HIV molecular immunology database
Found 73 matching records:
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(311-320) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | RI10 | |
Species (MHC/HLA) | human(A*02) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120(311-320) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*02) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | rate of progression, acute/early infection |
Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120(311-320 IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*02:01) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160(318-327 IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*02:01) | |
Immunogen | in vitro stimulation or selection | |
Experimental methods | ||
Keywords |
Alexander-Miller1996 M. A. Alexander-Miller, K. C. Parker, T. Tsukui, C. D. Pendleton, J. E. Coligan, and J. A. Berzofsky. Molecular analysis of presentation by HLA-A2.1 of a promiscuously binding V3 loop peptide from the HIV-1 Envelope protein to human cytotoxic T lymphocytes. Int. Immunol., 8:641-649, 1996. PubMed ID: 8671651. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160(318-327 IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | LR25 | |
Subtype | B | |
Species (MHC/HLA) | mouse(A*02:01) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords | binding affinity, vaccine-induced immune responses, immunodominance |
Vaccine type | peptide |
---|---|
Vaccine strain | B clade LAI |
Adjuvant | Incomplete Freund's Adjuvant (IFA), Montanide (ISA 720), P30, PLG |
Peter2001 Katrin Peter, Ying Men, Giuseppe Pantaleo, Bruno Gander, and Giampietro Corradin. Induction of a Cytotoxic T-Cell Response to HIV-1 Proteins with Short Synthetic Peptides and Human Compatible Adjuvants. Vaccine, 19(30):4121-4129, 20 Jul 2001. PubMed ID: 11457536. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(311-320) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | RI10 | |
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120 | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | A2-RI10(gp120) | |
Species (MHC/HLA) | human(A2) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | ||
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | RGP | |
Species (MHC/HLA) | transgenic mouse(A2) | |
Immunogen | vaccine | |
Experimental methods | Flow cytometric T-cell cytokine assay | |
Keywords | epitope processing, vaccine antigen design |
Vaccine type | DNA prime with vaccinia boost, polyepitope |
---|---|
Vaccine strain | A clade, B clade, C clade |
Vaccine component | Env, Gag, Nef, Pol, Vpr |
Bazhan2010 S. I. Bazhan, L. I. Karpenko, T. N. Ilyicheva, P. A. Belavin, S. V. Seregin, N. K. Danilyuk, D. V. Antonets, and A. A. Ilyichev. Rational Design Based Synthetic Polyepitope DNA Vaccine for Eliciting HIV-Specific CD8+ T Cell Responses. Mol Immunol, 47(7-8):1507-1515, Apr 2010. PubMed ID: 20189249. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160(318-327 IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | human(A2) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords |
Vaccine type | vaccinia |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | gp160 |
Achour1996 A. Achour, F. Bex, P. Hermans, A. Burny, and D. Zagury. Induction of anti-gp160 cytotoxic T cells cross-reacting with various V3 loop P18 peptides in human immunodeficiency virus type 1 envelope-immunized individuals. J. Virol., 70:6741-6750, 1996. PubMed ID: 8794311. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160(311-320) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A2) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding | |
Keywords | acute/early infection, optimal epitope |
Altfeld2005a Marcus Altfeld, Todd M. Allen, Elizabeth T. Kalife, Nicole Frahm, Marylyn M. Addo, Bianca R. Mothe, Almas Rathod, Laura L. Reyor, Jason Harlow, Xu G. Yu, Beth Perkins, Loren K. Robinson, John Sidney, Galit Alter, Mathias Lichterfeld, Alessandro Sette, Eric S. Rosenberg, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. The Majority of Currently Circulating Human Immunodeficiency Virus Type 1 Clade B Viruses Fail To Prime Cytotoxic T-Lymphocyte Responses against an Otherwise Immunodominant HLA-A2-Restricted Epitope: Implications for Vaccine Design. J. Virol., 79(8):5000-5005, Apr 2005. PubMed ID: 15795285. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(311-320) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | RI10 | |
Species (MHC/HLA) | human(A*31) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(311-320) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | RI10 | |
Species (MHC/HLA) | human(B*40) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(311-320) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | RI10 | |
Species (MHC/HLA) | human(B*42:02) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(311-320) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | RI10 | |
Species (MHC/HLA) | human(C*14) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | Env | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Subtype | A, B | |
Species (MHC/HLA) | mouse(H-2d) | |
Immunogen | vaccine | |
Country | Finland | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay | |
Keywords | vaccine antigen design |
Vaccine type | DNA |
---|---|
Vaccine strain | A clade, B clade |
Vaccine component | Env, Gag |
Malm2007 Maria Malm, Rein Sikut, Kai Krohn, and Vesna Blazevic. GTU-MultiHIV DNA Vaccine Results in Protection in a Novel P815 Tumor Challenge Model. Vaccine, 25(17):3293-301, 30 Apr 2007. PubMed ID: 17289222. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160(318-327 IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords | immunodominance |
Vaccine type | DNA prime with vaccinia boost |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | gp160 |
Adjuvant | beta-glucan lentinan, IL-2/Ig, liposome, PLG |
