HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 72 matching records:

Displaying record number 58852

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name RK9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country Canada
Experimental methods Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Keywords characterizing CD8+ T cells

Notes

References

Trautmann2012 Lydie Trautmann, Florentin-Martial Mbitikon-Kobo, Jean-Philippe Goulet, Yoav Peretz, Yu Shi, Julien Van Grevenynghe, Francesco Andrea Procopio, Mohamad Rachid Boulassel, Jean-Pierre Routy, Nicolas Chomont, Elias K. Haddad, and Rafick-Pierre Sekaly. Profound Metabolic, Functional, and Cytolytic Differences Characterize HIV-Specific CD8 T Cells in Primary and Chronic HIV Infection. Blood, 120(17):3466-3477, 25 Oct 2012. PubMed ID: 22955926. Show all entries for this paper.


Displaying record number 57408

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name RK9
Subtype B
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection, in vitro stimulation or selection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords TCR usage, assay or method development

Notes

References

Balamurugan2010 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Rapid T Cell Receptor Delineation Reveals Clonal Expansion Limitation of the Magnitude of the HIV-1-Specific CD8+ T Cell Response. J. Immunol., 185(10):5935-5942, 15 Nov 2010. PubMed ID: 20944001. Show all entries for this paper.


Displaying record number 57290

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location  
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name RK9
Subtype B
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Country Barbados, Haiti, Jamaica
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords mother-to-infant transmission, elite controllers

Notes

References

Schneidewind2009 Arne Schneidewind, Yanhua Tang, Mark A. Brockman, Elizabeth G. Ryland, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, M. Anne St. John, Joseph A. Conrad, Spyros A. Kalams, Francine Noel, Todd M. Allen, Celia D. Christie, and Margaret E. Feeney. Maternal Transmission of Human Immunodeficiency Virus Escape Mutations Subverts HLA-B57 Immunodominance but Facilitates Viral Control in the Haploidentical Infant. J. Virol., 83(17):8616-8627, Sep 2009. PubMed ID: 19515764. Show all entries for this paper.


Displaying record number 56356

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name RK9
Subtype B
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 18

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Show epitope variants
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Patient MHC/HLA 003: A*02, A*03, B*07, B*51
Experimental methods  
Keywords review, escape

Notes

References

Goulder1997 P. J. Goulder, A. K. Sewell, D. G. Lalloo, D. A. Price, J. A. Whelan, J. Evans, G. P. Taylor, G. Luzzi, P. Giangrande, R. E. Phillips, and A. J. McMichael. Patterns of Immunodominance in HIV-1-Specific Cytotoxic T Lymphocyte Responses in Two Human Histocompatibility Leukocyte Antigens (HLA)-Identical Siblings with HLA-A*0201 Are Influenced by Epitope Mutation. J. Exp. Med., 8:1423-1433, 1997. Primary human immunodeficiency virus (HIV) infection is controlled principally by HIV-specific cytotoxic T lymphocytes (CTL) to a steady- state level of virus load, which strongly influences the ultimate rate of progression to disease. Epitope selection by CTL may be an important determinant of the degree of immune control over the virus. This report describes the CTL responses of two HLA-identical hemophiliac brothers who were exposed to identical batches of Factor VIII and became seropositive within 10 wk of one another. Both have HLA-A*0201. The CTL responses of the two siblings were very dissimilar, one donor making strong responses to two epitopes within p17 Gag (HLA-A*0201-restricted SLYNTVATL and HLA-A3-restricted RLRPGGKKK). The sibling responded to neither epitope, but made strong responses to two epitopes presented by HLA-B7. This was not the result of differences in presentation of the epitopes. However, mutations in both immunodominant epitopes of the p17 Gag responder were seen in proviral sequences of the nonresponder. We then documented the CTL responses to two HLA-A*0201-restricted epitopes, in Gag (SLYNTVATL) and Pol (ILKEPVHGV) in 22 other HIV-infected donors with HLA-A*0201. The majority (71\%) generated responses to the Gag epitope. In the 29\% of donors failing to respond to the Gag epitope in standard assays, there was evidence of low frequency memory CTL responses using peptide stimulation of PBMC, and most of these donors also showed mutations in or around the Gag epitope. PubMed ID: 9126923. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 60129

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name RK9
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59127

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28 NL4.3)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name RK9
Subtype B
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infected monocyte-derived, HIV-1 infection
Country United States
Experimental methods Chromium-release assay, Other
Keywords epitope processing, dendritic cells

Notes

References

Dinter2014 Jens Dinter, Pauline Gourdain, Nicole Y. Lai, Ellen Duong, Edith Bracho-Sanchez, Marijana Rucevic, Paul H. Liebesny, Yang Xu, Mariko Shimada, Musie Ghebremichael, Daniel G. Kavanagh, and Sylvie Le Gall. Different Antigen-Processing Activities in Dendritic Cells, Macrophages, and Monocytes Lead to Uneven Production of HIV Epitopes and Affect CTL Recognition. J. Immunol., 193(9):4322-4334, 1 Nov 2014. PubMed ID: 25230751. Show all entries for this paper.


