HIV molecular immunology database
Found 86 matching records:
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Gag(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | QK10 | |
Species (MHC/HLA) | human(A*02:01) | |
Immunogen | HIV-1 infection | |
Country | Canada | |
Experimental methods | Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding | |
Keywords | characterizing CD8+ T cells |
Trautmann2012 Lydie Trautmann, Florentin-Martial Mbitikon-Kobo, Jean-Philippe Goulet, Yoav Peretz, Yu Shi, Julien Van Grevenynghe, Francesco Andrea Procopio, Mohamad Rachid Boulassel, Jean-Pierre Routy, Nicolas Chomont, Elias K. Haddad, and Rafick-Pierre Sekaly. Profound Metabolic, Functional, and Cytolytic Differences Characterize HIV-Specific CD8 T Cells in Primary and Chronic HIV Infection. Blood, 120(17):3466-3477, 25 Oct 2012. PubMed ID: 22955926. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | QK10 | |
Species (MHC/HLA) | human(A*02:01) | |
Immunogen | in vitro stimulation or selection | |
Experimental methods | Tetramer binding | |
Keywords |
Brockman2009 Mark A. Brockman, Douglas S. Kwon, Daniel P. Tighe, David F. Pavlik, Pamela C. Rosato, Jennifer Sela, Filippos Porichis, Sylvie Le Gall, Michael T. Waring, Kristin Moss, Heiko Jessen, Florencia Pereyra, Daniel G. Kavanagh, Bruce D. Walker, and Daniel E. Kaufmann. IL-10 Is Up-Regulated in Multiple Cell Types During Viremic HIV Infection and Reversibly Inhibits Virus-Specific T Cells. Blood, 114(2):346-356, 9 Jul 2009. PubMed ID: 19365081. Show all entries for this paper.
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HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(71-80) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infection | |
Country | Spain | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation | |
Keywords | HAART, ART, supervised treatment interruptions (STI) |
Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | MM39: A*02:01, A*03:01, B*15:01, B*35:01, C*03:03:01, C*04:01:01:01; MM12: A*03, A*68, B*07, B*44, C*07, C*07 | |
Country | United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Tetramer binding | |
Keywords | acute/early infection, optimal epitope |
Turnbull2009 Emma L. Turnbull, MaiLee Wong, Shuyi Wang, Xiping Wei, Nicola A. Jones, Karen E. Conrod, Diana Aldam, Jo Turner, Pierre Pellegrino, Brandon F. Keele, Ian Williams, George M. Shaw, and Persephone Borrow. Kinetics of Expansion of Epitope-Specific T Cell Responses During primary HIV-1 Infection. J. Immunol., 182(11):7131-7145, 1 Jun 2009. PubMed ID: 19454710. Show all entries for this paper.