Wierzbicki2002 Andrzej Wierzbicki, Irena Kiszka, Hiroshi Kaneko, Dariusz Kmieciak, Thomas J Wasik, Jaroslaw Gzyl, Yutaro Kaneko, and Danuta Kozbor. Immunization Strategies to Augment Oral Vaccination with DNA and Viral Vectors Expressing HIV Envelope Glycoprotein. Vaccine, 20(9-10):1295-1307, 31 Jan 2002. PubMed ID: 11818148. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120( LAI) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | P18 | |
Subtype | B | |
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords |
Vaccine type | protein |
---|---|
Vaccine strain | B clade LAI |
Vaccine component | Gag, gp120 |
Adjuvant | CpG immunostimulatory sequence (ISS) |
Horner2001 A. A. Horner, G. F. Widhopf, J. A. Burger, K. Takabayashi, N. Cinman, A. Ronaghy, H. L. Spiegelberg, and E. Raz. Immunostimulatory DNA Inhibits IL-4-Dependent IgE Synthesis by Human B Cells. J Allergy Clin Immunol, 108(3):417-423, Sep 2001. PubMed ID: 11544462. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160 (V3)( IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | I10 | |
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords | acute/early infection |
Vaccine type | vaccinia |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | gp160 |
Takahashi2002 Megumi Takahashi, Eiichi Osono, Yohko Nakagawa, Jian Wang, Jay A. Berzofsky, David H. Margulies, and Hidemi Takahashi. Rapid Induction of Apoptosis in CD8+ HIV-1 Envelope-Specific Murine CTLs by Short Exposure to Antigenic Peptide. J. Immunol., 169(11):6588-6593, 1 Dec 2002. PubMed ID: 12444171. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160 (V3)( HIV-IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | P18-I10 | |
Subtype | B | |
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | vaccine | |
Patient MHC/HLA | H-2d | |
Experimental methods | Chromium-release assay, Cytokine production, Tetramer binding | |
Keywords |
Vaccine type | vaccinia |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | gp160 |
Adjuvant | IL-15, IL-2 |
Oh2003a SangKon Oh, Jay A. Berzofsky, Donald S. Burke, Thomas A. Waldmann, and Liyanage P. Perera. Coadministration of HIV Vaccine Vectors with Vaccinia Viruses Expressing IL-15 But Not IL-2 Induces Long-Lasting Cellular Immunity. Proc. Natl. Acad. Sci. U.S.A., 100(6):3392-3397, 18 Mar 2003. PubMed ID: 12626740. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160( IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | P18-I10 | |
Subtype | B | |
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | vaccine | |
Patient MHC/HLA | H-2d | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Proliferation, Tetramer binding | |
Keywords |
Vaccine type | vaccinia |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | Env V3 |
Adjuvant | B7, ICAM, LFA-3 |
Oh2003b SangKon Oh, James W Hodge, Jeffrey D Ahlers, Donald S Burke, Jeffrey Schlom, and Jay A Berzofsky. Selective Induction of High Avidity CTL by Altering the Balance of Signals from APC. J. Immunol., 170(5):2523-2530, Mar 2003. PubMed ID: 12594278. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120 (V3) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | vaccine | |
Patient MHC/HLA | H-2d | |
Experimental methods | Cytotoxicity assay, Tetramer binding | |
Keywords | kinetics, memory cells |
Vaccine type | herpes simplex virus type-1 (HSV-1) amplicon |
---|---|
Vaccine component | gp120 |
Wang2003 Lai-Xi Wang. Bioorganic Approaches towards HIV Vaccine Design. Curr. Pharm. Des., 9(22):1771-87, 2003. PubMed ID: 12871196. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120 (V3) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | P18-I10 | |
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | vaccine | |
Experimental methods | Chromium-release assay, Flow cytometric T-cell cytokine assay | |
Keywords | dendritic cells, Th1, Th2, genital and mucosal immunity |
Vaccine type | peptide, vaccinia |
---|---|
Vaccine strain | B clade 89.6, B clade IIIB |
Vaccine component | gp160ΔV3 |
Adjuvant | Cholera toxin (CT), E. coli mutant heat labile enterotoxin (LT-R72), Incomplete Freund's Adjuvant (IFA), CpG immunostimulatory sequence (ISS) |
Belyakov2004 Igor M. Belyakov, Scott A. Hammond, Jeffrey D. Ahlers, Gregory M. Glenn, and Jay A. Berzofsky. Transcutaneous Immunization Induces Mucosal CTLs and Protective Immunity by Migration of Primed Skin Dendritic Cells. J. Clin. Invest., 113(7):998-1007, Apr 2004. PubMed ID: 15057306. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120 (V3) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Cytotoxicity assay, Tetramer binding | |
Keywords | vaccine antigen design |
Vaccine type | herpes simplex virus type-1 (HSV-1) amplicon |
---|---|
Vaccine strain | B clade LAI, B clade MN |
Vaccine component | gp120 |
Hocknell2002 Peter K. Hocknell, Rebecca D. Wiley, Xiuqing Wang, Thomas G. Evans, William J. Bowers, Tomas Hanke, Howard J. Federoff, and Stephen Dewhurst. Expression of Human Immunodeficiency Virus Type 1 gp120 from Herpes Simplex Virus Type 1-Derived Amplicons Results in Potent, Specific, and Durable Cellular and Humoral Immune Responses. J. Virol., 76(11):5565-5580, Jun 2002. PubMed ID: 11991985. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | ||
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | R10I | |
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | vaccine | |
Experimental methods | Chromium-release assay, Cytokine production | |
Keywords | epitope processing, vaccine-induced immune responses, immunodominance |
Vaccine type | DNA, virus-like particle (VLP), polyepitope |
---|---|
Vaccine component | Gag, p24 Gag, Env V3 |
Wild2004 Jens Wild, Alexandra Bojak, Ludwig Deml, and Ralf Wagner. Influence of Polypeptide Size and Intracellular Sorting on the Induction of Epitope-Specific CTL Responses by DNA Vaccines in a Mouse Model. Vaccine, 22(13-14):1732-1743, 15 Apr 2004. PubMed ID: 15068857. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(318-327) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | R10I | |
