HIV molecular immunology database
Found 38 matching records:
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160(557-565) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B15, B51) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A3, A32, B15, B51, C*03, Cw6, DQ7, DR4, DR8 | |
Country | Netherlands | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, escape |
Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(46-54) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*15:01, B*51:01, C*03:04) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Cytokine production, HLA binding, Other | |
Keywords | vaccine-induced immune responses, HLA cross-presentation, HLA associated polymorphism |
Reche2006 Pedro A. Reche, Derin B. Keskin, Rebecca E. Hussey, Petronela Ancuta, Dana Gabuzda, and Ellis L. Reinherz. Elicitation from Virus-Naive Individuals of Cytotoxic T Lymphocytes Directed against Conserved HIV-1 Epitopes. Med. Immunol., 5:1, 2006. PubMed ID: 16674822. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(46-54 DU422) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*15:01, C*03:04) | |
Immunogen | in vitro stimulation or selection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Tetramer binding | |
Keywords | dendritic cells |
Colleton2009 Bonnie A. Colleton, Xiao-Li Huang, Nada M. Melhem, Zheng Fan, Luann Borowski, Giovanna Rappocciolo, and Charles R. Rinaldo. Primary Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses Induced by Myeloid Dendritic Cells. J. Virol., 83(12):6288-6299, Jun 2009. PubMed ID: 19357176. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(557-565) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Epitope Name | RL9 | |
Species (MHC/HLA) | human(B*15:03) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(557-565) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Epitope Name | RL9 | |
Species (MHC/HLA) | human(B*49) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | ( IIIB, MN) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*51) | |
Immunogen | HIV-1 infection | |
Country | China | |
Experimental methods | CD8 T-cell Elispot - IFNγ, CTL suppression of replication | |
Keywords | rate of progression, HLA associated polymorphism, elite controllers |
Zhang2011 YongHong Zhang, YanChun Peng, HuiPing Yan, Keyi Xu, Masumichi Saito, Hao Wu, XinYue Chen, Srinika Ranasinghe, Nozomi Kuse, Tim Powell, Yan Zhao, WeiHua Li, Xin Zhang, Xia Feng, Ning Li, Aleksandra Leligdowicz, XiaoNing Xu, Mina John, Masafumi Takiguchi, Andrew McMichael, Sarah Rowland-Jones, and Tao Dong. Multilayered Defense in HLA-B51-Associated HIV Viral Control. J. Immunol., 187(2):684-691, 15 Jul 2011. PubMed ID: 21670313. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(557-565 LAI) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Epitope Name | E3 | |
Subtype | B | |
Species (MHC/HLA) | human(B*51) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART |
Mollet2000 L. Mollet, T. S. Li, A. Samri, C. Tournay, R. Tubiana, V. Calvez, P. Debre, C. Katlama, and B. Autran. Dynamics of HIV-specific CD8+ T lymphocytes with changes in viral load. J. Immunol., 165(3):1692-704, 1 Aug 2000. URL: http://www.jimmunol.org/v165n3/1692/1692-abs-frame.html. PubMed ID: 10903781. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(557-565) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Epitope Name | RL9 | |
Subtype | A | |
Species (MHC/HLA) | human(B*51, C*03) | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Cytokine production, Proliferation | |
Keywords | assay or method development |
McKinnon2007 Lyle R. McKinnon, T. Blake Ball, Charles Wachihi, Paul J. McLaren, Jillian L. M. Waruk, Xiaojuan Mao, Sue Ramdahin, A. Omu Anzala, Jane Kamene, Ma Luo, Keith R. Fowke, and Francis A. Plummer. Epitope Cross-Reactivity Frequently Differs between Central and Effector Memory HIV-Specific CD8+ T Cells. J. Immunol., 178(6):3750-3756, 15 Mar 2007. PubMed ID: 17339473. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(557-565 IIIB) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Show epitope variants | ||
Species (MHC/HLA) | human(B51) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Sipsas1997 N. V. Sipsas, S. A. Kalams, A. Trocha, S. He, W. A. Blattner, B. D. Walker, and R. P. Johnson. Identification of Type-Specific Cytotoxic T Lymphocyte Responses to Homologous Viral Proteins in Laboratory Workers Accidentally Infected with HIV-1. J. Clin. Invest., 99:752-762, 1997. To examine a situation where the autologous strain and the reference reagents would be the same, the CTL response of three lab workers accidentally infected with HIV IIIB was studied. Both group specific and type specific epitopes were targets for CTL clones. One subject had a broadening of CTL response over time, using a broad range of restricting HLA class I alleles. Characterization of the cytotoxic T lymphocyte (CTL) response against HIV-1 has been limited by the use of target cells expressing viral proteins from laboratory isolates of HIV-1. This approach has favored