Yang2019 Yiding Yang, and Vitaly V. Ganusov. Defining Kinetic Properties of HIV-Specific CD8(+) T-Cell Responses in Acute Infection. Microorganisms, 7(3):microorganisms7030069 doi, Mar 2019. PubMed ID: 30836625 Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*03) | |
Immunogen | peptide-HLA interaction | |
Experimental methods | Tetramer binding | |
Keywords | binding affinity |
Gillespie2007 Geraldine M. A. Gillespie, Arman Bashirova, Tao Dong, Daniel W. McVicar, Sarah L. Rowland-Jones, and Mary Carrington. Lack of KIR3DS1 Binding to MHC Class I Bw4 Tetramers in Complex with CD8+ T Cell Epitopes. AIDS Res. Hum. Retroviruses, 23(3):451-455, Mar 2007. PubMed ID: 17411378. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | QK10 | |
Subtype | B | |
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infection | |
Country | Barbados, Haiti, Jamaica | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | mother-to-infant transmission, elite controllers |
Schneidewind2009 Arne Schneidewind, Yanhua Tang, Mark A. Brockman, Elizabeth G. Ryland, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, M. Anne St. John, Joseph A. Conrad, Spyros A. Kalams, Francine Noel, Todd M. Allen, Celia D. Christie, and Margaret E. Feeney. Maternal Transmission of Human Immunodeficiency Virus Escape Mutations Subverts HLA-B57 Immunodominance but Facilitates Viral Control in the Haploidentical Infant. J. Virol., 83(17):8616-8627, Sep 2009. PubMed ID: 19515764. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | QK10 | |
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | Nef-QK10 | |
Subtype | B | |
Species (MHC/HLA) | human(A*03) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | HAART, ART |
Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*03, A*11, A*31, B*27, B*35) | |
Immunogen | HIV-1 infection | |
Country | Canada | |
Experimental methods | Other | |
Keywords | characterizing CD8+ T cells, elite controllers |
Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | acute/early infection |
Wilson2000 J. D. Wilson, G. S. Ogg, R. L. Allen, C. Davis, S. Shaunak, J. Downie, W. Dyer, C. Workman, S. Sullivan, A. J. McMichael, and S. L. Rowland-Jones. Direct Visualization of HIV-1-Specific Cytotoxic T Lymphocytes During Primary Infection. AIDS, 14:225-233, 2000. PubMed ID: 10716497. Show all entries for this paper.
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HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82 NL43) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Koenig1990 S. Koenig, T. R. Fuerst, L. V. Wood, R. M. Woods, J. A. Suzich, G. M. Jones, V. F. de la Cruz, R. T. Davey, Jr., S. Venkatesan, B. Moss, W. E. Biddison, and A. S. Fauci. Mapping the Fine Specificity of a Cytotoxic T Cell Response to HIV-1 Nef Protein. J. Immunol., 145:127-135, 1990. A 10 residue peptide that triggers CTL in association with the HLA A3.1 molecule was studied. Human cell transfectants were used to map a critical residue in the HLA A3.1 molecule for recognition, amino acid 152, which is present on the alpha-2 helix in HLA-A3.1 and is modified in the HLA A3.2 A3 allele. PubMed ID: 1694201. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 25122: A*01:01, A*03:01, B*07:02, B*37:01, C*06:02, C*07:02; 51314: A*03:01, A*11:01, B*35:03, B*53:01, C*04:01, C*04:01 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection |
Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.
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HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82 LAI) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | in vitro stimulation or selection | |
Experimental methods | ||
Keywords | epitope processing, dendritic cells |
Andrieu2003 Muriel Andrieu, Jean-François Desoutter, Estelle Loing, Jésintha Gaston, Daniel Hanau, Jean-Gérard Guillet, and Anne Hosmalin. Two Human Immunodeficiency Virus Vaccinal Lipopeptides Follow Different Cross-Presentation Pathways in Human Dendritic Cells. J. Virol., 77(2):1564-1570, Jan 2003. PubMed ID: 12502869. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Country | United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | rate of progression, early treatment |
Cellerai2011 Cristina Cellerai, Alexandre Harari, Hans Stauss, Sabine Yerly, Anna-Maria Geretti, Anne Carroll, Thynn Yee, Jonathan Ainsworth, Ian Williams, John Sweeney, Andrew Freedman, Margaret Johnson, Giuseppe Pantaleo, and Sabine Kinloch-de Loes. Early and Prolonged Antiretroviral Therapy Is Associated with an HIV-1-Specific T-Cell Profile Comparable to That of Long-Term Non-Progressors. PLoS One, 6(4):e18164, 2011. PubMed ID: 21483676. Show all entries for this paper.
