HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 86 matching records:

Displaying record number 57516

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location  
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name QK10
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods Tetramer binding
Keywords  

Notes

References

Brockman2009 Mark A. Brockman, Douglas S. Kwon, Daniel P. Tighe, David F. Pavlik, Pamela C. Rosato, Jennifer Sela, Filippos Porichis, Sylvie Le Gall, Michael T. Waring, Kristin Moss, Heiko Jessen, Florencia Pereyra, Daniel G. Kavanagh, Bruce D. Walker, and Daniel E. Kaufmann. IL-10 Is Up-Regulated in Multiple Cell Types During Viremic HIV Infection and Reversibly Inhibits Virus-Specific T Cells. Blood, 114(2):346-356, 9 Jul 2009. PubMed ID: 19365081. Show all entries for this paper.


Displaying record number 58853

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Gag(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name QK10
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country Canada
Experimental methods Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Keywords characterizing CD8+ T cells

Notes

References

Trautmann2012 Lydie Trautmann, Florentin-Martial Mbitikon-Kobo, Jean-Philippe Goulet, Yoav Peretz, Yu Shi, Julien Van Grevenynghe, Francesco Andrea Procopio, Mohamad Rachid Boulassel, Jean-Pierre Routy, Nicolas Chomont, Elias K. Haddad, and Rafick-Pierre Sekaly. Profound Metabolic, Functional, and Cytolytic Differences Characterize HIV-Specific CD8 T Cells in Primary and Chronic HIV Infection. Blood, 120(17):3466-3477, 25 Oct 2012. PubMed ID: 22955926. Show all entries for this paper.


Displaying record number 56756

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location  
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Subtype B
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Turnbull2009 Emma L. Turnbull, MaiLee Wong, Shuyi Wang, Xiping Wei, Nicola A. Jones, Karen E. Conrod, Diana Aldam, Jo Turner, Pierre Pellegrino, Brandon F. Keele, Ian Williams, George M. Shaw, and Persephone Borrow. Kinetics of Expansion of Epitope-Specific T Cell Responses During primary HIV-1 Infection. J. Immunol., 182(11):7131-7145, 1 Jun 2009. PubMed ID: 19454710. Show all entries for this paper.


Displaying record number 60067

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name QK10
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54753

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human(A*03)
Immunogen peptide-HLA interaction
Experimental methods Tetramer binding
Keywords binding affinity

Notes

References

Gillespie2007 Geraldine M. A. Gillespie, Arman Bashirova, Tao Dong, Daniel W. McVicar, Sarah L. Rowland-Jones, and Mary Carrington. Lack of KIR3DS1 Binding to MHC Class I Bw4 Tetramers in Complex with CD8+ T Cell Epitopes. AIDS Res. Hum. Retroviruses, 23(3):451-455, Mar 2007. PubMed ID: 17411378. Show all entries for this paper.


Displaying record number 53098

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(71-80)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Country Spain
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.


Displaying record number 57291

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location  
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name QK10
Subtype B
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Country Barbados, Haiti, Jamaica
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords mother-to-infant transmission, elite controllers

Notes

References

Schneidewind2009 Arne Schneidewind, Yanhua Tang, Mark A. Brockman, Elizabeth G. Ryland, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, M. Anne St. John, Joseph A. Conrad, Spyros A. Kalams, Francine Noel, Todd M. Allen, Celia D. Christie, and Margaret E. Feeney. Maternal Transmission of Human Immunodeficiency Virus Escape Mutations Subverts HLA-B57 Immunodominance but Facilitates Viral Control in the Haploidentical Infant. J. Virol., 83(17):8616-8627, Sep 2009. PubMed ID: 19515764. Show all entries for this paper.


Displaying record number 1990

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name Nef-QK10
Subtype B
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 58533

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Subtype B
Species (MHC/HLA) human(A*03, A*11, A*31, B*27, B*35)
Immunogen HIV-1 infection
Country Canada
Experimental methods Other
Keywords characterizing CD8+ T cells, elite controllers

Notes

References

Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.


Displaying record number 57096

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82 DU422)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen in vitro stimulation or selection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Tetramer binding
Keywords dendritic cells

Notes

References

Colleton2009 Bonnie A. Colleton, Xiao-Li Huang, Nada M. Melhem, Zheng Fan, Luann Borowski, Giovanna Rappocciolo, and Charles R. Rinaldo. Primary Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses Induced by Myeloid Dendritic Cells. J. Virol., 83(12):6288-6299, Jun 2009. PubMed ID: 19357176. Show all entries for this paper.


Displaying record number 55009

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Show epitope variants
Epitope Name QVP
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, TCR usage, variant cross-reactivity, characterizing CD8+ T cells

Notes

References

Turnbull2006 Emma L. Turnbull, A. Ross Lopes, Nicola A. Jones, David Cornforth, Phillipa Newton, Diana Aldam, Pierre Pellegrino, Jo Turner, Ian Williams, Craig M. Wilson, Paul A. Goepfert, Mala K. Maini, and Persephone Borrow. HIV-1 Epitope-Specific CD8+ T Cell Responses Strongly Associated with Delayed Disease Progression Cross-Recognize Epitope Variants Efficiently. J. Immunol., 176(10):6130-6146, 15 May 2006. PubMed ID: 16670322. Show all entries for this paper.