identification of group-specific CTL responses and precluded assessment of the extent of type-specific CTL responses directed against HIV-1. Using cells expressing viral proteins from the HIV-1 IIIB strain, we performed a detailed characterization of HIV-1-specific CTL response in three laboratory workers accidentally infected with HIV-1 IIIB. Eight of the epitopes identified were group specific, lying in relatively conserved regions of Gag, reverse transcriptase, and envelope. Three type-specific epitopes were identified, two of them in highly variable regions of envelope. In longitudinal studies in one subject, seven different epitopes and five different restricting HLA class I alleles were identified, with a progressive increase in the number of CTL epitopes recognized by this subject over time. Our data demonstrate that type-specific CTL responses make up a significant proportion of the host cellular immune response against HIV-1 and that a broadening of epitope specificity may occur. PubMed ID: 9045880. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(47-55) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B51) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41 | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Epitope Name | B51-RL9(qp41) | |
Species (MHC/HLA) | human(B51) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(557-565) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B51) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Ferris1999 R. L. Ferris, C. Hall, N. V. Sipsas, J. T. Safrit, A. Trocha, R. A. Koup, R. P. Johnson, and R. F. Siliciano. Processing of HIV-1 Envelope Glycoprotein for Class I-Restricted Recognition: Dependence on TAP1/2 and Mechanisms for Cytosolic Localization. J. Immunol., 162:1324-1332, 1999. PubMed ID: 9973386. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41 | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Epitope Name | RL9(gp41) | |
Subtype | B | |
Species (MHC/HLA) | human(B51) | |
Immunogen | HIV-1 infection | |
Country | China | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | chronic infection |
Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(46-54 HIV-MN) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Epitope Name | RL9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*51:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | PIC1362: A*02:01, A*25:01, B*18:01, B*51:01, C*01:02, C*12:03 | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | optimal epitope |
Liu2006 Yi Liu, John McNevin, Jianhong Cao, Hong Zhao, Indira Genowati, Kim Wong, Sherry McLaughlin, Matthew D. McSweyn, Kurt Diem, Claire E. Stevens, Janine Maenza, Hongxia He, David C. Nickle, Daniel Shriner, Sarah E. Holte, Ann C. Collier, Lawrence Corey, M. Juliana McElrath, and James I. Mullins. Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection. J. Virol., 80(19):9519-9529, Oct 2006. PubMed ID: 16973556. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(46-54) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*51:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | PIC1362: A*02:01, A*25:01, B*18:01, B*51:01, C*01:02, C*12:03 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | viral fitness and reversion |
Liu2007a Yi Liu, John McNevin, Hong Zhao, Denis M. Tebit, Ryan M. Troyer, Matthew McSweyn, Ananta K. Ghosh, Daniel Shriner, Eric J. Arts, M. Juliana McElrath, and James I. Mullins. Evolution of Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitopes: Fitness-Balanced Escape. J. Virol., 81(22):12179-12188, Nov 2007. PubMed ID: 17728222. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(46-54) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Epitope Name | RL9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*51:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | PIC1362: A*02:01, A*25:01, B*18:01, B*51:01, C*01:02, C*12:03 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | escape, acute/early infection |
Liu2011a Yi Liu, John P. McNevin, Sarah Holte, M. Juliana McElrath, and James I. Mullins. Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection. PLoS One, 6(1):e15639, 2011. PubMed ID: 21283794. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(557-565) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Epitope Name | RL9 | |
Species (MHC/HLA) | human(B*52) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41 | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Subtype | B, C | |
Species (MHC/HLA) | human(B57, B58, B63) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | HLA cross-presentation, optimal epitope, novel epitope |
Frahm2005a Nicole Frahm, Sharon Adams, Photini Kiepiela, Caitlyn H. Linde, Hannah S. Hewitt, Mathias Lichterfeld, Kaori Sango, Nancy V. Brown, Eunice Pae, Alysse G. Wurcel, Marcus Altfeld, Margaret E. Feeney, Todd M. Allen, Timothy Roach, M. Anne St. John, Eric S. Daar, Eric Rosenberg, Bette Korber, Francesco Marincola, Bruce D. Walker, Philip J. R. Goulder, and Christian Brander. HLA-B63 Presents HLA-B57/B58-Restricted Cytotoxic T-Lymphocyte Epitopes and Is Associated with Low Human Immunodeficiency Virus Load. J. Virol., 79(16):10218-10225, Aug 2005. PubMed ID: 16051815. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(557-565) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Epitope Name | RL9 | |