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | vaccine | |
Patient MHC/HLA | H-2D | |
Experimental methods | Intracellular cytokine staining | |
Keywords | vaccine antigen design |
Vaccine type | vaccinia |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | gp160 |
Samino2004 Yolanda Samino, Daniel López, Sara Guil, Patricia de León, and Margarita Del Val. An Endogenous HIV Envelope-Derived Peptide without the Terminal NH3+ Group Anchor Is Physiologically Presented by Major Histocompatibility Complex Class I Molecules. J. Biol. Chem., 279(2):1151-1160, 9 Jan 2004. PubMed ID: 14583622. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | p18( IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | vaccine | |
Patient MHC/HLA | H-2D | |
Experimental methods | CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Chromium-release assay, Cytokine production, Proliferation | |
Keywords | vaccine-induced immune responses, memory cells, characterizing CD8+ T cells |
Vaccine type | DNA with CMV promotor |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | gp120 |
Adjuvant | IL-12 |
Seaman2004 Michael S. Seaman, Fred W. Peyerl, Shawn S. Jackson, Michelle A. Lifton, Darci A. Gorgone, Jörn E. Schmitz, and Norman L. Letvin. Subsets of Memory Cytotoxic T Lymphocytes Elicited by Vaccination Influence the Efficiency of Secondary Expansion In Vivo. J. Virol., 78(1):206-15, Jan 2004. PubMed ID: 14671102. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120 | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | macaque, mouse(H-2Dd) | |
Immunogen | vaccine | |
Experimental methods | CD4 T-cell Elispot - IFNγ, Chromium-release assay, Other, Proliferation, Tetramer binding | |
Keywords | adjuvant comparison, vaccine antigen design, SIV |
Vaccine type | DNA |
---|---|
Vaccine strain | B clade IIIB, SIV |
Vaccine component | gp120 |
Fuller2007 Deborah Heydenburg Fuller, Tim Shipley, Todd M. Allen, James T. Fuller, Mary S. Wu, Helen Horton, Nancy Wilson, Georg Widera, and David I. Watkins. Immunogenicity of Hybrid DNA Vaccines Expressing Hepatitis B Core Particles Carrying Human AND Simian Immunodeficiency Virus Epitopes in Mice and Rhesus Macaques. Virology, 364(2):245-255, 1 Aug 2007. PubMed ID: 17428516. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | Env (gp160)(318-327 HIV-1 IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | P18-I10 | |
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | peptide-HLA interaction | |
Experimental methods | Chromium-release assay, Other | |
Keywords | binding affinity, structure |
Nakagawa2007 Yohko Nakagawa, Hiroto Kikuchi, and Hidemi Takahashi. Molecular Analysis of TCR and Peptide/MHC Interaction Using P18-I10-Derived Peptides with a Single D-Amino Acid Substitution. Biophys. J., 92(7):2570-2582, 1 Apr 2007. PubMed ID: 17208967. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120 | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | humanized mouse(H-2Dd) | |
Immunogen | vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | epitope processing, vaccine-induced immune responses, immunodominance, immunotherapy |
Vaccine type | DNA, polyepitope |
---|---|
Vaccine strain | B clade MN |
Vaccine component | gp120, Protease, RT |
Adjuvant | Incomplete Freund's Adjuvant (IFA) |
Isaguliants2004 Maria G. Isaguliants, Bartek Zuber, Andreas Boberg, Dan Sjöstrand, Sergey V. Belikov, Erik Rollman, Anne Kjerrström Zuber, Vladimir O. Rechinsky, Ann-Sofie Rytting, Clas F. R. Källander, Jorma Hinkula, Sergey N. Kochetkov, Margaret Liu, and Britta Wahren. Reverse Transcriptase-Based DNA Vaccines against Drug-Resistant HIV-1 Tested in a Mouse Model. Vaccine, 22(13-14):1810-1819, 16 Apr 2004. PubMed ID: 15068865. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160(318-327 IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords | dendritic cells |
Vaccine type | peptide |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | Env V3 |
Takahashi1993 H. Takahashi, Y. Nakagawa, K. Yokomuro, and J. A. Berzofsky. Induction of CD8+ Cytotoxic T Lymphocytes by Immunization with Syngeneic Irradiated HIV-1 Envelope Derived Peptide-Pulsed Dendritic Cells. Internatl. Immunol., 5:849-857, 1993. PubMed ID: 8398980. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160( IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords |
Vaccine type | non-replicating adenovirus |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | Env, Rev |
Bruce1999 C. B. Bruce, A. Akrigg, S. A. Sharpe, T. Hanke, G. W. Wilkinson, and M. P. Cranage. Replication-Deficient Recombinant Adenoviruses Expressing the Human Immunodeficiency Virus Env Antigen Can Induce Both Humoral and CTL Immune Responses in Mice. J. Gen. Virol., 80(Pt 10):2621-2628, 1999. PubMed ID: 10573155. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160(318-327 IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords |
Vaccine type | peptide |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | Env V3 |
Takahashi1996 H. Takahashi, Y. Nakagawa, G. R. Leggatt, Y. Ishida, T. Saito, K. Yokomuro, and J. A. Berzofsky. Inactivation of Human Immunodeficiency Virus (HIV-1) Envelope-Specific CD8+ Cytotoxic T Lymphocytes by Free Antigenic Peptide: A Self-Veto Mechanism? J. Exp. Med., 183:879-889, 1996. PubMed ID: 8642292. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | Env | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | Peptide H | |
Subtype | C | |
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Cytokine production | |
Keywords | vaccine-induced immune responses, vaccine antigen design |
Chapman2013 Rosamund Chapman, Helen Stutz, William Jacobs, Jr., Enid Shephard, and Anna-Lise Williamson. Priming with Recombinant Auxotrophic BCG Expressing HIV-1 Gag, RT and Gp120 and Boosting with Recombinant MVA Induces a Robust T Cell Response in Mice. PLoS One, 8(8):e71601, 20 Aug 2013. PubMed ID: 23977084. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160(318-327 IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | peptide-HLA interaction | |