Displaying record number 59214

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name Gag 20-28
Subtype B
Species (MHC/HLA) human(A*03)
Immunogen vaccine
Country France
Experimental methods CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Tetramer binding
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type lipopeptide

Notes

References

Figueiredo2014 Suzanne Figueiredo, Benedicte Charmeteau, Mathieu Surenaud, Dominique Salmon, Odile Launay, Jean-Gérard Guillet, Anne Hosmalin, and Hanne Gahery. Memory CD8+ T Cells Elicited by HIV-1 Lipopeptide Vaccines Display Similar Phenotypic Profiles but Differences in Term of Magnitude and Multifunctionality Compared with FLU- or EBV-Specific Memory T Cells in Humans. Vaccine, 32(4):492-501, 16 Jan 2014. PubMed ID: 24291199. Show all entries for this paper.


Displaying record number 1774

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, acute/early infection

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 58547

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name A3-RK9
Subtype B
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Country United States
Experimental methods  
Keywords review, rate of progression, acute/early infection

Notes

References

Streeck2010 Hendrik Streeck and Douglas F. Nixon. T Cell Immunity in Acute HIV-1 Infection. J. Infect. Dis., 202(Suppl 2):S302-8, 15 Oct 2010. PubMed ID: 20846037. Show all entries for this paper.


Displaying record number 1989

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name Gag-RK9; p17-RK9
Subtype B
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot granzyme B
Keywords HAART, ART

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 58364

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name A3 RK9
Subtype B
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection, in vitro stimulation or selection, vaccine
Country South Africa, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Keywords vaccine antigen design

Vaccine Details

Vaccine type adenovirus type 5 (Ad5)
Vaccine strain B clade, C clade
Vaccine component Gag

Notes

References

Ndhlovu2011 Zaza M. Ndhlovu, Alicja Piechocka-Trocha, Seanna Vine, Ashley McMullen, Kegakilwe C. Koofhethile, Phillip J. R. Goulder, Thumbi Ndung'u, Dan H. Barouch, and Bruce D. Walker. Mosaic HIV-1 Gag Antigens Can Be Processed and Presented to Human HIV-Specific CD8+ T Cells. J. Immunol., 186(12):6914-6924, 15 Jun 2011. PubMed ID: 21576505. Show all entries for this paper.


Displaying record number 58006

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name RK9
Subtype B
Species (MHC/HLA) human(A*03)
Immunogen in vitro stimulation or selection
Experimental methods Chromium-release assay, Cytotoxicity assay, Other
Keywords epitope processing

Notes

References

Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.


Displaying record number 59193

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28 NL4.3)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name RK9
Subtype B
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Experimental methods In vitro proteasome digestion, Other
Keywords epitope processing

Notes

References

Kourjian2014 Georgio Kourjian, Yang Xu, Ijah Mondesire-Crump, Mariko Shimada, Pauline Gourdain, and Sylvie Le Gall. Sequence-Specific Alterations of Epitope Production by HIV Protease Inhibitors. J. Immunol., 192(8):3496-3506, 15 Apr 2014. PubMed ID: 24616479. Show all entries for this paper.


Displaying record number 57575

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name RK9
Subtype B
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.


Displaying record number 57607

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location  
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name RK9
Subtype B
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Country United States
Experimental methods Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Proliferation
Keywords acute/early infection

Notes

References

Heath2011 Sonya L. Heath, Steffanie Sabbaj, Anju Bansal, J Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Proliferative Capacity Is Compromised in Primary HIV-1 Infection. J. Acquir. Immune Defic. Syndr., 56(3):213-221, Mar 2011. PubMed ID: 21079516. Show all entries for this paper.


