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Displaying record number 1279

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HXB2 Location	Gag(76-86) p17(76-86) DNA(1015..1047)	Gag Epitope Map
Author Location	Gag( 96ZM651.8)
Epitope	RLSYNTVATLY	Epitope Alignment
Subtype	C
Species (MHC/HLA)	human(A*30:02)
Immunogen	HIV-1 infection
Country	Botswana
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

• This study provides a survey of CTL responses and full length HIV-1 genome sequences from a C subtype-infected Botswanan cohort.
• Only 3/13 (23.1%) A*3002-positive subjects demonstrated moderate CTL responses to the peptide GTEELRSLYNTVATLYCVHE (residues 71 to 90), which contains the previously described A*3002 epitope RLSYNTVATLY.

References

Novitsky2001 V. Novitsky, N. Rybak, M. F. McLane, P. Gilbert, P. Chigwedere, I. Klein, S. Gaolekwe, S. Y. Chang, T. Peter, I. Thior, T. Ndung'u, F. Vannberg, B. T. Foley, R. Marlink, T. H. Lee, and M. Essex. Identification of human immunodeficiency virus type 1 subtype C Gag-, Tat-, Rev-, and Nef-specific elispot-based cytotoxic T-lymphocyte responses for AIDS vaccine design. J. Virol., 75(19):9210-28, Oct 2001. URL: http://jvi.asm.org/cgi/content/full/75/19/9210. PubMed ID: 11533184. Show all entries for this paper.