HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 14 matching records:

Displaying record number 58495

HXB2 Location Gag(294-304)
p24(162-172)
DNA(1669..1701)
Gag Epitope Map
Author Location Gag(294-)
Epitope RDYVDRFYKTL Epitope Alignment
RDYVDRFYKTL epitope logo
Subtype B
Species (MHC/HLA) human(A*24, A*26, B*44, B*70)
Immunogen HIV-1 infection
Country Canada
Experimental methods Other
Keywords characterizing CD8+ T cells, elite controllers

Notes

References

Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.


Displaying record number 57207

HXB2 Location Gag(294-304)
p24(162-172)
DNA(1669..1701)
Gag Epitope Map
Author Location Gag
Epitope RDYVDRFYKTL Epitope Alignment
RDYVDRFYKTL epitope logo
Species (MHC/HLA) (A24)
Immunogen HIV-1 infection
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords mother-to-infant transmission

Notes

References

Lohman-Payne2009 B. Lohman-Payne, J. A. Slyker, B. A. Richardson, C. Farquhar, M. Majiwa, E. Maleche-Obimbo, D. Mbori-Ngacha, J. Overbaugh, S. Rowland-Jones, and G. John-Stewart. Infants with Late Breast Milk Acquisition of HIV-1 Generate Interferon-gamma Responses More Rapidly than Infants with Early Peripartum Acquisition. Clin. Exp. Immunol., 156(3):511-517, Jun 2009. PubMed ID: 19438605. Show all entries for this paper.


Displaying record number 314

HXB2 Location Gag(294-304)
p24(162-172)
DNA(1669..1701)
Gag Epitope Map
Author Location p24(293-312 LAI)
Epitope RDYVDRFYKTL Epitope Alignment
RDYVDRFYKTL epitope logo
Subtype B
Species (MHC/HLA) human(A26, B44, B70)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

References

Ogg1998b G. S. Ogg, T. Dong, P. Hansasuta, L. Dorrell, J. Clarke, R. Coker, G. Luzzi, C. Conlon, A. P. McMichael, and S. Rowland-Jones. Four Novel Cytotoxic T-Lymphocyte Epitopes in the Highly Conserved Major Homology Region of HIV-1 Gag, Restricted through B*4402, B*1801, A*2601, B*70 (B*1509). AIDS, 12:1561-1563, 1998. PubMed ID: 9727585. Show all entries for this paper.


Displaying record number 60097

HXB2 Location Gag(294-304)
p24(162-172)
DNA(1669..1701)
Gag Epitope Map
Author Location Gag(294-304)
Epitope RDYVDRFYKTL Epitope Alignment
RDYVDRFYKTL epitope logo
Epitope Name RL11
Species (MHC/HLA) human(B*18)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 58535

HXB2 Location Gag(294-304)
p24(162-172)
DNA(1669..1701)
Gag Epitope Map
Author Location p24(162-172)
Epitope RDYVDRFYKTL Epitope Alignment
RDYVDRFYKTL epitope logo
Subtype B
Species (MHC/HLA) human(B*18, B*44, B*70)
Immunogen HIV-1 infection
Country Canada
Experimental methods Other
Keywords characterizing CD8+ T cells, elite controllers

Notes

References

Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.


Displaying record number 1806

HXB2 Location Gag(294-304)
p24(162-172)
DNA(1669..1701)
Gag Epitope Map
Author Location p24(162-172)
Epitope RDYVDRFYKTL Epitope Alignment
RDYVDRFYKTL epitope logo
Species (MHC/HLA) human(B*44)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, acute/early infection

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 57713

HXB2 Location Gag(294-304)
p24(162-172)
DNA(1669..1701)
Gag Epitope Map
Author Location Gag
Epitope RDYVDRFYKTL Epitope Alignment
RDYVDRFYKTL epitope logo
Species (MHC/HLA) human(B*44)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supervised treatment interruptions (STI), escape

Notes

References

Schweighardt2010 Becky Schweighardt, Terri Wrin, Duncan A. Meiklejohn, Gerald Spotts, Christos J. Petropoulos, Douglas F. Nixon, and Frederick M. Hecht. Immune Escape Mutations Detected within HIV-1 Epitopes Associated with Viral Control During Treatment Interruption. J. Acquir. Immune Defic. Syndr., 53(1):36-46, Jan 2010. PubMed ID: 19910798. Show all entries for this paper.


Displaying record number 1457

HXB2 Location Gag(294-304)
p24(162-172)
DNA(1669..1701)
Gag Epitope Map
Author Location p24(162-172)
Epitope RDYVDRFYKTL Epitope Alignment
RDYVDRFYKTL epitope logo
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.


Displaying record number 52426

HXB2 Location Gag(294-304)
p24(162-172)
DNA(1669..1701)
Gag Epitope Map
Author Location p24
Epitope RDYVDRFYKTL Epitope Alignment
RDYVDRFYKTL epitope logo
Subtype B, D
Species (MHC/HLA) human, macaque(B44)
Immunogen HIV-1 infection, vaccine
Experimental methods  
Keywords subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain A clade
Vaccine component p17 Gag, p24 Gag

Notes

References

Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.

Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.


Displaying record number 52927

HXB2 Location Gag(294-304)
p24(162-172)
DNA(1669..1701)
Gag Epitope Map
Author Location Gag( B con)
Epitope RDYVDRFYKTL Epitope Alignment
RDYVDRFYKTL epitope logo
Epitope Name RL11
Subtype B
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords variant cross-reactivity

Notes

References

Draenert2004b R. Draenert, C. L. Verrill, Y. Tang, T. M. Allen, A. G. Wurcel, M. Boczanowski, A. Lechner, A. Y. Kim, T. Suscovich, N. V. Brown, M. M. Addo, and B. D. Walker. Persistent Recognition of Autologous Virus by High-Avidity CD8 T Cells in Chronic, Progressive Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(2):630-641, Jan 2004. PubMed ID: 14694094. Show all entries for this paper.


Displaying record number 54371

HXB2 Location Gag(294-304)
p24(162-172)
DNA(1669..1701)
Gag Epitope Map
Author Location p24
Epitope RDYVDRFYKTL Epitope Alignment
RDYVDRFYKTL epitope logo
Epitope Name B44-RL11(p24)
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 315

HXB2 Location Gag(294-304)
p24(162-172)
DNA(1669..1701)
Gag Epitope Map
Author Location p24(293-312 LAI)
Epitope RDYVDRFYKTL Epitope Alignment
RDYVDRFYKTL epitope logo
Subtype B
Species (MHC/HLA) human(B*4402)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 60096

HXB2 Location Gag(294-304)
p24(162-172)
DNA(1669..1701)
Gag Epitope Map
Author Location Gag(294-304)
Epitope RDYVDRFYKTL Epitope Alignment
RDYVDRFYKTL epitope logo
Epitope Name RL11
Species (MHC/HLA) human(C*03)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 55936

HXB2 Location Gag(294-304)
p24(162-172)
DNA(1669..1701)
Gag Epitope Map
Author Location p24
Epitope RDYVDRFYKTL Epitope Alignment
RDYVDRFYKTL epitope logo
Show epitope variants
Epitope Name RL11(p24)
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords variant cross-reactivity

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


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