HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 17 matching records:

Displaying record number 1311

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HXB2 Location Vpr(62-70)
DNA(5742..5768)
Vpr Epitope Map
Author Location Vpr(62-)
Epitope RILQQLLFI Epitope Alignment
RILQQLLFI epitope logo
Epitope Name Vpr-62
Species (MHC/HLA) human(A*02:01)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, supertype, computational epitope prediction, HLA cross-presentation

Notes

References

Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.


Displaying record number 52410

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HXB2 Location Vpr(62-70)
DNA(5742..5768)
Vpr Epitope Map
Author Location Vpr(62-70)
Epitope RILQQLLFI Epitope Alignment
RILQQLLFI epitope logo
Subtype B
Species (MHC/HLA) human(A*02:01)
Immunogen HIV-1 infection
Experimental methods  
Keywords early-expressed proteins

Notes

References

Addo2002a M. M. Addo, X. G. Yu, E. S. Rosenberg, B. D. Walker, and M. Altfeld. Cytotoxic T-Lymphocyte (CTL) Responses Directed against Regulatory and Accessory Proteins in HIV-1 Infection. DNA Cell Biol., 21(9):671-678, Sep 2002. PubMed ID: 12396610. Show all entries for this paper.


Displaying record number 56189

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HXB2 Location Vpr(62-70)
DNA(5742..5768)
Vpr Epitope Map
Author Location Vpr(162-)
Epitope RILQQLLFI Epitope Alignment
RILQQLLFI epitope logo
Species (MHC/HLA) human(A*02:01)
Immunogen vaccine
Country Botswana, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords vaccine antigen design

Vaccine Details

Vaccine type DNA, polyepitope
Vaccine strain multiple epitope immunogen

Notes

References

Gorse2008a Geoffrey J. Gorse, Lindsey R. Baden, Margaret Wecker, Mark J. Newman, Guido Ferrari, Kent J. Weinhold, Brian D. Livingston, Tonya L. Villafana, Hongli Li, Elizabeth Noonan, Nina D. Russell, and HIV Vaccine Trials Network. Safety and Immunogenicity of Cytotoxic T-Lymphocyte Poly-Epitope, DNA Plasmid (EP HIV-1090) Vaccine in Healthy, Human Immunodeficiency Virus Type 1 (HIV-1)-Uninfected Adults. Vaccine, 26(2):215-223, 10 Jan 2008. PubMed ID: 18055072. Show all entries for this paper.


Displaying record number 53070

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HXB2 Location Vpr(62-70)
DNA(5742..5768)
Vpr Epitope Map
Author Location Vpr
Epitope RILQQLLFI Epitope Alignment
RILQQLLFI epitope logo
Show epitope variants
Epitope Name Vpr 62
Subtype M group
Species (MHC/HLA) human, humanized mouse, mouse(A*02:01)
Immunogen in vitro stimulation or selection, vaccine
Experimental methods Cytokine production, T-cell Elispot
Keywords subtype comparisons, computational epitope prediction, escape, TCR usage, variant cross-reactivity

Vaccine Details

Vaccine type DNA, peptide
Adjuvant Incomplete Freund's Adjuvant (IFA)

Notes

References

McKinney2004 Denise M. McKinney, Rhonda Skvoretz, Brian D. Livingston, Cara C. Wilson, Michelle Anders, Robert W. Chesnut, Alessandro Sette, Max Essex, Vladimir Novitsky, and Mark J. Newman. Recognition of Variant HIV-1 Epitopes from Diverse Viral Subtypes by Vaccine-Induced CTL. J. Immunol., 173(3):1941-1950, 1 Aug 2004. PubMed ID: 15265928. Show all entries for this paper.


Displaying record number 56530

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HXB2 Location Vpr(62-70)
DNA(5742..5768)
Vpr Epitope Map
Author Location Vpr
Epitope RILQQLLFI Epitope Alignment
RILQQLLFI epitope logo
Epitope Name Vpr62
Subtype B
Species (MHC/HLA) human(A2)
Immunogen vaccine
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords antibody binding site

Vaccine Details

Vaccine type DNA, polyepitope
Vaccine component other

Notes

References

Wilson2008 Cara C. Wilson, Mark J. Newman, Brian D. Livingston, Samantha MaWhinney, Jeri E. Forster, Jim Scott, Robert T. Schooley, and Constance A. Benson. Clinical Phase 1 Testing of the Safety and Immunogenicity of an Epitope-Based DNA Vaccine in Human Immunodeficiency Virus Type 1-Infected Subjects Receiving Highly Active Antiretroviral Therapy. Clin. Vaccine Immunol., 15(6):986-994, Jun 2008. PubMed ID: 18400976. Show all entries for this paper.


Displaying record number 53580

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HXB2 Location Vpr(62-70)
DNA(5742..5768)
Vpr Epitope Map
Author Location Vpr(62-70)
Epitope RILQQLLFI Epitope Alignment
RILQQLLFI epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords acute/early infection, optimal epitope

Notes

References

Altfeld2005a Marcus Altfeld, Todd M. Allen, Elizabeth T. Kalife, Nicole Frahm, Marylyn M. Addo, Bianca R. Mothe, Almas Rathod, Laura L. Reyor, Jason Harlow, Xu G. Yu, Beth Perkins, Loren K. Robinson, John Sidney, Galit Alter, Mathias Lichterfeld, Alessandro Sette, Eric S. Rosenberg, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. The Majority of Currently Circulating Human Immunodeficiency Virus Type 1 Clade B Viruses Fail To Prime Cytotoxic T-Lymphocyte Responses against an Otherwise Immunodominant HLA-A2-Restricted Epitope: Implications for Vaccine Design. J. Virol., 79(8):5000-5005, Apr 2005. PubMed ID: 15795285. Show all entries for this paper.


