Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 55704

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HXB2 Location	Gag(20-29) p17(20-29) DNA(847..876)	Gag Epitope Map
Author Location	Gag
Epitope	RLRPGGKKKK	Epitope Alignment
Subtype	B, F
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Country	Argentina
Experimental methods
Keywords	dynamics, escape, HLA associated polymorphism

Notes

• Dynamics of CTL escape mutations was studied theoretically by analyzing plasma samples from 302 subjects (collected over 20 years). HLA associated polymorphisms accumulated in a subtype-specific manner.
• Epitope RLRPGGKKKK with anchor residues at R(L)RPGGKKK(K) contains polymorphisms RLRPGGKKKq and RLRPGGKKKr, that are strongly supported as escape by phylogenetic correction.

References

Dilernia2008 Dario Alberto Dilernia, Leandro Jones, Sabrina Rodriguez, Gabriela Turk, Andrea E Rubio, Sandra Pampuro, Manuel Gomez-Carrillo, Christian Bautista, Gabriel Deluchi, Jorge Benetucci, María Beatriz Lasala, Leonardo Lourtau, Marcelo Horacio Losso, Héctor Perez, Pedro Cahn, and Horacio Salomón. HLA-Driven Convergence of HIV-1 Viral Subtypes B and F Toward the Adaptation to Immune Responses in Human Populations. PLoS ONE, 3(10):e3429, 2008. PubMed ID: 18941505. Show all entries for this paper.

Displaying record number 55912

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HXB2 Location	Gag(20-29) p17(20-29) DNA(847..876)	Gag Epitope Map
Author Location	p17
Epitope	RLRPGGKKKK	Epitope Alignment
Epitope Name	RK9(p17)
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	chronic infection

Notes

• 49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-γ assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.
• An inverse correlation was found between CTL response and viral load.
• Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.
• Previously described HLA-A3-restricted epitope RLRPGGKKKK elicited an immune response in Chinese HIV-1 positive subjects as part of peptide EKIRLRPGGKKKKYRLKHL.
• 2 of the 3 HLA-A3 carriers responded to the RLRPGGKKKK-containing peptide with average magnitude of CTL response of 285 SFC/million PBMC (author communication and Fig.1).

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.