HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 20 matching records:

Displaying record number 60076

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HXB2 Location Gag(305-313)
p24(173-181)
DNA(1702..1728)
Gag Epitope Map
Author Location Gag(305-313)
Epitope RAEQASQEV Epitope Alignment
RAEQASQEV epitope logo
Epitope Name RV9
Species (MHC/HLA) human(B*14)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60077

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HXB2 Location Gag(305-313)
p24(173-181)
DNA(1702..1728)
Gag Epitope Map
Author Location Gag(305-313)
Epitope RAEQASQEV Epitope Alignment
RAEQASQEV epitope logo
Epitope Name RV9
Species (MHC/HLA) human(B*18)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60079

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HXB2 Location Gag(305-313)
p24(173-181)
DNA(1702..1728)
Gag Epitope Map
Author Location Gag(305-313)
Epitope RAEQASQEV Epitope Alignment
RAEQASQEV epitope logo
Epitope Name RV9
Species (MHC/HLA) human(B*35:02, B*35:03, B*53:01)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60081

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HXB2 Location Gag(305-313)
p24(173-181)
DNA(1702..1728)
Gag Epitope Map
Author Location Gag(305-313)
Epitope RAEQASQEV Epitope Alignment
RAEQASQEV epitope logo
Epitope Name RV9
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60078

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HXB2 Location Gag(305-313)
p24(173-181)
DNA(1702..1728)
Gag Epitope Map
Author Location Gag(305-313)
Epitope RAEQASQEV Epitope Alignment
RAEQASQEV epitope logo
Epitope Name RV9
Species (MHC/HLA) human(B*45)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60075

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HXB2 Location Gag(305-313)
p24(173-181)
DNA(1702..1728)
Gag Epitope Map
Author Location Gag(305-313)
Epitope RAEQASQEV Epitope Alignment
RAEQASQEV epitope logo
Epitope Name RV9
Species (MHC/HLA) human(B*49)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 57635

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HXB2 Location Gag(305-313)
p24(173-181)
DNA(1702..1728)
Gag Epitope Map
Author Location p24(173-181)
Epitope RAEQASQEV Epitope Alignment
RAEQASQEV epitope logo
Epitope Name p24 173-181
Subtype B
Species (MHC/HLA) human(B*51:01)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords dendritic cells, optimal epitope

Notes

References

Huang2010a Xiao-Li Huang, Zheng Fan, LuAnn Borowski, Robbie B. Mailliard, Morgane Rolland, James I. Mullins, Richard D. Day, and Charles R. Rinaldo. Dendritic Cells Reveal a Broad Range of MHC Class I Epitopes for HIV-1 in Persons with Suppressed Viral Load on Antiretroviral Therapy. PLoS One, 5(9):e12936, 2010. PubMed ID: 20886040. Show all entries for this paper.


Displaying record number 60080

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HXB2 Location Gag(305-313)
p24(173-181)
DNA(1702..1728)
Gag Epitope Map
Author Location Gag(305-313)
Epitope RAEQASQEV Epitope Alignment
RAEQASQEV epitope logo
Epitope Name RV9
Species (MHC/HLA) human(C*05)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 57286

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HXB2 Location Gag(305-313)
p24(173-181)
DNA(1702..1728)
Gag Epitope Map
Author Location  
Epitope RAEQASQEV Epitope Alignment
RAEQASQEV epitope logo
Epitope Name RV9
Subtype B
Species (MHC/HLA) human(C*08)
Immunogen HIV-1 infection
Country Barbados, Haiti, Jamaica
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords mother-to-infant transmission, elite controllers

Notes

References

Schneidewind2009 Arne Schneidewind, Yanhua Tang, Mark A. Brockman, Elizabeth G. Ryland, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, M. Anne St. John, Joseph A. Conrad, Spyros A. Kalams, Francine Noel, Todd M. Allen, Celia D. Christie, and Margaret E. Feeney. Maternal Transmission of Human Immunodeficiency Virus Escape Mutations Subverts HLA-B57 Immunodominance but Facilitates Viral Control in the Haploidentical Infant. J. Virol., 83(17):8616-8627, Sep 2009. PubMed ID: 19515764. Show all entries for this paper.


