HIV molecular immunology database
Found 37 matching records:
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Epitope Name | RY10 | |
Subtype | B | |
Species (MHC/HLA) | human(A*03) | |
Immunogen | in vitro stimulation or selection, HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | TCR usage, assay or method development, chronic infection |
Balamurugan2010 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Rapid T Cell Receptor Delineation Reveals Clonal Expansion Limitation of the Magnitude of the HIV-1-Specific CD8+ T Cell Response. J. Immunol., 185(10):5935-5942, 15 Nov 2010. PubMed ID: 20944001. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Epitope Name | RY10 | |
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | p17(20-29 NL4.3) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Epitope Name | RY9 | |
Subtype | B | |
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infected monocyte-derived, HIV-1 infection | |
Country | United States | |
Experimental methods | Chromium-release assay, Other | |
Keywords | epitope processing, dendritic cells |
Dinter2014 Jens Dinter, Pauline Gourdain, Nicole Y. Lai, Ellen Duong, Edith Bracho-Sanchez, Marijana Rucevic, Paul H. Liebesny, Yang Xu, Mariko Shimada, Musie Ghebremichael, Daniel G. Kavanagh, and Sylvie Le Gall. Different Antigen-Processing Activities in Dendritic Cells, Macrophages, and Monocytes Lead to Uneven Production of HIV Epitopes and Affect CTL Recognition. J. Immunol., 193(9):4322-4334, 1 Nov 2014. PubMed ID: 25230751. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Epitope Name | RY10-G | |
Subtype | B | |
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | S00016: A*03, A*32, B*18, B*40, C*02, C*07 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | dynamics, chronic infection |
Balamurugan2017 Arumugam Balamurugan, Deon Claiborne, Hwee L. Ng, and Otto O. Yang. HIV-1 Epitope Variability Is Associated with T Cell Receptor Repertoire Instability and Breadth. J. Virol., 91(16), 15 Aug 2017. PubMed ID: 28592539. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | RY10 | |
Subtype | A1, B, C, D | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Country | Uganda | |
Experimental methods | HLA binding, Relative replication capacity assay | |
Keywords | subtype comparisons, escape, HLA associated polymorphism |
Kinloch2019 Natalie N. Kinloch, Guinevere Q. Lee, Jonathan M. Carlson, Steven W. Jin, Chanson J. Brumme, Helen Byakwaga, Conrad Muzoora, Mwebesa B. Bwana, Kyle D. Cobarrubias, Peter W. Hunt, Jeff N. Martin, Mary Carrington, David R. Bangsberg, P. Richard Harrigan, Mark A. Brockman, and Zabrina L. Brumme. Genotypic and Mechanistic Characterization of Subtype-Specific HIV Adaptation to Host Cellular Immunity. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30305354. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Epitope Name | RY10 | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | Other | |
Keywords | review, immunodominance, TCR usage, variant cross-reactivity |
Lissina2016 Anna Lissina, Lisa A. Chakrabarti, Masafumi Takiguchi, and Victor Appay. TCR Clonotypes: Molecular Determinants of T-Cell Efficacy against HIV. Curr. Opin. Virol., 16:77-85, Feb 2016. PubMed ID: 26874617. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | p17(20-29 LAI) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | p17(20-29 LAI) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Wilkens1999 B. Wilkens and D. Ruhl. Personal communication, 1999. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | p17-p24(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Epitope Name | RY10 | |
Subtype | B | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Intracellular cytokine staining, Tetramer binding | |
Keywords | binding affinity, TCR usage |
Lissina2014 Anna Lissina, Solène Fastenackels, Maria C. Inglesias, Kristin Ladell, James E. McLaren, Olivia Briceño, Emma Gostick, Laura Papagno, Brigitte Autran, Delphine Sauce, David A. Price, Asier Saez-Cirion, and Victor Appay. The Link between CD8+ T-Cell Antigen-Sensitivity and HIV-Suppressive Capacity Depends on HLA Restriction, Target Epitope and Viral Isolate. AIDS, 28(4):477-486, 20 Feb 2014. PubMed ID: 24384691. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Subtype | A1 | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | ML0415: A*30:02, A*34:02, B*13:02, B*53:01, C*04:01, C*08:04 | |
Country | Kenya | |
Experimental methods | Other | |
Keywords | assay or method development |
Liang2011 Binhua Liang, Ma Luo, Joel Scott-Herridge, Christina Semeniuk, Mark Mendoza, Rupert Capina, Brent Sheardown, Hezhao Ji, Joshua Kimani, Blake T. Ball, Gary Van Domselaar, Morag Graham, Shane Tyler, Steven J. M. Jones, and Francis A. Plummer. A Comparison of Parallel Pyrosequencing and Sanger Clone-Based Sequencing and Its Impact on the Characterization of the Genetic Diversity of HIV-1. PLoS One, 6(10):e26745, 2011. PubMed ID: 22039546. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | p17(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Brander1995a Christian Brander and Bruce Walker. The HLA-Class I Restricted CTL Response in HIV-1 Infection: Identification of Optimal Epitopes. In The HLA-Class I Restricted CTL Response in HIV-1 Infection: Identification of Optimal Epitopes. pages IV--1--IV--9. Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico, 1995. URL: http://hiv-web.lanl.gov/immunology. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | computational epitope prediction, HLA associated polymorphism |
