HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 73 matching records:

Displaying record number 60103

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location Env(311-320)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name RI10
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 1770

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp120(311-320)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, acute/early infection

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 1106

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp120(311-320 IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 759

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp160(318-327 IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords  

Notes

References

Alexander-Miller1996 M. A. Alexander-Miller, K. C. Parker, T. Tsukui, C. D. Pendleton, J. E. Coligan, and J. A. Berzofsky. Molecular analysis of presentation by HLA-A2.1 of a promiscuously binding V3 loop peptide from the HIV-1 Envelope protein to human cytotoxic T lymphocytes. Int. Immunol., 8:641-649, 1996. PubMed ID: 8671651. Show all entries for this paper.


Displaying record number 52295

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp160(318-327 IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name LR25
Subtype B
Species (MHC/HLA) mouse(A*0201)
Immunogen vaccine
Experimental methods  
Keywords binding affinity, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type peptide
Vaccine strain B clade LAI
Adjuvant Incomplete Freund's Adjuvant (IFA), Montanide (ISA 720), P30, PLG

Notes

References

Peter2001 Katrin Peter, Ying Men, Giuseppe Pantaleo, Bruno Gander, and Giampietro Corradin. Induction of a Cytotoxic T-Cell Response to HIV-1 Proteins with Short Synthetic Peptides and Human Compatible Adjuvants. Vaccine, 19(30):4121-4129, 20 Jul 2001. PubMed ID: 11457536. Show all entries for this paper.


Displaying record number 60101

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location Env(311-320)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name RI10
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54232

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp120
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name A2-RI10(gp120)
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 57631

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location  
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name RGP
Species (MHC/HLA) transgenic mouse(A2)
Immunogen vaccine
Experimental methods Flow cytometric T-cell cytokine assay
Keywords epitope processing, vaccine antigen design

Vaccine Details

Vaccine type DNA prime with vaccinia boost, polyepitope
Vaccine strain A clade, B clade, C clade
Vaccine component Env, Gag, Nef, Pol, Vpr

Notes

References

Bazhan2010 S. I. Bazhan, L. I. Karpenko, T. N. Ilyicheva, P. A. Belavin, S. V. Seregin, N. K. Danilyuk, D. V. Antonets, and A. A. Ilyichev. Rational Design Based Synthetic Polyepitope DNA Vaccine for Eliciting HIV-Specific CD8+ T Cell Responses. Mol Immunol, 47(7-8):1507-1515, Apr 2010. PubMed ID: 20189249. Show all entries for this paper.


Displaying record number 762

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp160(318-327 IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) human(A2)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type vaccinia
Vaccine strain B clade IIIB
Vaccine component gp160

Notes

References

Achour1996 A. Achour, F. Bex, P. Hermans, A. Burny, and D. Zagury. Induction of anti-gp160 cytotoxic T cells cross-reacting with various V3 loop P18 peptides in human immunodeficiency virus type 1 envelope-immunized individuals. J. Virol., 70:6741-6750, 1996. PubMed ID: 8794311. Show all entries for this paper.


Displaying record number 53585

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp160(311-320)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords acute/early infection, optimal epitope

Notes

References

Altfeld2005a Marcus Altfeld, Todd M. Allen, Elizabeth T. Kalife, Nicole Frahm, Marylyn M. Addo, Bianca R. Mothe, Almas Rathod, Laura L. Reyor, Jason Harlow, Xu G. Yu, Beth Perkins, Loren K. Robinson, John Sidney, Galit Alter, Mathias Lichterfeld, Alessandro Sette, Eric S. Rosenberg, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. The Majority of Currently Circulating Human Immunodeficiency Virus Type 1 Clade B Viruses Fail To Prime Cytotoxic T-Lymphocyte Responses against an Otherwise Immunodominant HLA-A2-Restricted Epitope: Implications for Vaccine Design. J. Virol., 79(8):5000-5005, Apr 2005. PubMed ID: 15795285. Show all entries for this paper.


Displaying record number 60105

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location Env(311-320)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name RI10
Species (MHC/HLA) human(A*31)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60106

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location Env(311-320)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name RI10
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60104

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location Env(311-320)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name RI10
Species (MHC/HLA) human(B*4202)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60102

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location Env(311-320)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name RI10
Species (MHC/HLA) human(C*14)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 55110

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location Env
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Subtype A, B
Species (MHC/HLA) mouse(H-2d)
Immunogen vaccine
Country Finland
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords vaccine antigen design

Vaccine Details

Vaccine type DNA
Vaccine strain A clade, B clade
Vaccine component Env, Gag

Notes

References

Malm2007 Maria Malm, Rein Sikut, Kai Krohn, and Vesna Blazevic. GTU-MultiHIV DNA Vaccine Results in Protection in a Novel P815 Tumor Challenge Model. Vaccine, 25(17):3293-301, 30 Apr 2007. PubMed ID: 17289222. Show all entries for this paper.


Displaying record number 52242

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp160(318-327 IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Experimental methods  
Keywords immunodominance

Vaccine Details

Vaccine type DNA prime with vaccinia boost
Vaccine strain B clade IIIB
Vaccine component gp160
Adjuvant beta-glucan lentinan, IL-2/Ig, liposome, PLG

Notes

References

Wierzbicki2002 Andrzej Wierzbicki, Irena Kiszka, Hiroshi Kaneko, Dariusz Kmieciak, Thomas J Wasik, Jaroslaw Gzyl, Yutaro Kaneko, and Danuta Kozbor. Immunization Strategies to Augment Oral Vaccination with DNA and Viral Vectors Expressing HIV Envelope Glycoprotein. Vaccine, 20(9-10):1295-1307, 31 Jan 2002. PubMed ID: 11818148. Show all entries for this paper.


Displaying record number 52287

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp120( LAI)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name P18
Subtype B
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type protein
Vaccine strain B clade LAI
Vaccine component Gag, gp120
Adjuvant CpG immunostimulatory sequence (ISS)

Notes

References

Horner2001 A. A. Horner, G. F. Widhopf, J. A. Burger, K. Takabayashi, N. Cinman, A. Ronaghy, H. L. Spiegelberg, and E. Raz. Immunostimulatory DNA Inhibits IL-4-Dependent IgE Synthesis by Human B Cells. J Allergy Clin Immunol, 108(3):417-423, Sep 2001. PubMed ID: 11544462. Show all entries for this paper.


