HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 31 matching records:

Displaying record number 57392

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location Gag(20-29)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Epitope Name RY10
Subtype B
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection, in vitro stimulation or selection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords TCR usage, assay or method development

Notes

References

Balamurugan2010 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Rapid T Cell Receptor Delineation Reveals Clonal Expansion Limitation of the Magnitude of the HIV-1-Specific CD8+ T Cell Response. J. Immunol., 185(10):5935-5942, 15 Nov 2010. PubMed ID: 20944001. Show all entries for this paper.


Displaying record number 60133

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location Gag(20-29)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Epitope Name RY10
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59128

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location p17(20-29 NL4.3)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Epitope Name RY9
Subtype B
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infected monocyte-derived, HIV-1 infection
Country United States
Experimental methods Chromium-release assay, Other
Keywords epitope processing, dendritic cells

Notes

References

Dinter2014 Jens Dinter, Pauline Gourdain, Nicole Y. Lai, Ellen Duong, Edith Bracho-Sanchez, Marijana Rucevic, Paul H. Liebesny, Yang Xu, Mariko Shimada, Musie Ghebremichael, Daniel G. Kavanagh, and Sylvie Le Gall. Different Antigen-Processing Activities in Dendritic Cells, Macrophages, and Monocytes Lead to Uneven Production of HIV Epitopes and Affect CTL Recognition. J. Immunol., 193(9):4322-4334, 1 Nov 2014. PubMed ID: 25230751. Show all entries for this paper.


Displaying record number 58436

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location Gag(20-29)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Subtype A1
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Country Kenya
Experimental methods Other
Keywords assay or method development

Notes

References

Liang2011 Binhua Liang, Ma Luo, Joel Scott-Herridge, Christina Semeniuk, Mark Mendoza, Rupert Capina, Brent Sheardown, Hezhao Ji, Joshua Kimani, Blake T. Ball, Gary Van Domselaar, Morag Graham, Shane Tyler, Steven J. M. Jones, and Francis A. Plummer. A Comparison of Parallel Pyrosequencing and Sanger Clone-Based Sequencing and Its Impact on the Characterization of the Genetic Diversity of HIV-1. PLoS One, 6(10):e26745, 2011. PubMed ID: 22039546. Show all entries for this paper.


Displaying record number 28

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location p17(20-29 LAI)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Wilkens1999 B. Wilkens and D. Ruhl. Personal communication, 1999. Show all entries for this paper.


Displaying record number 57788

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location Gag
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction, HLA associated polymorphism

Notes

References

Almeida2011 Coral-Ann M. Almeida, Corine Bronke, Steven G. Roberts, Elizabeth McKinnon, Niamh M. Keane, Abha Chopra, Carl Kadie, Jonathan Carlson, David W. Haas, Sharon A. Riddler, Richard Haubrich, David Heckerman, Simon Mallal, and Mina John. Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts to Inflate CD8 T Cell Responses against Nef and HLA-Adapted Variant Epitopes. J. Immunol., 187(5):2502-2513, 1 Sep 2011. PubMed ID: 21821798. Show all entries for this paper.


Displaying record number 1112

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location p17(20-29 LAI)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 26

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location p17(20-29)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Brander1995a Christian Brander and Bruce Walker. The HLA-Class I Restricted CTL Response in HIV-1 Infection: Identification of Optimal Epitopes. In The HLA-Class I Restricted CTL Response in HIV-1 Infection: Identification of Optimal Epitopes. pages IV--1--IV--9. Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico, 1995. URL: http://hiv-web.lanl.gov/immunology. Show all entries for this paper.


Displaying record number 59122

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location p17-p24(20-29)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Epitope Name RY10
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Intracellular cytokine staining, Tetramer binding
Keywords binding affinity, TCR usage

Notes

References

Lissina2014 Anna Lissina, Solène Fastenackels, Maria C. Inglesias, Kristin Ladell, James E. McLaren, Olivia Briceño, Emma Gostick, Laura Papagno, Brigitte Autran, Delphine Sauce, David A. Price, Asier Saez-Cirion, and Victor Appay. The Link between CD8+ T-Cell Antigen-Sensitivity and HIV-Suppressive Capacity Depends on HLA Restriction, Target Epitope and Viral Isolate. AIDS, 28(4):477-486, 20 Feb 2014. PubMed ID: 24384691. Show all entries for this paper.