Almeida2011 Coral-Ann M. Almeida, Corine Bronke, Steven G. Roberts, Elizabeth McKinnon, Niamh M. Keane, Abha Chopra, Carl Kadie, Jonathan Carlson, David W. Haas, Sharon A. Riddler, Richard Haubrich, David Heckerman, Simon Mallal, and Mina John. Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts to Inflate CD8 T Cell Responses against Nef and HLA-Adapted Variant Epitopes. J. Immunol., 187(5):2502-2513, 1 Sep 2011. PubMed ID: 21821798. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | p17(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*03:01, A30) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | immunodominance |
Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | p17(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Goulder2000a P. J. Goulder, Y. Tang, S. I. Pelton, and B. D. Walker. HLA-B57-Restricted Cytotoxic T-Lymphocyte Activity in a Single Infected Subject toward Two Optimal Epitopes, One of Which Is Entirely Contained Within the Other. J. Virol., 74:5291-5299, 2000. PubMed ID: 10799606. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | p17 | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Epitope Name | A3-RY11(p17) | |
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | EnvRY10 | |
Subtype | A, B, C, D | |
Species (MHC/HLA) | human(A3) | |
Immunogen | vaccine | |
Patient MHC/HLA | Subject J: A*03, A*24, B*07, B*18, C*07 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other | |
Keywords | subtype comparisons, vaccine-induced immune responses |
Vaccine type | DNA prime with Ad5 boost |
---|---|
Vaccine strain | A clade, B clade, C clade |
Koup2010 Richard A. Koup, Mario Roederer, Laurie Lamoreaux, Jennifer Fischer, Laura Novik, Martha C. Nason, Brenda D. Larkin, Mary E. Enama, Julie E. Ledgerwood, Robert T. Bailer, John R. Mascola, Gary J. Nabel, Barney S. Graham, VRC 009 Study Team, and VRC 010 Study Team. Priming Immunization with DNA Augments Immunogenicity of Recombinant Adenoviral Vectors for Both HIV-1 Specific Antibody and T-Cell Responses. PLoS One, 5(2):e9015, 2010. PubMed ID: 20126394. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | p17(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Species (MHC/HLA) | human(A3, A30, B42, B62) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A2, A3, B44, B7 | |
Country | United States | |
Experimental methods | Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | HAART, ART |
Casazza2005a Joseph P. Casazza, Michael R. Betts, Brenna J. Hill, Jason M. Brenchley, David A. Price, Daniel C. Douek, and Richard A. Koup. Immunologic Pressure within Class I-Restricted Cognate Human Immunodeficiency Virus Epitopes during Highly Active Antiretroviral Therapy. J. Virol., 79(6):3653-3663, Mar 2005. PubMed ID: 15731259. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | p17(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | RY10 | |
Species (MHC/HLA) | human(A*30) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | M-1003: A*24, A*30, B*39, B*47, C*12, C*17; P-1189: A*23, A*24, B*07, B*39, C*12, C*17; P-1031: A*02, A*30, B*13, B*18, C*01, C*05; M-1002: A*30, B*18, B*40, C*02, C*05 | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | responses in children, mother-to-infant transmission, escape, acute/early infection, viral fitness and reversion |
Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Epitope Name | RY10 | |
Species (MHC/HLA) | human(A*30) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | RY10 | |
Subtype | A1, B, C, D | |
Species (MHC/HLA) | human(A*30:01) | |
Immunogen | HIV-1 infection | |
Country | Uganda | |
Experimental methods | HLA binding, Relative replication capacity assay | |
Keywords | subtype comparisons, escape, HLA associated polymorphism |
Kinloch2019 Natalie N. Kinloch, Guinevere Q. Lee, Jonathan M. Carlson, Steven W. Jin, Chanson J. Brumme, Helen Byakwaga, Conrad Muzoora, Mwebesa B. Bwana, Kyle D. Cobarrubias, Peter W. Hunt, Jeff N. Martin, Mary Carrington, David R. Bangsberg, P. Richard Harrigan, Mark A. Brockman, and Zabrina L. Brumme. Genotypic and Mechanistic Characterization of Subtype-Specific HIV Adaptation to Host Cellular Immunity. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30305354. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Epitope Name | Gag-RY10 | |
Subtype | B | |
Species (MHC/HLA) | human(B*15) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, United States | |
Experimental methods | Chromium-release assay | |
Keywords | class I down-regulation by Nef |
Chen2012 Diana Y. Chen, Arumugam Balamurugan, Hwee L. Ng, William G. Cumberland, and Otto O. Yang. Epitope Targeting and Viral Inoculum Are Determinants of Nef-Mediated Immune Evasion of HIV-1 from Cytotoxic T Lymphocytes. Blood, 120(1):100-111, 5 Jul 2012. PubMed ID: 22613796. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Epitope Name | RY10 | |
Species (MHC/HLA) | human(B*15) | |
Immunogen | in vitro stimulation or selection | |
Experimental methods | Chromium-release assay | |
