HIV molecular immunology database
Found 24 matching records:
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(786-778) | |
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infection | |
Country | Spain | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation | |
Keywords | HAART, ART, supervised treatment interruptions (STI) |
Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | ||
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Epitope Name | RR11 | |
Subtype | B | |
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infection | |
Country | Barbados, Haiti, Jamaica | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | mother-to-infant transmission, elite controllers |
Schneidewind2009 Arne Schneidewind, Yanhua Tang, Mark A. Brockman, Elizabeth G. Ryland, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, M. Anne St. John, Joseph A. Conrad, Spyros A. Kalams, Francine Noel, Todd M. Allen, Celia D. Christie, and Margaret E. Feeney. Maternal Transmission of Human Immunodeficiency Virus Escape Mutations Subverts HLA-B57 Immunodominance but Facilitates Viral Control in the Haploidentical Infant. J. Virol., 83(17):8616-8627, Sep 2009. PubMed ID: 19515764. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(770-780) | |
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | rate of progression, acute/early infection |
Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | rate of progression, acute/early infection |
Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(770-780) | |
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Epitope Name | RR11 | |
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(259-269) | |
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, Spain, Switzerland | |
Experimental methods | Other | |
Keywords | mutation acquisition |
Bartha2013 István Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. McLaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López-Galíndez, Concepción Casado, Andri Rauch, Huldrych F. Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M. Allen, Viktor Müller, P. Richard Harrigan, David Heckerman, Amalio Telenti, and Jacques Fellay. A Genome-to-Genome Analysis of Associations between Human Genetic Variation, HIV-1 Sequence Diversity, and Viral Control. eLife, 2:e01123, 2013. PubMed ID: 24171102. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(775-785 LAI) | |
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(768-778 NL43) | |
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Takahashi1991 K. Takahashi, L.-C. Dai, T. R. Fuerst, W. E. Biddison, P. L. Earl, B. Moss, and F. A. Ennis. Specific Lysis of Human Immunodeficiency Virus Type 1-Infected Cells by a HLA-A3.1-Restricted CD8+ Cytotoxic T-Lymphocyte Clone That Recognizes a Conserved Peptide Sequence within the gp41 Subunit of the Envelope Protein. Proc. Natl. Acad. Sci. U.S.A., 88:10277-10281, 1991. gp41 epitope: RLRDLLLIVTR, HLA A3.1 (NL43). Synthetic peptides of RF and CDC4 were recognized by CTL clone despite non-conservative Thr to (Val or Ala) change, but an MN peptide with four natural substitutions was not recognized. PubMed ID: 1719555. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(775-785) | |
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 exposed seronegative, HIV-1 infection | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS) |
Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(768-778 NL43) | |
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Show epitope variants | ||
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | subtype comparisons |
Cao1997a H. Cao, P. Kanki, J. L. Sankale, A. Dieng-Sarr, Gail P. Mazzara, S. Kalams, B. Korber, S. M'Boup, and B. D. Walker. CTL Cross-Reactivity among Different HIV-1 Clades: Implications for Vaccine Development. J. Virol., 71:8615-8623, 1997. PubMed ID: 9343219. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(769-780) | |
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Epitope Name | A3-RR11 | |
Subtype | B | |
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A3, B7, Cw7 | |
Experimental methods | ||
Keywords | dynamics, supervised treatment interruptions (STI), acute/early infection |
Yu2002b Xu G. Yu, Marylyn M. Addo, Eric S. Rosenberg, William R. Rodriguez, Paul K. Lee, Cecily A. Fitzpatrick, Mary N. Johnston, Daryld. Strick, Philip J. R. Goulder, Bruce D. Walker, and Marcus Altfeld. Consistent Patterns in the Development and Immunodominance of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T-Cell Responses Following Acute HIV-1 Infection. J. Virol., 76(17):8690-8701, Sep 2002. PubMed ID: 12163589. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(770-780) | |
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Show epitope variants | ||
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A3, A32, B15, B51, C*03, Cw6, DQ7, DR4, DR8 | |
Country | Netherlands | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, escape |
Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | ||
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Species (MHC/HLA) | human(A3, A31) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, HLA binding | |
Keywords | binding affinity, immunodominance, optimal epitope |
Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160 | |
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Epitope Name | RR11(gp160) | |
Subtype | B | |
Species (MHC/HLA) | human(A3, A31) | |
Immunogen | HIV-1 infection | |
Country | China | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | chronic infection |
Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | ||
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Species (MHC/HLA) | human(A3, A31) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | supertype, HLA cross-presentation |
Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(770-780) | |
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Epitope Name | RR11 | |
Species (MHC/HLA) | human(A*31) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | Env | |
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Epitope Name | RR11 | |
Subtype | C | |
Species (MHC/HLA) | human(A31) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay | |
Keywords | epitope processing, escape |
Draenert2004a Rika Draenert, Sylvie Le Gall, Katja J. Pfafferott, Alasdair J. Leslie, Polan Chetty, Christian Brander, Edward C. Holmes, Shih-Chung Chang, Margaret E. Feeney, Marylyn M. Addo, Lidia Ruiz, Danni Ramduth, Prakash Jeena, Marcus Altfeld, Stephanie Thomas, Yanhua Tang, Cori L. Verrill, Catherine Dixon, Julia G. Prado, Photini Kiepiela, Javier Martinez-Picado, Bruce D. Walker, and Philip J. R. Goulder. Immune Selection for Altered Antigen Processing Leads to Cytotoxic T Lymphocyte Escape in Chronic HIV-1 Infection. J. Exp. Med., 199(7):905-915, 5 Apr 2004. PubMed ID: 15067030. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(770-780) | |
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Species (MHC/HLA) | human(A31) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Ferris1999 R. L. Ferris, C. Hall, N. V. Sipsas, J. T. Safrit, A. Trocha, R. A. Koup, R. P. Johnson, and R. F. Siliciano. Processing of HIV-1 Envelope Glycoprotein for Class I-Restricted Recognition: Dependence on TAP1/2 and Mechanisms for Cytosolic Localization. J. Immunol., 162:1324-1332, 1999. PubMed ID: 9973386. Show all entries for this paper.
