HIV molecular immunology database
Found 20 matching records:
Download this epitope record as JSON.
HXB2 Location | Vif(17-26) DNA(5089..5118) |
Vif Epitope Map |
---|---|---|
Author Location | Vif(17-26) | |
Epitope |
RIRTWKSLVK
|
Epitope Alignment
|
Epitope Name | RK10 | |
Subtype | B | |
Species (MHC/HLA) | human(A*03) | |
Immunogen | in vitro stimulation or selection, HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | TCR usage, assay or method development, chronic infection |
Balamurugan2010 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Rapid T Cell Receptor Delineation Reveals Clonal Expansion Limitation of the Magnitude of the HIV-1-Specific CD8+ T Cell Response. J. Immunol., 185(10):5935-5942, 15 Nov 2010. PubMed ID: 20944001. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vif(17-26) DNA(5089..5118) |
Vif Epitope Map |
---|---|---|
Author Location | Vif(17-26) | |
Epitope |
RIRTWKSLVK
|
Epitope Alignment
|
Epitope Name | RK10 | |
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vif(17-26) DNA(5089..5118) |
Vif Epitope Map |
---|---|---|
Author Location | ||
Epitope |
RIRTWKSLVK
|
Epitope Alignment
|
Epitope Name | Vif-RK10 | |
Subtype | B | |
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vif(17-26) DNA(5089..5118) |
Vif Epitope Map |
---|---|---|
Author Location | ||
Epitope |
RIRTWKSLVK
|
Epitope Alignment
|
Epitope Name | RK10 | |
Subtype | B | |
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infection | |
Country | Barbados, Haiti, Jamaica | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | mother-to-infant transmission, elite controllers |
Schneidewind2009 Arne Schneidewind, Yanhua Tang, Mark A. Brockman, Elizabeth G. Ryland, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, M. Anne St. John, Joseph A. Conrad, Spyros A. Kalams, Francine Noel, Todd M. Allen, Celia D. Christie, and Margaret E. Feeney. Maternal Transmission of Human Immunodeficiency Virus Escape Mutations Subverts HLA-B57 Immunodominance but Facilitates Viral Control in the Haploidentical Infant. J. Virol., 83(17):8616-8627, Sep 2009. PubMed ID: 19515764. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vif(17-26) DNA(5089..5118) |
Vif Epitope Map |
---|---|---|
Author Location | Vif(17-26 SF2) | |
Epitope |
RIRTWKSLVK
|
Epitope Alignment
|
Epitope Name | RK10 | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Altfeld2001c M. Altfeld, M. M. Addo, R. L. Eldridge, X. G. Yu, S. Thomas, A. Khatri, D. Strick, M. N. Phillips, G. B. Cohen, S. A. Islam, S. A. Kalams, C. Brander, P. J. Goulder, E. S. Rosenberg, B. D. Walker, and The HIV Study Collaboration.. Vpr is preferentially targeted by CTL during HIV-1 infection. J. Immunol., 167(5):2743-52, 1 Sep 2001. URL: http://www.jimmunol.org/cgi/content/full/167/5/2743. PubMed ID: 11509618. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vif(17-26) DNA(5089..5118) |
Vif Epitope Map |
---|---|---|
Author Location | ( LAI) | |
Epitope |
RIRTWKSLVK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Altfeld2000c M. Altfeld. Personal communication, 2000. Show all entries for this paper.
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vif(17-26) DNA(5089..5118) |
Vif Epitope Map |
---|---|---|
Author Location | Vif(17-26) | |
Epitope |
RIRTWKSLVK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | early-expressed proteins |
Addo2002a M. M. Addo, X. G. Yu, E. S. Rosenberg, B. D. Walker, and M. Altfeld. Cytotoxic T-Lymphocyte (CTL) Responses Directed against Regulatory and Accessory Proteins in HIV-1 Infection. DNA Cell Biol., 21(9):671-678, Sep 2002. PubMed ID: 12396610. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vif(17-26) DNA(5089..5118) |
Vif Epitope Map |
---|---|---|
Author Location | Vif(17-26) | |
Epitope |
RIRTWKSLVK
|
Epitope Alignment
|
Epitope Name | RK10 | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | review |
Silver2017 Zachary A. Silver and David I. Watkins. The Role of MHC Class I Gene Products in SIV Infection of Macaques. Immunogenetics, 69(8-9):511-519, Aug 2017. PubMed ID: 28695289. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vif(17-26) DNA(5089..5118) |
Vif Epitope Map |
---|---|---|
Author Location | Vif(17-26) | |
Epitope |
RIRTWKSLVK
|
Epitope Alignment
|
Epitope Name | RK10 | |
Species (MHC/HLA) | human(A*29) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vif(17-26) DNA(5089..5118) |
Vif Epitope Map |
---|---|---|
Author Location | Vif | |
Epitope |
RIRTWKSLVK
|
Epitope Alignment
|
Epitope Name | A3-RK10(Vif) | |
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vif(17-26) DNA(5089..5118) |
Vif Epitope Map |
---|---|---|
Author Location | Vif(17-26) | |
Epitope |
RIRTWKSLVK
|
Epitope Alignment
|