Displaying record number 53247

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HXB2 Location Gag(305-313)
p24(173-181)
DNA(1702..1728)
Gag Epitope Map
Author Location Gag(305-313 SUMA)
Epitope RAEQASQEV Epitope Alignment
RAEQASQEV epitope logo
Epitope Name Gag RV9
Subtype B
Species (MHC/HLA) human(C*08:02)
Immunogen HIV-1 infection
Patient MHC/HLA SUMA: A*11:03, A*24:02, B*14:02, B*15:01, C*08:02, C*12:03
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords dynamics, acute/early infection, autologous responses, optimal epitope

Notes

References

Jones2004 Nicola A. Jones, Xiping Wei, Darren R. Flower, MaiLee Wong, Franziska Michor, Michael S. Saag, Beatrice H. Hahn, Martin A. Nowak, George M. Shaw, and Persephone Borrow. Determinants of Human Immunodeficiency Virus Type 1 Escape from the Primary CD8+ Cytotoxic T Lymphocyte Response. J. Exp. Med., 200(10):1243-1256, 15 Nov 2004. PubMed ID: 15545352. Show all entries for this paper.

Yang2019 Yiding Yang, and Vitaly V. Ganusov. Defining Kinetic Properties of HIV-Specific CD8(+) T-Cell Responses in Acute Infection. Microorganisms, 7(3):microorganisms7030069 doi, Mar 2019. PubMed ID: 30836625 Show all entries for this paper.


Displaying record number 332

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HXB2 Location Gag(305-313)
p24(173-181)
DNA(1702..1728)
Gag Epitope Map
Author Location p24(305-313)
Epitope RAEQASQEV Epitope Alignment
RAEQASQEV epitope logo
Species (MHC/HLA) human(Cw8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Johnson1991 R. P. Johnson, A. Trocha, L. Yang, G. P. Mazzara, D. L. Panicali, T. M. Buchanan, and B. D. Walker. HIV-1 Gag-Specific Cytotoxic T Lymphocytes Recognize Multiple Highly Conserved Epitopes. Fine Specificity of the Gag-Specific Response Defined by Using Unstimulated Peripheral Blood Mononuclear Cells and Cloned Effector Cells. J. Immunol., 147:1512-1521, 1991. This study presented a detailed study of gag-specific CTL from HIV-1 seropositive individuals. Seven p24 and two p17 epitopes were described, that were recognized by class I-restricted CD3+CD8+ CTL. p17 epitopes: KIRLRPGGKKKYKLKHIVWASRELE and QTGSEELRSLYNTVATLYCVHQRIE; p24 epitopes: NPPIPVGEIYKRWIILGLNKIV, VHQAISPRTLNAWVKVVEEKAF, NAWVKVVEEKAFSPEVIPMFSA, SALSEGATPQDLNTMLNTVGGH, GHQAAMQMLKETINEEAAEWDR, and RAEQASQEVK. PubMed ID: 1715361. Show all entries for this paper.


Displaying record number 333

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HXB2 Location Gag(305-313)
p24(173-181)
DNA(1702..1728)
Gag Epitope Map
Author Location p24
Epitope RAEQASQEV Epitope Alignment
RAEQASQEV epitope logo
Show epitope variants
Species (MHC/HLA) human(Cw8)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons, HIV exposed persistently seronegative (HEPS)

Notes

References

RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.


Displaying record number 334

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HXB2 Location Gag(305-313)
p24(173-181)
DNA(1702..1728)
Gag Epitope Map
Author Location p24(305-313)
Epitope RAEQASQEV Epitope Alignment
RAEQASQEV epitope logo
Species (MHC/HLA) human(Cw8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Price1995 P. Price, R. P. Johnson, D. T. Scadden, C. Jassoy, T. Rosenthal, S. Kalams, and B. D. Walker. Cytotoxic CD8+ T Lymphocytes Reactive with Human Immunodeficiency Virus-1 Produce Granulocyte/Macrophage Colony-Stimulating Factor and Variable Amounts of Interleukins 2, 3, and 4 following Stimulation with the Cognate Epitope. Clin. Immunol. Immunopathol., 74:100-106, 1995. Cytokine release from stimulated CTL clones derived from either the peripheral blood or CSF of 3 patients was studied. HLA restriction was determined for two of seven clones. GM-CSF and TNF-$\alpha$ and IFN-$\gamma$ were produced by all clones; most clones produced low amounts of IL-2, IL-3, and IL-4. PubMed ID: 7527747. Show all entries for this paper.