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HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(263-272) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | QK10 | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | Other | |
Keywords | review, immunodominance, TCR usage, variant cross-reactivity |
Lissina2016 Anna Lissina, Lisa A. Chakrabarti, Masafumi Takiguchi, and Victor Appay. TCR Clonotypes: Molecular Determinants of T-Cell Efficacy against HIV. Curr. Opin. Virol., 16:77-85, Feb 2016. PubMed ID: 26874617. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | immunodominance |
Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82 LAI) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | rate of progression, escape |
Koenig1995 S. Koenig, A. J. Conley, Y. A. Brewah, G. M. Jones, S. Leath, L. J. Boots, V. Davey V, G. Pantaleo, J. F. Demarest, and C. Carter. Transfer of HIV-1-Specific Cytotoxic T Lymphocytes to an AIDS Patient Leads to Selection for Mutant HIV Variants and Subsequent Disease Progression. Nat. Med., 1(4):330-336, 1995. PubMed ID: 7585062. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | MM39: A*02:01, A*03:01, B*15:01, B*35:01, C*03:03:01, C*04:01:01:01 | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | dynamics, escape, acute/early infection, autologous responses, characterizing CD8+ T cells |
Ferrari2011 Guido Ferrari, Bette Korber, Nilu Goonetilleke, Michael K. P. Liu, Emma L. Turnbull, Jesus F. Salazar-Gonzalez, Natalie Hawkins, Steve Self, Sydeaka Watson, Michael R. Betts, Cynthia Gay, Kara McGhee, Pierre Pellegrino, Ian Williams, Georgia D. Tomaras, Barton F. Haynes, Clive M. Gray, Persephone Borrow, Mario Roederer, Andrew J. McMichael, and Kent J. Weinhold. Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection. PLoS Pathog., 7(2):e1001273, 2011. PubMed ID: 21347345. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | nef 020-028 | |
Subtype | B | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Country | France | |
Experimental methods | CD8 T-cell Elispot - IFNγ, CTL suppression of replication, HLA binding, Intracellular cytokine staining, Other | |
Keywords | binding affinity, elite controllers |
Lecuroux2014 Camille Lécuroux, Asier Sáez-Cirión, Isabelle Girault, Pierre Versmisse, Faroudy Boufassa, Véronique Avettand-Fenoël, Christine Rouzioux, Laurence Meyer, Gianfranco Pancino, Olivier Lambotte, Martine Sinet, and Alain Venet. Both HLA-B*57 and Plasma HIV RNA Levels Contribute to the HIV-Specific CD8+ T Cell Response in HIV Controllers. J. Virol., 88(1):176-187, Jan 2014. PubMed ID: 24131719. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82 DU422) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | in vitro stimulation or selection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Tetramer binding | |
Keywords | dendritic cells |
Colleton2009 Bonnie A. Colleton, Xiao-Li Huang, Nada M. Melhem, Zheng Fan, Luann Borowski, Giovanna Rappocciolo, and Charles R. Rinaldo. Primary Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses Induced by Myeloid Dendritic Cells. J. Virol., 83(12):6288-6299, Jun 2009. PubMed ID: 19357176. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*01:01, A*03:01, B*08:01, B*51:01 | |
Country | United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, HLA binding | |
Keywords | escape |
Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*03:01, A*74:01, B*49:01, B*58:02, C*06:02, C*07:01 | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, acute/early infection |
Mlotshwa2010 Mandla Mlotshwa, Catherine Riou, Denis Chopera, Debra de Assis Rosa, Roman Ntale, Florette Treunicht, Zenda Woodman, Lise Werner, Francois van Loggerenberg, Koleka Mlisana, Salim Abdool Karim, Carolyn Williamson, Clive M Gray, and CAPRISA 002 Study Team. Fluidity of HIV-1-Specific T-Cell Responses during Acute and Early Subtype C HIV-1 Infection and Associations with Early Disease Progression. J. Virol., 84(22):12018-12029, Nov 2010. PubMed ID: 20826686. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | QVP | |