Displaying record number 52327

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp160 (V3)( IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name I10
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Experimental methods  
Keywords acute/early infection

Vaccine Details

Vaccine type vaccinia
Vaccine strain B clade IIIB
Vaccine component gp160

Notes

References

Takahashi2002 Megumi Takahashi, Eiichi Osono, Yohko Nakagawa, Jian Wang, Jay A. Berzofsky, David H. Margulies, and Hidemi Takahashi. Rapid Induction of Apoptosis in CD8+ HIV-1 Envelope-Specific Murine CTLs by Short Exposure to Antigenic Peptide. J. Immunol., 169(11):6588-6593, 1 Dec 2002. PubMed ID: 12444171. Show all entries for this paper.


Displaying record number 52764

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp160 (V3)( HIV-IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name P18-I10
Subtype B
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Patient MHC/HLA H-2d
Experimental methods Chromium-release assay, Cytokine production, Tetramer binding
Keywords  

Vaccine Details

Vaccine type vaccinia
Vaccine strain B clade IIIB
Vaccine component gp160
Adjuvant IL-15, IL-2

Notes

References

Oh2003a SangKon Oh, Jay A. Berzofsky, Donald S. Burke, Thomas A. Waldmann, and Liyanage P. Perera. Coadministration of HIV Vaccine Vectors with Vaccinia Viruses Expressing IL-15 But Not IL-2 Induces Long-Lasting Cellular Immunity. Proc. Natl. Acad. Sci. U.S.A., 100(6):3392-3397, 18 Mar 2003. PubMed ID: 12626740. Show all entries for this paper.


Displaying record number 52765

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp160( IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name P18-I10
Subtype B
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Patient MHC/HLA H-2d
Experimental methods CD8 T-cell Elispot - IFNγ, Proliferation, Tetramer binding
Keywords  

Vaccine Details

Vaccine type vaccinia
Vaccine strain B clade IIIB
Vaccine component Env V3
Adjuvant B7, ICAM, LFA-3

Notes

References

Oh2003b SangKon Oh, James W Hodge, Jeffrey D Ahlers, Donald S Burke, Jeffrey Schlom, and Jay A Berzofsky. Selective Induction of High Avidity CTL by Altering the Balance of Signals from APC. J. Immunol., 170(5):2523-2530, Mar 2003. PubMed ID: 12594278. Show all entries for this paper.


Displaying record number 52786

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp120 (V3)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Patient MHC/HLA H-2d
Experimental methods Cytotoxicity assay, Tetramer binding
Keywords kinetics, memory cells

Vaccine Details

Vaccine type herpes simplex virus type-1 (HSV-1) amplicon
Vaccine component gp120

Notes

References

Wang2003 Lai-Xi Wang. Bioorganic Approaches towards HIV Vaccine Design. Curr. Pharm. Des., 9(22):1771-87, 2003. PubMed ID: 12871196. Show all entries for this paper.


Displaying record number 52843

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp120 (V3)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name P18-I10
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Experimental methods Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords dendritic cells, Th1, Th2, genital and mucosal immunity

Vaccine Details

Vaccine type peptide, vaccinia
Vaccine strain B clade 89.6, B clade IIIB
Vaccine component gp160ΔV3
Adjuvant Cholera toxin (CT), E. coli mutant heat labile enterotoxin (LT-R72), Incomplete Freund's Adjuvant (IFA), CpG immunostimulatory sequence (ISS)

Notes

References

Belyakov2004 Igor M. Belyakov, Scott A. Hammond, Jeffrey D. Ahlers, Gregory M. Glenn, and Jay A. Berzofsky. Transcutaneous Immunization Induces Mucosal CTLs and Protective Immunity by Migration of Primed Skin Dendritic Cells. J. Clin. Invest., 113(7):998-1007, Apr 2004. PubMed ID: 15057306. Show all entries for this paper.


Displaying record number 53001

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp120 (V3)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Subtype B
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Cytotoxicity assay, Tetramer binding
Keywords vaccine antigen design

Vaccine Details

Vaccine type herpes simplex virus type-1 (HSV-1) amplicon
Vaccine strain B clade LAI, B clade MN
Vaccine component gp120

Notes

References

Hocknell2002 Peter K. Hocknell, Rebecca D. Wiley, Xiuqing Wang, Thomas G. Evans, William J. Bowers, Tomas Hanke, Howard J. Federoff, and Stephen Dewhurst. Expression of Human Immunodeficiency Virus Type 1 gp120 from Herpes Simplex Virus Type 1-Derived Amplicons Results in Potent, Specific, and Durable Cellular and Humoral Immune Responses. J. Virol., 76(11):5565-5580, Jun 2002. PubMed ID: 11991985. Show all entries for this paper.


Displaying record number 53147

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location  
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name R10I
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Experimental methods Chromium-release assay, Cytokine production
Keywords epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA, virus-like particle (VLP), polyepitope
Vaccine component Gag, p24 Gag, Env V3

Notes

References

Wild2004 Jens Wild, Alexandra Bojak, Ludwig Deml, and Ralf Wagner. Influence of Polypeptide Size and Intracellular Sorting on the Induction of Epitope-Specific CTL Responses by DNA Vaccines in a Mouse Model. Vaccine, 22(13-14):1732-1743, 15 Apr 2004. PubMed ID: 15068857. Show all entries for this paper.


Displaying record number 53427

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location Env(318-327)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name R10I
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Patient MHC/HLA H-2D
Experimental methods Intracellular cytokine staining
Keywords vaccine antigen design

Vaccine Details

Vaccine type vaccinia
Vaccine strain B clade IIIB
Vaccine component gp160

Notes

References

Samino2004 Yolanda Samino, Daniel López, Sara Guil, Patricia de León, and Margarita Del Val. An Endogenous HIV Envelope-Derived Peptide without the Terminal NH3+ Group Anchor Is Physiologically Presented by Major Histocompatibility Complex Class I Molecules. J. Biol. Chem., 279(2):1151-1160, 9 Jan 2004. PubMed ID: 14583622. Show all entries for this paper.


Displaying record number 53428

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location p18( IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Subtype B
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Patient MHC/HLA H-2D
Experimental methods CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Chromium-release assay, Cytokine production, Proliferation
Keywords vaccine-induced immune responses, memory cells, characterizing CD8+ T cells

Vaccine Details

Vaccine type DNA with CMV promotor
Vaccine strain B clade IIIB
Vaccine component gp120
Adjuvant IL-12

Notes

References

Seaman2004 Michael S. Seaman, Fred W. Peyerl, Shawn S. Jackson, Michelle A. Lifton, Darci A. Gorgone, Jörn E. Schmitz, and Norman L. Letvin. Subsets of Memory Cytotoxic T Lymphocytes Elicited by Vaccination Influence the Efficiency of Secondary Expansion In Vivo. J. Virol., 78(1):206-15, Jan 2004. PubMed ID: 14671102. Show all entries for this paper.