Displaying record number 986

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82 LAI)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, escape

Notes

References

Koenig1995 S. Koenig, A. J. Conley, Y. A. Brewah, G. M. Jones, S. Leath, L. J. Boots, V. Davey V, G. Pantaleo, J. F. Demarest, and C. Carter. Transfer of HIV-1-Specific Cytotoxic T Lymphocytes to an AIDS Patient Leads to Selection for Mutant HIV Variants and Subsequent Disease Progression. Nat. Med., 1(4):330-336, 1995. PubMed ID: 7585062. Show all entries for this paper.


Displaying record number 1123

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance

Notes

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.


Displaying record number 1124

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Experimental methods  
Keywords acute/early infection

Notes

References

Wilson2000 J. D. Wilson, G. S. Ogg, R. L. Allen, C. Davis, S. Shaunak, J. Downie, W. Dyer, C. Workman, S. Sullivan, A. J. McMichael, and S. L. Rowland-Jones. Direct Visualization of HIV-1-Specific Cytotoxic T Lymphocytes During Primary Infection. AIDS, 14:225-233, 2000. PubMed ID: 10716497. Show all entries for this paper.


Displaying record number 1125

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82 LAI)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 58242

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A*0301, B*1501, B*3501, Cw*0401, Cw*09
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords escape, acute/early infection, autologous responses, characterizing CD8+ T cells

Notes

References

Ferrari2011 Guido Ferrari, Bette Korber, Nilu Goonetilleke, Michael K. P. Liu, Emma L. Turnbull, Jesus F. Salazar-Gonzalez, Natalie Hawkins, Steve Self, Sydeaka Watson, Michael R. Betts, Cynthia Gay, Kara McGhee, Pierre Pellegrino, Ian Williams, Georgia D. Tomaras, Barton F. Haynes, Clive M. Gray, Persephone Borrow, Mario Roederer, Andrew J. McMichael, and Kent J. Weinhold. Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection. PLoS Pathog., 7(2):e1001273, 2011. PubMed ID: 21347345. Show all entries for this paper.


Displaying record number 978

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82 NL43)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Koenig1990 S. Koenig, T. R. Fuerst, L. V. Wood, R. M. Woods, J. A. Suzich, G. M. Jones, V. F. de la Cruz, R. T. Davey, Jr., S. Venkatesan, B. Moss, W. E. Biddison, and A. S. Fauci. Mapping the Fine Specificity of a Cytotoxic T Cell Response to HIV-1 Nef Protein. J. Immunol., 145:127-135, 1990. A 10 residue peptide that triggers CTL in association with the HLA A3.1 molecule was studied. Human cell transfectants were used to map a critical residue in the HLA A3.1 molecule for recognition, amino acid 152, which is present on the alpha-2 helix in HLA-A3.1 and is modified in the HLA A3.2 A3 allele. PubMed ID: 1694201. Show all entries for this paper.


Displaying record number 57853

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords rate of progression, early treatment

Notes

References

Cellerai2011 Cristina Cellerai, Alexandre Harari, Hans Stauss, Sabine Yerly, Anna-Maria Geretti, Anne Carroll, Thynn Yee, Jonathan Ainsworth, Ian Williams, John Sweeney, Andrew Freedman, Margaret Johnson, Giuseppe Pantaleo, and Sabine Kinloch-de Loes. Early and Prolonged Antiretroviral Therapy Is Associated with an HIV-1-Specific T-Cell Profile Comparable to That of Long-Term Non-Progressors. PLoS One, 6(4):e18164, 2011. PubMed ID: 21483676. Show all entries for this paper.


Displaying record number 57758

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Subtype C
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Patient MHC/HLA A*0301, A*7401, B*4901, B*5802, Cw*0602, Cw*0701
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, acute/early infection

Notes

References

Mlotshwa2010 Mandla Mlotshwa, Catherine Riou, Denis Chopera, Debra de Assis Rosa, Roman Ntale, Florette Treunicht, Zenda Woodman, Lise Werner, Francois van Loggerenberg, Koleka Mlisana, Salim Abdool Karim, Carolyn Williamson, Clive M Gray, and CAPRISA 002 Study Team. Fluidity of HIV-1-Specific T-Cell Responses during Acute and Early Subtype C HIV-1 Infection and Associations with Early Disease Progression. J. Virol., 84(22):12018-12029, Nov 2010. PubMed ID: 20826686. Show all entries for this paper.


Displaying record number 53827

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Patient MHC/HLA A*0101, A*0301, B*0801, B*5101
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords escape

Notes

References

Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.


Displaying record number 59175

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name nef 020-028
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Country France
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, HLA binding, Intracellular cytokine staining, Other
Keywords binding affinity, elite controllers

Notes

References

Lecuroux2014 Camille Lécuroux, Asier Sáez-Cirión, Isabelle Girault, Pierre Versmisse, Faroudy Boufassa, Véronique Avettand-Fenoël, Christine Rouzioux, Laurence Meyer, Gianfranco Pancino, Olivier Lambotte, Martine Sinet, and Alain Venet. Both HLA-B*57 and Plasma HIV RNA Levels Contribute to the HIV-Specific CD8+ T Cell Response in HIV Controllers. J. Virol., 88(1):176-187, Jan 2014. PubMed ID: 24131719. Show all entries for this paper.


Displaying record number 61241

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(263-272)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name QK10
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Experimental methods Other
Keywords review, TCR usage

Notes

References

Lissina2016 Anna Lissina, Lisa A. Chakrabarti, Masafumi Takiguchi, and Victor Appay. TCR Clonotypes: Molecular Determinants of T-Cell Efficacy against HIV. Curr. Opin. Virol., 16:77-85, Feb 2016. PubMed ID: 26874617. Show all entries for this paper.