Species (MHC/HLA) | human(A*03:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, TCR usage, variant cross-reactivity, characterizing CD8+ T cells |
Turnbull2006 Emma L. Turnbull, A. Ross Lopes, Nicola A. Jones, David Cornforth, Phillipa Newton, Diana Aldam, Pierre Pellegrino, Jo Turner, Ian Williams, Craig M. Wilson, Paul A. Goepfert, Mala K. Maini, and Persephone Borrow. HIV-1 Epitope-Specific CD8+ T Cell Responses Strongly Associated with Delayed Disease Progression Cross-Recognize Epitope Variants Efficiently. J. Immunol., 176(10):6130-6146, 15 May 2006. PubMed ID: 16670322. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | QK10 | |
Subtype | B | |
Species (MHC/HLA) | human(A*03:01, A*11) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Intracellular cytokine staining, Tetramer binding | |
Keywords | binding affinity, TCR usage |
Lissina2014 Anna Lissina, Solène Fastenackels, Maria C. Inglesias, Kristin Ladell, James E. McLaren, Olivia Briceño, Emma Gostick, Laura Papagno, Brigitte Autran, Delphine Sauce, David A. Price, Asier Saez-Cirion, and Victor Appay. The Link between CD8+ T-Cell Antigen-Sensitivity and HIV-Suppressive Capacity Depends on HLA Restriction, Target Epitope and Viral Isolate. AIDS, 28(4):477-486, 20 Feb 2014. PubMed ID: 24384691. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*03:01, A11) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B | |
Keywords | Th1, characterizing CD8+ T cells |
Kleen2004 Thomas O. Kleen, Robert Asaad, Samuel J. Landry, Bernhard O. Boehm, and Magdalena Tary-Lehmann. Tc1 Effector Diversity Shows Dissociated Expression of Granzyme B and Interferon-gamma in HIV Infection. AIDS, 18(3):383-392, 20 Feb 2004. PubMed ID: 15090789. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Subtype | A, B, D | |
Species (MHC/HLA) | human, macaque(A*03:01, A11) | |
Immunogen | HIV-1 infection, vaccine | |
Experimental methods | ||
Keywords | subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance |
Vaccine type | DNA prime with modified vaccinia Ankara (MVA) boost |
---|---|
Vaccine strain | A clade |
Vaccine component | p17 Gag, p24 Gag |
Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.
Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82 LAI) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | N1 | |
Subtype | B | |
Species (MHC/HLA) | human(A03 supertype) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, supertype |
Mollet2000 L. Mollet, T. S. Li, A. Samri, C. Tournay, R. Tubiana, V. Calvez, P. Debre, C. Katlama, and B. Autran. Dynamics of HIV-specific CD8+ T lymphocytes with changes in viral load. J. Immunol., 165(3):1692-704, 1 Aug 2000. URL: http://www.jimmunol.org/v165n3/1692/1692-abs-frame.html. PubMed ID: 10903781. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(71-80 93TH253 subtype CRF01) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Subtype | CRF01_AE | |
Species (MHC/HLA) | human(A*11) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | subtype comparisons |
Bond2001 K. B. Bond, B. Sriwanthana, T. W. Hodge, A. S. De Groot, T. D. Mastro, N. L. Young, N. Promadej, J. D. Altman, K. Limpakarnjanarat, and J. M. McNicholl. An HLA-directed molecular and bioinformatics approach identifies new HLA-A11 HIV-1 subtype E cytotoxic T lymphocyte epitopes in HIV-1-infected Thais. AIDS Res. Hum. Retroviruses, 17(8):703-17, 20 May 2001. PubMed ID: 11429111. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*11) | |
Immunogen | HIV-1 infection | |
Country | China | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other | |
Keywords | immunodominance, assay or method development, optimal epitope |
Wang2007 Shaoyang Wang, Yongtao Sun, Song Zhai, Yan Zhuang, Shuguang Zhao, Whenzhen Kang, Xinhong Li, Dedong Huang, Xu G. Yu, Bruce D. Walker, and Marcus A. Altfeld. Identification of HLA-A11-Restricted HIV-1-Specific Cytotoxic T-Lymphocyte Epitopes in China. Curr. HIV Res., 5(1):119-128, Jan 2007. PubMed ID: 17266563. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | QK10 | |
