Found 18 matching records:
Download this epitope record as JSON.
HXB2 Location | Vpr(62-70) DNA(5742..5768) |
Vpr Epitope Map |
---|---|---|
Author Location | Vpr(62-) | |
Epitope |
RILQQLLFI
|
Epitope Alignment
|
Epitope Name | Vpr-62 | |
Species (MHC/HLA) | human(A*02:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 14279: A*02:01, A*11, B*13, B*35, C*04, DQ2, DQ7, DR11, DR3, DRw52; 17697: A*02:01, A25, B18, B7 | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | binding affinity, supertype, immunodominance, HLA cross-presentation, novel epitope, chronic infection |
Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vpr(62-70) DNA(5742..5768) |
Vpr Epitope Map |
---|---|---|
Author Location | Vpr(62-70) | |
Epitope |
RILQQLLFI
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*02:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | early-expressed proteins |
Addo2002a M. M. Addo, X. G. Yu, E. S. Rosenberg, B. D. Walker, and M. Altfeld. Cytotoxic T-Lymphocyte (CTL) Responses Directed against Regulatory and Accessory Proteins in HIV-1 Infection. DNA Cell Biol., 21(9):671-678, Sep 2002. PubMed ID: 12396610. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vpr(62-70) DNA(5742..5768) |
Vpr Epitope Map |
---|---|---|
Author Location | Vpr(162-) | |
Epitope |
RILQQLLFI
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*02:01) | |
Immunogen | vaccine | |
Country | Botswana, United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay | |
Keywords | vaccine antigen design |
Vaccine type | DNA, polyepitope |
---|---|
Vaccine strain | multiple epitope immunogen |
Gorse2008a Geoffrey J. Gorse, Lindsey R. Baden, Margaret Wecker, Mark J. Newman, Guido Ferrari, Kent J. Weinhold, Brian D. Livingston, Tonya L. Villafana, Hongli Li, Elizabeth Noonan, Nina D. Russell, and HIV Vaccine Trials Network. Safety and Immunogenicity of Cytotoxic T-Lymphocyte Poly-Epitope, DNA Plasmid (EP HIV-1090) Vaccine in Healthy, Human Immunodeficiency Virus Type 1 (HIV-1)-Uninfected Adults. Vaccine, 26(2):215-223, 10 Jan 2008. PubMed ID: 18055072. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vpr(62-70) DNA(5742..5768) |
Vpr Epitope Map |
---|---|---|
Author Location | Vpr | |
Epitope |
RILQQLLFI
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | Vpr 62 | |
Subtype | M group | |
Species (MHC/HLA) | human, humanized mouse, mouse(A*02:01) | |
Immunogen | in vitro stimulation or selection, vaccine | |
Experimental methods | Cytokine production, T-cell Elispot | |
Keywords | subtype comparisons, computational prediction, escape, TCR usage, variant cross-reactivity |
Vaccine type | DNA, peptide |
---|---|
Adjuvant | Incomplete Freund's Adjuvant (IFA) |
McKinney2004 Denise M. McKinney, Rhonda Skvoretz, Brian D. Livingston, Cara C. Wilson, Michelle Anders, Robert W. Chesnut, Alessandro Sette, Max Essex, Vladimir Novitsky, and Mark J. Newman. Recognition of Variant HIV-1 Epitopes from Diverse Viral Subtypes by Vaccine-Induced CTL. J. Immunol., 173(3):1941-1950, 1 Aug 2004. PubMed ID: 15265928. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vpr(62-70) DNA(5742..5768) |
Vpr Epitope Map |
---|---|---|
Author Location | ||
Epitope |
RILQQLLFI
|
Epitope Alignment
|
Epitope Name | RIL | |
Subtype | A, B, C | |
Species (MHC/HLA) | transgenic mouse(A2) | |
Immunogen | vaccine | |
Experimental methods | Flow cytometric T-cell cytokine assay | |
Keywords | epitope processing, vaccine antigen design |