Displaying record number 54603

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp120
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Subtype B
Species (MHC/HLA) macaque, mouse(H-2Dd)
Immunogen vaccine
Experimental methods CD4 T-cell Elispot - IFNγ, Chromium-release assay, Other, Proliferation, Tetramer binding
Keywords adjuvant comparison, vaccine antigen design, SIV

Vaccine Details

Vaccine type DNA
Vaccine strain B clade IIIB, SIV
Vaccine component gp120

Notes

References

Fuller2007 Deborah Heydenburg Fuller, Tim Shipley, Todd M. Allen, James T. Fuller, Mary S. Wu, Helen Horton, Nancy Wilson, Georg Widera, and David I. Watkins. Immunogenicity of Hybrid DNA Vaccines Expressing Hepatitis B Core Particles Carrying Human AND Simian Immunodeficiency Virus Epitopes in Mice and Rhesus Macaques. Virology, 364(2):245-255, 1 Aug 2007. PubMed ID: 17428516. Show all entries for this paper.


Displaying record number 54791

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location Env (gp160)(318-327 HIV-1 IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name P18-I10
Species (MHC/HLA) mouse(H-2Dd)
Immunogen peptide-HLA interaction
Experimental methods Chromium-release assay, Other
Keywords binding affinity, structure

Notes

References

Nakagawa2007 Yohko Nakagawa, Hiroto Kikuchi, and Hidemi Takahashi. Molecular Analysis of TCR and Peptide/MHC Interaction Using P18-I10-Derived Peptides with a Single D-Amino Acid Substitution. Biophys. J., 92(7):2570-2582, 1 Apr 2007. PubMed ID: 17208967. Show all entries for this paper.


Displaying record number 53002

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp120
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Subtype B
Species (MHC/HLA) humanized mouse(H-2Dd)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords epitope processing, vaccine-induced immune responses, immunodominance, immunotherapy

Vaccine Details

Vaccine type DNA, polyepitope
Vaccine strain B clade MN
Vaccine component gp120, Protease, RT
Adjuvant Incomplete Freund's Adjuvant (IFA)

Notes

References

Isaguliants2004 Maria G. Isaguliants, Bartek Zuber, Andreas Boberg, Dan Sjöstrand, Sergey V. Belikov, Erik Rollman, Anne Kjerrström Zuber, Vladimir O. Rechinsky, Ann-Sofie Rytting, Clas F. R. Källander, Jorma Hinkula, Sergey N. Kochetkov, Margaret Liu, and Britta Wahren. Reverse Transcriptase-Based DNA Vaccines against Drug-Resistant HIV-1 Tested in a Mouse Model. Vaccine, 22(13-14):1810-1819, 16 Apr 2004. PubMed ID: 15068865. Show all entries for this paper.


Displaying record number 751

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp160(318-327 IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Experimental methods  
Keywords dendritic cells

Vaccine Details

Vaccine type peptide
Vaccine strain B clade IIIB
Vaccine component Env V3

Notes

References

Takahashi1993 H. Takahashi, Y. Nakagawa, K. Yokomuro, and J. A. Berzofsky. Induction of CD8+ Cytotoxic T Lymphocytes by Immunization with Syngeneic Irradiated HIV-1 Envelope Derived Peptide-Pulsed Dendritic Cells. Internatl. Immunol., 5:849-857, 1993. PubMed ID: 8398980. Show all entries for this paper.


Displaying record number 752

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp160( IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type non-replicating adenovirus
Vaccine strain B clade IIIB
Vaccine component Env, Rev

Notes

References

Bruce1999 C. B. Bruce, A. Akrigg, S. A. Sharpe, T. Hanke, G. W. Wilkinson, and M. P. Cranage. Replication-Deficient Recombinant Adenoviruses Expressing the Human Immunodeficiency Virus Env Antigen Can Induce Both Humoral and CTL Immune Responses in Mice. J. Gen. Virol., 80(Pt 10):2621-2628, 1999. PubMed ID: 10573155. Show all entries for this paper.


Displaying record number 754

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp160(318-327 IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type peptide
Vaccine strain B clade IIIB
Vaccine component Env V3

Notes

References

Takahashi1996 H. Takahashi, Y. Nakagawa, G. R. Leggatt, Y. Ishida, T. Saito, K. Yokomuro, and J. A. Berzofsky. Inactivation of Human Immunodeficiency Virus (HIV-1) Envelope-Specific CD8+ Cytotoxic T Lymphocytes by Free Antigenic Peptide: A Self-Veto Mechanism? J. Exp. Med., 183:879-889, 1996. PubMed ID: 8642292. Show all entries for this paper.


Displaying record number 59453

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location Env
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name Peptide H
Subtype C
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Cytokine production
Keywords vaccine-induced immune responses, vaccine antigen design

Notes

References

Chapman2013 Rosamund Chapman, Helen Stutz, William Jacobs, Jr., Enid Shephard, and Anna-Lise Williamson. Priming with Recombinant Auxotrophic BCG Expressing HIV-1 Gag, RT and Gp120 and Boosting with Recombinant MVA Induces a Robust T Cell Response in Mice. PLoS One, 8(8):e71601, 20 Aug 2013. PubMed ID: 23977084. Show all entries for this paper.


Displaying record number 761

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp160(318-327 IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) mouse(H-2Dd)
Immunogen peptide-HLA interaction
Experimental methods  
Keywords  

Notes

References

Takeshita1995 T. Takeshita, H. Takahashi, S. Kozlowski, J. D. Ahlers, C. D. Pendleton, R. L. Moore, Y. Nakagawa, K. Yokomuro, B. S. Fox, D. H. Margulies, and J. A. Berzofsky. Molecular Analysis of the Same HIV Peptide Functionally Binding to Both a Class I and a Class II MHC Molecule. J. Immunol., 154:1973-1986, 1995. Of RGPGRAFVTI, the upper case amino acids iGPgRaFvtI are critical for binding, consistent with H-2D$d$ motif XGPX(RKH)XXX(X)(LIF). Stimulation of the HLA class II I-A$^d$ required a longer peptide, IQRGPGRAFVTI or RIQRGPGRAFVTI, and riqrgPgRaFvti were essential for binding to the Class II molecule. PubMed ID: 7530749. Show all entries for this paper.