Displaying record number 52578

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords epitope processing, dendritic cells

Notes

References

Andrieu2003 Muriel Andrieu, Jean-François Desoutter, Estelle Loing, Jésintha Gaston, Daniel Hanau, Jean-Gérard Guillet, and Anne Hosmalin. Two Human Immunodeficiency Virus Vaccinal Lipopeptides Follow Different Cross-Presentation Pathways in Human Dendritic Cells. J. Virol., 77(2):1564-1570, Jan 2003. PubMed ID: 12502869. Show all entries for this paper.


Displaying record number 60987

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen HIV-1 infection
Patient MHC/HLA 25122: A*0101, A*0301, B*0701, B*3701, Cw*0602, Cw*0702; 51314: A*0301, A*1101, B*3503, B*5301, Cw*0401, Cw*0401
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 52434

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Subtype A, B, D
Species (MHC/HLA) human, macaque(A*0301, A11)
Immunogen HIV-1 infection, vaccine
Experimental methods  
Keywords subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain A clade
Vaccine component p17 Gag, p24 Gag

Notes

References

Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.

Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.


Displaying record number 53016

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Subtype B
Species (MHC/HLA) human(A*0301, A11)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords Th1, characterizing CD8+ T cells

Notes

References

Kleen2004 Thomas O. Kleen, Robert Asaad, Samuel J. Landry, Bernhard O. Boehm, and Magdalena Tary-Lehmann. Tc1 Effector Diversity Shows Dissociated Expression of Granzyme B and Interferon-gamma in HIV Infection. AIDS, 18(3):383-392, 20 Feb 2004. PubMed ID: 15090789. Show all entries for this paper.


Displaying record number 59120

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Show epitope variants
Epitope Name QK10
Subtype B
Species (MHC/HLA) human(A*0301, A*11)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Intracellular cytokine staining, Tetramer binding
Keywords binding affinity, TCR usage

Notes

References

Lissina2014 Anna Lissina, Solène Fastenackels, Maria C. Inglesias, Kristin Ladell, James E. McLaren, Olivia Briceño, Emma Gostick, Laura Papagno, Brigitte Autran, Delphine Sauce, David A. Price, Asier Saez-Cirion, and Victor Appay. The Link between CD8+ T-Cell Antigen-Sensitivity and HIV-Suppressive Capacity Depends on HLA Restriction, Target Epitope and Viral Isolate. AIDS, 28(4):477-486, 20 Feb 2014. PubMed ID: 24384691. Show all entries for this paper.


Displaying record number 1507

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82 LAI)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name N1
Subtype B
Species (MHC/HLA) human(A03 supertype)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, supertype

Notes

References

Mollet2000 L. Mollet, T. S. Li, A. Samri, C. Tournay, R. Tubiana, V. Calvez, P. Debre, C. Katlama, and B. Autran. Dynamics of HIV-specific CD8+ T lymphocytes with changes in viral load. J. Immunol., 165(3):1692-704, 1 Aug 2000. URL: http://www.jimmunol.org/v165n3/1692/1692-abs-frame.html. PubMed ID: 10903781. Show all entries for this paper.


Displaying record number 974

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

LeBorgne2000 S. Le Borgne, M. Fevrier, C. Callebaut, S. P. Lee, and Y. Riviere. CD8(+)-Cell antiviral factor activity is not restricted to human immunodeficiency virus (HIV)-specific T cells and can block HIV replication after initiation of reverse transcription. J. Virol., 74:4456-64, 2000. PubMed ID: 10775581. Show all entries for this paper.


Displaying record number 980

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82 LAI)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Robertson1993 M. N. Robertson, F. Buseyne, O. Schwartz, and Y. Riviere. Efficient Antigen Presentation to Cytotoxic T Lymphocytes by Cells Transduced with a Retroviral Vector Expressing the HIV-1 Nef Protein. AIDS Res. Hum. Retroviruses, 9:1217-1223, 1993. This paper presents a retroviral vector system for antigen presentation to CTLs. As part of the controls to test their system, they study the response to specific Nef peptides, which contain the dominant CTL epitopes in Nef in their study subject. PubMed ID: 7511396. Show all entries for this paper.


Displaying record number 981

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82 LAI)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, escape

Notes

References

Couillin1994 I. Couillin, B. Culmann-Penciolelli, E. Gomard, J. Choppin, J. P Levy, J. G. Guillet, and S. Sarasgosti. Impaired Cytotoxic T Lymphocyte Recognition Due to Genetic Variations in the Main Immunogenic Region of the Human Immunodeficiency Virus 1 NEF Protein. J. Exp. Med., 180:1129-11234, 1994. HIV-1 HLA-A11 and -B18 restricted epitopes were sequenced from donors who do and do not express the HLA-A11 and B18 molecule. Selective variations were only detected in virus isolated from individuals expressing the appropriate HLA type. Variant peptides with single substitutions within the minimal epitope did not always completely abrogate HLA binding, suggesting that multiple alterations within a particular epitope may need to accumulate during disease progression to allow viral escape. PubMed ID: 7520468. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 982

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82 LAI)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Couillin1995 I. Couillin, F. Connan, B. Culmann-Penciolelli, E. Gomard, J.-G. Guillet, and J. Choppin. HLA-Dependent Variations in Human Immunodeficiency Virus Nef Protein Alter Peptide/HLA binding. Eur. J. Immunol., 25:728-732, 1995. Viral sequences across this region were compared from 3 HLA-A11 positive and 10 negative donors. Substitutions that were found only in the 3 HLA-A11 donors did not promote HLA-A11 assembly. Substitutions that were found in both HLA-A11 positive and negative donors, however, did not markedly alter the reactivity of the peptides. This suggests that substitutions that result in loss of HLA-A11 occur mainly in HLA-A11 positive donors. PubMed ID: 7705402. Show all entries for this paper.