Displaying record number 55347

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Species (MHC/HLA) human(A*0301)
Immunogen  
Experimental methods  
Keywords  

Notes

References

Zimbwa2007 Peter Zimbwa, Anita Milicic, John Frater, Thomas J. Scriba, Antony Willis, Philip J. R. Goulder, Tilly Pillay, Huldrych Gunthard, Jonathan N. Weber, Hua-Tang Zhang, and Rodney E. Phillips. Precise Identification of a Human Immunodeficiency Virus Type 1 Antigen Processing Mutant. J. Virol., 81(4):2031-2038, Feb 2007. PubMed ID: 17108020. Show all entries for this paper.


Displaying record number 19

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 1113

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Experimental methods  
Keywords acute/early infection

Notes

References

Wilson2000 J. D. Wilson, G. S. Ogg, R. L. Allen, C. Davis, S. Shaunak, J. Downie, W. Dyer, C. Workman, S. Sullivan, A. J. McMichael, and S. L. Rowland-Jones. Direct Visualization of HIV-1-Specific Cytotoxic T Lymphocytes During Primary Infection. AIDS, 14:225-233, 2000. PubMed ID: 10716497. Show all entries for this paper.


Displaying record number 1260

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28 SF2)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Altfeld2001c M. Altfeld, M. M. Addo, R. L. Eldridge, X. G. Yu, S. Thomas, A. Khatri, D. Strick, M. N. Phillips, G. B. Cohen, S. A. Islam, S. A. Kalams, C. Brander, P. J. Goulder, E. S. Rosenberg, B. D. Walker, and The HIV Study Collaboration.. Vpr is preferentially targeted by CTL during HIV-1 infection. J. Immunol., 167(5):2743-52, 1 Sep 2001. URL: http://www.jimmunol.org/cgi/content/full/167/5/2743. PubMed ID: 11509618. Show all entries for this paper.


Displaying record number 52252

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name RK9
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A3, B35, B51
Experimental methods  
Keywords mother-to-infant transmission

Notes

References

Sabbaj2002a Steffanie Sabbaj, Bradley H. Edwards, Mrinal K. Ghosh, Katherine Semrau, Sanford Cheelo, Donald M. Thea, Louise Kuhn, G. Douglas Ritter, Mark J. Mulligan, Paul A. Goepfert, and Grace M. Aldrovandi. Human Immunodeficiency Virus-Specific CD8(+) T Cells in Human Breast Milk. J. Virol., 76(15):7365-7373, Aug 2002. PubMed ID: 12097549. Show all entries for this paper.


Displaying record number 53602

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Show epitope variants
Epitope Name RK9
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A*0301, B*3501, B*51, Cw*04, Cw*06
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining
Keywords escape, acute/early infection

Notes

References

Bansal2005a Anju Bansal, Ethan Gough, Steffanie Sabbaj, Doug Ritter, Karina Yusim, Greg Sfakianos, Grace Aldrovandi, Richard A. Kaslow, Craig M. Wilson, Mark J. Mulligan, J. Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Responses in Early HIV-1 Infection Are Skewed Towards High Entropy Peptides. AIDS, 19(3):241-250, 18 Feb 2005. PubMed ID: 15718834. Show all entries for this paper.


Displaying record number 53817

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Show epitope variants
Subtype A
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Patient MHC/HLA A*0101, A*0301, B*0801; A*0201, A*3101, B*3501, B*3905
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords escape, acute/early infection, variant cross-reactivity

Notes

References

Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.


Displaying record number 54678

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Patient MHC/HLA A*0101, A*0301, B*0801
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords HAART, ART, escape, viral fitness and reversion

Notes

References

Asquith2006 Becca Asquith, Charles T. T. Edwards, Marc Lipsitch, and Angela R. McLean. Inefficient Cytotoxic T Lymphocyte-Mediated Killing of HIV-1-Infected Cells In Vivo. PLoS Biol., 4(4):e90, Apr 2006. PubMed ID: 16515366. Show all entries for this paper.


Displaying record number 55010

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name RLR
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, TCR usage, variant cross-reactivity, characterizing CD8+ T cells

Notes

References

Turnbull2006 Emma L. Turnbull, A. Ross Lopes, Nicola A. Jones, David Cornforth, Phillipa Newton, Diana Aldam, Pierre Pellegrino, Jo Turner, Ian Williams, Craig M. Wilson, Paul A. Goepfert, Mala K. Maini, and Persephone Borrow. HIV-1 Epitope-Specific CD8+ T Cell Responses Strongly Associated with Delayed Disease Progression Cross-Recognize Epitope Variants Efficiently. J. Immunol., 176(10):6130-6146, 15 May 2006. PubMed ID: 16670322. Show all entries for this paper.