Displaying record number 59282

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location  
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name epitope H
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type modified vaccinia Ankara (MVA), adenovirus
Vaccine component p17 Gag, p24 Gag

Notes

References

Ondondo2014 Beatrice Ondondo, Sultan Abdul-Jawad, Anne Bridgeman, and Tomáš Hanke. Characterization of T-Cell Responses to Conserved Regions of the HIV-1 Proteome in BALB/c Mice. Clin. Vaccine Immunol., 21(11):1565-1572, Nov 2014. PubMed ID: 25230940. Show all entries for this paper.


Displaying record number 58376

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location  
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name H, P18-I10
Subtype A
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Cytotoxicity assay, Intracellular cytokine staining
Keywords mother-to-infant transmission, vaccine antigen design

Vaccine Details

Vaccine type Bacillus BCG prime with vaccinia Ankara (MVA) boost
Vaccine strain A clade, multiple epitope immunogen
Vaccine component p17 Gag, p24 Gag, Other

Notes

References

Saubi2011 Narcis Saubi, Eung-Jun Im, Raquel Fernández-Lloris, Olga Gil, Pere-Joan Cardona, Josep Maria Gatell, Tomáš Hanke, and Joan Joseph. Newborn Mice Vaccination with BCG.HIVA222 + MVA.HIVA Enhances HIV-1-Specific Immune Responses: Influence of Age and Immunization Routes. Clin. Dev. Immunol., 2011:516219, 2011. PubMed ID: 21603216. Show all entries for this paper.


Displaying record number 58372

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location  
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name H, P18-I10
Subtype A
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Experimental methods Cytotoxicity assay, Intracellular cytokine staining
Keywords mother-to-infant transmission, immunodominance, vaccine antigen design

Vaccine Details

Vaccine type Bacillus BCG prime with vaccinia Ankara (MVA) boost
Vaccine strain A clade, multiple epitope immunogen
Vaccine component p17 Gag, p24 Gag, Other

Notes

References

Im2007 Eung-Jun Im, Narcis Saubi, Goretti Virgili, Clare Sander, Denise Teoh, Jose M. Gatell, Helen McShane, Joan Joseph, and Tomáš Hanke. Vaccine Platform for Prevention of Tuberculosis and Mother-to-Child Transmission of Human Immunodeficiency Virus Type 1 through Breastfeeding. J. Virol., 81(17):9408-9418, Sep 2007. PubMed ID: 17596303. Show all entries for this paper.


Displaying record number 1351

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location Env( IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name I-10
Subtype B
Species (MHC/HLA) mouse(H-2Dd)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords epitope processing, immunodominance, optimal epitope

Notes

References

Nakagawa2000 Y. Nakagawa, T. Takeshita, J. A. Berzofsky, and H. Takahashi. Analysis of the mechanism for extracellular processing in the presentation of human immunodeficiency virus-1 envelope protein-derived peptide to epitope-specific cytotoxic T lymphocytes. Immunology, 101(1):76-82, Sep 2000. PubMed ID: 11012756. Show all entries for this paper.


Displaying record number 58371

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location  
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name H
Subtype A
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Cytotoxicity assay, Flow cytometric T-cell cytokine assay
Keywords mother-to-infant transmission, immunodominance, vaccine antigen design

Vaccine Details

Vaccine type Bacillus BCG prime with vaccinia Ankara (MVA) boost
Vaccine strain A clade, multiple epitope immunogen
Vaccine component p17 Gag, p24 Gag, Other

Notes

References

Hopkins2011 Richard Hopkins, Anne Bridgeman, Joan Joseph, Sarah C Gilbert, Helen McShane, and Tomáš Hanke. Dual Neonate Vaccine Platform against HIV-1 and M. tuberculosis. PLoS One, 6(5):e20067, 2011. PubMed ID: 21603645. Show all entries for this paper.


Displaying record number 58166

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location ( IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name I10
Subtype B
Species (MHC/HLA) human, mouse(H-2Dd)
Immunogen HIV-1 infection, vaccine
Country Argentina
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, vaccine antigen design

Vaccine Details

Vaccine type DNA, vaccinia
Vaccine strain B clade IIIB, CRF12 ARMA159
Vaccine component gp160

Notes

References

Monaco2011 Daniela C. Mónaco, Ana M. Rodríguez, María F. Pascutti, Mauricio Carobene, Juliana Falivene, Alejandro Gómez, Cynthia Maeto, Gabriela Turk, José L. Nájera, Mariano Esteban, and M. Magdalena Gherardi. T-Cell Immune Responses against Env from CRF12\_BF and Subtype B HIV-1 Show High Clade-Specificity that Can Be Overridden by Multiclade Immunizations. PLoS One, 6(2):e17185, 2011. PubMed ID: 21364754. Show all entries for this paper.


Displaying record number 52189

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location Env( IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name p18-I10
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Experimental methods  
Keywords immunodominance

Vaccine Details

Vaccine type vaccinia, vesicular stomatitis virus (VSV)
Vaccine strain B clade HXB2, B clade IIIB
Vaccine component Env, Gag

Notes

References

Haglund2002a Karl Haglund, Ingrid Leiner, Kristen Kerksiek, Linda Buonocore, Eric Pamer, and John K. Rose. High-Level Primary CD8(+) T-Cell Response to Human Immunodeficiency Virus Type 1 Gag and Env Generated by Vaccination with Recombinant Vesicular Stomatitis Viruses. J. Virol., 76(6):2730-2738, Mar 2002. PubMed ID: 11861840. Show all entries for this paper.


Displaying record number 52211

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location Env( IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name p18-I10
Subtype B
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Experimental methods  
Keywords immunodominance

Vaccine Details

Vaccine type vaccinia, vesicular stomatitis virus (VSV)
Vaccine strain B clade HXB2
Vaccine component Env, Gag

Notes

References

Haglund2002b Karl Haglund, Ingrid Leiner, Kristen Kerksiek, Linda Buonocore, Eric Pamer, and John K. Rose. Robust Recall and Long-Term Memory T-Cell Responses Induced by Prime-Boost Regimens with Heterologous Live Viral Vectors Expressing Human Immunodeficiency Virus Type 1 Gag and Env Proteins. J. Virol., 76(15):7506-7517, Aug 2002. PubMed ID: 12097563. Show all entries for this paper.


