had a significantly positive association with HLA C*16; it was recognized by 3/26 C*16-positive subjects and 5/235 C*16-negative subjects.