Species (MHC/HLA) | human(B*81) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | Env | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Epitope Name | RL9 | |
Species (MHC/HLA) | human(C*03) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, CTL neutralization assay, Chromium-release assay, Other | |
Keywords | elite controllers, neutralization by CTL |
Chen2009a Huabiao Chen, Alicja Piechocka-Trocha, Toshiyuki Miura, Mark A. Brockman, Boris D. Julg, Brett M. Baker, Alissa C. Rothchild, Brian L. Block, Arne Schneidewind, Tomohiko Koibuchi, Florencia Pereyra, Todd M. Allen, and Bruce D. Walker. Differential Neutralization of Human Immunodeficiency Virus (HIV) Replication in Autologous CD4 T Cells by HIV-Specific Cytotoxic T Lymphocytes. J. Virol., 83(7):3138-3149, Apr 2009. PubMed ID: 19158248. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(557-565) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Epitope Name | RL9 | |
Species (MHC/HLA) | human(C*03) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | Env (gp160)(557-565) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B | |
Species (MHC/HLA) | human(C*03:04) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | subtype comparisons |
Currier2002b Jeffrey R Currier, Mark deSouza, Penprapa Chanbancherd, Wendy Bernstein, Deborah L Birx, and Josephine H Cox. Comprehensive Screening for Human Immunodeficiency Virus Type 1 Subtype-Specific CD8 Cytotoxic T Lymphocytes and Definition of Degenerate Epitopes Restricted by HLA-A0207 and -Cw0304 Alleles. J. Virol., 76(10):4971-4986, May 2002. PubMed ID: 11967314. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(46-54) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Species (MHC/HLA) | human(C*03:04) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160(557-565) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(C*12) | |
Immunogen | HIV-1 infection | |
Country | China | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other | |
Keywords | assay or method development, optimal epitope |
Wang2007 Shaoyang Wang, Yongtao Sun, Song Zhai, Yan Zhuang, Shuguang Zhao, Whenzhen Kang, Xinhong Li, Dedong Huang, Xu G. Yu, Bruce D. Walker, and Marcus A. Altfeld. Identification of HLA-A11-Restricted HIV-1-Specific Cytotoxic T-Lymphocyte Epitopes in China. Curr. HIV Res., 5(1):119-128, Jan 2007. PubMed ID: 17266563. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(557-566) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | Env-RL9 | |
Subtype | B | |
Species (MHC/HLA) | human(C*12:02) | |
Immunogen | in vitro stimulation or selection, HIV-1 infection, virus | |
Patient MHC/HLA | KI-1407: A*24:02, B*52:01, C*12:02 | |
Country | Japan | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other, T2 stabilization assay | |
Keywords | immunodominance, variant cross-reactivity, novel epitope, chronic infection, protective allele |
Chikata2019 Takayuki Chikata, Wayne Paes, Tomohiro Akahoshi, Thomas Partridge, Hayato Murakoshi, Hiroyuki Gatanaga, Nicola Ternette, Shinichi Oka, Persephone Borrow, and Masafumi Takiguchi. Identification of Immunodominant HIV-1 Epitopes Presented by HLA-C*12:02, a Protective Allele, Using an Immunopeptidomics Approach. J. Virol., 93(17), 1 Sep 2019. PubMed ID: 31217245. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Epitope Name | Cw15-RL9 | |
Subtype | B | |
Species (MHC/HLA) | human(C*15) | |
Immunogen | HIV-1 infection | |
Country | Canada | |
Experimental methods | Chromium-release assay, Other | |
Keywords | epitope processing, escape |
Zhang2012 Shao Chong Zhang, Eric Martin, Mariko Shimada, Sasha Blue Godfrey, Jennifer Fricke, Shirley Locastro, Nicole Y. Lai, Paul Liebesny, Jonathan M. Carlson, Chanson J. Brumme, Oluwatobi Awele Ogbechie, Huabiao Chen, Bruce D. Walker, Zabrina L. Brumme, Daniel G. Kavanagh, and Sylvie Le Gall. Aminopeptidase Substrate Preference Affects HIV Epitope Presentation and Predicts Immune Escape Patterns in HIV-Infected Individuals. J. Immunol., 188(12):5924-5934, 15 Jun 2012. PubMed ID: 22586036. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(46-54) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Species (MHC/HLA) | human(C*15) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(46-54) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Species (MHC/HLA) | human(C*15) | |
Immunogen | HIV-1 infection | |
Country | United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | rate of progression, early treatment |
