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Displaying record number 56221

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HXB2 Location	Nef(73-82) DNA(9013..9042)	Nef Epitope Map
Author Location
Epitope	QVPLRPMYTK	Epitope Alignment
Subtype	C
Species (MHC/HLA)	human(A11, A3)
Immunogen	HIV-1 infection
Patient MHC/HLA	A*30:01, A*33:03, B*53:01, B*81:01, C*04:01; A*03:01, A*23:01, B*15:03, B*58:02, C*02:10, C*06:02
Country	South Africa
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords	rate of progression

Notes

• 47 HIV-1 subtype C infected patients were followed longitudinally to determine whether there was a relation between magnitude and breadth of CTL responses in primary, acute infection (measured by IFN-gamma ELISpot) and disease progression (measured as viral load at 12 months). CTL responses to Nef were dominant (targeting 6 epitopic regions), followed by responses to Gag, Pol, Rev, Vpr, Env, Vpu, Vif and finally Tat.
• QVPLRPMTYK is a known HLA-A3 and -A11 epitope that is part of peptide EVGFPVRPQVPLRPMTYKA which elicited responses in 3/9 patients. HLA-A*0301-restricted response to a peptide containing this epitope was detected in an early controller and 2 rapid progressors 12 weeks post-infection.

References

Gray2009 Clive M. Gray, Mandla Mlotshwa, Catherine Riou, Tiyani Mathebula, Debra de Assis Rosa, Tumelo Mashishi, Cathal Seoighe, Nobubelo Ngandu, Francois van Loggerenberg, Lynn Morris, Koleka Mlisana, Carolyn Williamson, Salim Abdool Karim, and CAPRISA 002 Acute Infection Study Team. Human Immunodeficiency Virus-Specific gamma Interferon Enzyme-Linked Immunospot Assay Responses Targeting Specific Regions of the Proteome during Primary Subtype C Infection Are Poor Predictors of the Course of Viremia and Set Point. J. Virol., 83(1):470-478, Jan 2009. PubMed ID: 18945774. Show all entries for this paper.