Displaying record number 52240

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp120 (V3)( IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type peptide
Vaccine strain B clade IIIB
Vaccine component Env V3
Adjuvant Cholera toxin (CT), GM-CSF, IL-12, IL-18, IL-1α

Notes

References

Staats2001 Herman F. Staats, Curtis P. Bradney, William M. Gwinn, Shawn S. Jackson, Gregory D. Sempowski, Hua-Xin Liao, Norman L. Letvin, and Barton F. Haynes. Cytokine Requirements for Induction of Systemic and Mucosal CTL After Nasal Immunization. J. Immunol., 167(9):5386-5394, 1 Nov 2001. PubMed ID: 11673557. Show all entries for this paper.


Displaying record number 55322

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp120
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Show epitope variants
Epitope Name H
Subtype A
Species (MHC/HLA) mouse(H-2Dd)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords subtype comparisons, vaccine-induced immune responses, variant cross-reactivity, antagonism

Vaccine Details

Vaccine type DNA with CMV promotor, modified vaccinia Ankara (MVA), DNA prime with modified vaccinia Ankara (MVA) boost, other
Vaccine strain A clade, B clade, C clade Du422, other
Vaccine component Gag, Nef, RT

Notes

References

Larke2007 Natasha Larke, Eung-Jun Im, Ralf Wagner, Carolyn Williamson, Anna-Lise Williamson, Andrew J. McMichael, and Tomáš Hanke. Combined Single-Clade Candidate HIV-1 Vaccines Induce T Cell Responses Limited by Multiple Forms of In Vivo Immune Interference. Eur. J. Immunol., 37(2):566-577, Feb 2007. PubMed ID: 17230443. Show all entries for this paper.


Displaying record number 57935

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location  
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name H
Subtype A
Species (MHC/HLA) mouse(H-2Dd, H-2Ld)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Cytotoxicity assay, HLA binding, Intracellular cytokine staining
Keywords immunodominance, vaccine antigen design, optimal epitope

Vaccine Details

Vaccine type DNA, modified vaccinia Ankara (MVA)
Vaccine strain A clade, multiple epitope immunogen
Vaccine component p17 Gag, p24 Gag, Other

Notes

References

Im2011 Eung-Jun Im, Jessie P. Hong, Yaowaluck Roshorm, Anne Bridgeman, Sven Létourneau, Peter Liljeström, Mary Jane Potash, David J. Volsky, Andrew J. McMichael, and Tomáš Hanke. Protective Efficacy of Serially Up-Ranked Subdominant CD8+ T Cell Epitopes against Virus Challenges. PLoS Pathog., 7(5):e1002041, May 2011. PubMed ID: 21625575. Show all entries for this paper.


Displaying record number 56265

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location  
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Subtype C
Species (MHC/HLA) mouse(H-2Kd)
Immunogen vaccine
Country South Africa
Experimental methods CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, Th1

Vaccine Details

Vaccine type DNA, DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain C clade Du422, C clade Du151
Vaccine component Gag, gp160 deletions, Nef, RT, Tat

Notes

References

Shephard2008 Enid Shephard, Wendy A. Burgers, Joanne H. Van Harmelen, James E. Monroe, Trish Greenhalgh, Carolyn Williamson, and Anna-Lise Williamson. A Multigene HIV Type 1 Subtype C Modified Vaccinia Ankara (MVA) Vaccine Efficiently Boosts Immune Responses to a DNA Vaccine in Mice. AIDS Res. Hum. Retroviruses, 24(2):207-217, Feb 2008. PubMed ID: 18240963. Show all entries for this paper.


Displaying record number 755

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp160(318-327 IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) mouse(H-2Ld)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type vaccinia
Vaccine strain B clade IIIB
Vaccine component Env, Nef

Notes

References

Tobery1997 T. W. Tobery and R. F. Siliciano. Targeting of HIV-1 Antigens for Rapid Intracellular Degradation Enhances Cytotoxic T Lymphocyte (CTL) Recognition and the Induction of De Novo CTL Responses In Vivo after Immunization. J. Exp. Med., 185:909-920, 1997. CD8+ cytotoxic T lymphocytes (CTLs) have the ability to recognize and eliminate virally infected cells before new virions are produced within that cell. Therefore, a rapid and vigorous CD8+ CTL response, induced by vaccination, can, in principle, prevent disseminated infection in vaccinated individuals who are exposed to the relevant virus. There has thus been interest in novel vaccine strategies that will enhance the induction of CD8+ CTLs. In this study, we have tested the hypothesis that targeting an antigen to undergo more efficient processing by the class I processing pathway will elicit a more vigorous CD8+ CTL response against that antigen. Targeting a type I transmembrane protein, the HIV-1 envelope (env) protein, for expression in the cytoplasm, rather than allowing its normal co-translational translocation into the endoplasmic reticulum, sensitized target cells expressing this mutant more rapidly for lysis by an env-specific CTL clone. Additionally, a greatly enhanced de novo env-specifc CTL response was induced in vivo after immunization of mice with recombinant vaccinia vectors expressing the cytoplasmic env mutant. Similarly, targeting a cytoplasmic protein, HIV-1 nef, to undergo rapid cytoplasmic degradation induced a greatly enhanced de novo nef-specific CD8+ CTL response in vivo after immunization of mice with either recombinant vaccinia vectors or DNA expression plasmids expressing the degradation targeted nef mutant. The targeting of viral antigens for rapid cytoplasmic degradation represents a novel and highly effective vaccine strategy for the induction of enhanced de novo CTL responses in vivo. PubMed ID: 9120397. Show all entries for this paper.


Displaying record number 749

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp160
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) mouse(H-2d17)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type vaccinia

Notes

References

Hanke1998b T. Hanke, T. J. Blanchard, J. Schneider, G. S. Ogg, R. Tan, M. Becker, S. C. Gilbert, A. V. Hill, G. L. Smith, and A. McMichael. Immunogenicities of Intravenous and Intramuscular Administrations of Modified Vaccinia Virus Ankara-Based Multi-CTL Epitope Vaccine for Human Immunodeficiency Virus Type 1 in Mice. J. Gen. Virol., 79:83-90, 1998. PubMed ID: 9460927. Show all entries for this paper.


Displaying record number 1475

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp160(318-327 IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name I-10
Species (MHC/HLA) mouse(H-2d)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords  

Notes

References

Takahashi2001 M. Takahashi, Y. Nakagawa, J. A. Berzofsky, and H. Takahashi. Counter-regulation of cytolytic activity and cytokine production in HIV-1-specific murine CD8+ cytotoxic T lymphocytes by free antigenic peptide. Int. Immunol., 13(1):43-51, Jan 2001. URL: http://intimm.oupjournals.org/cgi/content/full/13/1/43. PubMed ID: 11133833. Show all entries for this paper.