Experimental methods | ||
Keywords |
Takeshita1995 T. Takeshita, H. Takahashi, S. Kozlowski, J. D. Ahlers, C. D. Pendleton, R. L. Moore, Y. Nakagawa, K. Yokomuro, B. S. Fox, D. H. Margulies, and J. A. Berzofsky. Molecular Analysis of the Same HIV Peptide Functionally Binding to Both a Class I and a Class II MHC Molecule. J. Immunol., 154:1973-1986, 1995. Of RGPGRAFVTI, the upper case amino acids iGPgRaFvtI are critical for binding, consistent with H-2D$d$ motif XGPX(RKH)XXX(X)(LIF). Stimulation of the HLA class II I-A$^d$ required a longer peptide, IQRGPGRAFVTI or RIQRGPGRAFVTI, and riqrgPgRaFvti were essential for binding to the Class II molecule. PubMed ID: 7530749. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | ||
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | epitope H | |
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | vaccine-induced immune responses |
Vaccine type | modified vaccinia Ankara (MVA), adenovirus |
---|---|
Vaccine component | p17 Gag, p24 Gag |
Ondondo2014 Beatrice Ondondo, Sultan Abdul-Jawad, Anne Bridgeman, and Tomáš Hanke. Characterization of T-Cell Responses to Conserved Regions of the HIV-1 Proteome in BALB/c Mice. Clin. Vaccine Immunol., 21(11):1565-1572, Nov 2014. PubMed ID: 25230940. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | ||
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | H, P18-I10 | |
Subtype | A | |
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Cytotoxicity assay, Intracellular cytokine staining | |
Keywords | mother-to-infant transmission, vaccine antigen design |
Vaccine type | Bacillus BCG prime with vaccinia Ankara (MVA) boost |
---|---|
Vaccine strain | A clade, multiple epitope immunogen |
Vaccine component | p17 Gag, p24 Gag, other |
Saubi2011 Narcis Saubi, Eung-Jun Im, Raquel Fernández-Lloris, Olga Gil, Pere-Joan Cardona, Josep Maria Gatell, Tomáš Hanke, and Joan Joseph. Newborn Mice Vaccination with BCG.HIVA222 + MVA.HIVA Enhances HIV-1-Specific Immune Responses: Influence of Age and Immunization Routes. Clin. Dev. Immunol., 2011:516219, 2011. PubMed ID: 21603216. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | ||
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | H, P18-I10 | |
Subtype | A | |
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | vaccine | |
Experimental methods | Cytotoxicity assay, Intracellular cytokine staining | |
Keywords | mother-to-infant transmission, immunodominance, vaccine antigen design |
Vaccine type | Bacillus BCG prime with vaccinia Ankara (MVA) boost |
---|---|
Vaccine strain | A clade, multiple epitope immunogen |
Vaccine component | p17 Gag, p24 Gag, other |
Im2007 Eung-Jun Im, Narcis Saubi, Goretti Virgili, Clare Sander, Denise Teoh, Jose M. Gatell, Helen McShane, Joan Joseph, and Tomáš Hanke. Vaccine Platform for Prevention of Tuberculosis and Mother-to-Child Transmission of Human Immunodeficiency Virus Type 1 through Breastfeeding. J. Virol., 81(17):9408-9418, Sep 2007. PubMed ID: 17596303. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | Env( IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | I-10 | |
Subtype | B | |
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | in vitro stimulation or selection | |
Experimental methods | ||
Keywords | epitope processing, immunodominance, optimal epitope |
Nakagawa2000 Y. Nakagawa, T. Takeshita, J. A. Berzofsky, and H. Takahashi. Analysis of the mechanism for extracellular processing in the presentation of human immunodeficiency virus-1 envelope protein-derived peptide to epitope-specific cytotoxic T lymphocytes. Immunology, 101(1):76-82, Sep 2000. PubMed ID: 11012756. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | ||
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | H | |
Subtype | A | |
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Cytotoxicity assay, Flow cytometric T-cell cytokine assay | |
Keywords | mother-to-infant transmission, immunodominance, vaccine antigen design |
Vaccine type | Bacillus BCG prime with vaccinia Ankara (MVA) boost |
---|---|
Vaccine strain | A clade, multiple epitope immunogen |
Vaccine component | p17 Gag, p24 Gag, other |
Hopkins2011 Richard Hopkins, Anne Bridgeman, Joan Joseph, Sarah C Gilbert, Helen McShane, and Tomáš Hanke. Dual Neonate Vaccine Platform against HIV-1 and M. tuberculosis. PLoS One, 6(5):e20067, 2011. PubMed ID: 21603645. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | ( IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | I10 | |
Subtype | B | |
Species (MHC/HLA) | human, mouse(H-2Dd) | |
Immunogen | HIV-1 infection, vaccine | |
Country | Argentina | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons, vaccine antigen design |
Vaccine type | DNA, vaccinia |
---|---|
Vaccine strain | B clade IIIB, CRF12 ARMA159 |
Vaccine component | gp160 |
Monaco2011 Daniela C. Mónaco, Ana M. Rodríguez, María F. Pascutti, Mauricio Carobene, Juliana Falivene, Alejandro Gómez, Cynthia Maeto, Gabriela Turk, José L. Nájera, Mariano Esteban, and M. Magdalena Gherardi. T-Cell Immune Responses against Env from CRF12\_BF and Subtype B HIV-1 Show High Clade-Specificity that Can Be Overridden by Multiclade Immunizations. PLoS One, 6(2):e17185, 2011. PubMed ID: 21364754. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | Env( IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | p18-I10 | |
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords | immunodominance |
Vaccine type | vaccinia, vesicular stomatitis virus (VSV) |
---|---|
Vaccine strain | B clade HXB2, B clade IIIB |
Vaccine component | Env, Gag |
Haglund2002a Karl Haglund, Ingrid Leiner, Kristen Kerksiek, Linda Buonocore, Eric Pamer, and John K. Rose. High-Level Primary CD8(+) T-Cell Response to Human Immunodeficiency Virus Type 1 Gag and Env Generated by Vaccination with Recombinant Vesicular Stomatitis Viruses. J. Virol., 76(6):2730-2738, Mar 2002. PubMed ID: 11861840. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | Env( IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | p18-I10 | |