Displaying record number 58244

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A*0301, B*1501, B*3501, Cw*0401, Cw*09
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords escape, acute/early infection, autologous responses, characterizing CD8+ T cells

Notes

References

Ferrari2011 Guido Ferrari, Bette Korber, Nilu Goonetilleke, Michael K. P. Liu, Emma L. Turnbull, Jesus F. Salazar-Gonzalez, Natalie Hawkins, Steve Self, Sydeaka Watson, Michael R. Betts, Cynthia Gay, Kara McGhee, Pierre Pellegrino, Ian Williams, Georgia D. Tomaras, Barton F. Haynes, Clive M. Gray, Persephone Borrow, Mario Roederer, Andrew J. McMichael, and Kent J. Weinhold. Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection. PLoS Pathog., 7(2):e1001273, 2011. PubMed ID: 21347345. Show all entries for this paper.


Displaying record number 58435

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Subtype A1
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Country Kenya
Experimental methods Other
Keywords assay or method development

Notes

References

Liang2011 Binhua Liang, Ma Luo, Joel Scott-Herridge, Christina Semeniuk, Mark Mendoza, Rupert Capina, Brent Sheardown, Hezhao Ji, Joshua Kimani, Blake T. Ball, Gary Van Domselaar, Morag Graham, Shane Tyler, Steven J. M. Jones, and Francis A. Plummer. A Comparison of Parallel Pyrosequencing and Sanger Clone-Based Sequencing and Its Impact on the Characterization of the Genetic Diversity of HIV-1. PLoS One, 6(10):e26745, 2011. PubMed ID: 22039546. Show all entries for this paper.


Displaying record number 58970

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Country Australia, Canada, Spain, Switzerland
Experimental methods Other
Keywords mutation acquisition

Notes

References

Bartha2013 István Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. McLaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López-Galíndez, Concepción Casado, Andri Rauch, Huldrych F. Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M. Allen, Viktor Müller, P. Richard Harrigan, David Heckerman, Amalio Telenti, and Jacques Fellay. A Genome-to-Genome Analysis of Associations between Human Genetic Variation, HIV-1 Sequence Diversity, and Viral Control. eLife, 2:e01123, 2013. PubMed ID: 24171102. Show all entries for this paper.


Displaying record number 59173

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name gag 020-028
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Country France
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, HLA binding, Intracellular cytokine staining, Other
Keywords binding affinity, elite controllers

Notes

References

Lecuroux2014 Camille Lécuroux, Asier Sáez-Cirión, Isabelle Girault, Pierre Versmisse, Faroudy Boufassa, Véronique Avettand-Fenoël, Christine Rouzioux, Laurence Meyer, Gianfranco Pancino, Olivier Lambotte, Martine Sinet, and Alain Venet. Both HLA-B*57 and Plasma HIV RNA Levels Contribute to the HIV-Specific CD8+ T Cell Response in HIV Controllers. J. Virol., 88(1):176-187, Jan 2014. PubMed ID: 24131719. Show all entries for this paper.


Displaying record number 60994

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Patient MHC/HLA 51314: A*0301, A*1101, B*3503, B*5301, Cw*0401, Cw*0401
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 61187

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Show epitope variants
Epitope Name RK9
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords acute/early infection, variant cross-reactivity

Notes

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 52892

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name 1332
Subtype multiple
Species (MHC/HLA) human(A*0301, A3, B42, B62)
Immunogen HIV-1 infection
Patient MHC/HLA A23, A3, B49, B57; A24, A3, B27, B57, Cw13, Cw18; A26, A3, B52, B8
Country United States
Experimental methods T-cell Elispot
Keywords binding affinity, computational epitope prediction, immunodominance, HLA cross-presentation

Notes

References

DeGroot2003 Anne S. De Groot, Bill Jesdale, William Martin, Caitlin Saint Aubin, Hakima Sbai, Andrew Bosma, Judy Lieberman, Gail Skowron, Fadi Mansourati, and Kenneth H. Mayer. Mapping Cross-Clade HIV-1 Vaccine Epitopes Using a Bioinformatics Approach. Vaccine, 21(27-30):4486-4504, 1 Oct 2003. PubMed ID: 14505932. Show all entries for this paper.


Displaying record number 54838

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag( Henan isolate)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Gong2006 Xiaoyan Gong, Xien Gui, Yuxia Zhang, and Po Tien. Screening for CD8 Cytotoxic T Lymphocytes Specific for Gag of Human Immunodeficiency Virus Type 1 Subtype B' Henan Isolate from China and Identification of Novel Epitopes Restricted by the HLA-A2 and HLA-A11 Alleles. J. Gen. Virol., 87(Pt 1):151-158, Jan 2006. PubMed ID: 16361427. Show all entries for this paper.