Keywords | assay or method development, variant cross-reactivity, characterizing CD8+ T cells |
Balamurugan2018 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Cross-Reactivity against Multiple HIV-1 Epitopes Is Characteristic of HIV-1-Specific Cytotoxic T Lymphocyte Clones. J. Virol., 92(16), 15 Aug 2018. PubMed ID: 29899094. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Epitope Name | RY10-G | |
Subtype | B | |
Species (MHC/HLA) | human(B*15) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | S00024: A*02, B*13, B*15, C*06, C*07 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | dynamics, chronic infection |
Balamurugan2017 Arumugam Balamurugan, Deon Claiborne, Hwee L. Ng, and Otto O. Yang. HIV-1 Epitope Variability Is Associated with T Cell Receptor Repertoire Instability and Breadth. J. Virol., 91(16), 15 Aug 2017. PubMed ID: 28592539. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Epitope Name | RY10 | |
Species (MHC/HLA) | human(B*15:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Epitope Name | RY10 | |
Species (MHC/HLA) | human(B*15:40) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | p17(20-29 IIIB) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Species (MHC/HLA) | human(B42) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | responses in children, mother-to-infant transmission |
Walkerpercom1996 C. Wilson, B. Wilkes, D. Ruhl, and B. Walker. Personal communication, 1996. Defined in the context of the Pediatric AIDS Foundation ARIEL Project, a mother-infant HIV transmission study. Personal communication. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | p17(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Species (MHC/HLA) | human(B42, B62) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Epitope Name | RY10 | |
Species (MHC/HLA) | human(B*44) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | p17(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Species (MHC/HLA) | human(B62) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Brodie2000 S. J. Brodie, B. K. Patterson, D. A. Lewinsohn, K. Diem, D. Spach, P. D. Greenberg, S. R. Riddell, and L. Corey. HIV-Specific Cytotoxic T Lymphocytes Traffic to Lymph Nodes and Localize at Sites of HIV Replication and Cell Death. J. Clin. Invest., 105:1407-1417, 2000. PubMed ID: 10811848. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | RY10 | |
Subtype | B | |
Species (MHC/HLA) | human(B62) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*01, A*11, B*08, B*15, C*04, C*07 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay | |
Keywords | escape, variant cross-reactivity |
Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | p17(20-29 LAI) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B62) | |
Immunogen | ||
Experimental methods | ||
Keywords | review |
McMichael1994 A. J. McMichael and B. D. Walker. Cytotoxic T Lymphocytes Epitopes: Implications for HIV Vaccine. AIDS, 8S:S155-S173, 1994. Comprehensive review summarizing CTL epitopes that have known HLA type and are fine mapped to indicate epitope boundaries. Anchor residues are indicated when known for different HLA restricted epitopes. Includes a summary of the published literature, as well as much work that was in press or submitted for publication. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Epitope Name | RY10 | |
Species (MHC/HLA) | human(C*02) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Epitope Name | RY10 | |
Species (MHC/HLA) | human(C*06) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Epitope Name | RY10 | |
Species (MHC/HLA) | human(C*14) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Epitope Name | RY10 | |
Species (MHC/HLA) | human(C*16) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | vaccine | |
Country | Australia, Brazil, Canada, Dominican Republic, Haiti, Jamaica, Peru, Puerto Rico, United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | vaccine-induced immune responses, assay or method development, optimal epitope |
Vaccine type | adenovirus type 5 (Ad5) |
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Vaccine component | Gag, Nef, Pol |
Fiore-Gartland2016 Andrew Fiore-Gartland, Bryce A. Manso, David P. Friedrich, Erin E. Gabriel, Greg Finak, Zoe Moodie, Tomer Hertz, Stephen C. De Rosa, Nicole Frahm, Peter B. Gilbert, and M Juliana McElrath. Pooled-Peptide Epitope Mapping Strategies Are Efficient and Highly Sensitive: An Evaluation of Methods for Identifying Human T Cell Epitope Specificities in Large-Scale HIV Vaccine Efficacy Trials. PLoS One, 11(2):e0147812, 2016. PubMed ID: 26863315. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(20-29) p17(20-29) DNA(847..876) |
Gag Epitope Map |
---|---|---|
Author Location | p17(20-29) | |
Epitope |
RLRPGGKKKY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | engineered | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | assay or method development, protective allele |
Du2017 Yushen Du, Tian-Hao Zhang, Lei Dai, Xiaojuan Zheng, Aleksandr M. Gorin, John Oishi, Ting-Ting Wu, Janice M. Yoshizawa, Xinmin Li, Otto O. Yang, Otoniel Martinez-Maza, Roger Detels, and Ren Sun. Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes. mBio, 8(6), 28 Nov 2017. PubMed ID: 29184023. Show all entries for this paper.