Displaying record number 766

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp120(318-327 IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) mouse(H-2d)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type fusion protein with anthrax delivery domain
Vaccine component gp120

Notes

References

Goletz1997 T. J. Goletz, K. R. Klimpel, N. Arora, S. H. Leppla, J. M. Keith, and J. A. Berzofsky. Targeting HIV Proteins to the Major Histocompatibility Complex Class I Processing Pathway with a Novel gp120-Anthrax Toxin Fusion Protein. Proc. Natl. Acad. Sci. U.S.A., 94:12059-12064, 1997. PubMed ID: 9342362. Show all entries for this paper.


Displaying record number 763

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp160(318-327 IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) mouse(H-2d)
Immunogen vaccine
Experimental methods  
Keywords Th1, Th2

Vaccine Details

Vaccine type DNA
Vaccine strain B clade IIIB
Vaccine component gp160

Notes

References

Arai2000 H. Arai, K. Q. Xin, K. Hamajima, Y. Lu, S. Watabe, T. Takahashi, S. Toda, K. Okuda, I. Kudoh, M. Suzuki, and K. Okuda. 8 Br-cAMP enhances both humoral and cell-mediated immune responses induced by an HIV-1 DNA vaccine. Gene Ther., 7(8):694-702, Apr 2000. PubMed ID: 10800093. Show all entries for this paper.


Displaying record number 757

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp160(318-327 IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) mouse(H-2d)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type peptide
Vaccine component CD4BS, HPG30, Env V3
Adjuvant IL-12

Notes

References

Hamajima1997 K. Hamajima, J. Fukushima, H. Bukawa, T. Kaneko, T. Tsuji, Y. Asakura, S. Sasaki, K. Q. Xin, and K. Okuda. Strong Augment Effect of IL-12 Expression Plasmid on the Induction of HIV-Specific Cytotoxic T Lymphocyte Activity by a Peptide Vaccine Candidate. Clin. Immunol. Immunopathol., 83:179-184, 1997. We previously reported that repeated inoculation of VC1, a macromolecular multicomponent peptide vaccine emulsified with Freund's adjuvant (VC1-F), induced high cytotoxic T lymphocyte (CTL) levels and a substantial level of multivalent antibodies which neutralized various human immunodeficiency virus type 1 (HIV-1) isolates. In the present study, we report that inoculation of VC1-F plus interleukin (IL)-12 expression plasmid can induce a higher antigen-specific CTL response compared to that with VC1-F alone. VC1-F plus IL-12 expression plasmid or VC1-F alone were inoculated to BALB/c mice twice at interval of 2 weeks. Two weeks after the second inoculation, spleen effector cells from these mice were examined. Stronger CTL responses against target cells were observed from the inoculation of VC1-F plus IL-12 plasmid than from that with VC-1F alone, but there was no difference in antibody induction. The inoculation of VC1 plus IL-12 plasmid also produced higher CTL activity than the inoculation of VC1 alone. These augmented CTL activities were not observed using target cells pulsed with non-HIV-specific peptides and different class I haplotype cells. These data demonstrate that co-inoculation of cell-mediated immune potent antigen and IL-12 plasmids can enhance the antigen-specific CTL response. This may be a potential approach for the induction of cellular immunization against HIV-1 and other diseases. PubMed ID: 9143379. Show all entries for this paper.


Displaying record number 745

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp160
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) mouse(H-2d)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type DNA, vaccinia
Vaccine component Env
Adjuvant IL-12

Notes

References

Gherardi2000 M. M. Gherardi, J. C. Ramirez, and M. Esteban. Interleukin-12 (IL-12) Enhancement of the Cellular Immune Response against Human Immunodeficiency Virus Type 1 Env Antigen in a DNA Prime/Vaccinia Virus Boost Vaccine Regimen Is Time and Dose Dependent: Suppressive Effects of IL-12 Boost Are Mediated by Nitric Oxide. J. Virol., 74:6278-6286, 2000. PubMed ID: 10864637. Show all entries for this paper.


Displaying record number 753

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp120
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) mouse(H-2d)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type vaccinia

Notes

References

Hanke1998b T. Hanke, T. J. Blanchard, J. Schneider, G. S. Ogg, R. Tan, M. Becker, S. C. Gilbert, A. V. Hill, G. L. Smith, and A. McMichael. Immunogenicities of Intravenous and Intramuscular Administrations of Modified Vaccinia Virus Ankara-Based Multi-CTL Epitope Vaccine for Human Immunodeficiency Virus Type 1 in Mice. J. Gen. Virol., 79:83-90, 1998. PubMed ID: 9460927. Show all entries for this paper.

Hanke1998c T. Hanke, J. Schneider, S. G. Gilbert, A. V. S. Hill, and A. McMichael. DNA Multi-CTL Epitope Vaccines for HIV and Plasmodium falciparum: Immunogenicity in Mice. Vaccine, 16:426-435, 1998. PubMed ID: 9607066. Show all entries for this paper.


Displaying record number 52969

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp120 (V3)( IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) mouse(H-2d)
Immunogen vaccine
Experimental methods Chromium-release assay, Intracellular cytokine staining
Keywords genital and mucosal immunity, memory cells, vaccine antigen design

Vaccine Details

Vaccine type influenza
Vaccine strain B clade IIIB
Vaccine component Env V3

Notes

References

Garulli2004 Bruno Garulli, Yoshihiro Kawaoka, and Maria R. Castrucci. Mucosal and Systemic Immune Responses to a Human Immunodeficiency Virus Type 1 Epitope Induced upon Vaginal Infection with a Recombinant Influenza A Virus. J. Virol., 78(2):1020-1025, Jan 2004. PubMed ID: 14694134. Show all entries for this paper.


Displaying record number 1481

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp160( IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) mouse(H-2d)
Immunogen vaccine
Experimental methods  
Keywords Th1, Th2

Vaccine Details

Vaccine type vaccinia
Vaccine strain B clade IIIB
Vaccine component gp160

Notes

References

Shirai2001 M. Shirai, R. Fujinaga, T. Masaki, and J. A. Berzofsky. Impaired development of HIV-1 gp160-specific CD8(+) cytotoxic T cells by a delayed switch from Th1 to Th2 cytokine phenotype in mice with Helicobacter pylori infection. Eur. J. Immunol., 31(2):516-26, Feb 2001. PubMed ID: 11180117. Show all entries for this paper.