Vaccine type | DNA prime with vaccinia boost, polyepitope |
---|---|
Vaccine strain | A clade, B clade, C clade |
Vaccine component | Env, Gag, Nef, Pol, Vpr |
Bazhan2010 S. I. Bazhan, L. I. Karpenko, T. N. Ilyicheva, P. A. Belavin, S. V. Seregin, N. K. Danilyuk, D. V. Antonets, and A. A. Ilyichev. Rational Design Based Synthetic Polyepitope DNA Vaccine for Eliciting HIV-Specific CD8+ T Cell Responses. Mol Immunol, 47(7-8):1507-1515, Apr 2010. PubMed ID: 20189249. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vpr(62-70) DNA(5742..5768) |
Vpr Epitope Map |
---|---|---|
Author Location | Vpr(62-70) | |
Epitope |
RILQQLLFI
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A2) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding | |
Keywords | acute/early infection, optimal epitope |
Altfeld2005a Marcus Altfeld, Todd M. Allen, Elizabeth T. Kalife, Nicole Frahm, Marylyn M. Addo, Bianca R. Mothe, Almas Rathod, Laura L. Reyor, Jason Harlow, Xu G. Yu, Beth Perkins, Loren K. Robinson, John Sidney, Galit Alter, Mathias Lichterfeld, Alessandro Sette, Eric S. Rosenberg, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. The Majority of Currently Circulating Human Immunodeficiency Virus Type 1 Clade B Viruses Fail To Prime Cytotoxic T-Lymphocyte Responses against an Otherwise Immunodominant HLA-A2-Restricted Epitope: Implications for Vaccine Design. J. Virol., 79(8):5000-5005, Apr 2005. PubMed ID: 15795285. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vpr(62-70) DNA(5742..5768) |
Vpr Epitope Map |
---|---|---|
Author Location | Vpr | |
Epitope |
RILQQLLFI
|
Epitope Alignment
|
Epitope Name | A2-RI9(Vpr) | |
Species (MHC/HLA) | human(A2) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vpr(62-70) DNA(5742..5768) |
Vpr Epitope Map |
---|---|---|
Author Location | Vpr | |
Epitope |
RILQQLLFI
|
Epitope Alignment
|
Epitope Name | Vpr62 | |
Subtype | B | |
Species (MHC/HLA) | human(A2) | |
Immunogen | vaccine | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | antibody binding site |
Vaccine type | DNA, polyepitope |
---|---|
Vaccine component | other |
Wilson2008 Cara C. Wilson, Mark J. Newman, Brian D. Livingston, Samantha MaWhinney, Jeri E. Forster, Jim Scott, Robert T. Schooley, and Constance A. Benson. Clinical Phase 1 Testing of the Safety and Immunogenicity of an Epitope-Based DNA Vaccine in Human Immunodeficiency Virus Type 1-Infected Subjects Receiving Highly Active Antiretroviral Therapy. Clin. Vaccine Immunol., 15(6):986-994, Jun 2008. PubMed ID: 18400976. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vpr(62-70) DNA(5742..5768) |
Vpr Epitope Map |
---|---|---|
Author Location | Vpr(62-70) | |
Epitope |
RILQQLLFI
|
Epitope Alignment
|
Epitope Name | RI9 | |
Species (MHC/HLA) | human(A*29) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vpr(62-70) DNA(5742..5768) |
Vpr Epitope Map |
---|---|---|
Author Location | Vpr(62-70) | |
Epitope |
RILQQLLFI
|
Epitope Alignment
|
Species (MHC/HLA) | human(A2 supertype) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | supertype, rate of progression |
Propato2001 A. Propato, E. Schiaffella, E. Vicenzi, V. Francavilla, L. Baloni, M. Paroli, L. Finocchi, N. Tanigaki, S. Ghezzi, R. Ferrara, R. Chesnut, B. Livingston, A. Sette, R. Paganelli, F. Aiuti, G. Poli, and V. Barnaba. Spreading of HIV-specific CD8+ T-cell repertoire in long-term nonprogressors and its role in the control of viral load and disease activity. Hum. Immunol., 62(6):561-76, Jun 2001. PubMed ID: 11390031. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vpr(62-70) DNA(5742..5768) |