Displaying record number 54533

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Show epitope variants
Epitope Name RK9
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity, subtype comparisons, acute/early infection

Notes

References

Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.


Displaying record number 53037

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Koning2004 Fransje A. Koning, Christine A. Jansen, Jos Dekker, Richard A. Kaslow, Nicole Dukers, Debbie van Baarle, Maria Prins, and Hanneke Schuitemaker. Correlates of Resistance to HIV-1 Infection in Homosexual Men with High-Risk Sexual Behaviour. AIDS, 18(8):1117-1126, 21 May 2004. PubMed ID: 15166527. Show all entries for this paper.


Displaying record number 54239

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name A3-RK9(p17)
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 52994

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Show epitope variants
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Patient MHC/HLA A3, A32, B15, B51, Cw03, Cw6, DQ7, DR4, DR8
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, escape

Notes

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.


Displaying record number 57171

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location  
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords immunodominance, acute/early infection

Notes

References

Liu2009c Yi Liu, John McNevin, Morgane Rolland, Hong Zhao, Wenjie Deng, Janine Maenza, Claire E. Stevens, Ann C. Collier, M. Juliana McElrath, and James I. Mullins. Conserved HIV-1 Epitopes Continuously Elicit Subdominant Cytotoxic T-Lymphocyte Responses. J. Infect. Dis., 200(12):1825-1833, 15 Dec 2009. PubMed ID: 19909083. Show all entries for this paper.


Displaying record number 21

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Goulder2000a P. J. Goulder, Y. Tang, S. I. Pelton, and B. D. Walker. HLA-B57-Restricted Cytotoxic T-Lymphocyte Activity in a Single Infected Subject toward Two Optimal Epitopes, One of Which Is Entirely Contained Within the Other. J. Virol., 74:5291-5299, 2000. PubMed ID: 10799606. Show all entries for this paper.


Displaying record number 54891

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location  
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name RK9
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords vaccine-induced immune responses, characterizing CD8+ T cells

Vaccine Details

Vaccine type canarypox, canarypox prime with recombinant protein boost
Vaccine strain B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen
Vaccine component Gag, gp120, gp41, Nef, Pol, Protease

Notes

References

Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.


Displaying record number 53202

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28 B consensus)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Show epitope variants
Epitope Name RK9
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords immunodominance, escape, acute/early infection, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Allen2004 Todd M Allen, Marcus Altfeld, Xu G. Yu, Kristin M. O'Sullivan, Mathias Lichterfeld, Sylvie Le Gall, Mina John, Bianca R. Mothe, Paul K. Lee, Elizabeth T. Kalife, Daniel E. Cohen, Kenneth A. Freedberg, Daryld A. Strick, Mary N. Johnston, Alessandro Sette, Eric S. Rosenberg, Simon A. Mallal, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. Selection, Transmission, and Reversion of an Antigen-Processing Cytotoxic T-Lymphocyte Escape Mutation in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(13):7069-7078, Jul 2004. PubMed ID: 15194783. Show all entries for this paper.


Displaying record number 52824

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Show epitope variants
Epitope Name A3-RK9 Ga9
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supervised treatment interruptions (STI), escape, early treatment, superinfection

Notes

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.


Displaying record number 57552

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location  
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords acute/early infection, assay or method development

Notes

References

Turnbull2009 Emma L. Turnbull, MaiLee Wong, Shuyi Wang, Xiping Wei, Nicola A. Jones, Karen E. Conrod, Diana Aldam, Jo Turner, Pierre Pellegrino, Brandon F. Keele, Ian Williams, George M. Shaw, and Persephone Borrow. Kinetics of Expansion of Epitope-Specific T Cell Responses During primary HIV-1 Infection. J. Immunol., 182(11):7131-7145, 1 Jun 2009. PubMed ID: 19454710. Show all entries for this paper.


Displaying record number 52621

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A3, B44, B57, Cw5, Cw6; A1, A3, B14, B7, Cw*0702, Cw*0802; A1, A3, B35, B8; A1, A3, B62, B8, Cw3, Cw7
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection, early-expressed proteins

Notes

References

Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.


Displaying record number 57595

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, genital and mucosal immunity

Notes

References

Ferre2010 April L. Ferre, Donna Lemongello, Peter W. Hunt, Megan M. Morris, Juan Carlos Garcia, Richard B. Pollard, Hal F. Yee, Jr., Jeffrey N. Martin, Steven G. Deeks, and Barbara L. Shacklett. Immunodominant HIV-Specific CD8+ T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers. J. Virol., 84(19):10354-10365, Oct 2010. PubMed ID: 20668079. Show all entries for this paper.