Displaying record number 748

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location Env(318-327)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) mouse(H-2d)
Immunogen  
Experimental methods  
Keywords epitope processing, immunodominance

Notes

References

Lopez2000 D. Lopez, B. C. Gil-Torregrosa, C. Bergmann, and M. Del Val. Sequential Cleavage by Metallopeptidases and Proteasomes Is Involved in Processing HIV-1 ENV Epitope for Endogenous MHC Class I Antigen Presentation. J. Immunol., 164:5070-5077, 2000. PubMed ID: 10799863. Show all entries for this paper.


Displaying record number 747

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location Env
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) mouse(H-2d)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type vaccinia, Sindbis
Vaccine component Env V3

Notes

References

Villacres1999 M. C. Villacres and C. C. Bergmann. Enhanced Cytotoxic T Cell Activity in IL-4-Deficient Mice. J. Immunol., 162:2663-2670, 1999. PubMed ID: 10072509. Show all entries for this paper.


Displaying record number 746

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location Env
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) mouse(H-2d)
Immunogen vaccine
Experimental methods  
Keywords Th1

Vaccine Details

Vaccine type DNA
Vaccine strain B clade IIIB
Vaccine component gp160, Rev
Adjuvant IL-12, IL-15, IL-2

Notes

References

Xin1999 K. Q. Xin, K. Hamajima, S. Sasaki, T. Tsuji, S. Watabe, E. Okada, and K. Okuda. IL-15 expression plasmid enhances cell-mediated immunity induced by an HIV-1 DNA vaccine. Vaccine, 17:858-66, 1999. PubMed ID: 10067692. Show all entries for this paper.


Displaying record number 765

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp120(318-327 IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) mouse(H-2d, H-2p, H-2u)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type vaccinia
Vaccine strain B clade IIIB
Vaccine component gp160

Notes

References

Shirai1997 M. Shirai, S. Kozlowski, D. H. Margulies, and J. A. Berzofsky. Degenerate MHC Restriction Reveals the Contribution of Class I MHC Molecules in Determining the Fine Specificity of CTL Recognition of an Immunodominant Determinant of HIV-1 gp160 V3 Loop. J. Immunol., 158:3181-3188, 1997. The novel allogeneic presentation of an immunodominant determinant within the HIV-1 gp160 V3 loop by three different class I MHC molecules to the same CD8+ CTL is used to study the influence of the MHC molecule on the fine specificity of CTL recognition. We previously reported that four distinct class I molecules of H-2d,u,p,q presented the V3 decapeptide P18-I10 (RGPGRAFVTI) to CTL. Surprisingly, we found that H- 2d,u,p cells mutually cross-present the P18-I10 peptide to allogeneic CTL clones of each of the other haplotypes, whereas none of these cross- presents to H-2q CTL, nor do H-2q targets present to CTL of the other haplotypes. Here, we explore the critical amino acid residues for the cross-presentation using 10 variant peptides with single amino acid substitutions. The fine specificity examined using these mutant peptides presented by the same MHC class I molecule showed striking similarity among the CTL of each haplotype, expressing either V beta 8.1 or V beta 14. In contrast, the fine specificity is different between the distinct MHC class I molecules even for the lysis by the same CTL, as shown by reciprocal effects of the same substitutions. Thus, peptide fine specificity of a single TCR is influenced by changes in the class I MHC molecules presenting the Ag. PubMed ID: 9120272. Show all entries for this paper.


Displaying record number 52188

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp120(313-322 BRU)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name Pep 09
Subtype B, C
Species (MHC/HLA) mouse
Immunogen vaccine
Experimental methods  
Keywords subtype comparisons, Th1

Vaccine Details

Vaccine type DNA
Vaccine strain B clade BRU
Vaccine component gp160, Rev, Tat

Notes

References

Arora2001 A. Arora and P. Seth. Immunization with HIV-1 Subtype B gp160-DNA Induces Specific as Well as Cross Reactive Immune Responses in Mice. Indian J Med Res, 114:1-9, Jul 2001. PubMed ID: 11762199. Show all entries for this paper.


Displaying record number 55667

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp120
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Subtype C
Species (MHC/HLA) human, mouse
Immunogen vaccine
Country South Africa, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords vaccine antigen design

Vaccine Details

Vaccine type modified vaccinia Ankara (MVA)
Vaccine strain C clade Du422
Vaccine component Env, Gag, Nef, RT, Tat

Notes

References

Burgers2008 Wendy A. Burgers, Enid Shephard, James E. Monroe, Trish Greenhalgh, Anke Binder, Etienne Hurter, Joanne H. Van Harmelen, Carolyn Williamson, and Anna-Lise Williamson. Construction, Characterization, and Immunogenicity of a Multigene Modified Vaccinia Ankara (MVA) Vaccine Based on HIV Type 1 Subtype C. AIDS Res. Hum. Retroviruses, 24(2):195-206, Feb 2008. PubMed ID: 18240957. Show all entries for this paper.


Displaying record number 53046

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp160
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name P18-I10
Subtype B
Species (MHC/HLA) mouse
Immunogen vaccine
Experimental methods Chromium-release assay
Keywords genital and mucosal immunity

Vaccine Details

Vaccine type vaccinia with H1 influenza HA gene cassette
Vaccine strain B clade IIIB
Vaccine component gp160

Notes

References

Kuribayashi2004 Hideki Kuribayashi, Ayako Wakabayashi, Masumi Shimizu, Hiroshi Kaneko, Yoshihiko Norose, Yohko Nakagawa, Jian Wang, Yoshihiro Kumagai, David H. Margulies, and Hidemi Takahashi. Resistance to Viral Infection by Intraepithelial Lymphocytes in HIV-1 P18-I10-Specific T-Cell Receptor Transgenic Mice. Biochem. Biophys. Res. Commun., 316(2):356-363, 2 Apr 2004. PubMed ID: 15020225. Show all entries for this paper.


Displaying record number 55283

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location Env
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Country United States
Experimental methods Other, Tetramer binding
Keywords memory cells

Vaccine Details

Vaccine type vesicular stomatitis virus (VSV)
Vaccine strain B clade
Vaccine component Env

Notes

References

Ramsburg2007 Elizabeth A. Ramsburg, Jean M. Publicover, Dagan Coppock, and John K. Rose. Requirement for CD4 T Cell Help in Maintenance of Memory CD8 T Cell Responses Is Epitope Dependent. J. Immunol., 178(10):6350-6358, 15 May 2007. PubMed ID: 17475864. Show all entries for this paper.


