HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 37 matching records:

Displaying record number 52977

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location gp160(557-565)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Species (MHC/HLA) human(B15, B51)
Immunogen HIV-1 infection
Patient MHC/HLA A3, A32, B15, B51, Cw03, Cw6, DQ7, DR4, DR8
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, escape

Notes

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.


Displaying record number 54325

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location gp41(46-54)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Species (MHC/HLA) human(B*1501, B*5101, Cw*0304)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Cytokine production, HLA binding, Other
Keywords vaccine-induced immune responses, HLA cross-presentation, HLA associated polymorphism

Notes

References

Reche2006 Pedro A. Reche, Derin B. Keskin, Rebecca E. Hussey, Petronela Ancuta, Dana Gabuzda, and Ellis L. Reinherz. Elicitation from Virus-Naive Individuals of Cytotoxic T Lymphocytes Directed against Conserved HIV-1 Epitopes. Med. Immunol., 5:1, 2006. PubMed ID: 16674822. Show all entries for this paper.


Displaying record number 57085

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location gp41(46-54 DU422)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Subtype B
Species (MHC/HLA) human(B*1501, Cw*0304)
Immunogen in vitro stimulation or selection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Tetramer binding
Keywords dendritic cells

Notes

References

Colleton2009 Bonnie A. Colleton, Xiao-Li Huang, Nada M. Melhem, Zheng Fan, Luann Borowski, Giovanna Rappocciolo, and Charles R. Rinaldo. Primary Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses Induced by Myeloid Dendritic Cells. J. Virol., 83(12):6288-6299, Jun 2009. PubMed ID: 19357176. Show all entries for this paper.


Displaying record number 60087

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location Env(557-565)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Epitope Name RL9
Species (MHC/HLA) human(B*1503)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60086

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location Env(557-565)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Epitope Name RL9
Species (MHC/HLA) human(B*49)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 56446

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location gp41
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Epitope Name RL9(gp41)
Subtype B
Species (MHC/HLA) human(B51)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 809

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location gp41(557-565)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Species (MHC/HLA) human(B51)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferris1999 R. L. Ferris, C. Hall, N. V. Sipsas, J. T. Safrit, A. Trocha, R. A. Koup, R. P. Johnson, and R. F. Siliciano. Processing of HIV-1 Envelope Glycoprotein for Class I-Restricted Recognition: Dependence on TAP1/2 and Mechanisms for Cytosolic Localization. J. Immunol., 162:1324-1332, 1999. PubMed ID: 9973386. Show all entries for this paper.


Displaying record number 1438

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location gp41(47-55)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Species (MHC/HLA) human(B51)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.


Displaying record number 806

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location gp41(557-565 IIIB)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Show epitope variants
Species (MHC/HLA) human(B51)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Sipsas1997 N. V. Sipsas, S. A. Kalams, A. Trocha, S. He, W. A. Blattner, B. D. Walker, and R. P. Johnson. Identification of Type-Specific Cytotoxic T Lymphocyte Responses to Homologous Viral Proteins in Laboratory Workers Accidentally Infected with HIV-1. J. Clin. Invest., 99:752-762, 1997. To examine a situation where the autologous strain and the reference reagents would be the same, the CTL response of three lab workers accidentally infected with HIV IIIB was studied. Both group specific and type specific epitopes were targets for CTL clones. One subject had a broadening of CTL response over time, using a broad range of restricting HLA class I alleles. Characterization of the cytotoxic T lymphocyte (CTL) response against HIV-1 has been limited by the use of target cells expressing viral proteins from laboratory isolates of HIV-1. This approach has favored identification of group-specific CTL responses and precluded assessment of the extent of type-specific CTL responses directed against HIV-1. Using cells expressing viral proteins from the HIV-1 IIIB strain, we performed a detailed characterization of HIV-1-specific CTL response in three laboratory workers accidentally infected with HIV-1 IIIB. Eight of the epitopes identified were group specific, lying in relatively conserved regions of Gag, reverse transcriptase, and envelope. Three type-specific epitopes were identified, two of them in highly variable regions of envelope. In longitudinal studies in one subject, seven different epitopes and five different restricting HLA class I alleles were identified, with a progressive increase in the number of CTL epitopes recognized by this subject over time. Our data demonstrate that type-specific CTL responses make up a significant proportion of the host cellular immune response against HIV-1 and that a broadening of epitope specificity may occur. PubMed ID: 9045880. Show all entries for this paper.