Hammond1995 S. A. Hammond, R. P. Johnson, S. A. Kalams, B. D. Walker, M. Takiguchi, J. T. Safrit, R. A. Koup, and R. F. Siliciano. An Epitope-Selective Transporter Associated with Antigen Presentation TAP-1/2-Independent Pathway and a More General TAP-1/2-Dependent Antigen-Processing Pathway Allow Recognition of the HIV-1 Envelope Glycoprotein by CD8+ CTL. J. Immunol., 154:6140-6156, 1995. Two peptide-processing pathways are utilized for MHC class I presentation of HIV-1 Env epitopes. The previously characterized TAP-1 and TAP-2 dependent pathway can generate all Env epitopes and uses Env protein mislocalized in the cytosol to produce peptides. The second, novel pathway uses a TAP-1/2 independent pathway, and allows a subset of MHC-restricted epitopes to be processed in the endoplasmic reticulum or a Golgi compartment. PubMed ID: 7538543. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(770-780) | |
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Species (MHC/HLA) | human(A31) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*02:01, A31, B44, B60, C*16, Cw3 | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | binding affinity, acute/early infection, early-expressed proteins |
Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160(770-780 LAI) | |
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*31:01) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(770-780 BH10) | |
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*31:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Safrit1994a J. T. Safrit, C. A. Andrews, T. Zhu, D. D. Ho, and R. A. Koup. Characterization of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocyte Clones Isolated during Acute Seroconversion: Recognition of Autologous Virus Sequences within a Conserved Immunodominant Epitope. J. Exp. Med., 179:463-472, 1994. HIV-1 specific CTL clones were isolated from two individuals at acute seroconversion. In one patient, two HLA A31-restricted clones recognized the same fragment of gp41, peptide RLRDLLLIVTR, but one was sensitive to a Thr to Val substitution, while the other was not. A CTL HLA A32-restricted clone from the other patient recognized the gp41 peptide VLSIVNRVRQGYSPLSFQTH. Autologous viral sequences from seroconversion were recognized by the CTL clones, but not the HIV-1 strain MN. PubMed ID: 8294860. Show all entries for this paper.
Safrit1994b J. T. Safrit, A. Y. Lee, C. A. Andrews, and R. A. Koup. A Region of the Third Variable Loop of HIV-1 gp120 Is Recognized by HLA-B7-Restricted CTLs from Two Acute Seroconversion Patients. J. Immunol., 153:3822-3830, 1994. HIV-1 envelope-specific CTL clones were isolated from the peripheral blood of two patients within weeks of seroconversion. These clones were CD8+ and restricted by the HLA-B7 molecule. The minimum epitope was defined, RPNNNTRKSI, with anchor residues at the proline and isoleucine; the anchor residues are relatively well conserved. A Serine to Arginine change at position 9 of the epitope abrogated clone recognition in one of the patients. This amino acid change is one factor that has been associated with a change from a nonsyncytium-inducing to a syncytium-inducing phenotype of HIV-1.. PubMed ID: 7523505. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(770-780) | |
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Epitope Name | RR11 | |
Species (MHC/HLA) | human(A*34) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(770-780) | |
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Epitope Name | RR11 | |
Species (MHC/HLA) | human(A*74) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(770-780) gp41(259-269) DNA(8532..8564) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(775-785) | |
Epitope |
RLRDLLLIVTR
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | immunodominance |
Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.