Displaying record number 1372

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name QVP
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI), immunodominance, acute/early infection

Notes

References

Oxenius2000b A. Oxenius, D. A. Price, P. J. Easterbrook, C. A. O'Callaghan, A. D. Kelleher, J. A. Whelan, G. Sontag, A. K. Sewell, and R. E. Phillips. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proc. Natl. Acad. Sci. U.S.A., 97(7):3382-7, 28 Mar 2000. URL: http://www.pnas.org/cgi/content/full/97/7/3382. PubMed ID: 10737796. Show all entries for this paper.


Displaying record number 1656

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human(A11)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 1702

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Appay2000 V. Appay, D. F. Nixon, S. M. Donahoe, G. M. Gillespie, T. Dong, A. King, G. S. Ogg, H. M. Spiegel, C. Conlon, C. A. Spina, D. V. Havlir, D. D. Richman, A. Waters, P. Easterbrook, A. J. McMichael, and S. L. Rowland-Jones. HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J. Exp. Med., 192(1):63-75, 3 Jul 2000. URL: http://www.jem.org/cgi/content/full/192/1/63. PubMed ID: 10880527. Show all entries for this paper.


Displaying record number 1724

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(71-80 93TH253 subtype CRF01)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name N73-82
Subtype CRF01_AE
Species (MHC/HLA) human(A11)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.


Displaying record number 52318

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name QVP
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Oxenius2002b Annette Oxenius, Angela R. McLean, Marek Fischer, David A. Price, Sarah J. Dawson, Roland Hafner, Christine Schneider, Helen Joller, Bernard Hirschel, Rodney E. Phillips, Rainer Weber, Huldrych F. Günthard, and Swiss HIV Cohort Study Group. Human Immunodeficiency Virus-Specific CD8+ T-Cell Responses Do Not Predict Viral Growth and Clearance Rates During Structured Intermittent Antiretroviral Therapy. J. Virol., 76(20):10169-10176, Oct 2002. PubMed ID: 12239291. Show all entries for this paper.


Displaying record number 52358

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A2, B60, B8, Bw6
Experimental methods  
Keywords HAART, ART

Notes

References

Appay2002 Victor Appay, Pokrath Hansasuta, Julian Sutton, Rachel D. Schrier, Joseph K. Wong, Manohar Furtado, Diane V. Havlir, Steven M. Wolinsky, Andrew J. McMichael, Douglas D. Richman, Sarah L. Rowland-Jones, and Celsa A. Spina. Persistent HIV-1-Specific Cellular Responses Despite Prolonged Therapeutic Viral Suppression. AIDS, 16(2):161-170, 25 Jan 2002. PubMed ID: 11807299. Show all entries for this paper.


Displaying record number 53484

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name QK10
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A2, B18, B44, Cw12, Cw5
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords  

Notes

References

Allen2005 Todd M. Allen, Xu G. Yu, Elizabeth T. Kalife, Laura L. Reyor, Mathias Lichterfeld, Mina John, Michael Cheng, Rachel L. Allgaier, Stanley Mui, Nicole Frahm, Galit Alter, Nancy V. Brown, Mary N. Johnston, Eric S. Rosenberg, Simon A. Mallal, Christian Brander, Bruce D. Walker, and Marcus Altfeld. De Novo Generation of Escape Variant-Specific CD8+ T-Cell Responses Following Cytotoxic T-Lymphocyte Escape in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(20):12952-12960, Oct 2005. PubMed ID: 16188997. Show all entries for this paper.


Displaying record number 53564

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A2, B18, B44, Cw12, Cw5
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 53780

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name QK9
Species (MHC/HLA) (A11)
Immunogen  
Experimental methods  
Keywords review, immunodominance, escape, acute/early infection, early-expressed proteins, kinetics, viral fitness and reversion

Notes

References

Lichterfeld2005 Mathias Lichterfeld, Xu G. Yu, Sylvie Le Gall, and Marcus Altfeld. Immunodominance of HIV-1-Specific CD8+ T-Cell Responses in Acute HIV-1 Infection: At the Crossroads of Viral and Host Genetics. Trends Immunol., 26(3):166-171, Mar 2005. PubMed ID: 15745859. Show all entries for this paper.


Displaying record number 54255

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name A11-QK10(Nef)
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 54504

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(74-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A24, B44, B55
Country United Kingdom
Experimental methods Flow cytometric T-cell cytokine assay, Other
Keywords HAART, ART, immunodominance, TCR usage, memory cells

Notes

References

Weekes2006 Michael P. Weekes, Mark R. Wills, J. G. Patrick Sissons, and Andrew J. Carmichael. Large HIV-Specific CD8 Cytotoxic T-Lymphocyte (CTL) Clones Reduce Their Overall Size But Maintain High Frequencies of Memory CTL Following Highly Active Antiretroviral Therapy. Immunology, 118(1):25-38, May 2006. PubMed ID: 16630020. Show all entries for this paper.


Displaying record number 1415

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-81)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human(A11, A2, A3, B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.


Displaying record number 55914

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name QK10(Nef)
Subtype B
Species (MHC/HLA) human(A11, A3)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords variant cross-reactivity

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 55190

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location  
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human(A11, A3)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supertype, HLA cross-presentation

Notes

References

Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.