Displaying record number 54375

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location gp41
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Epitope Name B51-RL9(qp41)
Species (MHC/HLA) human(B51)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 1505

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location gp41(557-565 LAI)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Epitope Name E3
Subtype B
Species (MHC/HLA) human(B*51)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Mollet2000 L. Mollet, T. S. Li, A. Samri, C. Tournay, R. Tubiana, V. Calvez, P. Debre, C. Katlama, and B. Autran. Dynamics of HIV-specific CD8+ T lymphocytes with changes in viral load. J. Immunol., 165(3):1692-704, 1 Aug 2000. URL: http://www.jimmunol.org/v165n3/1692/1692-abs-frame.html. PubMed ID: 10903781. Show all entries for this paper.


Displaying record number 58401

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location ( IIIB, MN)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Subtype B
Species (MHC/HLA) human(B*51)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication
Keywords rate of progression, HLA associated polymorphism, elite controllers

Notes

References

Zhang2011 YongHong Zhang, YanChun Peng, HuiPing Yan, Keyi Xu, Masumichi Saito, Hao Wu, XinYue Chen, Srinika Ranasinghe, Nozomi Kuse, Tim Powell, Yan Zhao, WeiHua Li, Xin Zhang, Xia Feng, Ning Li, Aleksandra Leligdowicz, XiaoNing Xu, Mina John, Masafumi Takiguchi, Andrew McMichael, Sarah Rowland-Jones, and Tao Dong. Multilayered Defense in HLA-B51-Associated HIV Viral Control. J. Immunol., 187(2):684-691, 15 Jul 2011. PubMed ID: 21670313. Show all entries for this paper.


Displaying record number 54521

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location gp41(557-565)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Epitope Name RL9
Subtype A
Species (MHC/HLA) human(B*51, Cw*03)
Immunogen HIV-1 infection
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Cytokine production, Proliferation
Keywords assay or method development

Notes

References

McKinnon2007 Lyle R. McKinnon, T. Blake Ball, Charles Wachihi, Paul J. McLaren, Jillian L. M. Waruk, Xiaojuan Mao, Sue Ramdahin, A. Omu Anzala, Jane Kamene, Ma Luo, Keith R. Fowke, and Francis A. Plummer. Epitope Cross-Reactivity Frequently Differs between Central and Effector Memory HIV-Specific CD8+ T Cells. J. Immunol., 178(6):3750-3756, 15 Mar 2007. PubMed ID: 17339473. Show all entries for this paper.


Displaying record number 54166

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location gp41(46-54 HIV-MN)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Epitope Name RL9
Subtype B
Species (MHC/HLA) human(B*5101)
Immunogen HIV-1 infection
Patient MHC/HLA PIC1362: A*0201, A*2501, B*1801, B*5101, Cw*0102, Cw*1203
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords optimal epitope

Notes

References

Liu2006 Yi Liu, John McNevin, Jianhong Cao, Hong Zhao, Indira Genowati, Kim Wong, Sherry McLaughlin, Matthew D. McSweyn, Kurt Diem, Claire E. Stevens, Janine Maenza, Hongxia He, David C. Nickle, Daniel Shriner, Sarah E. Holte, Ann C. Collier, Lawrence Corey, M. Juliana McElrath, and James I. Mullins. Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection. J. Virol., 80(19):9519-9529, Oct 2006. PubMed ID: 16973556. Show all entries for this paper.