Subtype | B | |
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords | immunodominance |
Vaccine type | vaccinia, vesicular stomatitis virus (VSV) |
---|---|
Vaccine strain | B clade HXB2 |
Vaccine component | Env, Gag |
Haglund2002b Karl Haglund, Ingrid Leiner, Kristen Kerksiek, Linda Buonocore, Eric Pamer, and John K. Rose. Robust Recall and Long-Term Memory T-Cell Responses Induced by Prime-Boost Regimens with Heterologous Live Viral Vectors Expressing Human Immunodeficiency Virus Type 1 Gag and Env Proteins. J. Virol., 76(15):7506-7517, Aug 2002. PubMed ID: 12097563. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120 (V3)( IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords |
Vaccine type | peptide |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | Env V3 |
Adjuvant | Cholera toxin (CT), GM-CSF, IL-12, IL-18, IL-1α |
Staats2001 Herman F. Staats, Curtis P. Bradney, William M. Gwinn, Shawn S. Jackson, Gregory D. Sempowski, Hua-Xin Liao, Norman L. Letvin, and Barton F. Haynes. Cytokine Requirements for Induction of Systemic and Mucosal CTL After Nasal Immunization. J. Immunol., 167(9):5386-5394, 1 Nov 2001. PubMed ID: 11673557. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120 | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | H | |
Subtype | A | |
Species (MHC/HLA) | mouse(H-2Dd) | |
Immunogen | vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other | |
Keywords | subtype comparisons, vaccine-induced immune responses, variant cross-reactivity, antagonism |
Vaccine type | DNA with CMV promotor, modified vaccinia Ankara (MVA), DNA prime with modified vaccinia Ankara (MVA) boost, other |
---|---|
Vaccine strain | A clade, B clade, C clade Du422, other |
Vaccine component | Gag, Nef, RT |
Larke2007 Natasha Larke, Eung-Jun Im, Ralf Wagner, Carolyn Williamson, Anna-Lise Williamson, Andrew J. McMichael, and Tomáš Hanke. Combined Single-Clade Candidate HIV-1 Vaccines Induce T Cell Responses Limited by Multiple Forms of In Vivo Immune Interference. Eur. J. Immunol., 37(2):566-577, Feb 2007. PubMed ID: 17230443. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | ||
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | H | |
Subtype | A | |
Species (MHC/HLA) | mouse(H-2Dd, H-2Ld) | |
Immunogen | vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Cytotoxicity assay, HLA binding, Intracellular cytokine staining | |
Keywords | immunodominance, vaccine antigen design, optimal epitope |
Vaccine type | DNA, modified vaccinia Ankara (MVA) |
---|---|
Vaccine strain | A clade, multiple epitope immunogen |
Vaccine component | p17 Gag, p24 Gag, other |
Im2011 Eung-Jun Im, Jessie P. Hong, Yaowaluck Roshorm, Anne Bridgeman, Sven Létourneau, Peter Liljeström, Mary Jane Potash, David J. Volsky, Andrew J. McMichael, and Tomáš Hanke. Protective Efficacy of Serially Up-Ranked Subdominant CD8+ T Cell Epitopes against Virus Challenges. PLoS Pathog., 7(5):e1002041, May 2011. PubMed ID: 21625575. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | ||
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | mouse(H-2Kd) | |
Immunogen | vaccine | |
Country | South Africa | |
Experimental methods | CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | vaccine-induced immune responses, Th1 |
Vaccine type | DNA, DNA prime with modified vaccinia Ankara (MVA) boost |
---|---|
Vaccine strain | C clade Du422, C clade Du151 |
Vaccine component | Gag, gp160 deletions, Nef, RT, Tat |
Shephard2008 Enid Shephard, Wendy A. Burgers, Joanne H. Van Harmelen, James E. Monroe, Trish Greenhalgh, Carolyn Williamson, and Anna-Lise Williamson. A Multigene HIV Type 1 Subtype C Modified Vaccinia Ankara (MVA) Vaccine Efficiently Boosts Immune Responses to a DNA Vaccine in Mice. AIDS Res. Hum. Retroviruses, 24(2):207-217, Feb 2008. PubMed ID: 18240963. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160(318-327 IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | mouse(H-2Ld) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords |
Vaccine type | vaccinia |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | Env, Nef |
Tobery1997 T. W. Tobery and R. F. Siliciano. Targeting of HIV-1 Antigens for Rapid Intracellular Degradation Enhances Cytotoxic T Lymphocyte (CTL) Recognition and the Induction of De Novo CTL Responses In Vivo after Immunization. J. Exp. Med., 185:909-920, 1997. CD8+ cytotoxic T lymphocytes (CTLs) have the ability to recognize and eliminate virally infected cells before new virions are produced within that cell. Therefore, a rapid and vigorous CD8+ CTL response, induced by vaccination, can, in principle, prevent disseminated infection in vaccinated individuals who are exposed to the relevant virus. There has thus been interest in novel vaccine strategies that will enhance the induction of CD8+ CTLs. In this study, we have tested the hypothesis that targeting an antigen to undergo more efficient processing by the class I processing pathway will elicit a more vigorous CD8+ CTL response against that antigen. Targeting a type I transmembrane protein, the HIV-1 envelope (env) protein, for expression in the cytoplasm, rather than allowing its normal co-translational translocation into the endoplasmic reticulum, sensitized target cells expressing this mutant more rapidly for lysis by an env-specific CTL clone. Additionally, a greatly enhanced de novo env-specifc CTL response was induced in vivo after immunization of mice with recombinant vaccinia vectors expressing the cytoplasmic env mutant. Similarly, targeting a cytoplasmic protein, HIV-1 nef, to undergo rapid cytoplasmic degradation induced a greatly enhanced de novo nef-specific CD8+ CTL response in vivo after immunization of mice with either recombinant vaccinia vectors or DNA expression plasmids expressing the degradation targeted nef mutant. The targeting of viral antigens for rapid cytoplasmic degradation represents a novel and highly effective vaccine strategy for the induction of enhanced de novo CTL responses in vivo. PubMed ID: 9120397. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160 | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | mouse(H-2d17) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords |
Vaccine type | vaccinia |
---|
Hanke1998b T. Hanke, T. J. Blanchard, J. Schneider, G. S. Ogg, R. Tan, M. Becker, S. C. Gilbert, A. V. Hill, G. L. Smith, and A. McMichael. Immunogenicities of Intravenous and Intramuscular Administrations of Modified Vaccinia Virus Ankara-Based Multi-CTL Epitope Vaccine for Human Immunodeficiency Virus Type 1 in Mice. J. Gen. Virol., 79:83-90, 1998. PubMed ID: 9460927. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160(318-327 IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | I-10 | |
Species (MHC/HLA) | mouse(H-2d) | |
Immunogen | in vitro stimulation or selection | |
Experimental methods | ||
Keywords |
Takahashi2001 M. Takahashi, Y. Nakagawa, J. A. Berzofsky, and H. Takahashi. Counter-regulation of cytolytic activity and cytokine production in HIV-1-specific murine CD8+ cytotoxic T lymphocytes by free antigenic peptide. Int. Immunol., 13(1):43-51, Jan 2001. URL: http://intimm.oupjournals.org/cgi/content/full/13/1/43. PubMed ID: 11133833. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120(318-327 IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | mouse(H-2d) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords |
Vaccine type | fusion protein with anthrax delivery domain |
---|---|
Vaccine component | gp120 |
Goletz1997 T. J. Goletz, K. R. Klimpel, N. Arora, S. H. Leppla, J. M. Keith, and J. A. Berzofsky. Targeting HIV Proteins to the Major Histocompatibility Complex Class I Processing Pathway with a Novel gp120-Anthrax Toxin Fusion Protein. Proc. Natl. Acad. Sci. U.S.A., 94:12059-12064, 1997. PubMed ID: 9342362. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160(318-327 IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | mouse(H-2d) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords | Th1, Th2 |
Vaccine type | DNA |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | gp160 |
Arai2000 H. Arai, K. Q. Xin, K. Hamajima, Y. Lu, S. Watabe, T. Takahashi, S. Toda, K. Okuda, I. Kudoh, M. Suzuki, and K. Okuda. 8 Br-cAMP enhances both humoral and cell-mediated immune responses induced by an HIV-1 DNA vaccine. Gene Ther., 7(8):694-702, Apr 2000. PubMed ID: 10800093. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160(318-327 IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | mouse(H-2d) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords |
Vaccine type | peptide |
---|---|
Vaccine component | CD4BS, HPG30, Env V3 |
Adjuvant | IL-12 |
Hamajima1997 K. Hamajima, J. Fukushima, H. Bukawa, T. Kaneko, T. Tsuji, Y. Asakura, S. Sasaki, K. Q. Xin, and K. Okuda. Strong Augment Effect of IL-12 Expression Plasmid on the Induction of HIV-Specific Cytotoxic T Lymphocyte Activity by a Peptide Vaccine Candidate. Clin. Immunol. Immunopathol., 83:179-184, 1997. We previously reported that repeated inoculation of VC1, a macromolecular multicomponent peptide vaccine emulsified with Freund's adjuvant (VC1-F), induced high cytotoxic T lymphocyte (CTL) levels and a substantial level of multivalent antibodies which neutralized various human immunodeficiency virus type 1 (HIV-1) isolates. In the present study, we report that inoculation of VC1-F plus interleukin (IL)-12 expression plasmid can induce a higher antigen-specific CTL response compared to that with VC1-F alone. VC1-F plus IL-12 expression plasmid or VC1-F alone were inoculated to BALB/c mice twice at interval of 2 weeks. Two weeks after the second inoculation, spleen effector cells from these mice were examined. Stronger CTL responses against target cells were observed from the inoculation of VC1-F plus IL-12 plasmid than from that with VC-1F alone, but there was no difference in antibody induction. The inoculation of VC1 plus IL-12 plasmid also produced higher CTL activity than the inoculation of VC1 alone. These augmented CTL activities were not observed using target cells pulsed with non-HIV-specific peptides and different class I haplotype cells. These data demonstrate that co-inoculation of cell-mediated immune potent antigen and IL-12 plasmids can enhance the antigen-specific CTL response. This may be a potential approach for the induction of cellular immunization against HIV-1 and other diseases. PubMed ID: 9143379. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160 | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | mouse(H-2d) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords |
Vaccine type | DNA, vaccinia |
---|---|
Vaccine component | Env |
Adjuvant | IL-12 |
Gherardi2000 M. M. Gherardi, J. C. Ramirez, and M. Esteban. Interleukin-12 (IL-12) Enhancement of the Cellular Immune Response against Human Immunodeficiency Virus Type 1 Env Antigen in a DNA Prime/Vaccinia Virus Boost Vaccine Regimen Is Time and Dose Dependent: Suppressive Effects of IL-12 Boost Are Mediated by Nitric Oxide. J. Virol., 74:6278-6286, 2000. PubMed ID: 10864637. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120 | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | mouse(H-2d) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords |
Vaccine type | vaccinia |
---|
Hanke1998b T. Hanke, T. J. Blanchard, J. Schneider, G. S. Ogg, R. Tan, M. Becker, S. C. Gilbert, A. V. Hill, G. L. Smith, and A. McMichael. Immunogenicities of Intravenous and Intramuscular Administrations of Modified Vaccinia Virus Ankara-Based Multi-CTL Epitope Vaccine for Human Immunodeficiency Virus Type 1 in Mice. J. Gen. Virol., 79:83-90, 1998. PubMed ID: 9460927. Show all entries for this paper.
