Search CTL/CD8+ T-Cell Epitope Database

Found 9 matching records:

Displaying record number 60093

HXB2 Location	gp160(557-565) gp41(46-54) DNA(7893..7919)	gp160 Epitope Map
Author Location	Env(557-565)
Epitope	`RAIEAQQHM`	Epitope Alignment
Epitope Name	RM9
Species (MHC/HLA)	human(A*34)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
RAIEAQQHM had a significantly positive association with HLA A*34; it was recognized by 2/9 A*34-positive subjects and 1/232 A*34-negative subjects.

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.

Displaying record number 60092

HXB2 Location	gp160(557-565) gp41(46-54) DNA(7893..7919)	gp160 Epitope Map
Author Location	Env(557-565)
Epitope	`RAIEAQQHM`	Epitope Alignment
Epitope Name	RM9
Species (MHC/HLA)	human(B*1516)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
RAIEAQQHM had a significantly positive association with HLA B*1516; it was recognized by 2/5 B*1516-positive subjects and 3/241 B*1516-negative subjects.

References

Displaying record number 60091

HXB2 Location	gp160(557-565) gp41(46-54) DNA(7893..7919)	gp160 Epitope Map
Author Location	Env(557-565)
Epitope	`RAIEAQQHM`	Epitope Alignment
Epitope Name	RM9
Species (MHC/HLA)	human(B*52)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
RAIEAQQHM had a significantly positive association with HLA B*52; it was recognized by 4/12 B*52-positive subjects and 5/246 B*52-negative subjects.

References

Displaying record number 60088

HXB2 Location	gp160(557-565) gp41(46-54) DNA(7893..7919)	gp160 Epitope Map
Author Location	Env(557-565)
Epitope	`RAIEAQQHM`	Epitope Alignment
Epitope Name	RM9
Species (MHC/HLA)	human(B*81)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
RAIEAQQHM had a significantly positive association with HLA B*81; it was recognized by 5/10 B*81-positive subjects and 9/258 B*81-negative subjects.

References

Displaying record number 60089

HXB2 Location	gp160(557-565) gp41(46-54) DNA(7893..7919)	gp160 Epitope Map
Author Location	Env(557-565)
Epitope	`RAIEAQQHM`	Epitope Alignment
Epitope Name	RM9
Species (MHC/HLA)	human(C*03)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
RAIEAQQHM had a significantly positive association with HLA C*03; it was recognized by 12/49 C*03-positive subjects and 14/268 C*03-negative subjects.

References

Displaying record number 60090

HXB2 Location	gp160(557-565) gp41(46-54) DNA(7893..7919)	gp160 Epitope Map
Author Location	Env(557-565)
Epitope	`RAIEAQQHM`	Epitope Alignment
Epitope Name	RM9
Species (MHC/HLA)	human(C*15)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
RAIEAQQHM had a significantly positive association with HLA C*15; it was recognized by 9/24 C*15-positive subjects and 26/317 C*15-negative subjects.

References

Displaying record number 54111

HXB2 Location	gp160(557-565) gp41(46-54) DNA(7893..7919)	gp160 Epitope Map
Author Location
Epitope	`RAIEAQQHM`	Epitope Alignment
Epitope Name	RM9
Species (MHC/HLA)	human(Cw*08)
Immunogen
Experimental methods
Keywords	optimal epitope

Notes

C. Brander notes this is a Cw08 epitope.

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.

Displaying record number 53316

HXB2 Location	gp160(557-565) gp41(46-54) DNA(7893..7919)	gp160 Epitope Map
Author Location	( C consensus)
Epitope	`RAIEAQQHM`	Epitope Alignment
Subtype	C
Species (MHC/HLA)	human(Cw*0801)
Immunogen	HIV-1 infection
Country	South Africa
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	HLA cross-presentation, characterizing CD8+ T cells

Notes

HLA class I restricted CD8+ T-cell responses against HIV-1 were analyzed in African patients. Significantly more responses were shown to be HLA-B restricted. Viral load, CD4 count, and thus rate of disease progression were also associated with HLA-B alleles. In addition, the selection pressure imposed on HIV-1 by HLA-B alleles was shown to be substantially greater than by other alleles.
This epitope was suggested to be the epitope within a longer reactive peptide based on correspondence with a known epitope in the HIV database. Also, a significantly higher frequency of people in the Durban cohort who reacted with the peptide had this HLA type.

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.

Displaying record number 58256

HXB2 Location	gp160(557-565) gp41(46-54) DNA(7893..7919)	gp160 Epitope Map
Author Location	Env
Epitope	`RAIEAQQHM`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
Env epitope RAIEAQQHM stimulated peak EliSpot response in 1 subject, and stimulated peak proliferation response in 1 other subject. The subject with peak EliSpot response had peak proliferative response to RAIEAQQQM and had not reached disease end point.

References

McKinnon2012 Lyle R. McKinnon, Rupert Kaul, Joshua Kimani, Nico J. Nagelkerke, Charles Wachihi, Keith R. Fowke, Terry Blake Ball, and Francis A. Plummer. HIV-Specific CD8+ T-Cell Proliferation Is Prospectively Associated with Delayed Disease Progression. Immunol. Cell Biol., 90(3):346-351, Mar 2012. PubMed ID: 21606945. Show all entries for this paper.