Displaying record number 58848

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp160
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name P18-I10
Subtype B
Species (MHC/HLA) humanized mouse
Immunogen in vitro stimulation or selection
Experimental methods Chromium-release assay, Other
Keywords  

Notes

References

Takaku2012 Shun Takaku, Yohko Nakagawa, Atsuko Owaki, Masumi Shimizu, Megumi Takahashi, and Hidemi Takahashi. Induction of Apoptosis-Resistant and TGF-beta-Insensitive Murine CD8+ Cytotoxic T Lymphocytes Specific for HIV-1 gp160. Cell. Immunol., 280(2):138-147, Dec 2012. PubMed ID: 23399840. Show all entries for this paper.


Displaying record number 758

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp160(318-327 IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name R10I
Species (MHC/HLA) mouse
Immunogen vaccine
Experimental methods  
Keywords optimal epitope

Vaccine Details

Vaccine type peptide
Vaccine strain B clade IIIB
Vaccine component Env V3

Notes

References

Nehete1995 P. N. Nehete, K. S. Casement, R. B. Arlinghus, and K. J. Sastry. Studies on In Vivo Induction of HIV-1 Envelope-Specific Cytotoxic T Lymphocytes by Synthetic Peptides from the V3 Loop Region of HIV-1 IIIB gp120. Cell. Immunol., 160:217-223, 1995. PubMed ID: 7720083. Show all entries for this paper.


Displaying record number 744

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp160(318-327 IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) macaque
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type DNA prime with peptide boost
Vaccine strain B clade IIIB
Vaccine component CD4BS, gp160, HPG30, Env V3

Notes

References

Okuda1997 K. Okuda, K. O. Xin, T. Tsuji, H. Bukawa, S. Tanaka, W. C. Koff, K. Tani, K. Okuda, K. Honma, S. Kawamoto, K. Hamajima, and J. Fukushima. DNA vaccination followed by macromolecular multicomponent peptide vaccination against HIV-1 induces strong antigen-specific immunity. Vaccine, 15:1049-56, 1997. PubMed ID: 9269046. Show all entries for this paper.


Displaying record number 767

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location Env( IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) mouse
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type DNA
Vaccine strain B clade IIIB
Vaccine component gp160, Rev
Adjuvant MIP-1α

Notes

References

Lu1999 Y. Lu, K. Q. Xin, K. Hamajima, T. Tsuji, I. Aoki, J. Yang, S. Sasaki, J. Fukushima, T. Yoshimura, S. Toda, E. Okada, and K. Okuda. Macrophage inflammatory protein-1alpha (MIP-1alpha) expression plasmid enhances DNA vaccine-induced immune response against HIV-1. Clin. Exp. Immunol., 115(2):335-41, Feb 1999. PubMed ID: 9933462. Show all entries for this paper.


Displaying record number 750

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp120(318-327)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Kmieciak1998 D. Kmieciak, T. J. Wasik, H. Teppler, J. Pientka, S. H. Hsu, H. Takahashi, K. Okumura, Y. Kaneko, and D. Kozbor. The effect of deletion of the V3 loop of gp120 on cytotoxic T cell responses and HIV gp120-mediated pathogenesis. J. Immunol., 160:5676-83, 1998. PubMed ID: 9605175. Show all entries for this paper.


Displaying record number 57570

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location Env
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name H
Subtype A
Species (MHC/HLA) mouse
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Vaccine Details

Vaccine type adenovirus
Vaccine strain A clade
Vaccine component Gag, Other

Notes

References

Bridgeman2009 Anne Bridgeman, Yaowaluck Roshorm, Linda J. Lockett, Zheng-Zhou Xu, Richard Hopkins, Jan Shaw, Gerald W. Both, and Tomáš Hanke. Ovine Atadenovirus, a Novel and Highly Immunogenic Vector in Prime-Boost Studies of a Candidate HIV-1 Vaccine. Vaccine, 28(2):474-483, 11 Dec 2009. PubMed ID: 19853074. Show all entries for this paper.


Displaying record number 58375

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location gp120( IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name L
Subtype B
Species (MHC/HLA) mouse
Immunogen vaccine
Experimental methods Cytokine production, Other
Keywords vaccine antigen design

Vaccine Details

Vaccine type DNA, bacteriophage coat protein
Vaccine strain B clade IIIB
Vaccine component gp120

Notes

References

Charles-Nino2011 Claudia Charles-Niño, Cesar Pedroza-Roldan, Monica Viveros, Goar Gevorkian, and Karen Manoutcharian. Variable Epitope Libraries: New Vaccine Immunogens Capable of Inducing Broad Human Immunodeficiency Virus Type 1-Neutralizing Antibody Response. Vaccine, 29(32):5313-5321, 18 Jul 2011. PubMed ID: 21600948. Show all entries for this paper.


Displaying record number 52715

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location Env( IIIB)
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name 10 Env
Subtype B
Species (MHC/HLA) mouse
Immunogen vaccine
Patient MHC/HLA H-2d
Experimental methods CD8 T-cell Elispot - IFNγ, Cytokine production, Proliferation
Keywords Th1, Th2, genital and mucosal immunity

Vaccine Details

Vaccine type influenza prime with vaccinia boost
Vaccine strain B clade IIIB
Vaccine component gp160

Notes

References

Gherardi2003 M. Magdalena Gherardi, José Luis Nájera, Eva Pérez-Jiménez, Susana Guerra, Adolfo García-Sastre, and Mariano Esteban. Prime-Boost Immunization Schedules Based on Influenza Virus and Vaccinia Virus Vectors Potentiate Cellular Immune Responses against Human Immunodeficiency Virus Env Protein Systemically and in the Genitorectal Draining Lymph Nodes. J. Virol., 77(12):7048-7057, Jun 2003. PubMed ID: 12768024. Show all entries for this paper.


Displaying record number 52016

HXB2 Location gp160(311-320)
gp120(311-320)
DNA(7155..7184)
gp160 Epitope Map
Author Location  
Epitope RGPGRAFVTI Epitope Alignment
RGPGRAFVTI epitope logo
Epitope Name P18
Subtype B
Species (MHC/HLA) mouse
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type DNA
Vaccine strain B clade BH10
Vaccine component gp120
Adjuvant GM-CSF

Notes

References

Barouch2002 Dan H. Barouch, Sampa Santra, Klara Tenner-Racz, Paul Racz, Marcelo J. Kuroda, Joern E. Schmitz, Shawn S. Jackson, Michelle A. Lifton, Dan C. Freed, Helen C. Perry, Mary-Ellen Davies, John W. Shiver, and Norman L. Letvin. Potent CD4+ T cell responses elicited by a bicistronic HIV-1 DNA vaccine expressing gp120 and GM-CSF. J. Immunol., 168(2):562-568, 15 Jan 2002. PubMed ID: 11777947. Show all entries for this paper.


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