Hanke1998c T. Hanke, J. Schneider, S. G. Gilbert, A. V. S. Hill, and A. McMichael. DNA Multi-CTL Epitope Vaccines for HIV and Plasmodium falciparum: Immunogenicity in Mice. Vaccine, 16:426-435, 1998. PubMed ID: 9607066. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120 (V3)( IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | mouse(H-2d) | |
Immunogen | vaccine | |
Experimental methods | Chromium-release assay, Intracellular cytokine staining | |
Keywords | genital and mucosal immunity, memory cells, vaccine antigen design |
Vaccine type | influenza |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | Env V3 |
Garulli2004 Bruno Garulli, Yoshihiro Kawaoka, and Maria R. Castrucci. Mucosal and Systemic Immune Responses to a Human Immunodeficiency Virus Type 1 Epitope Induced upon Vaginal Infection with a Recombinant Influenza A Virus. J. Virol., 78(2):1020-1025, Jan 2004. PubMed ID: 14694134. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160( IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | mouse(H-2d) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords | Th1, Th2 |
Vaccine type | vaccinia |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | gp160 |
Shirai2001 M. Shirai, R. Fujinaga, T. Masaki, and J. A. Berzofsky. Impaired development of HIV-1 gp160-specific CD8(+) cytotoxic T cells by a delayed switch from Th1 to Th2 cytokine phenotype in mice with Helicobacter pylori infection. Eur. J. Immunol., 31(2):516-26, Feb 2001. PubMed ID: 11180117. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(318-327) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | mouse(H-2d) | |
Immunogen | ||
Experimental methods | ||
Keywords | epitope processing, immunodominance |
Lopez2000 D. Lopez, B. C. Gil-Torregrosa, C. Bergmann, and M. Del Val. Sequential Cleavage by Metallopeptidases and Proteasomes Is Involved in Processing HIV-1 ENV Epitope for Endogenous MHC Class I Antigen Presentation. J. Immunol., 164:5070-5077, 2000. PubMed ID: 10799863. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | Env | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | mouse(H-2d) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords |
Vaccine type | vaccinia, Sindbis |
---|---|
Vaccine component | Env V3 |
Villacres1999 M. C. Villacres and C. C. Bergmann. Enhanced Cytotoxic T Cell Activity in IL-4-Deficient Mice. J. Immunol., 162:2663-2670, 1999. PubMed ID: 10072509. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | Env | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | mouse(H-2d) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords | Th1 |
Vaccine type | DNA |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | gp160, Rev |
Adjuvant | IL-12, IL-15, IL-2 |
Xin1999 K. Q. Xin, K. Hamajima, S. Sasaki, T. Tsuji, S. Watabe, E. Okada, and K. Okuda. IL-15 expression plasmid enhances cell-mediated immunity induced by an HIV-1 DNA vaccine. Vaccine, 17:858-66, 1999. PubMed ID: 10067692. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120(318-327 IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | mouse(H-2d, H-2p, H-2u) | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords |
Vaccine type | vaccinia |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | gp160 |
Shirai1997 M. Shirai, S. Kozlowski, D. H. Margulies, and J. A. Berzofsky. Degenerate MHC Restriction Reveals the Contribution of Class I MHC Molecules in Determining the Fine Specificity of CTL Recognition of an Immunodominant Determinant of HIV-1 gp160 V3 Loop. J. Immunol., 158:3181-3188, 1997. The novel allogeneic presentation of an immunodominant determinant within the HIV-1 gp160 V3 loop by three different class I MHC molecules to the same CD8+ CTL is used to study the influence of the MHC molecule on the fine specificity of CTL recognition. We previously reported that four distinct class I molecules of H-2d,u,p,q presented the V3 decapeptide P18-I10 (RGPGRAFVTI) to CTL. Surprisingly, we found that H- 2d,u,p cells mutually cross-present the P18-I10 peptide to allogeneic CTL clones of each of the other haplotypes, whereas none of these cross- presents to H-2q CTL, nor do H-2q targets present to CTL of the other haplotypes. Here, we explore the critical amino acid residues for the cross-presentation using 10 variant peptides with single amino acid substitutions. The fine specificity examined using these mutant peptides presented by the same MHC class I molecule showed striking similarity among the CTL of each haplotype, expressing either V beta 8.1 or V beta 14. In contrast, the fine specificity is different between the distinct MHC class I molecules even for the lysis by the same CTL, as shown by reciprocal effects of the same substitutions. Thus, peptide fine specificity of a single TCR is influenced by changes in the class I MHC molecules presenting the Ag. PubMed ID: 9120272. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120(313-322 BRU) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | Pep 09 | |
Subtype | B, C | |
Species (MHC/HLA) | mouse | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords | subtype comparisons, Th1 |
Vaccine type | DNA |
---|---|
Vaccine strain | B clade BRU |
Vaccine component | gp160, Rev, Tat |
Arora2001 A. Arora and P. Seth. Immunization with HIV-1 Subtype B gp160-DNA Induces Specific as Well as Cross Reactive Immune Responses in Mice. Indian J Med Res, 114:1-9, Jul 2001. PubMed ID: 11762199. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120 | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human, mouse | |
Immunogen | vaccine | |
Country | South Africa, United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | vaccine antigen design |
Vaccine type | modified vaccinia Ankara (MVA) |
---|---|
Vaccine strain | C clade Du422 |
Vaccine component | Env, Gag, Nef, RT, Tat |
Burgers2008 Wendy A. Burgers, Enid Shephard, James E. Monroe, Trish Greenhalgh, Anke Binder, Etienne Hurter, Joanne H. Van Harmelen, Carolyn Williamson, and Anna-Lise Williamson. Construction, Characterization, and Immunogenicity of a Multigene Modified Vaccinia Ankara (MVA) Vaccine Based on HIV Type 1 Subtype C. AIDS Res. Hum. Retroviruses, 24(2):195-206, Feb 2008. PubMed ID: 18240957. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160 | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | P18-I10 | |
Subtype | B | |
Species (MHC/HLA) | mouse | |
Immunogen | vaccine | |
Experimental methods | Chromium-release assay | |
Keywords | genital and mucosal immunity |
Vaccine type | vaccinia with H1 influenza HA gene cassette |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | gp160 |
