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Displaying record number 1094

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HXB2 Location	Nef(188-201) DNA(9358..9399)	Nef Epitope Map
Author Location	Nef(188-201 LAI)
Epitope	RLAFHHVARELHPE	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B35, Cw4)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

• Vertical transmission of HIV ranges from 13% to 39%
• Primary assays showed that cytotoxic activity against at least one HIV protein was detected in 70% of infected children.
• Epitopes recognized in five children were mapped using synthetic peptides and secondary cultures.
• Patient EM13, who had a CTL response to three epitopes in Nef, was infected via blood transfusion after birth and went from CDC stage P2A to P2E during the study.

References

Buseyne1993b F. Buseyne, S. Blanche, D. Schmitt, C. Griscelli, and Y. Riviere. Detection of HIV-Specific Cell-Mediated Cytotoxicity in the Peripheral Blood from Infected Children. J. Immunol., 150:3569-3581, 1993. PubMed ID: 8096852. Show all entries for this paper.