Displaying record number 335

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HXB2 Location Gag(305-313)
p24(173-181)
DNA(1702..1728)
Gag Epitope Map
Author Location p24(305-313)
Epitope RAEQASQEV Epitope Alignment
RAEQASQEV epitope logo
Species (MHC/HLA) human(Cw8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Lubaki1997 N. M. Lubaki, S. C. Ray, B. Dhruva, T. C. Quinn, R. F. Siliciano, and R. C. Bollinger. Characterization of a Polyclonal Cytolytic T Lymphocyte Response to Human Immunodeficiency Virus in Persons without Clinical Progression. J. Infect. Dis., 6:1360-1367, 1997. Five individuals were studied who survived HIV infection in good health for over 5 years. A broad polyclonal response was found to multiple proteins. PubMed ID: 9180175. Show all entries for this paper.


Displaying record number 1678

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HXB2 Location Gag(305-313)
p24(173-181)
DNA(1702..1728)
Gag Epitope Map
Author Location p24(305-313)
Epitope RAEQASQEV Epitope Alignment
RAEQASQEV epitope logo
Species (MHC/HLA) human(Cw8)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 53756

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HXB2 Location Gag(305-313)
p24(173-181)
DNA(1702..1728)
Gag Epitope Map
Author Location Gag(305-313)
Epitope RAEQASQEV Epitope Alignment
RAEQASQEV epitope logo
Show epitope variants
Epitope Name RV9
Subtype B
Species (MHC/HLA) human(Cw8)
Immunogen HIV-1 infection
Patient MHC/HLA A*02, A*68, B*14, B*52, C*08, C*12
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords escape, optimal epitope

Notes

References

Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.


Displaying record number 54276

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HXB2 Location Gag(305-313)
p24(173-181)
DNA(1702..1728)
Gag Epitope Map
Author Location p24
Epitope RAEQASQEV Epitope Alignment
RAEQASQEV epitope logo
Epitope Name Cw8-RV9(p24)
Species (MHC/HLA) human(Cw8)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 55050

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HXB2 Location Gag(305-313)
p24(173-181)
DNA(1702..1728)
Gag Epitope Map
Author Location  
Epitope RAEQASQEV Epitope Alignment
RAEQASQEV epitope logo
Species (MHC/HLA) human(Cw8)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, immunodominance, optimal epitope

Notes

References

Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.


Displaying record number 1328

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HXB2 Location Gag(305-313)
p24(173-181)
DNA(1702..1728)
Gag Epitope Map
Author Location  
Epitope RAEQASQEV Epitope Alignment
RAEQASQEV epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Kaul2001 R. Kaul, S. L. Rowland-Jones, J. Kimani, T. Dong, H. B. Yang, P. Kiama, T. Rostron, E. Njagi, J. J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Late Seroconversion in HIV-Resistant Nairobi Prostitutes Despite Pre-Existing HIV-Specific CD8+ Responses. J. Clin. Invest., 107(3):341-349, Feb 2001. URL: http://www.jci.org/cgi/content/full/107/3/341. PubMed ID: 11160158. Show all entries for this paper.


Displaying record number 61472

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HXB2 Location Gag(305-313)
p24(173-181)
DNA(1702..1728)
Gag Epitope Map
Author Location Gag( 90TH_BK132, US1_GS004/7, J3222, JR-CSF, NL4-3, LAI)
Epitope RAEQASQEV Epitope Alignment
RAEQASQEV epitope logo
Epitope Name RV9
Subtype B
Species (MHC/HLA) human
Immunogen in vitro stimulation or selection, HIV-1 infection, peptide-HLA interaction
Country Canada, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords assay or method development, memory cells

Notes

References

Jones2016 R. Brad Jones, Stefanie Mueller, Rachel O'Connor, Katherine Rimpel, Derek D. Sloan, Dan Karel, Hing C. Wong, Emily K. Jeng, Allison S. Thomas, James B. Whitney, So-Yon Lim, Colin Kovacs, Erika Benko, Sara Karandish, Szu-Han Huang, Maria J. Buzon, Mathias Lichterfeld, Alivelu Irrinki, Jeffrey P. Murry, Angela Tsai, Helen Yu, Romas Geleziunas, Alicja Trocha, Mario A. Ostrowski, Darrell J. Irvine, and Bruce D. Walker. A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes. PLoS Pathog., 12(4):e1005545, Apr 2016. PubMed ID: 27082643. Show all entries for this paper.


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