Displaying record number 52257

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A3, B35, B51
Experimental methods  
Keywords mother-to-infant transmission

Notes

References

Sabbaj2002a Steffanie Sabbaj, Bradley H. Edwards, Mrinal K. Ghosh, Katherine Semrau, Sanford Cheelo, Donald M. Thea, Louise Kuhn, G. Douglas Ritter, Mark J. Mulligan, Paul A. Goepfert, and Grace M. Aldrovandi. Human Immunodeficiency Virus-Specific CD8(+) T Cells in Human Breast Milk. J. Virol., 76(15):7365-7373, Aug 2002. PubMed ID: 12097549. Show all entries for this paper.


Displaying record number 57939

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name RK9
Subtype A1, B, C
Species (MHC/HLA) human(A3)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus
Vaccine strain B clade HXB2, A clade 92RW020, C clade 97ZA012
Vaccine component Env, Gag-Pol

Notes

References

Friedrich2011 David Friedrich, Emilie Jalbert, Warren L. Dinges, John Sidney, Alex Sette, Yunda Huang, M. Juliana McElrath, and Helen Horton. Vaccine-Induced HIV-Specific CD8+ T Cells Utilize Preferential HLA Alleles and Target-Specific Regions of HIV-1. J. Acquir. Immune Defic. Syndr., 58(3):248-252, 1 Nov 2011. PubMed ID: 21709567. Show all entries for this paper.


Displaying record number 57972

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name RK9
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords immunodominance, elite controllers

Notes

References

Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.


Displaying record number 52231

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag( LAI)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods  
Keywords class I down-regulation by Nef

Notes

References

Lewinsohn2002 Deborah A. Lewinsohn, Rebecca Lines, David M. Lewinsohn, Stanley R. Riddell, Philip D. Greenberg, Michael. Emerman, and Steven R. Bartz. HIV-1 Vpr Does Not Inhibit CTL-Mediated Apoptosis of HIV-1 Infected Cells. Virology, 294(1):13-21, 1 Mar 2002. PubMed ID: 11886261. Show all entries for this paper.


Displaying record number 53778

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p24
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name RK9
Species (MHC/HLA) (A3)
Immunogen  
Experimental methods  
Keywords review, immunodominance, escape, acute/early infection, early-expressed proteins, kinetics, viral fitness and reversion

Notes

References

Lichterfeld2005 Mathias Lichterfeld, Xu G. Yu, Sylvie Le Gall, and Marcus Altfeld. Immunodominance of HIV-1-Specific CD8+ T-Cell Responses in Acute HIV-1 Infection: At the Crossroads of Viral and Host Genetics. Trends Immunol., 26(3):166-171, Mar 2005. PubMed ID: 15745859. Show all entries for this paper.


Displaying record number 52141

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name A3-RK9
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Patient MHC/HLA A3, B7, Cw7
Experimental methods  
Keywords dynamics, supervised treatment interruptions (STI), immunodominance, acute/early infection

Notes

References

Yu2002b Xu G. Yu, Marylyn M. Addo, Eric S. Rosenberg, William R. Rodriguez, Paul K. Lee, Cecily A. Fitzpatrick, Mary N. Johnston, Daryld. Strick, Philip J. R. Goulder, Bruce D. Walker, and Marcus Altfeld. Consistent Patterns in the Development and Immunodominance of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T-Cell Responses Following Acute HIV-1 Infection. J. Virol., 76(17):8690-8701, Sep 2002. PubMed ID: 12163589. Show all entries for this paper.


Displaying record number 53727

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag(20-28 BRU)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Subtype B, CRF02_AG
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Country Cote D'Ivoire
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons

Notes

References

Inwoley2005 André Inwoley, Patricia Recordon-Pinson, Marion Dupuis, Jessintha Gaston, Mathieu Genête, Albert Minga, Franck Letourneur, François Rouet, Jeannine Choppin, Hervé Fleury, Jean-Gérard Guillet, Muriel Andrieu, and ANRS 1220 PRIMO-CI Study Group. Cross-Clade Conservation of HIV Type 1 Nef Immunodominant Regions Recognized by CD8+ T Cells of HIV Type 1 CRF02\_AG-Infected Ivorian (West Africa). AIDS Res. Hum. Retroviruses, 21(7):620-628, Jul 2005. PubMed ID: 16060833. Show all entries for this paper.


