HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 58058

Download this epitope record as JSON.

HXB2 Location Nef(35-43)
DNA(8899..8925)
Nef Epitope Map
Author Location Nef
Epitope RDLEKHGAI Epitope Alignment
RDLEKHGAI epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Patient MHC/HLA A*02:01, A*32:01, B*37:01, B*39:06, C*06:02, C*07:02; A*02:01, A*26:01, B*37:01, B*38:01, C*06:02, C*12:03
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus type 5 (Ad5), DNA prime with Ad5 boost
Vaccine strain B clade IIIB, B clade JRFL, B clade CAM-1
Vaccine component Gag, Nef, Pol

Notes

References

Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.


Displaying record number 59185

Download this epitope record as JSON.

HXB2 Location Nef(35-43)
DNA(8899..8925)
Nef Epitope Map
Author Location Nef(35-43 NL432)
Epitope RDLEKHGAI Epitope Alignment
RDLEKHGAI epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA AC01: A*01:01, A*31:01, B*37:01, B*51:09, C*01:02, C*06:02
Country Australia, Germany, United States
Experimental methods Other
Keywords class I down-regulation by Nef, acute/early infection

Notes

References

Kuang2014 Xiaomei T. Kuang, Xiaoguang Li, Gursev Anmole, Philip Mwimanzi, Aniqa Shahid, Anh Q. Le, Louise Chong, Hua Qian, Toshiyuki Miura, Tristan Markle, Bemuluyigza Baraki, Elizabeth Connick, Eric S. Daar, Heiko Jessen, Anthony D. Kelleher, Susan Little, Martin Markowitz, Florencia Pereyra, Eric S. Rosenberg, Bruce D. Walker, Takamasa Ueno, Zabrina L. Brumme, and Mark A. Brockman. Impaired Nef Function Is Associated with Early Control of HIV-1 Viremia. J. Virol., 88(17):10200-10213, 1 Sep 2014. PubMed ID: 24965469. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health