Displaying record number 54236

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HXB2 Location Vpr(62-70)
DNA(5742..5768)
Vpr Epitope Map
Author Location Vpr
Epitope RILQQLLFI Epitope Alignment
RILQQLLFI epitope logo
Epitope Name A2-RI9(Vpr)
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 57630

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HXB2 Location Vpr(62-70)
DNA(5742..5768)
Vpr Epitope Map
Author Location  
Epitope RILQQLLFI Epitope Alignment
RILQQLLFI epitope logo
Epitope Name RIL
Subtype A, B, C
Species (MHC/HLA) transgenic mouse(A2)
Immunogen vaccine
Experimental methods Flow cytometric T-cell cytokine assay
Keywords epitope processing, vaccine antigen design

Vaccine Details

Vaccine type DNA prime with vaccinia boost, polyepitope
Vaccine strain A clade, B clade, C clade
Vaccine component Env, Gag, Nef, Pol, Vpr

Notes

References

Bazhan2010 S. I. Bazhan, L. I. Karpenko, T. N. Ilyicheva, P. A. Belavin, S. V. Seregin, N. K. Danilyuk, D. V. Antonets, and A. A. Ilyichev. Rational Design Based Synthetic Polyepitope DNA Vaccine for Eliciting HIV-Specific CD8+ T Cell Responses. Mol Immunol, 47(7-8):1507-1515, Apr 2010. PubMed ID: 20189249. Show all entries for this paper.


Displaying record number 60113

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HXB2 Location Vpr(62-70)
DNA(5742..5768)
Vpr Epitope Map
Author Location Vpr(62-70)
Epitope RILQQLLFI Epitope Alignment
RILQQLLFI epitope logo
Epitope Name RI9
Species (MHC/HLA) human(A*29)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 1602

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HXB2 Location Vpr(62-70)
DNA(5742..5768)
Vpr Epitope Map
Author Location Vpr(62-70)
Epitope RILQQLLFI Epitope Alignment
RILQQLLFI epitope logo
Species (MHC/HLA) human(A2 supertype)
Immunogen HIV-1 infection
Experimental methods  
Keywords supertype, rate of progression

Notes

References

Propato2001 A. Propato, E. Schiaffella, E. Vicenzi, V. Francavilla, L. Baloni, M. Paroli, L. Finocchi, N. Tanigaki, S. Ghezzi, R. Ferrara, R. Chesnut, B. Livingston, A. Sette, R. Paganelli, F. Aiuti, G. Poli, and V. Barnaba. Spreading of HIV-specific CD8+ T-cell repertoire in long-term nonprogressors and its role in the control of viral load and disease activity. Hum. Immunol., 62(6):561-76, Jun 2001. PubMed ID: 11390031. Show all entries for this paper.


Displaying record number 56511

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HXB2 Location Vpr(62-70)
DNA(5742..5768)
Vpr Epitope Map
Author Location Vpr
Epitope RILQQLLFI Epitope Alignment
RILQQLLFI epitope logo
Epitope Name Vpr62
Subtype A, B, C, D
Species (MHC/HLA) human(A2 supertype)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords binding affinity, supertype, vaccine-induced immune responses, HLA cross-presentation

Notes

References

Wilson2003 Cara C. Wilson, Denise McKinney, Michelle Anders, Samantha MaWhinney, Jeri Forster, Claire Crimi, Scott Southwood, Alessandro Sette, Robert Chesnut, Mark J Newman, and Brian D Livingston. Development of a DNA Vaccine Designed to Induce Cytotoxic T Lymphocyte Responses to Multiple Conserved Epitopes in HIV-1. J. Immunol., 171(10):5611-5623, 15 Nov 2003. PubMed ID: 14607970. Show all entries for this paper.


Displaying record number 60115

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HXB2 Location Vpr(62-70)
DNA(5742..5768)
Vpr Epitope Map
Author Location Vpr(62-70)
Epitope RILQQLLFI Epitope Alignment
RILQQLLFI epitope logo
Epitope Name RI9
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60110

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HXB2 Location Vpr(62-70)
DNA(5742..5768)
Vpr Epitope Map
Author Location Vpr(62-70)
Epitope RILQQLLFI Epitope Alignment
RILQQLLFI epitope logo
Epitope Name RI9
Species (MHC/HLA) human(B*13)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60112

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HXB2 Location Vpr(62-70)
DNA(5742..5768)
Vpr Epitope Map
Author Location Vpr(62-70)
Epitope RILQQLLFI Epitope Alignment
RILQQLLFI epitope logo
Epitope Name RI9
Species (MHC/HLA) human(B*44)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60111

Download this epitope record as JSON.

HXB2 Location Vpr(62-70)
DNA(5742..5768)
Vpr Epitope Map
Author Location Vpr(62-70)
Epitope RILQQLLFI Epitope Alignment
RILQQLLFI epitope logo
Epitope Name RI9
Species (MHC/HLA) human(C*15)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60116

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HXB2 Location Vpr(62-70)
DNA(5742..5768)
Vpr Epitope Map
Author Location Vpr(62-70)
Epitope RILQQLLFI Epitope Alignment
RILQQLLFI epitope logo
Epitope Name RI9
Species (MHC/HLA) human(C*16)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60114

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HXB2 Location Vpr(62-70)
DNA(5742..5768)
Vpr Epitope Map
Author Location Vpr(62-70)
Epitope RILQQLLFI Epitope Alignment
RILQQLLFI epitope logo
Epitope Name RI9
Species (MHC/HLA) human(C*18)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


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