Search CTL/CD8+ T-Cell Epitope Database

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Displaying record number 1173

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HXB2 Location	Gag(91-101) p17(91-101) DNA(1060..1092)	Gag Epitope Map
Author Location	p17( SF2)
Epitope	RIDVKDTKEAL	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords	subtype comparisons, immunodominance

Notes

• The CTL-dominant response was focused on this epitope in an HIV+ Haitian living in Boston, who was A23/68 B45/72 Cw2/16 -- this epitope fell outside the most recognized peptides in the study.
• Three peptides GSEELRSLYNTVATL (p17 residues 71-85), SALSEGATPQDLNTMLNTVG (p24 41-60), and WEKIRLRPGGKKKYKLK (p17 16-30) contained the dominant Gag-specific epitope in 31/44 B-clade infected individuals from Boston who showed Gag-CTL responses.
• Five peptides RLRPGGKKHYMIKHLVW (p17 20-36), ELRSLYNTVATLYCV (p17Gag 74-88), SALSEGATPQDLNTMLNTVG (p24 41-60), FRDYVDRFFKTLRAEQA (p24 161-177), and SILDIKQGKEPFRDY (p24 149-164) contained dominant Gag-specific epitopes in 32/37 C-clade infected subjects from South Africa.

References

Goulder2000 P. J. Goulder, C. Brander, K. Annamalai, N. Mngqundaniso, U. Govender, Y. Tang, S. He, K. E. Hartman, C. A. O'Callaghan, G. S. Ogg, M. A. Altfeld, E. S. Rosenberg, H. Cao, S. A. Kalams, M. Hammond, M. Bunce, S. I. Pelton, S. A. Burchett, K. McIntosh, H. M. Coovadia, and B. D. Walker. Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children. J. Virol., 74:5679-90, 2000. PubMed ID: 10823876. Show all entries for this paper.