Epitope Name | A3-RK10 | |
Subtype | B | |
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A3, B7, Cw7 | |
Experimental methods | ||
Keywords | dynamics, supervised treatment interruptions (STI), acute/early infection |
Yu2002b Xu G. Yu, Marylyn M. Addo, Eric S. Rosenberg, William R. Rodriguez, Paul K. Lee, Cecily A. Fitzpatrick, Mary N. Johnston, Daryld. Strick, Philip J. R. Goulder, Bruce D. Walker, and Marcus Altfeld. Consistent Patterns in the Development and Immunodominance of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T-Cell Responses Following Acute HIV-1 Infection. J. Virol., 76(17):8690-8701, Sep 2002. PubMed ID: 12163589. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vif(17-26) DNA(5089..5118) |
Vif Epitope Map |
---|---|---|
Author Location | Vif(17-26) | |
Epitope |
RIRTWKSLVK
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | A3-RK10 Vif | |
Subtype | B | |
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | supervised treatment interruptions (STI), escape, early treatment, superinfection |
Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vif(17-26) DNA(5089..5118) |
Vif Epitope Map |
---|---|---|
Author Location | Vif(17-26) | |
Epitope |
RIRTWKSLVK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A3, A32, B15, B51, C*03, Cw6, DQ7, DR4, DR8 | |
Country | Netherlands | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, escape |
Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vif(17-26) DNA(5089..5118) |
Vif Epitope Map |
---|---|---|
Author Location | ( B consensus) | |
Epitope |
RIRTWKSLVK
|
Epitope Alignment
|
Epitope Name | RK10 | |
Subtype | B | |
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A2, A3, B62, B8, Cw10, Cw7; A3, B7, Cw7 | |
Experimental methods | Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | assay or method development, memory cells, characterizing CD8+ T cells |
Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vif(17-26) DNA(5089..5118) |
Vif Epitope Map |
---|---|---|
Author Location | Vif | |
Epitope |
RIRTWKSLVK
|
Epitope Alignment
|
Epitope Name | RK10 | |
Subtype | B | |
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A1, A3, B57, B7, Cw6, Cw7 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion |
Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vif(17-26) DNA(5089..5118) |
Vif Epitope Map |
---|---|---|
Author Location | Vif | |
Epitope |
RIRTWKSLVK
|
Epitope Alignment
|
Epitope Name | RK10(Vif) | |
Subtype | B | |
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Country | China | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | chronic infection |
Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vif(17-26) DNA(5089..5118) |
Vif Epitope Map |
---|---|---|
Author Location | ||
Epitope |
RIRTWKSLVK
|
Epitope Alignment
|
Epitope Name | RK10 | |
Species (MHC/HLA) | human(A*30:01) | |
Immunogen | HIV-1 infection, vaccine | |
Patient MHC/HLA | VID403: A*01:01, A*30:01, B*13:02, B*39:01, C*06:02, C*07:01, DQB1*02, DQB1*05, DRB1*07:01, DRB1*16:01, DRB4, DRB5 | |
Country | United Kingdom | |
Experimental methods | Intracellular cytokine staining, Other | |
Keywords | vaccine-induced immune responses, novel epitope |
Borthwick2017 Nicola Borthwick, Zhansong Lin, Tomohiro Akahoshi, Anuska Llano, Sandra Silva-Arrieta, Tina Ahmed, Lucy Dorrell, Christian Brander, Hayato Murakoshi, Masafumi Takiguchi, and Tomáš Hanke. Novel, In-Natural-Infection Subdominant HIV-1 CD8+ T-Cell Epitopes Revealed in Human Recipients of Conserved-Region T-Cell Vaccines. PLoS One, 12(4):1-19, 2017. PubMed ID: 28448594. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vif(17-26) DNA(5089..5118) |
Vif Epitope Map |
---|---|---|
Author Location | Vif(17-26) | |
Epitope |
RIRTWKSLVK
|
Epitope Alignment
|
Epitope Name | RK10 | |
Species (MHC/HLA) | human(A*66) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vif(17-26) DNA(5089..5118) |
Vif Epitope Map |
---|---|---|
Author Location | Vif(17-26) | |
Epitope |
RIRTWKSLVK
|
Epitope Alignment
|
Epitope Name | RK10 | |
Species (MHC/HLA) | human(C*14) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vif(17-26) DNA(5089..5118) |
Vif Epitope Map |
---|---|---|
Author Location | ||
Epitope |
RIRTWKSLVK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | epitope processing, escape |
Yusim2002 Karina Yusim, Can Kesmir, Brian Gaschen, Marylyn M. Addo, Marcus Altfeld, S\oren Brunak, Alexandre Chigaev, Vincent Detours, and Bette T. Korber. Clustering Patterns of Cytotoxic T-Lymphocyte Epitopes in Human Immunodeficiency Virus Type 1 (HIV-1) Proteins Reveal Imprints of Immune Evasion on HIV-1 Global Variation. J. Virol., 76(17):8757-8768, Sep 2002. PubMed ID: 12163596. Show all entries for this paper.