Displaying record number 59079

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location gp41(46-54)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Subtype B
Species (MHC/HLA) human(B*5101)
Immunogen HIV-1 infection
Patient MHC/HLA PIC1362: A*0201, A*2501, B*1801, B*5101, Cw*0102, Cw*1203
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords viral fitness and reversion

Notes

References

Liu2007a Yi Liu, John McNevin, Hong Zhao, Denis M. Tebit, Ryan M. Troyer, Matthew McSweyn, Ananta K. Ghosh, Daniel Shriner, Eric J. Arts, M. Juliana McElrath, and James I. Mullins. Evolution of Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitopes: Fitness-Balanced Escape. J. Virol., 81(22):12179-12188, Nov 2007. PubMed ID: 17728222. Show all entries for this paper.


Displaying record number 58144

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location gp41(46-54)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Epitope Name RL9
Subtype B
Species (MHC/HLA) human(B*5101)
Immunogen HIV-1 infection
Patient MHC/HLA PIC1362: A*0201, A*2501, B*1801, B*5101, Cw*0102, Cw*1203
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, acute/early infection

Notes

References

Liu2011a Yi Liu, John P. McNevin, Sarah Holte, M. Juliana McElrath, and James I. Mullins. Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection. PLoS One, 6(1):e15639, 2011. PubMed ID: 21283794. Show all entries for this paper.


Displaying record number 60085

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location Env(557-565)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Epitope Name RL9
Species (MHC/HLA) human(B*52)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 53671

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location gp41
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Subtype B, C
Species (MHC/HLA) human(B57, B58, B63)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HLA cross-presentation, optimal epitope

Notes

References

Frahm2005a Nicole Frahm, Sharon Adams, Photini Kiepiela, Caitlyn H. Linde, Hannah S. Hewitt, Mathias Lichterfeld, Kaori Sango, Nancy V. Brown, Eunice Pae, Alysse G. Wurcel, Marcus Altfeld, Margaret E. Feeney, Todd M. Allen, Timothy Roach, M. Anne St. John, Eric S. Daar, Eric Rosenberg, Bette Korber, Francesco Marincola, Bruce D. Walker, Philip J. R. Goulder, and Christian Brander. HLA-B63 Presents HLA-B57/B58-Restricted Cytotoxic T-Lymphocyte Epitopes and Is Associated with Low Human Immunodeficiency Virus Load. J. Virol., 79(16):10218-10225, Aug 2005. PubMed ID: 16051815. Show all entries for this paper.


Displaying record number 60083

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location Env(557-565)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Epitope Name RL9
Species (MHC/HLA) human(B*81)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60084

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location Env(557-565)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Epitope Name RL9
Species (MHC/HLA) human(C*03)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60082

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location Env(557-565)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Epitope Name RL9
Species (MHC/HLA) human(C*15)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 57044

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location Env
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Epitope Name RL9
Species (MHC/HLA) human(Cw*03)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, CTL neutralization assay, Chromium-release assay, Other
Keywords elite controllers, neutralization by CTL

Notes

References

Chen2009a Huabiao Chen, Alicja Piechocka-Trocha, Toshiyuki Miura, Mark A. Brockman, Boris D. Julg, Brett M. Baker, Alissa C. Rothchild, Brian L. Block, Arne Schneidewind, Tomohiko Koibuchi, Florencia Pereyra, Todd M. Allen, and Bruce D. Walker. Differential Neutralization of Human Immunodeficiency Virus (HIV) Replication in Autologous CD4 T Cells by HIV-Specific Cytotoxic T Lymphocytes. J. Virol., 83(7):3138-3149, Apr 2009. PubMed ID: 19158248. Show all entries for this paper.


Displaying record number 52607

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location gp41(46-54)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Species (MHC/HLA) human(Cw*0304)
Immunogen  
Experimental methods  
Keywords optimal epitope

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 52331

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location Env (gp160)(557-565)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(Cw*0304)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

Currier2002b Jeffrey R Currier, Mark deSouza, Penprapa Chanbancherd, Wendy Bernstein, Deborah L Birx, and Josephine H Cox. Comprehensive Screening for Human Immunodeficiency Virus Type 1 Subtype-Specific CD8 Cytotoxic T Lymphocytes and Definition of Degenerate Epitopes Restricted by HLA-A0207 and -Cw0304 Alleles. J. Virol., 76(10):4971-4986, May 2002. PubMed ID: 11967314. Show all entries for this paper.