Displaying record number 57830

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name QK10
Subtype B
Species (MHC/HLA) human(A11, A3)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, TCR binding
Keywords rate of progression, TCR usage, optimal epitope

Notes

References

Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.


Displaying record number 53728

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82 BRU)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Show epitope variants
Subtype B, CRF02_AG
Species (MHC/HLA) human(A11, A3)
Immunogen HIV-1 infection
Country Cote D'Ivoire
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons

Notes

References

Inwoley2005 André Inwoley, Patricia Recordon-Pinson, Marion Dupuis, Jessintha Gaston, Mathieu Genête, Albert Minga, Franck Letourneur, François Rouet, Jeannine Choppin, Hervé Fleury, Jean-Gérard Guillet, Muriel Andrieu, and ANRS 1220 PRIMO-CI Study Group. Cross-Clade Conservation of HIV Type 1 Nef Immunodominant Regions Recognized by CD8+ T Cells of HIV Type 1 CRF02\_AG-Infected Ivorian (West Africa). AIDS Res. Hum. Retroviruses, 21(7):620-628, Jul 2005. PubMed ID: 16060833. Show all entries for this paper.


Displaying record number 54958

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) (A11, A3, A30)
Immunogen peptide-HLA interaction
Experimental methods HLA binding
Keywords binding affinity, immunodominance

Notes

References

Racape2006a Judith Racape, Francine Connan, Johan Hoebeke, Jeannine Choppin, and Jean-Gérard Guillet. Influence of Dominant HIV-1 Epitopes on HLA-A3/Peptide Complex Formation. Proc. Natl. Acad. Sci. U.S.A., 103(48):18208-18213, 28 Nov 2006. PubMed ID: 17116886. Show all entries for this paper.


Displaying record number 979

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82 BRU)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human(A11, A3, B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Culmann1991 B. Culmann, E. Gomard, M.-P. Kieny, B. Guy, F. Dreyfus, A.-D. Saimot, D. Sereni, D. Sicard, and J.-P. Levy. Six Epitopes with Human Cytotoxic CD8+ Cells in the Central Region of the HIV-1 Nef Protein. J. Immunol., 146:1560-1565, 1991. Nef-specific CTL were generated from six seropositive donors. Six epitopes were defined, all localized to two regions in the central part of Nef. Some epitopes could be recognized in the contexts of several HLA class I molecules. Peptides were based on BRU epitopes: QVPLRPMTYK, HLA A3, A11, B35; AAVDLSHFLKEK, HLA A11; HTQGYFPQWQ, HLA B17;TQGYFPQWQNYT, HLA B17, B37, NYTPGPGVRYPLT, HLA B7; and GVRYPLTFGWCYKLVP, HLA B18). PubMed ID: 1704397. Show all entries for this paper.


Displaying record number 1744

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(71-80 93TH253 subtype CRF01)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Subtype CRF01_AE
Species (MHC/HLA) human(A*11)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

Bond2001 K. B. Bond, B. Sriwanthana, T. W. Hodge, A. S. De Groot, T. D. Mastro, N. L. Young, N. Promadej, J. D. Altman, K. Limpakarnjanarat, and J. M. McNicholl. An HLA-directed molecular and bioinformatics approach identifies new HLA-A11 HIV-1 subtype E cytotoxic T lymphocyte epitopes in HIV-1-infected Thais. AIDS Res. Hum. Retroviruses, 17(8):703-17, 20 May 2001. PubMed ID: 11429111. Show all entries for this paper.


Displaying record number 55240

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Subtype B
Species (MHC/HLA) human(A*11)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords immunodominance, assay or method development, optimal epitope

Notes

References

Wang2007 Shaoyang Wang, Yongtao Sun, Song Zhai, Yan Zhuang, Shuguang Zhao, Whenzhen Kang, Xinhong Li, Dedong Huang, Xu G. Yu, Bruce D. Walker, and Marcus A. Altfeld. Identification of HLA-A11-Restricted HIV-1-Specific Cytotoxic T-Lymphocyte Epitopes in China. Curr. HIV Res., 5(1):119-128, Jan 2007. PubMed ID: 17266563. Show all entries for this paper.


Displaying record number 60068

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name QK10
Species (MHC/HLA) human(A*11)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59488

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef( pNL4-3)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name QK10
Subtype B
Species (MHC/HLA) human(A*1101)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, TCR binding
Keywords assay or method development, novel epitope

Notes

References

Yaciuk2014 Jane C. Yaciuk, Matthew Skaley, Wilfried Bardet, Fredda Schafer, Danijela Mojsilovic, Steven Cate, Christopher J. Stewart, Curtis McMurtrey, Kenneth W. Jackson, Rico Buchli, Alex Olvera, Samandhy Cedeño, Montserrat Plana, Beatriz Mothe, Christian Brander, John T. West, and William H. Hildebrand. Direct Interrogation of Viral Peptides Presented by the Class I HLA of HIV-Infected T Cells. J. Virol., 88(22):12992-13004, Nov 2014. PubMed ID: 25165114. Show all entries for this paper.


Displaying record number 1205

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location ( LAI)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Subtype B
Species (MHC/HLA) human(A*1101)
Immunogen  
Experimental methods  
Keywords optimal epitope

References

BuseynePerCom1999 F. Buseyne. Personal communication, 1999. Show all entries for this paper.