Vpr Epitope Map |
---|---|---|
Author Location | Vpr | |
Epitope |
RILQQLLFI
|
Epitope Alignment
|
Epitope Name | Vpr62 | |
Subtype | A, B, C, D | |
Species (MHC/HLA) | human(A2 supertype) | |
Immunogen | HIV-1 infection, vaccine | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | binding affinity, supertype, computational prediction, vaccine-induced immune responses, HLA cross-presentation |
Vaccine type | DNA |
---|---|
Vaccine strain | multiple epitope immunogen |
Wilson2003 Cara C. Wilson, Denise McKinney, Michelle Anders, Samantha MaWhinney, Jeri Forster, Claire Crimi, Scott Southwood, Alessandro Sette, Robert Chesnut, Mark J Newman, and Brian D Livingston. Development of a DNA Vaccine Designed to Induce Cytotoxic T Lymphocyte Responses to Multiple Conserved Epitopes in HIV-1. J. Immunol., 171(10):5611-5623, 15 Nov 2003. PubMed ID: 14607970. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vpr(62-70) DNA(5742..5768) |
Vpr Epitope Map |
---|---|---|
Author Location | Vpr(62-70) | |
Epitope |
RILQQLLFI
|
Epitope Alignment
|
Epitope Name | RI9 | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vpr(62-70) DNA(5742..5768) |
Vpr Epitope Map |
---|---|---|
Author Location | Vpr(62-70) | |
Epitope |
RILQQLLFI
|
Epitope Alignment
|
Epitope Name | RI9 | |
Species (MHC/HLA) | human(B*13) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vpr(62-70) DNA(5742..5768) |
Vpr Epitope Map |
---|---|---|
Author Location | Vpr(62-70) | |
Epitope |
RILQQLLFI
|
Epitope Alignment
|
Epitope Name | RI9 | |
Species (MHC/HLA) | human(B*44) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vpr(62-70) DNA(5742..5768) |
Vpr Epitope Map |
---|---|---|
Author Location | Vpr(62-70) | |
Epitope |
RILQQLLFI
|
Epitope Alignment
|
Epitope Name | RI9 | |
Species (MHC/HLA) | human(C*15) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vpr(62-70) DNA(5742..5768) |
Vpr Epitope Map |
---|---|---|
Author Location | Vpr(62-70) | |
Epitope |
RILQQLLFI
|
Epitope Alignment
|
Epitope Name | RI9 | |
Species (MHC/HLA) | human(C*16) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vpr(62-70) DNA(5742..5768) |
Vpr Epitope Map |
---|---|---|
Author Location | Vpr(62-70) | |
Epitope |
RILQQLLFI
|
Epitope Alignment
|
Epitope Name | RI9 | |
Species (MHC/HLA) | human(C*18) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Vpr(62-70) DNA(5742..5768) |
Vpr Epitope Map |
---|---|---|
Author Location | Vpr | |
Epitope |
RILQQLLFI
|
Epitope Alignment
|
Epitope Name | A2-RI9 | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | immunodominance, acute/early infection, chronic infection |
Streeck2009a Hendrik Streeck, Jonathan S. Jolin, Ying Qi, Bader Yassine-Diab, Randall C. Johnson, Douglas S. Kwon, Marylyn M. Addo, Chanson Brumme, Jean-Pierre Routy, Susan Little, Heiko K. Jessen, Anthony D. Kelleher, Frederick M. Hecht, Rafick-Pierre Sekaly, Eric S. Rosenberg, Bruce D. Walker, Mary Carrington, and Marcus Altfeld. Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses during Primary Infection Are Major Determinants of the Viral Set Point and Loss of CD4+ T Cells. J. Virol., 83(15):7641-7648, Aug 2009. PubMed ID: 19458000. Show all entries for this paper.
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