Displaying record number 1820

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name RK9
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods  
Keywords acute/early infection

Notes

References

Goulder2001c P. J. Goulder, C. Brander, Y. Tang, C. Tremblay, R. A. Colbert, M. M. Addo, E. S. Rosenberg, T. Nguyen, R. Allen, A. Trocha, M. Altfeld, S. He, M. Bunce, R. Funkhouser, S. I. Pelton, S. K. Burchett, K. McIntosh, B. T. Korber, and B. D. Walker. Evolution and transmission of stable CTL escape mutations in HIV infection. Nature, 412(6844):334-8, 19 Jul 2001. PubMed ID: 11460164. Show all entries for this paper.


Displaying record number 1521

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28 SF2)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 53496

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name RK9
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 1159

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17( SF2)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons, immunodominance

Notes

References

Goulder2000 P. J. Goulder, C. Brander, K. Annamalai, N. Mngqundaniso, U. Govender, Y. Tang, S. He, K. E. Hartman, C. A. O'Callaghan, G. S. Ogg, M. A. Altfeld, E. S. Rosenberg, H. Cao, S. A. Kalams, M. Hammond, M. Bunce, S. I. Pelton, S. A. Burchett, K. McIntosh, H. M. Coovadia, and B. D. Walker. Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children. J. Virol., 74:5679-90, 2000. PubMed ID: 10823876. Show all entries for this paper.


Displaying record number 53356

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location ( B consensus)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name RK9
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A3, B62, B8, Cw10, Cw7; A1, A3, B14, B8, Cw7, Cw8
Country United States
Experimental methods Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords assay or method development, memory cells, characterizing CD8+ T cells

Notes

References

Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.


Displaying record number 23

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Show epitope variants
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

Cao1997a H. Cao, P. Kanki, J. L. Sankale, A. Dieng-Sarr, Gail P. Mazzara, S. Kalams, B. Korber, S. M'Boup, and B. D. Walker. CTL Cross-Reactivity among Different HIV-1 Clades: Implications for Vaccine Development. J. Virol., 71:8615-8623, 1997. PubMed ID: 9343219. Show all entries for this paper.


Displaying record number 22

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Goulder1997b P. J. R. Goulder, R. E. Phillips, R. A. Colbert, S. McAdam, G. Ogg, M. A. Nowak, P. Giangrande, G. Luzzi, B. Morgan, A. Edwards, A. McMichael, and S. Rowland-Jones. Late Escape from an Immunodominant Cytotoxic T-Lymphocyte Response Associated with Progression to AIDS. Nat. Med., 3:212-216, 1997. The CTL response was studied in six HIV+ individuals who make a strong immunodominat response to the same B27 epitope. In two donors an escape mutation arose after close to 10 years of epitope stability, around the time of progression to AIDS. PubMed ID: 9018241. Show all entries for this paper.


Displaying record number 54960

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Species (MHC/HLA) (A3, A30, A31, A68)
Immunogen peptide-HLA interaction
Experimental methods HLA binding
Keywords binding affinity, immunodominance

Notes

References

Racape2006a Judith Racape, Francine Connan, Johan Hoebeke, Jeannine Choppin, and Jean-Gérard Guillet. Influence of Dominant HIV-1 Epitopes on HLA-A3/Peptide Complex Formation. Proc. Natl. Acad. Sci. U.S.A., 103(48):18208-18213, 28 Nov 2006. PubMed ID: 17116886. Show all entries for this paper.


Displaying record number 53633

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Show epitope variants
Species (MHC/HLA) human(A3, A30, B42, B62)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A31, B51, B58w4
Country United States
Experimental methods Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords HAART, ART, escape, variant cross-reactivity

Notes

References

Casazza2005a Joseph P. Casazza, Michael R. Betts, Brenna J. Hill, Jason M. Brenchley, David A. Price, Daniel C. Douek, and Richard A. Koup. Immunologic Pressure within Class I-Restricted Cognate Human Immunodeficiency Virus Epitopes during Highly Active Antiretroviral Therapy. J. Virol., 79(6):3653-3663, Mar 2005. PubMed ID: 15731259. Show all entries for this paper.


