HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 5 matching records:

Displaying record number 58995

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HXB2 Location Gag(150-158)
p24(18-26)
DNA(1237..1263)
Gag Epitope Map
Author Location Gag(150-)
Epitope RLLNAWVKV Epitope Alignment
RLLNAWVKV epitope logo
Epitope Name Gag150
Subtype A
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection, vaccine
Country Guinea-Bissau
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses, vaccine antigen design, therapeutic vaccine, chronic infection

Vaccine Details

Vaccine type peptide
Vaccine strain A clade
Adjuvant CAF01

Notes

References

Roman2013 Victor Raúl Gómez Román, Kristoffer Jarlov Jensen, Sanne Skov Jensen, Christian Leo-Hansen, Sanne Jespersen, David da Silva Té, Candida Medina Rodrigues, Christoph Mikkel Janitzek, Lasse Vinner, Terese Lea Katzenstein, Peter Andersen, Ingrid Kromann, Lars Vibe Andreasen, Ingrid Karlsson, and Anders Fomsgaard. Therapeutic Vaccination Using Cationic Liposome-Adjuvanted HIV Type 1 Peptides Representing HLA-Supertype-Restricted Subdominant T Cell Epitopes: Safety, Immunogenicity, and Feasibility in Guinea-Bissau. AIDS Res Hum Retroviruses, 29(11):1504-1512, Nov 2013. PubMed ID: 23634822. Show all entries for this paper.


Displaying record number 57135

Download this epitope record as JSON.

HXB2 Location Gag(150-158)
p24(18-26)
DNA(1237..1263)
Gag Epitope Map
Author Location Gag
Epitope RLLNAWVKV Epitope Alignment
RLLNAWVKV epitope logo
Epitope Name Gag150 T2L
Species (MHC/HLA) human(A*02:01)
Immunogen HIV-1 infection, vaccine
Country Denmark
Experimental methods Intracellular cytokine staining, Pentamer labeling
Keywords vaccine-induced immune responses, therapeutic vaccine

Vaccine Details

Vaccine type peptide
Vaccine strain multiple epitope immunogen
Vaccine component HIV-1, other

Notes

References

Kloverpris2009a Henrik Kloverpris, Ingrid Karlsson, Jesper Bonde, Mette Thorn, Lasse Vinner, Anders E. Pedersen, Julie L. Hentze, Betina S. Andresen, Inge M. Svane, Jan Gerstoft, Gitte Kronborg, and Anders Fomsgaard. Induction of Novel CD8+ T-Cell Responses during Chronic Untreated HIV-1 Infection by Immunization with Subdominant Cytotoxic T-Lymphocyte Epitopes. AIDS, 23(11):1329-1340, 17 Jul 2009. PubMed ID: 19528789. Show all entries for this paper.


Displaying record number 57142

Download this epitope record as JSON.

HXB2 Location Gag(150-158)
p24(18-26)
DNA(1237..1263)
Gag Epitope Map
Author Location Gag
Epitope RLLNAWVKV Epitope Alignment
RLLNAWVKV epitope logo
Epitope Name Gag150mod
Species (MHC/HLA) transgenic mouse(A*02:01)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords immunodominance, dendritic cells

Vaccine Details

Vaccine type polyepitope
Vaccine strain multiple epitope immunogen
Vaccine component Env, Gag, Pol, Vif, Vpu

Notes

References

Kloverpris2009 Henrik N. Kloverpris, Ingrid Karlsson, Mette Thorn, Søren Buus, and Anders Fomsgaard. Immune Hierarchy among HIV-1 CD8+ T Cell Epitopes Delivered by Dendritic Cells Depends on MHC-I Binding Irrespective of Mode of Loading and Immunization in HLA-A*0201 Mice. APMIS, 117(11):849-585, Nov 2009. PubMed ID: 19845536. Show all entries for this paper.


Displaying record number 57506

Download this epitope record as JSON.

HXB2 Location Gag(150-158)
p24(18-26)
DNA(1237..1263)
Gag Epitope Map
Author Location  
Epitope RLLNAWVKV Epitope Alignment
RLLNAWVKV epitope logo
Epitope Name Gag150
Species (MHC/HLA) transgenic mouse(A2)
Immunogen vaccine
Experimental methods T-cell Elispot
Keywords vaccine-induced immune responses, adjuvant comparison, vaccine antigen design

Vaccine Details

Vaccine type polyepitope
Vaccine component Env, Gag, Nef, Pol, Vif, Vpu
Adjuvant CAF01

Notes

References

Fomsgaard2011 Anders Fomsgaard, Ingrid Karlsson, Gregers Gram, Christian Schou, Sheila Tang, Peter Bang, Ingrid Kromann, Peter Andersen, and Lars Vibe Andreasen. Development and Preclinical Safety Evaluation of a New Therapeutic HIV-1 Vaccine Based on 18 T-Cell Minimal Epitope Peptides Applying a Novel Cationic Adjuvant CAF01. Vaccine, 29(40):7067-7074, Sep 16 2011. PubMed ID: 21767590. Show all entries for this paper.


Displaying record number 58407

Download this epitope record as JSON.

HXB2 Location Gag(150-158)
p24(18-26)
DNA(1237..1263)
Gag Epitope Map
Author Location Gag
Epitope RLLNAWVKV Epitope Alignment
RLLNAWVKV epitope logo
Epitope Name Gag150
Subtype B, CRF02_AG
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Cote D'Ivoire, Denmark, Ghana, Guinea-Bissau, Mali, Senegal
Experimental methods Intracellular cytokine staining, Pentamer labeling
Keywords vaccine antigen design

Notes

References

Corbet2003 Sylvie Corbet, Henrik Vedel Nielsen, Lasse Vinner, Sanne Lauemoller, Dominic Therrien, Sheila Tang, Gitte Kronborg, Lars Mathiesen, Paul Chaplin, Søren Brunak, Søren Buus, and Anders Fomsgaard. Optimization and Immune Recognition of Multiple Novel Conserved HLA-A2, Human Immunodeficiency Virus Type 1-Specific CTL Epitopes. J. Gen. Virol., 84(Pt 9):2409-2421, Sep 2003. PubMed ID: 12917462. Show all entries for this paper.

Kloverpris2009 Henrik N. Kloverpris, Ingrid Karlsson, Mette Thorn, Søren Buus, and Anders Fomsgaard. Immune Hierarchy among HIV-1 CD8+ T Cell Epitopes Delivered by Dendritic Cells Depends on MHC-I Binding Irrespective of Mode of Loading and Immunization in HLA-A*0201 Mice. APMIS, 117(11):849-585, Nov 2009. PubMed ID: 19845536. Show all entries for this paper.

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.

Vinner2011 Lasse Vinner, Birgitta Holmgren, Kristoffer J. Jensen, Joakim Esbjornsson, Marie Borggren, Julie L. Hentze, Ingrid Karlsson, Betina S. Andresen, Gregers J. Gram, Henrik Kloverpris, Peter Aaby, Zacarias José Da Silva, Eva-Maria Fenyö, and Anders Fomsgaard. Sequence Analysis of HIV-1 Isolates from Guinea-Bissau: Selection of Vaccine Epitopes Relevant in Both West African and European Countries. APMIS, 119(8):487-497, Aug 2011. PubMed ID: 21749448. Show all entries for this paper.


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