Displaying record number 61243

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location Gag(20-29)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Epitope Name RY10
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Experimental methods Other
Keywords review, TCR usage

Notes

References

Lissina2016 Anna Lissina, Lisa A. Chakrabarti, Masafumi Takiguchi, and Victor Appay. TCR Clonotypes: Molecular Determinants of T-Cell Efficacy against HIV. Curr. Opin. Virol., 16:77-85, Feb 2016. PubMed ID: 26874617. Show all entries for this paper.


Displaying record number 1114

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location p17(20-29)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Species (MHC/HLA) human(A*0301, A30)
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance

Notes

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.


Displaying record number 20

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location p17(20-29)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Goulder2000a P. J. Goulder, Y. Tang, S. I. Pelton, and B. D. Walker. HLA-B57-Restricted Cytotoxic T-Lymphocyte Activity in a Single Infected Subject toward Two Optimal Epitopes, One of Which Is Entirely Contained Within the Other. J. Virol., 74:5291-5299, 2000. PubMed ID: 10799606. Show all entries for this paper.


Displaying record number 54238

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location p17
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Epitope Name A3-RY11(p17)
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 57682

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location Gag
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Show epitope variants
Epitope Name EnvRY10
Subtype A, B, C, D
Species (MHC/HLA) human(A3)
Immunogen vaccine
Patient MHC/HLA A24, A3, B18, B7, Cw7, Cw7
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords subtype comparisons, vaccine-induced immune responses

Vaccine Details

Vaccine type DNA prime with Ad5 boost
Vaccine strain A clade, B clade, C clade

Notes

References

Koup2010 Richard A. Koup, Mario Roederer, Laurie Lamoreaux, Jennifer Fischer, Laura Novik, Martha C. Nason, Brenda D. Larkin, Mary E. Enama, Julie E. Ledgerwood, Robert T. Bailer, John R. Mascola, Gary J. Nabel, Barney S. Graham, VRC 009 Study Team, and VRC 010 Study Team. Priming Immunization with DNA Augments Immunogenicity of Recombinant Adenoviral Vectors for Both HIV-1 Specific Antibody and T-Cell Responses. PLoS One, 5(2):e9015, 2010. PubMed ID: 20126394. Show all entries for this paper.


Displaying record number 53631

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location p17(20-29)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Species (MHC/HLA) human(A3, A30, B42, B62)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A3, B44, B7
Country United States
Experimental methods Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords HAART, ART

Notes

References

Casazza2005a Joseph P. Casazza, Michael R. Betts, Brenna J. Hill, Jason M. Brenchley, David A. Price, Daniel C. Douek, and Richard A. Koup. Immunologic Pressure within Class I-Restricted Cognate Human Immunodeficiency Virus Epitopes during Highly Active Antiretroviral Therapy. J. Virol., 79(6):3653-3663, Mar 2005. PubMed ID: 15731259. Show all entries for this paper.


Displaying record number 60136

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location Gag(20-29)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Epitope Name RY10
Species (MHC/HLA) human(A*30)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 53839

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location p17(20-29)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Show epitope variants
Epitope Name RY10
Species (MHC/HLA) human(A*30)
Immunogen HIV-1 infection
Patient MHC/HLA M-1003: A*24, A*30, B*39, B*47, Cw*12, Cw*17; P-1189: A*23, A*24, B*07, B*39, Cw*12, Cw*17; P-1031: A*02, A*30, B*13, B*18, Cw*01, Cw*05; M-1002: A*30, B*18, B*40, Cw*02, Cw*05
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords responses in children, mother-to-infant transmission, escape, acute/early infection, viral fitness and reversion

Notes

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.


Displaying record number 58760

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location Gag(20-29)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Epitope Name Gag-RY10
Subtype B
Species (MHC/HLA) human(B*15)
Immunogen HIV-1 infection
Country Australia, Canada, United States
Experimental methods Chromium-release assay
Keywords class I down-regulation by Nef

Notes

References

Chen2012 Diana Y. Chen, Arumugam Balamurugan, Hwee L. Ng, William G. Cumberland, and Otto O. Yang. Epitope Targeting and Viral Inoculum Are Determinants of Nef-Mediated Immune Evasion of HIV-1 from Cytotoxic T Lymphocytes. Blood, 120(1):100-111, 5 Jul 2012. PubMed ID: 22613796. Show all entries for this paper.


