HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 13 matching records:

Displaying record number 60123

HXB2 Location Pol(978-986)
Integrase(263-271)
DNA(5016..5042)
Pol Epitope Map
Author Location Pol(978-986)
Epitope RKAKIIRDY Epitope Alignment
RKAKIIRDY epitope logo
Epitope Name RY9
Species (MHC/HLA) human(A*24)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54347

HXB2 Location Pol(978-986)
Integrase(263-271)
DNA(5016..5042)
Pol Epitope Map
Author Location Integrase
Epitope RKAKIIRDY Epitope Alignment
RKAKIIRDY epitope logo
Epitope Name B15-RY9(Int)
Species (MHC/HLA) human(B15)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 56004

HXB2 Location Pol(978-986)
Integrase(263-271)
DNA(5016..5042)
Pol Epitope Map
Author Location Integrase
Epitope RKAKIIRDY Epitope Alignment
RKAKIIRDY epitope logo
Epitope Name RY9(Integrase)
Subtype B
Species (MHC/HLA) human(B15)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 60122

HXB2 Location Pol(978-986)
Integrase(263-271)
DNA(5016..5042)
Pol Epitope Map
Author Location Pol(978-986)
Epitope RKAKIIRDY Epitope Alignment
RKAKIIRDY epitope logo
Epitope Name RY9
Species (MHC/HLA) human(B*1501)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60121

HXB2 Location Pol(978-986)
Integrase(263-271)
DNA(5016..5042)
Pol Epitope Map
Author Location Pol(978-986)
Epitope RKAKIIRDY Epitope Alignment
RKAKIIRDY epitope logo
Epitope Name RY9
Species (MHC/HLA) human(B*1503)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 52555

HXB2 Location Pol(978-986)
Integrase(263-271)
DNA(5016..5042)
Pol Epitope Map
Author Location Integrase(263-271)
Epitope RKAKIIRDY Epitope Alignment
RKAKIIRDY epitope logo
Species (MHC/HLA) human(B*1503)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

References

Llano2019 Anuska Llano, Samandhy CedeƱo, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 52617

HXB2 Location Pol(978-986)
Integrase(263-271)
DNA(5016..5042)
Pol Epitope Map
Author Location Integrase(263-271)
Epitope RKAKIIRDY Epitope Alignment
RKAKIIRDY epitope logo
Subtype B
Species (MHC/HLA) human(B*1503)
Immunogen HIV-1 infection
Patient MHC/HLA A*2301, B*1503, B*3501, Cw2, Cw7
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity, acute/early infection, early-expressed proteins

Notes

References

Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.


Displaying record number 55077

HXB2 Location Pol(978-986)
Integrase(263-271)
DNA(5016..5042)
Pol Epitope Map
Author Location Integrase
Epitope RKAKIIRDY Epitope Alignment
RKAKIIRDY epitope logo
Show epitope variants
Subtype B, C
Species (MHC/HLA) human(B*1503)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, rate of progression, immunodominance

Notes

References

Frahm2006 Nicole Frahm, Photini Kiepiela, Sharon Adams, Caitlyn H. Linde, Hannah S. Hewitt, Kaori Sango, Margaret E. Feeney, Marylyn M. Addo, Mathias Lichterfeld, Matthew P. Lahaie, Eunice Pae, Alysse G. Wurcel, Timothy Roach, M Anne. St. John, Marcus Altfeld, Francesco M. Marincola, Corey Moore, Simon Mallal, Mary Carrington, David Heckerman, Todd M. Allen, James I. Mullins, Bette T. Korber, Philip J. R. Goulder, Bruce D. Walker, and Christian Brander. Control of Human Immunodeficiency Virus Replication by Cytotoxic T Lymphocytes Targeting Subdominant Epitopes. Nat. Immunol., 7(2):173-178, Feb 2006. PubMed ID: 16369537. Show all entries for this paper.


Displaying record number 57983

HXB2 Location Pol(978-986)
Integrase(263-271)
DNA(5016..5042)
Pol Epitope Map
Author Location Integrase(263-271)
Epitope RKAKIIRDY Epitope Alignment
RKAKIIRDY epitope logo
Subtype B
Species (MHC/HLA) human(B*1503)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords acute/early infection

Notes

References

Arnoczy2011 Gretchen S. Arnoczy, Guido Ferrari, Nilu Goonetilleke, Tumena Corrah, Hui Li, Joann Kuruc, John L. Schmitz, Kara McGee, Charles Hicks, and Joseph J. Eron. Massive CD8 T Cell Response to Primary HIV Infection in the Setting of Severe Clinical Presentation. AIDS Res. Hum. Retroviruses, 19 Oct 2011. PubMed ID: 22011008. Show all entries for this paper.


Displaying record number 60993

HXB2 Location Pol(978-986)
Integrase(263-271)
DNA(5016..5042)
Pol Epitope Map
Author Location Integrase(263-271)
Epitope RKAKIIRDY Epitope Alignment
RKAKIIRDY epitope logo
Subtype B
Species (MHC/HLA) human(B*1503)
Immunogen HIV-1 infection
Patient MHC/HLA 17543: A*0101, A*0202, B*0701, B*1503, Cw*0210, Cw*0702
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 61167

HXB2 Location Pol(978-986)
Integrase(263-271)
DNA(5016..5042)
Pol Epitope Map
Author Location Pol(978-986)
Epitope RKAKIIRDY Epitope Alignment
RKAKIIRDY epitope logo
Show epitope variants
Epitope Name RY9
Subtype B
Species (MHC/HLA) human(B*1503)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords acute/early infection, variant cross-reactivity

Notes

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 60124

HXB2 Location Pol(978-986)
Integrase(263-271)
DNA(5016..5042)
Pol Epitope Map
Author Location Pol(978-986)
Epitope RKAKIIRDY Epitope Alignment
RKAKIIRDY epitope logo
Epitope Name RY9
Species (MHC/HLA) human(B*49)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 58118

HXB2 Location Pol(978-986)
Integrase(263-271)
DNA(5016..5042)
Pol Epitope Map
Author Location Pol
Epitope RKAKIIRDY Epitope Alignment
RKAKIIRDY epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Patient MHC/HLA A*2402, A*6801, B*1503, B*4006, Cw*0202, Cw*1502
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus type 5 (Ad5), DNA prime with Ad5 boost
Vaccine strain B clade IIIB, B clade JRFL, B clade CAM-1
Vaccine component Gag, Nef, Pol

Notes

References

Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Operated by Los Alamos National Security, LLC, for the U.S. Department of Energy's National Nuclear Security Administration
Copyright © 2006-2017 LANS LLC All rights reserved | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health