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 57646

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name Nef73
Subtype B
Species (MHC/HLA) human(A*1101)
Immunogen HIV-1 infection
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining, Relative replication capacity assay, Tetramer binding
Keywords rate of progression, immunodominance

Notes

References

Koizumi2010 Hirokazu Koizumi, Masao Hashimoto, Mamoru Fujiwara, Hayato Murakoshi, Takayuki Chikata, Mohamed Ali Borghan, Atsuko Hachiya, Yuka Kawashima, Hiroshi Takata, Takamasa Ueno, Shinichi Oka, and Masafumi Takiguchi. Different In Vivo Effects of HIV-1 Immunodominant Epitope-Specific Cytotoxic T Lymphocytes on Selection of Escape Mutant Viruses. J. Virol., 84(11):5508-5519, Jun 2010. PubMed ID: 20335254. Show all entries for this paper.


Displaying record number 53049

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Subtype B, CRF01_AE
Species (MHC/HLA) (A*1101)
Immunogen  
Country Thailand
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS), immunodominance, structure

Notes

References

Li2004 Lenong Li and Marlene Bouvier. Structures of HLA-A*1101 Complexed with Immunodominant Nonamer and Decamer HIV-1 Epitopes Clearly Reveal the Presence of a Middle, Secondary Anchor Residue. J. Immunol., 172(10):6175-6184, 15 May 2004. PubMed ID: 15128805. Show all entries for this paper.


Displaying record number 54300

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name QK10
Subtype B
Species (MHC/HLA) human(A*1101)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords HAART, ART, responses in children, dendritic cells

Notes

References

Zhang2006 Zheng Zhang, Qing-xia Zhao, Jun-liang Fu, Jin-xia Yao, Yun He, Lei Jin, and Fu-sheng Wang. Characteristics of HIV-1-Specific CD8 T-Cell Responses and Their Role in Loss of Viremia in Children Chronically Infected with HIV-1 Undergoing Highly Active Antiretroviral Therapy. Chin. Med. J., 119(23):1949-1957, 5 Dec 2006. PubMed ID: 17199938. Show all entries for this paper.


Displaying record number 57817

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Subtype B
Species (MHC/HLA) human(A*1101)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction, HLA associated polymorphism

Notes

References

Almeida2011 Coral-Ann M. Almeida, Corine Bronke, Steven G. Roberts, Elizabeth McKinnon, Niamh M. Keane, Abha Chopra, Carl Kadie, Jonathan Carlson, David W. Haas, Sharon A. Riddler, Richard Haubrich, David Heckerman, Simon Mallal, and Mina John. Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts to Inflate CD8 T Cell Responses against Nef and HLA-Adapted Variant Epitopes. J. Immunol., 187(5):2502-2513, 1 Sep 2011. PubMed ID: 21821798. Show all entries for this paper.


Displaying record number 52624

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A3, B14, B7, Cw*0702, Cw*0802
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity, acute/early infection, early-expressed proteins

Notes

References

Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.


Displaying record number 53632

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A3, B44, B7
Country United States
Experimental methods Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords HAART, ART, escape, variant cross-reactivity

Notes

References

Casazza2005a Joseph P. Casazza, Michael R. Betts, Brenna J. Hill, Jason M. Brenchley, David A. Price, Daniel C. Douek, and Richard A. Koup. Immunologic Pressure within Class I-Restricted Cognate Human Immunodeficiency Virus Epitopes during Highly Active Antiretroviral Therapy. J. Virol., 79(6):3653-3663, Mar 2005. PubMed ID: 15731259. Show all entries for this paper.


Displaying record number 52978

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Patient MHC/HLA A3, A32, B15, B51, Cw03, Cw6, DQ7, DR4, DR8
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, escape

Notes

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.


Displaying record number 53828

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Show epitope variants
Subtype C
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Patient MHC/HLA A*0301, A*7401, B*1510, B*3501, Cw*0401; A*0301, A*68, B*0702, B*1510, Cw*0401, Cw*0702
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords responses in children, mother-to-infant transmission, escape, acute/early infection

Notes

References

Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.


Displaying record number 54240

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name A3-QK10(Nef)
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 975

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82 LAI)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods  
Keywords epitope processing, escape

Notes

References

Chassin1999 D. Chassin, M. Andrieu, W. Cohen, B. Culmann-Penciolelli, M. Ostankovitch, D. Hanau, and J. G. Guillet. Dendritic Cells Transfected with the nef Genes of HIV-1 Primary Isolates Specifically Activate Cytotoxic T Lymphocytes from Seropositive Subjects. Eur. J. Immunol., 29:196-202, 1999. PubMed ID: 9933101. Show all entries for this paper.


Displaying record number 54876

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location  
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, characterizing CD8+ T cells

Vaccine Details

Vaccine type canarypox, canarypox prime with recombinant protein boost
Vaccine strain B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen
Vaccine component Gag, gp120, gp41, Nef, Pol, Protease

Notes

References

Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.


Displaying record number 52359

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Patient MHC/HLA A3, B44, B64, Bw4, Bw6
Experimental methods  
Keywords HAART, ART

Notes

References

Appay2002 Victor Appay, Pokrath Hansasuta, Julian Sutton, Rachel D. Schrier, Joseph K. Wong, Manohar Furtado, Diane V. Havlir, Steven M. Wolinsky, Andrew J. McMichael, Douglas D. Richman, Sarah L. Rowland-Jones, and Celsa A. Spina. Persistent HIV-1-Specific Cellular Responses Despite Prolonged Therapeutic Viral Suppression. AIDS, 16(2):161-170, 25 Jan 2002. PubMed ID: 11807299. Show all entries for this paper.