Kuribayashi2004 Hideki Kuribayashi, Ayako Wakabayashi, Masumi Shimizu, Hiroshi Kaneko, Yoshihiko Norose, Yohko Nakagawa, Jian Wang, Yoshihiro Kumagai, David H. Margulies, and Hidemi Takahashi. Resistance to Viral Infection by Intraepithelial Lymphocytes in HIV-1 P18-I10-Specific T-Cell Receptor Transgenic Mice. Biochem. Biophys. Res. Commun., 316(2):356-363, 2 Apr 2004. PubMed ID: 15020225. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | Env | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | vaccine | |
Country | United States | |
Experimental methods | Other, Tetramer binding | |
Keywords | memory cells |
Vaccine type | vesicular stomatitis virus (VSV) |
---|---|
Vaccine strain | B clade |
Vaccine component | Env |
Ramsburg2007 Elizabeth A. Ramsburg, Jean M. Publicover, Dagan Coppock, and John K. Rose. Requirement for CD4 T Cell Help in Maintenance of Memory CD8 T Cell Responses Is Epitope Dependent. J. Immunol., 178(10):6350-6358, 15 May 2007. PubMed ID: 17475864. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160 | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | P18-I10 | |
Subtype | B | |
Species (MHC/HLA) | humanized mouse | |
Immunogen | in vitro stimulation or selection | |
Experimental methods | Chromium-release assay, Other | |
Keywords |
Takaku2012 Shun Takaku, Yohko Nakagawa, Atsuko Owaki, Masumi Shimizu, Megumi Takahashi, and Hidemi Takahashi. Induction of Apoptosis-Resistant and TGF-beta-Insensitive Murine CD8+ Cytotoxic T Lymphocytes Specific for HIV-1 gp160. Cell. Immunol., 280(2):138-147, Dec 2012. PubMed ID: 23399840. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160(318-327 IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | R10I | |
Species (MHC/HLA) | mouse | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords | optimal epitope |
Vaccine type | peptide |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | Env V3 |
Nehete1995 P. N. Nehete, K. S. Casement, R. B. Arlinghus, and K. J. Sastry. Studies on In Vivo Induction of HIV-1 Envelope-Specific Cytotoxic T Lymphocytes by Synthetic Peptides from the V3 Loop Region of HIV-1 IIIB gp120. Cell. Immunol., 160:217-223, 1995. PubMed ID: 7720083. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160(318-327 IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | macaque | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords |
Vaccine type | DNA prime with peptide boost |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | CD4BS, gp160, HPG30, Env V3 |
Okuda1997 K. Okuda, K. O. Xin, T. Tsuji, H. Bukawa, S. Tanaka, W. C. Koff, K. Tani, K. Okuda, K. Honma, S. Kawamoto, K. Hamajima, and J. Fukushima. DNA vaccination followed by macromolecular multicomponent peptide vaccination against HIV-1 induces strong antigen-specific immunity. Vaccine, 15:1049-56, 1997. PubMed ID: 9269046. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | Env( IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | mouse | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords |
Vaccine type | DNA |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | gp160, Rev |
Adjuvant | MIP-1α |
Lu1999 Y. Lu, K. Q. Xin, K. Hamajima, T. Tsuji, I. Aoki, J. Yang, S. Sasaki, J. Fukushima, T. Yoshimura, S. Toda, E. Okada, and K. Okuda. Macrophage inflammatory protein-1alpha (MIP-1alpha) expression plasmid enhances DNA vaccine-induced immune response against HIV-1. Clin. Exp. Immunol., 115(2):335-41, Feb 1999. PubMed ID: 9933462. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120(318-327) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Kmieciak1998 D. Kmieciak, T. J. Wasik, H. Teppler, J. Pientka, S. H. Hsu, H. Takahashi, K. Okumura, Y. Kaneko, and D. Kozbor. The effect of deletion of the V3 loop of gp120 on cytotoxic T cell responses and HIV gp120-mediated pathogenesis. J. Immunol., 160:5676-83, 1998. PubMed ID: 9605175. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | Env | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | H | |
Subtype | A | |
Species (MHC/HLA) | mouse | |
Immunogen | vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords |
Vaccine type | adenovirus |
---|---|
Vaccine strain | A clade |
Vaccine component | Gag, other |
Bridgeman2009 Anne Bridgeman, Yaowaluck Roshorm, Linda J. Lockett, Zheng-Zhou Xu, Richard Hopkins, Jan Shaw, Gerald W. Both, and Tomáš Hanke. Ovine Atadenovirus, a Novel and Highly Immunogenic Vector in Prime-Boost Studies of a Candidate HIV-1 Vaccine. Vaccine, 28(2):474-483, 11 Dec 2009. PubMed ID: 19853074. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | gp120( IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | L | |
Subtype | B | |
Species (MHC/HLA) | mouse | |
Immunogen | vaccine | |
Experimental methods | Cytokine production, Other | |
Keywords | vaccine antigen design |
Vaccine type | DNA, bacteriophage coat protein |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | gp120 |
Charles-Nino2011 Claudia Charles-Niño, Cesar Pedroza-Roldan, Monica Viveros, Goar Gevorkian, and Karen Manoutcharian. Variable Epitope Libraries: New Vaccine Immunogens Capable of Inducing Broad Human Immunodeficiency Virus Type 1-Neutralizing Antibody Response. Vaccine, 29(32):5313-5321, 18 Jul 2011. PubMed ID: 21600948. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | Env( IIIB) | |
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | 10 Env | |
Subtype | B | |
Species (MHC/HLA) | mouse | |
Immunogen | vaccine | |
Patient MHC/HLA | H-2d | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Cytokine production, Proliferation | |
Keywords | Th1, Th2, genital and mucosal immunity |
Vaccine type | influenza prime with vaccinia boost |
---|---|
Vaccine strain | B clade IIIB |
Vaccine component | gp160 |
Gherardi2003 M. Magdalena Gherardi, José Luis Nájera, Eva Pérez-Jiménez, Susana Guerra, Adolfo García-Sastre, and Mariano Esteban. Prime-Boost Immunization Schedules Based on Influenza Virus and Vaccinia Virus Vectors Potentiate Cellular Immune Responses against Human Immunodeficiency Virus Env Protein Systemically and in the Genitorectal Draining Lymph Nodes. J. Virol., 77(12):7048-7057, Jun 2003. PubMed ID: 12768024. Show all entries for this paper.
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HXB2 Location | gp160(311-320) gp120(311-320) DNA(7155..7184) |
gp160 Epitope Map |
---|---|---|
Author Location | ||
Epitope |
RGPGRAFVTI
|
Epitope Alignment
|
Epitope Name | P18 | |
Subtype | B | |
Species (MHC/HLA) | mouse | |
Immunogen | vaccine | |
Experimental methods | ||
Keywords |
Vaccine type | DNA |
---|---|
Vaccine strain | B clade BH10 |
Vaccine component | gp120 |
Adjuvant | GM-CSF |
Barouch2002 Dan H. Barouch, Sampa Santra, Klara Tenner-Racz, Paul Racz, Marcelo J. Kuroda, Joern E. Schmitz, Shawn S. Jackson, Michelle A. Lifton, Dan C. Freed, Helen C. Perry, Mary-Ellen Davies, John W. Shiver, and Norman L. Letvin. Potent CD4+ T cell responses elicited by a bicistronic HIV-1 DNA vaccine expressing gp120 and GM-CSF. J. Immunol., 168(2):562-568, 15 Jan 2002. PubMed ID: 11777947. Show all entries for this paper.