Displaying record number 56296

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28 SF2, HXBc2/Bal R5)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Show epitope variants
Epitope Name RK9
Subtype B
Species (MHC/HLA) human(A3, B7)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A3, B15, B7, Cw3, Cw6; A29, A3, B44, B7, Cw3, Cw7; A24, A3, B7, B8, Cw7
Country United States
Experimental methods Cytokine production, Degranulation, CD107a and b cell surface mobilization, Flow cytometric T-cell cytokine assay
Keywords supervised treatment interruptions (STI), immunodominance, variant cross-reactivity, characterizing CD8+ T cells, drug resistance

Notes

References

Daucher2008 Marybeth Daucher, David A. Price, Jason M. Brenchley, Laurie Lamoreaux, Julia A. Metcalf, Catherine Rehm, Elizabeth Nies-Kraske, Elizabeth Urban, Christian Yoder, Diane Rock, Julie Gumkowski, Michael R. Betts, Mark R. Dybul, and Daniel C. Douek. Virological Outcome after Structured Interruption of Antiretroviral Therapy for Human Immunodeficiency Virus Infection Is Associated with the Functional Profile of Virus-Specific CD8+ T Cells. J. Virol., 82(8):4102-4114, Apr 2008. PubMed ID: 18234797. Show all entries for this paper.


Displaying record number 60131

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name RK9
Species (MHC/HLA) human(A*30)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60130

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name RK9
Species (MHC/HLA) human(A*74)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 61970

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Subtype A, D
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection
Patient MHC/HLA 2127: A*0101, A*0301, B*0702, B*4101, Cw*0701, Cw*0723
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Other, Tetramer binding
Keywords HIV exposed persistently seronegative (HEPS), assay or method development

Notes

References

Luo2012 Ma Luo, Christina A. Daniuk, Tamsir O. Diallo, Rupert E. Capina, Joshua Kimani, Charles Wachihi, Makubo Kimani, Thomas Bielawny, Trevor Peterson, Mark G. R. Mendoza, Sandra Kiazyk, T. Blake Ball, and Francis A. Plummer. For Protection from HIV-1 Infection, More Might Not Be Better: A Systematic Analysis of HIV Gag Epitopes of Two Alleles Associated with Different Outcomes of HIV-1 Infection. J. Virol., 86(2):1166-1180, Jan 2012. PubMed ID: 22072744. Show all entries for this paper.


Displaying record number 60132

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Epitope Name RK9
Species (MHC/HLA) human(C*01)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 61322

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Species (MHC/HLA) human
Immunogen vaccine
Country Australia, Brazil, Canada, Dominican Republic, Haiti, Jamaica, Peru, Puerto Rico, United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses, assay or method development, optimal epitope

Vaccine Details

Vaccine type adenovirus type 5 (Ad5)
Vaccine component Gag, Nef, Pol

Notes

References

Fiore-Gartland2016 Andrew Fiore-Gartland, Bryce A. Manso, David P. Friedrich, Erin E. Gabriel, Greg Finak, Zoe Moodie, Tomer Hertz, Stephen C. De Rosa, Nicole Frahm, Peter B. Gilbert, and M Juliana McElrath. Pooled-Peptide Epitope Mapping Strategies Are Efficient and Highly Sensitive: An Evaluation of Methods for Identifying Human T Cell Epitope Specificities in Large-Scale HIV Vaccine Efficacy Trials. PLoS One, 11(2):e0147812, 2016. PubMed ID: 26863315. Show all entries for this paper.


Displaying record number 54932

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location  
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA A*0201, A*0301; B*4501, B*5301
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type canarypox
Vaccine strain B clade LAI, B clade MN
Vaccine component Gag-Pol, gp120, gp41

Notes

References

Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.


Displaying record number 54915

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location  
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA A3, A32; B38, B64
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses

Notes

References

Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.


Displaying record number 24

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance

Notes

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.


Displaying record number 58013

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus type 5 (Ad5), DNA prime with Ad5 boost
Vaccine strain B clade IIIB, B clade JRFL, B clade CAM-1
Vaccine component Gag, Nef, Pol

Notes

References

Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.


Displaying record number 59393

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location Gag
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA LTNP/EC-4: A*03, A*11, B*35, B*51, Cw*04, Cw*15
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, immunodominance

Notes

References

Migueles2015 Stephen A. Migueles, Daniel Mendoza, Matthew G. Zimmerman, Kelly M. Martins, Sushila A. Toulmin, Elizabeth P. Kelly, Bennett A. Peterson, Sarah A. Johnson, Eric Galson, Kate O. Poropatich, Andy Patamawenu, Hiromi Imamichi, Alexander Ober, Catherine A. Rehm, Sara Jones, Claire W. Hallahan, Dean A. Follmann, and Mark Connors. CD8+ T-Cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types. EBioMedicine, 2(1):46-58, Jan 2015. PubMed ID: 26137533. Show all entries for this paper.


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