Species (MHC/HLA) | human(A*11) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A11) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
LeBorgne2000 S. Le Borgne, M. Fevrier, C. Callebaut, S. P. Lee, and Y. Riviere. CD8(+)-Cell antiviral factor activity is not restricted to human immunodeficiency virus (HIV)-specific T cells and can block HIV replication after initiation of reverse transcription. J. Virol., 74:4456-64, 2000. PubMed ID: 10775581. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | QVP | |
Species (MHC/HLA) | human(A11) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, supervised treatment interruptions (STI), immunodominance, acute/early infection |
Oxenius2000b A. Oxenius, D. A. Price, P. J. Easterbrook, C. A. O'Callaghan, A. D. Kelleher, J. A. Whelan, G. Sontag, A. K. Sewell, and R. E. Phillips. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proc. Natl. Acad. Sci. U.S.A., 97(7):3382-7, 28 Mar 2000. URL: http://www.pnas.org/cgi/content/full/97/7/3382. PubMed ID: 10737796. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A11) | |
Immunogen | HIV-1 exposed seronegative, HIV-1 infection | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS) |
Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A11) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Appay2000 V. Appay, D. F. Nixon, S. M. Donahoe, G. M. Gillespie, T. Dong, A. King, G. S. Ogg, H. M. Spiegel, C. Conlon, C. A. Spina, D. V. Havlir, D. D. Richman, A. Waters, P. Easterbrook, A. J. McMichael, and S. L. Rowland-Jones. HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J. Exp. Med., 192(1):63-75, 3 Jul 2000. URL: http://www.jem.org/cgi/content/full/192/1/63. PubMed ID: 10880527. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(71-80 93TH253 subtype CRF01) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | N73-82 | |
Subtype | CRF01_AE | |
Species (MHC/HLA) | human(A11) | |
Immunogen | HIV-1 exposed seronegative, HIV-1 infection | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS) |
Sriwanthana2001 B. Sriwanthana, T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, R. B. Lal, D. Chandanayingyong, and J. M. McNicholl. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 delta32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses, 17(8):719-34, 20 May 2001. PubMed ID: 11429112. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82 LAI) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A11) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Robertson1993 M. N. Robertson, F. Buseyne, O. Schwartz, and Y. Riviere. Efficient Antigen Presentation to Cytotoxic T Lymphocytes by Cells Transduced with a Retroviral Vector Expressing the HIV-1 Nef Protein. AIDS Res. Hum. Retroviruses, 9:1217-1223, 1993. This paper presents a retroviral vector system for antigen presentation to CTLs. As part of the controls to test their system, they study the response to specific Nef peptides, which contain the dominant CTL epitopes in Nef in their study subject. PubMed ID: 7511396. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | QVP | |
Species (MHC/HLA) | human(A11) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, supervised treatment interruptions (STI) |
Oxenius2002b Annette Oxenius, Angela R. McLean, Marek Fischer, David A. Price, Sarah J. Dawson, Roland Hafner, Christine Schneider, Helen Joller, Bernard Hirschel, Rodney E. Phillips, Rainer Weber, Huldrych F. Günthard, and Swiss HIV Cohort Study Group. Human Immunodeficiency Virus-Specific CD8+ T-Cell Responses Do Not Predict Viral Growth and Clearance Rates During Structured Intermittent Antiretroviral Therapy. J. Virol., 76(20):10169-10176, Oct 2002. PubMed ID: 12239291. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A11) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A11, A2, B60, B8, Bw6 | |
Experimental methods | ||
Keywords | HAART, ART |