Cellerai2011 Cristina Cellerai, Alexandre Harari, Hans Stauss, Sabine Yerly, Anna-Maria Geretti, Anne Carroll, Thynn Yee, Jonathan Ainsworth, Ian Williams, John Sweeney, Andrew Freedman, Margaret Johnson, Giuseppe Pantaleo, and Sabine Kinloch-de Loes. Early and Prolonged Antiretroviral Therapy Is Associated with an HIV-1-Specific T-Cell Profile Comparable to That of Long-Term Non-Progressors. PLoS One, 6(4):e18164, 2011. PubMed ID: 21483676. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(557-565) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Epitope Name | RL9 | |
Species (MHC/HLA) | human(C*15) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | ||
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Species (MHC/HLA) | human(C*15, Cw3) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | supertype, HLA cross-presentation, optimal epitope |
Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(46-54) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Epitope Name | RL9 | |
Species (MHC/HLA) | human(C*15, Cw3) | |
Immunogen | HIV-1 infection | |
Experimental methods | CTL suppression of replication | |
Keywords | class I down-regulation by Nef |
Adnan2006 Sama Adnan, Arumugam Balamurugan, Alicja Trocha, Michael S. Bennett, Hwee L. Ng, Ayub Ali, Christian Brander, and Otto O. Yang. Nef Interference with HIV-1-Specific CTL Antiviral Activity Is Epitope Specific. Blood, 108(10):3414-3419, 15 Nov 2006. PubMed ID: 16882705. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | Env | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression |
McKinnon2012 Lyle R. McKinnon, Rupert Kaul, Joshua Kimani, Nico J. Nagelkerke, Charles Wachihi, Keith R. Fowke, Terry Blake Ball, and Francis A. Plummer. HIV-Specific CD8+ T-Cell Proliferation Is Prospectively Associated with Delayed Disease Progression. Immunol. Cell Biol., 90(3):346-351, Mar 2012. PubMed ID: 21606945. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | Env | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*01:01, B*15:67, B*81:01, C*14:02, C*18:01; A*02:01, A*29:01, B*08:01, B*48:05, C*03:04, C*15:05; A*68:02, A*74:01, B*15:10, B*49:01, C*03:04, C*07:01 | |
Country | Kenya | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Proliferation | |
Keywords | assay or method development |
McKinnon2008 Lyle R. McKinnon, T. Blake Ball, Charles Wachihi, Nyakio Chinga, Anne Maingi, Ma Luo, Keith R. Fowke, and Francis A. Plummer. Substantial Intrapatient Differences in the Breadth and Specificity of HIV-Specific CD8+ T-Cell Interferon-gamma and Proliferation Responses. J. Acquir. Immune Defic. Syndr., 49(2):123-127, 1 Oct 2008. PubMed ID: 18769359. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(557-565 IIIB) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | responses in children, mother-to-infant transmission |
Walkerpercom1996 C. Wilson, B. Wilkes, D. Ruhl, and B. Walker. Personal communication, 1996. Defined in the context of the Pediatric AIDS Foundation ARIEL Project, a mother-infant HIV transmission study. Personal communication. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | gp160 | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | A, B, C, D | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection, vaccine | |
Patient MHC/HLA | A*32:01, A*36:01, B*53:01, B*81:01, C*04:01, C*08:04 | |
Country | Kenya | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | subtype comparisons, variant cross-reactivity |
Vaccine type | vaccinia |
---|---|
Vaccine strain | A clade, B clade, D clade NDK, C clade consensus |
Vaccine component | Env |
McKinnon2005 Lyle R. McKinnon, T. Blake Ball, Joshua Kimani, Charles Wachihi, Lucy Matu, Ma Luo, Joanne Embree, Keith R. Fowke, and Francis A. Plummer. Cross-Clade CD8+ T-Cell Responses With a Preference for the Predominant Circulating Clade. J. Acquir. Immune Defic. Syndr., 40(3):245-249, 1 Nov 2005. PubMed ID: 16249696. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | Env(555-567 BH10, LAI) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | computer prediction | |
Experimental methods | Other | |
Keywords | computational epitope prediction, T-cell crossreactivity to human proteins |
Maksiutov2002 A. Z. Maksiutov, A. G. Bachinskii, and S. I. Bazhan. [Searching for Local Similarities Between HIV-1 and Human Proteins. Application to Vaccines]. Mol Biol (Mosk), 36(3):447-459, May-Jun 2002. Article in Russian. PubMed ID: 12068630. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(557-565 IIIB) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | mother-to-infant transmission, escape |
Wilson1999a C. C. Wilson, R. C. Brown, B. T. Korber, B. M. Wilkes, D. J. Ruhl, D. Sakamoto, K. Kunstman, K. Luzuriaga, I. C. Hanson, S. M. Widmayer, A. Wiznia, S. Clapp, A. J. Ammann, R. A. Koup, S. M. Wolinsky, and B. D. Walker. Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: The Ariel Project for the Prevention of Transmission of HIV from Mother to Infant. J. Virol., 73:3975-3985, 1999. PubMed ID: 10196293. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | gp160(557-565) gp41(46-54) DNA(7893..7919) |
gp160 Epitope Map |
---|---|---|
Author Location | gp41(557-565) | |
Epitope |
RAIEAQQHL
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | immunodominance |
Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.