Displaying record number 55248

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location gp160(557-565)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Subtype B
Species (MHC/HLA) human(Cw*12)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords assay or method development, optimal epitope

Notes

References

Wang2007 Shaoyang Wang, Yongtao Sun, Song Zhai, Yan Zhuang, Shuguang Zhao, Whenzhen Kang, Xinhong Li, Dedong Huang, Xu G. Yu, Bruce D. Walker, and Marcus A. Altfeld. Identification of HLA-A11-Restricted HIV-1-Specific Cytotoxic T-Lymphocyte Epitopes in China. Curr. HIV Res., 5(1):119-128, Jan 2007. PubMed ID: 17266563. Show all entries for this paper.


Displaying record number 54800

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location gp41(46-54)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Epitope Name RL9
Species (MHC/HLA) human(Cw15, Cw3)
Immunogen HIV-1 infection
Experimental methods CTL suppression of replication
Keywords class I down-regulation by Nef

Notes

References

Adnan2006 Sama Adnan, Arumugam Balamurugan, Alicja Trocha, Michael S. Bennett, Hwee L. Ng, Ayub Ali, Christian Brander, and Otto O. Yang. Nef Interference with HIV-1-Specific CTL Antiviral Activity Is Epitope Specific. Blood, 108(10):3414-3419, 15 Nov 2006. PubMed ID: 16882705. Show all entries for this paper.


Displaying record number 55191

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location  
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Species (MHC/HLA) human(Cw15, Cw3)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supertype, HLA cross-presentation, optimal epitope

Notes

References

Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.


Displaying record number 61638

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location Nef
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Epitope Name Cw15-RL9
Subtype B
Species (MHC/HLA) human(Cw*15)
Immunogen HIV-1 infection
Country Canada
Experimental methods Chromium-release assay, Other
Keywords epitope processing, escape

Notes

References

Zhang2012 Shao Chong Zhang, Eric Martin, Mariko Shimada, Sasha Blue Godfrey, Jennifer Fricke, Shirley Locastro, Nicole Y. Lai, Paul Liebesny, Jonathan M. Carlson, Chanson J. Brumme, Oluwatobi Awele Ogbechie, Huabiao Chen, Bruce D. Walker, Zabrina L. Brumme, Daniel G. Kavanagh, and Sylvie Le Gall. Aminopeptidase Substrate Preference Affects HIV Epitope Presentation and Predicts Immune Escape Patterns in HIV-Infected Individuals. J. Immunol., 188(12):5924-5934, 15 Jun 2012. PubMed ID: 22586036. Show all entries for this paper.


Displaying record number 52612

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location gp41(46-54)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Species (MHC/HLA) human(Cw*15)
Immunogen  
Experimental methods  
Keywords optimal epitope

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 57852

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location gp41(46-54)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Species (MHC/HLA) human(Cw*15)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords rate of progression, early treatment

Notes

References

Cellerai2011 Cristina Cellerai, Alexandre Harari, Hans Stauss, Sabine Yerly, Anna-Maria Geretti, Anne Carroll, Thynn Yee, Jonathan Ainsworth, Ian Williams, John Sweeney, Andrew Freedman, Margaret Johnson, Giuseppe Pantaleo, and Sabine Kinloch-de Loes. Early and Prolonged Antiretroviral Therapy Is Associated with an HIV-1-Specific T-Cell Profile Comparable to That of Long-Term Non-Progressors. PLoS One, 6(4):e18164, 2011. PubMed ID: 21483676. Show all entries for this paper.