Appay2002 Victor Appay, Pokrath Hansasuta, Julian Sutton, Rachel D. Schrier, Joseph K. Wong, Manohar Furtado, Diane V. Havlir, Steven M. Wolinsky, Andrew J. McMichael, Douglas D. Richman, Sarah L. Rowland-Jones, and Celsa A. Spina. Persistent HIV-1-Specific Cellular Responses Despite Prolonged Therapeutic Viral Suppression. AIDS, 16(2):161-170, 25 Jan 2002. PubMed ID: 11807299. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82 LAI) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B | |
Species (MHC/HLA) | human(A11) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | review, escape |
Couillin1994 I. Couillin, B. Culmann-Penciolelli, E. Gomard, J. Choppin, J. P Levy, J. G. Guillet, and S. Sarasgosti. Impaired Cytotoxic T Lymphocyte Recognition Due to Genetic Variations in the Main Immunogenic Region of the Human Immunodeficiency Virus 1 NEF Protein. J. Exp. Med., 180:1129-11234, 1994. HIV-1 HLA-A11 and -B18 restricted epitopes were sequenced from donors who do and do not express the HLA-A11 and B18 molecule. Selective variations were only detected in virus isolated from individuals expressing the appropriate HLA type. Variant peptides with single substitutions within the minimal epitope did not always completely abrogate HLA binding, suggesting that multiple alterations within a particular epitope may need to accumulate during disease progression to allow viral escape. PubMed ID: 7520468. Show all entries for this paper.
Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82 LAI) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A11) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Couillin1995 I. Couillin, F. Connan, B. Culmann-Penciolelli, E. Gomard, J.-G. Guillet, and J. Choppin. HLA-Dependent Variations in Human Immunodeficiency Virus Nef Protein Alter Peptide/HLA binding. Eur. J. Immunol., 25:728-732, 1995. Viral sequences across this region were compared from 3 HLA-A11 positive and 10 negative donors. Substitutions that were found only in the 3 HLA-A11 donors did not promote HLA-A11 assembly. Substitutions that were found in both HLA-A11 positive and negative donors, however, did not markedly alter the reactivity of the peptides. This suggests that substitutions that result in loss of HLA-A11 occur mainly in HLA-A11 positive donors. PubMed ID: 7705402. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | QK10 | |
Subtype | B | |
Species (MHC/HLA) | human(A11) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A11, A2, B18, B44, C*12, Cw5 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords |
Allen2005 Todd M. Allen, Xu G. Yu, Elizabeth T. Kalife, Laura L. Reyor, Mathias Lichterfeld, Mina John, Michael Cheng, Rachel L. Allgaier, Stanley Mui, Nicole Frahm, Galit Alter, Nancy V. Brown, Mary N. Johnston, Eric S. Rosenberg, Simon A. Mallal, Christian Brander, Bruce D. Walker, and Marcus Altfeld. De Novo Generation of Escape Variant-Specific CD8+ T-Cell Responses Following Cytotoxic T-Lymphocyte Escape in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(20):12952-12960, Oct 2005. PubMed ID: 16188997. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A11) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A11, A2, B18, B44, C*12, Cw5 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords |
Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | QK9 | |
Species (MHC/HLA) | (A11) | |
Immunogen | ||
Experimental methods | ||
Keywords | review, immunodominance, escape, acute/early infection, early-expressed proteins, kinetics, viral fitness and reversion |
Lichterfeld2005 Mathias Lichterfeld, Xu G. Yu, Sylvie Le Gall, and Marcus Altfeld. Immunodominance of HIV-1-Specific CD8+ T-Cell Responses in Acute HIV-1 Infection: At the Crossroads of Viral and Host Genetics. Trends Immunol., 26(3):166-171, Mar 2005. PubMed ID: 15745859. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | A11-QK10(Nef) | |
Species (MHC/HLA) | human(A11) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(74-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A11) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A11, A24, B44, B55 | |
Country | United Kingdom | |
Experimental methods | Flow cytometric T-cell cytokine assay, Other | |