Displaying record number 52150

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name A3-QK10
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Patient MHC/HLA A3, B7, Cw7
Experimental methods  
Keywords dynamics, supervised treatment interruptions (STI), acute/early infection

Notes

References

Yu2002b Xu G. Yu, Marylyn M. Addo, Eric S. Rosenberg, William R. Rodriguez, Paul K. Lee, Cecily A. Fitzpatrick, Mary N. Johnston, Daryld. Strick, Philip J. R. Goulder, Bruce D. Walker, and Marcus Altfeld. Consistent Patterns in the Development and Immunodominance of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T-Cell Responses Following Acute HIV-1 Infection. J. Virol., 76(17):8690-8701, Sep 2002. PubMed ID: 12163589. Show all entries for this paper.


Displaying record number 1847

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef( SF2)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Altfeld2000 M. A. Altfeld, A. Trocha, R. L. Eldridge, E. S. Rosenberg, M. N. Phillips, M. M. Addo, R. P. Sekaly, S. A. Kalams, S. A. Burchett, K. McIntosh, B. D. Walker, and P. J. Goulder. Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay. J. Virol., 74:8541, 2000. PubMed ID: 10954555. Show all entries for this paper.


Displaying record number 1471

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name N1
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, escape

Notes

References

Samri2000 A. Samri, G. Haas, J. Duntze, J. M. Bouley, V. Calvez, C. Katlama, and B. Autran. Immunogenicity of mutations induced by nucleoside reverse transcriptase inhibitors for human immunodeficiency virus type 1-specific cytotoxic T cells. J. Virol., 74(19):9306-12, Oct 2000. URL: http://jvi.asm.org/cgi/content/full/74/19/9306. PubMed ID: 10982378. Show all entries for this paper.


Displaying record number 984

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Lubaki1997 N. M. Lubaki, S. C. Ray, B. Dhruva, T. C. Quinn, R. F. Siliciano, and R. C. Bollinger. Characterization of a Polyclonal Cytolytic T Lymphocyte Response to Human Immunodeficiency Virus in Persons without Clinical Progression. J. Infect. Dis., 6:1360-1367, 1997. Five individuals were studied who survived HIV infection in good health for over 5 years. A broad polyclonal response was found to multiple proteins. PubMed ID: 9180175. Show all entries for this paper.


Displaying record number 983

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82 LAI)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Patient MHC/HLA 003: A*02, A*03, B*07, B*51; 023: A*02, A*03, B*07, B*51
Experimental methods  
Keywords review, escape

Notes

References

Goulder1997 P. J. Goulder, A. K. Sewell, D. G. Lalloo, D. A. Price, J. A. Whelan, J. Evans, G. P. Taylor, G. Luzzi, P. Giangrande, R. E. Phillips, and A. J. McMichael. Patterns of Immunodominance in HIV-1-Specific Cytotoxic T Lymphocyte Responses in Two Human Histocompatibility Leukocyte Antigens (HLA)-Identical Siblings with HLA-A*0201 Are Influenced by Epitope Mutation. J. Exp. Med., 8:1423-1433, 1997. Primary human immunodeficiency virus (HIV) infection is controlled principally by HIV-specific cytotoxic T lymphocytes (CTL) to a steady- state level of virus load, which strongly influences the ultimate rate of progression to disease. Epitope selection by CTL may be an important determinant of the degree of immune control over the virus. This report describes the CTL responses of two HLA-identical hemophiliac brothers who were exposed to identical batches of Factor VIII and became seropositive within 10 wk of one another. Both have HLA-A*0201. The CTL responses of the two siblings were very dissimilar, one donor making strong responses to two epitopes within p17 Gag (HLA-A*0201-restricted SLYNTVATL and HLA-A3-restricted RLRPGGKKK). The sibling responded to neither epitope, but made strong responses to two epitopes presented by HLA-B7. This was not the result of differences in presentation of the epitopes. However, mutations in both immunodominant epitopes of the p17 Gag responder were seen in proviral sequences of the nonresponder. We then documented the CTL responses to two HLA-A*0201-restricted epitopes, in Gag (SLYNTVATL) and Pol (ILKEPVHGV) in 22 other HIV-infected donors with HLA-A*0201. The majority (71\%) generated responses to the Gag epitope. In the 29\% of donors failing to respond to the Gag epitope in standard assays, there was evidence of low frequency memory CTL responses using peptide stimulation of PBMC, and most of these donors also showed mutations in or around the Gag epitope. PubMed ID: 9126923. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 977

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

Durali1998 D. Durali, J. Morvan, F. Letourneur, D. Schmitt, N. Guegan, M. Dalod, S. Saragosti, D. Sicard, J. P. Levy, and E. Gomard. Cross-Reactions between the Cytotoxic T-Lymphocyte Responses of Human Immunodeficiency Virus-Infected African and European Patients. J. Virol., 72:3547-3553, 1998. PubMed ID: 9557634. Show all entries for this paper.


Displaying record number 53036

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Koning2004 Fransje A. Koning, Christine A. Jansen, Jos Dekker, Richard A. Kaslow, Nicole Dukers, Debbie van Baarle, Maria Prins, and Hanneke Schuitemaker. Correlates of Resistance to HIV-1 Infection in Homosexual Men with High-Risk Sexual Behaviour. AIDS, 18(8):1117-1126, 21 May 2004. PubMed ID: 15166527. Show all entries for this paper.


Displaying record number 53378

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location ( B consensus)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name QK10
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Patient MHC/HLA A3, B14, B60, Cw3, Cw7; A1, A3, B14, B8, Cw7, Cw8
Experimental methods Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords assay or method development, memory cells, characterizing CD8+ T cells

Notes

References

Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.


