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Displaying record number 55652

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HXB2 Location	gp160(511-523) gp120(511)-gp41(12) DNA(7755..7793)	gp160 Epitope Map
Author Location	Env
Epitope	RAVGMGALIFEFL	Epitope Alignment
Subtype	CRF02_AG
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Cote D'Ivoire
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• Factors affecting cross-subtype immunity were evaluated by west Cote d'Ivoire subjects' INF-gamma ELISpot responses to OLPs from a CRF02_AG candidate vaccine, a west Kenyan subtype A virus and a Thai CRF01_AE sequence. 15 test subject sequences were primarily CRF02_AG or CRF02_AG-like, but also pure subtypes A and D. Cross-reactive responses to Gag as well as Env peptides were seen, though the response magnitude to Env was lower, perhaps due to its greater sequence variation.
• 1 subject responded to peptide RAVGMGALIFEFL from subtype CRF02_AG.

References

Aidoo2008 M. Aidoo, S. Sawadogo, E. C. Bile, C. Yang, J. N. Nkengasong, and J. M. McNicholl. Viral, HLA and T Cell Elements in Cross-Reactive Immune Responses to HIV-1 Subtype A, CRF01\_AE and CRF02\_AG Vaccine Sequence in Ivorian Blood Donors. Vaccine, 26(37):4830-4839, 2 Sep 2008. PubMed ID: 18640166. Show all entries for this paper.