Displaying record number 58253

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location Env
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression

Notes

References

McKinnon2012 Lyle R. McKinnon, Rupert Kaul, Joshua Kimani, Nico J. Nagelkerke, Charles Wachihi, Keith R. Fowke, Terry Blake Ball, and Francis A. Plummer. HIV-Specific CD8+ T-Cell Proliferation Is Prospectively Associated with Delayed Disease Progression. Immunol. Cell Biol., 90(3):346-351, Mar 2012. PubMed ID: 21606945. Show all entries for this paper.


Displaying record number 56131

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location Env
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA A*0101, B*1567, B*8101, Cw*1402, Cw*1801; A*0201, A*2901, B*0801, B*4805, Cw*0304, Cw*1505; A*6802, A*7401, B*1510, B*4901, Cw*0304, Cw*0701
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Proliferation
Keywords assay or method development

Notes

References

McKinnon2008 Lyle R. McKinnon, T. Blake Ball, Charles Wachihi, Nyakio Chinga, Anne Maingi, Ma Luo, Keith R. Fowke, and Francis A. Plummer. Substantial Intrapatient Differences in the Breadth and Specificity of HIV-Specific CD8+ T-Cell Interferon-gamma and Proliferation Responses. J. Acquir. Immune Defic. Syndr., 49(2):123-127, 1 Oct 2008. PubMed ID: 18769359. Show all entries for this paper.


Displaying record number 53807

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location gp160
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Show epitope variants
Subtype A, B, C, D
Species (MHC/HLA) human
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA A*3201, A*3601, B*5301, B*8101, Cw*0401, Cw*0804
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords subtype comparisons, variant cross-reactivity

Vaccine Details

Vaccine type vaccinia
Vaccine strain A clade, B clade, D clade NDK, C clade consensus
Vaccine component Env

Notes

References

McKinnon2005 Lyle R. McKinnon, T. Blake Ball, Joshua Kimani, Charles Wachihi, Lucy Matu, Ma Luo, Joanne Embree, Keith R. Fowke, and Francis A. Plummer. Cross-Clade CD8+ T-Cell Responses With a Preference for the Predominant Circulating Clade. J. Acquir. Immune Defic. Syndr., 40(3):245-249, 1 Nov 2005. PubMed ID: 16249696. Show all entries for this paper.


Displaying record number 52218

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location Env(555-567 BH10, LAI)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Species (MHC/HLA) human
Immunogen computer prediction
Experimental methods Other
Keywords computational epitope prediction, T-cell crossreactivity to human proteins

Notes

References

Maksiutov2002 A. Z. Maksiutov, A. G. Bachinskii, and S. I. Bazhan. [Searching for Local Similarities Between HIV-1 and Human Proteins. Application to Vaccines]. Mol Biol (Mosk), 36(3):447-459, May-Jun 2002. Article in Russian. PubMed ID: 12068630. Show all entries for this paper.


Displaying record number 810

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location gp41(557-565 IIIB)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords mother-to-infant transmission, escape

Notes

References

Wilson1999a C. C. Wilson, R. C. Brown, B. T. Korber, B. M. Wilkes, D. J. Ruhl, D. Sakamoto, K. Kunstman, K. Luzuriaga, I. C. Hanson, S. M. Widmayer, A. Wiznia, S. Clapp, A. J. Ammann, R. A. Koup, S. M. Wolinsky, and B. D. Walker. Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: The Ariel Project for the Prevention of Transmission of HIV from Mother to Infant. J. Virol., 73:3975-3985, 1999. PubMed ID: 10196293. Show all entries for this paper.


Displaying record number 807

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location gp41(557-565)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance

Notes

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.


Displaying record number 805

HXB2 Location gp160(557-565)
gp41(46-54)
DNA(7893..7919)
gp160 Epitope Map
Author Location gp41(557-565 IIIB)
Epitope RAIEAQQHL Epitope Alignment
RAIEAQQHL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords responses in children, mother-to-infant transmission

Notes

References

Walkerpercom1996 C. Wilson, B. Wilkes, D. Ruhl, and B. Walker. Personal communication, 1996. Defined in the context of the Pediatric AIDS Foundation ARIEL Project, a mother-infant HIV transmission study. Personal communication. Show all entries for this paper.


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