Displaying record number 60072

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name QK10
Species (MHC/HLA) human(A*33)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60071

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name QK10
Species (MHC/HLA) human(A*34)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 1619

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(94-103)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human(A3 supertype)
Immunogen HIV-1 infection
Experimental methods  
Keywords supertype, rate of progression

Notes

References

Propato2001 A. Propato, E. Schiaffella, E. Vicenzi, V. Francavilla, L. Baloni, M. Paroli, L. Finocchi, N. Tanigaki, S. Ghezzi, R. Ferrara, R. Chesnut, B. Livingston, A. Sette, R. Paganelli, F. Aiuti, G. Poli, and V. Barnaba. Spreading of HIV-specific CD8+ T-cell repertoire in long-term nonprogressors and its role in the control of viral load and disease activity. Hum. Immunol., 62(6):561-76, Jun 2001. PubMed ID: 11390031. Show all entries for this paper.


Displaying record number 60070

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name QK10
Species (MHC/HLA) human(A*66)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 57816

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Subtype B
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction, HLA associated polymorphism

Notes

References

Almeida2011 Coral-Ann M. Almeida, Corine Bronke, Steven G. Roberts, Elizabeth McKinnon, Niamh M. Keane, Abha Chopra, Carl Kadie, Jonathan Carlson, David W. Haas, Sharon A. Riddler, Richard Haubrich, David Heckerman, Simon Mallal, and Mina John. Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts to Inflate CD8 T Cell Responses against Nef and HLA-Adapted Variant Epitopes. J. Immunol., 187(5):2502-2513, 1 Sep 2011. PubMed ID: 21821798. Show all entries for this paper.


Displaying record number 976

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82 LAI)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Subtype B
Species (MHC/HLA) human(B27)
Immunogen  
Experimental methods  
Keywords  

Notes

References

CulmannPerCom B. Culmann. Personal communication, 1998. Show all entries for this paper.


Displaying record number 60069

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name QK10
Species (MHC/HLA) human(B*3502, B*3503, B*5301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 53346

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location  
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name QK10
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Proliferation, Tetramer binding
Keywords immunodominance, acute/early infection, characterizing CD8+ T cells

Notes

References

Lichterfeld2004 Mathias Lichterfeld, Daniel E. Kaufmann, Xu G. Yu, Stanley K. Mui, Marylyn M. Addo, Mary N. Johnston, Daniel Cohen, Gregory K. Robbins, Eunice Pae, Galit Alter, Alysse Wurcel, David Stone, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. Loss of HIV-1-Specific CD8+ T Cell Proliferation after Acute HIV-1 Infection and Restoration by Vaccine-Induced HIV-1-Specific CD4+ T Cells. J. Exp. Med., 200(6):701-12, Sep 20 2004. PubMed ID: 15381726. Show all entries for this paper.


Displaying record number 61659

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Epitope Name QK10
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA AC1: A*0201, A*3001, B*3701, B*3801, Cw*0602, Cw*1203; VP1: A*0201, A*0301, B*4101, B*5201, Cw*0303, Cw*1701; AP4: A*03, A*23, B*07, B*45; ES3: A*25, A*68, B*51, B*57; ES4: A*02, A*30, B*08, B*44; ES5: A*23, A*68, B*57, B*58; ES9: A*02, A*30, B*27, B*57; ES22: A*30, A*31, B*15, B*57; ES24: A*30, A*31, B*15, B*57; ES31: A*03, B*27, B*58; ES46: A*03, B*57, B*65; ES47: A*02, A*33, B*44, B*63; VC1: A*23, A*29, B*07, B*39; VC18: A*03, A*23, B*44, B*51
Country United States
Experimental methods Other, Relative replication capacity assay
Keywords NK cells, transmission pair

Notes

References

Walker-Sperling2017 Victoria E. Walker-Sperling, Christopher W. Pohlmeyer, Rebecca T. Veenhuis, Megan May, Krystle A. Luna, Allison R. Kirkpatrick, Oliver Laeyendecker, Andrea L. Cox, Mary Carrington, Justin R. Bailey, Roberto C. Arduino, and Joel N. Blankson. Factors Associated with the Control of Viral Replication and Virologic Breakthrough in a Recently Infected HIV-1 Controller. EBioMedicine, 16:141-149, Feb 2017. PubMed ID: 28159573. Show all entries for this paper.


Displaying record number 55098

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location  
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords binding affinity, acute/early infection

Notes

References

Lichterfeld2007 Mathias Lichterfeld, Xu G. Yu, Stanley K. Mui, Katie L. Williams, Alicja Trocha, Mark A. Brockman, Rachel L. Allgaier, Michael T. Waring, Tomohiko Koibuchi, Mary N. Johnston, Daniel Cohen, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. Selective Depletion of High-Avidity Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T Cells after Early HIV-1 Infection. J. Virol., 81(8):4199-4214, Apr 2007. PubMed ID: 17287271. Show all entries for this paper.


Displaying record number 985

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Garcia1997 S. Garcia, M. Fevrier, G. Dadaglio, H. Lecoeur, Y. Riviere, and M.-L. Gougeon. Potential Deleterious Effect of Anti-Viral Cytotoxic Lymphocyte through the CD95 (FAS/APO-1)-Mediated Pathway during Chronic HIV Infection. Immunol. Lett., 57:53-58, 1997. PubMed ID: 9232425. Show all entries for this paper.


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