Displaying record number 60134

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location Gag(20-29)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Epitope Name RY10
Species (MHC/HLA) human(B*1501)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60139

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location Gag(20-29)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Epitope Name RY10
Species (MHC/HLA) human(B*1540)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 25

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location p17(20-29 IIIB)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Species (MHC/HLA) human(B42)
Immunogen HIV-1 infection
Experimental methods  
Keywords responses in children, mother-to-infant transmission

Notes

References

Walkerpercom1996 C. Wilson, B. Wilkes, D. Ruhl, and B. Walker. Personal communication, 1996. Defined in the context of the Pediatric AIDS Foundation ARIEL Project, a mother-infant HIV transmission study. Personal communication. Show all entries for this paper.


Displaying record number 1447

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location p17(20-29)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Species (MHC/HLA) human(B42, B62)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.


Displaying record number 60141

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location Gag(20-29)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Epitope Name RY10
Species (MHC/HLA) human(B*44)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 27

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location p17(20-29 LAI)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Subtype B
Species (MHC/HLA) human(B62)
Immunogen  
Experimental methods  
Keywords review

Notes

References

McMichael1994 A. J. McMichael and B. D. Walker. Cytotoxic T Lymphocytes Epitopes: Implications for HIV Vaccine. AIDS, 8S:S155-S173, 1994. Comprehensive review summarizing CTL epitopes that have known HLA type and are fine mapped to indicate epitope boundaries. Anchor residues are indicated when known for different HLA restricted epitopes. Includes a summary of the published literature, as well as much work that was in press or submitted for publication. Show all entries for this paper.


Displaying record number 29

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location p17(20-29)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Species (MHC/HLA) human(B62)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Brodie2000 S. J. Brodie, B. K. Patterson, D. A. Lewinsohn, K. Diem, D. Spach, P. D. Greenberg, S. R. Riddell, and L. Corey. HIV-Specific Cytotoxic T Lymphocytes Traffic to Lymph Nodes and Localize at Sites of HIV Replication and Cell Death. J. Clin. Invest., 105:1407-1417, 2000. PubMed ID: 10811848. Show all entries for this paper.


Displaying record number 53748

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location Gag(20-29)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Show epitope variants
Epitope Name RY10
Subtype B
Species (MHC/HLA) human(B62)
Immunogen HIV-1 infection
Patient MHC/HLA A*01, A*11, B*08, B*15, Cw*04, Cw*07
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords escape, variant cross-reactivity

Notes

References

Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.


Displaying record number 60140

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location Gag(20-29)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Epitope Name RY10
Species (MHC/HLA) human(C*02)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60137

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location Gag(20-29)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Epitope Name RY10
Species (MHC/HLA) human(C*06)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60135

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location Gag(20-29)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Epitope Name RY10
Species (MHC/HLA) human(C*14)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60138

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location Gag(20-29)
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Epitope Name RY10
Species (MHC/HLA) human(C*16)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 61331

HXB2 Location Gag(20-29)
p17(20-29)
DNA(847..876)
Gag Epitope Map
Author Location Gag
Epitope RLRPGGKKKY Epitope Alignment
RLRPGGKKKY epitope logo
Species (MHC/HLA) human
Immunogen vaccine
Country Australia, Brazil, Canada, Dominican Republic, Haiti, Jamaica, Peru, Puerto Rico, United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses, assay or method development, optimal epitope

Vaccine Details

Vaccine type adenovirus type 5 (Ad5)
Vaccine component Gag, Nef, Pol

Notes

References

Fiore-Gartland2016 Andrew Fiore-Gartland, Bryce A. Manso, David P. Friedrich, Erin E. Gabriel, Greg Finak, Zoe Moodie, Tomer Hertz, Stephen C. De Rosa, Nicole Frahm, Peter B. Gilbert, and M Juliana McElrath. Pooled-Peptide Epitope Mapping Strategies Are Efficient and Highly Sensitive: An Evaluation of Methods for Identifying Human T Cell Epitope Specificities in Large-Scale HIV Vaccine Efficacy Trials. PLoS One, 11(2):e0147812, 2016. PubMed ID: 26863315. Show all entries for this paper.


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