Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 52991

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HXB2 Location	gp160(835-843) gp41(324-332) DNA(8727..8753)	gp160 Epitope Map
Author Location	Env(835-843)
Epitope	RAYRAILHI	Epitope Alignment
		Show epitope variants
Species (MHC/HLA)	human(B51)
Immunogen	HIV-1 infection
Patient MHC/HLA	A3, A32, B15, B51, C*03, Cw6, DQ7, DR4, DR8
Country	Netherlands
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, escape

Notes

• Both stable potential epitopes and epitopes with escape mutations were found in a patient with increasing viral load over a time period of 4 years. Fixation of escape mutations occurred sequentially and correlated with the rise in viral load and with the increased number of productively infected cells.
• This is one of 7 epitopes from this individual that varied over time, although the internal mutations did not become fixed. The rTFrailhi variant residues arose at early time points, rIyrailhX variant residues arose at intermediate time points.

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.

Displaying record number 887

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HXB2 Location	gp160(835-843) gp41(324-332) DNA(8727..8753)	gp160 Epitope Map
Author Location	Env(834-842 SF2)
Epitope	RAYRAILHI	Epitope Alignment
Species (MHC/HLA)	human(B*51:01)
Immunogen	HIV-1 infection
Experimental methods
Keywords	rate of progression

Notes

• HLA-B27, -B51, and -B57 are associated with slow progression to AIDS, while HLA-B35, -B8, -B24 are associated with a rapid progression to AIDS (Nat. Med. 2:405, 1996;Lancet 22:1187, 1986;Hum Immunol 22:73, 1988;Hum Immunol 44:156, 1995)
• 15% of Japanese populations carry HLA-B51 while HLA-B27 and -B57 are detected in less than 0.3%
• Of the 172 HIV-1 peptides with HLA-B*5101 anchor residues, 33 bound to HLA-B*5101, seven of these peptides were reactive with CTL from 3 B*5101 positive individuals, and six were properly processed.
• This peptide could stimulate CTL from one person, however this CTL clone did not recognize B*5101 positive target cells infected with HIV-1 recombinant vaccinia expressing Env, so it was not confirmed that this peptide was a properly processed epitope.

References

Tomiyama1999 H. Tomiyama, T. Sakaguchi, K. Miwa, S. Oka, A. Iwamoto, Y. Kaneko, and M. Takiguchi. Identification of multiple HIV-1 CTL epitopes presented by HLA-B*5101. Hum. Immunol., 60:177-86, 1999. PubMed ID: 10321954. Show all entries for this paper.