Keywords | HAART, ART, immunodominance, TCR usage, memory cells |
Weekes2006 Michael P. Weekes, Mark R. Wills, J. G. Patrick Sissons, and Andrew J. Carmichael. Large HIV-Specific CD8 Cytotoxic T-Lymphocyte (CTL) Clones Reduce Their Overall Size But Maintain High Frequencies of Memory CTL Following Highly Active Antiretroviral Therapy. Immunology, 118(1):25-38, May 2006. PubMed ID: 16630020. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-81) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A11, A2, A3, B35) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A11, A3) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | supertype, HLA cross-presentation |
Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | QK10(Nef) | |
Subtype | B | |
Species (MHC/HLA) | human(A11, A3) | |
Immunogen | HIV-1 infection | |
Country | China | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | variant cross-reactivity, chronic infection |
Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | QK10 | |
Subtype | B | |
Species (MHC/HLA) | human(A11, A3) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, TCR binding | |
Keywords | rate of progression, TCR usage, optimal epitope |
Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82 BRU) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B, CRF02_AG | |
Species (MHC/HLA) | human(A11, A3) | |
Immunogen | HIV-1 infection | |
Country | Cote D'Ivoire | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons |
Inwoley2005 André Inwoley, Patricia Recordon-Pinson, Marion Dupuis, Jessintha Gaston, Mathieu Genête, Albert Minga, Franck Letourneur, François Rouet, Jeannine Choppin, Hervé Fleury, Jean-Gérard Guillet, Muriel Andrieu, and ANRS 1220 PRIMO-CI Study Group. Cross-Clade Conservation of HIV Type 1 Nef Immunodominant Regions Recognized by CD8+ T Cells of HIV Type 1 CRF02\_AG-Infected Ivorian (West Africa). AIDS Res. Hum. Retroviruses, 21(7):620-628, Jul 2005. PubMed ID: 16060833. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | (A11, A3, A30) | |
Immunogen | peptide-HLA interaction | |
Experimental methods | HLA binding | |
Keywords | binding affinity, immunodominance |
Racape2006a Judith Racape, Francine Connan, Johan Hoebeke, Jeannine Choppin, and Jean-Gérard Guillet. Influence of Dominant HIV-1 Epitopes on HLA-A3/Peptide Complex Formation. Proc. Natl. Acad. Sci. U.S.A., 103(48):18208-18213, 28 Nov 2006. PubMed ID: 17116886. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82 BRU) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A11, A3, B35) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Culmann1991 B. Culmann, E. Gomard, M.-P. Kieny, B. Guy, F. Dreyfus, A.-D. Saimot, D. Sereni, D. Sicard, and J.-P. Levy. Six Epitopes with Human Cytotoxic CD8+ Cells in the Central Region of the HIV-1 Nef Protein. J. Immunol., 146:1560-1565, 1991. Nef-specific CTL were generated from six seropositive donors. Six epitopes were defined, all localized to two regions in the central part of Nef. Some epitopes could be recognized in the contexts of several HLA class I molecules. Peptides were based on BRU epitopes: QVPLRPMTYK, HLA A3, A11, B35; AAVDLSHFLKEK, HLA A11; HTQGYFPQWQ, HLA B17;TQGYFPQWQNYT, HLA B17, B37, NYTPGPGVRYPLT, HLA B7; and GVRYPLTFGWCYKLVP, HLA B18). PubMed ID: 1704397. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*11:01) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | computational epitope prediction, HLA associated polymorphism |
Almeida2011 Coral-Ann M. Almeida, Corine Bronke, Steven G. Roberts, Elizabeth McKinnon, Niamh M. Keane, Abha Chopra, Carl Kadie, Jonathan Carlson, David W. Haas, Sharon A. Riddler, Richard Haubrich, David Heckerman, Simon Mallal, and Mina John. Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts to Inflate CD8 T Cell Responses against Nef and HLA-Adapted Variant Epitopes. J. Immunol., 187(5):2502-2513, 1 Sep 2011. PubMed ID: 21821798. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef( pNL4-3) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | QK10 | |
Subtype | B | |
Species (MHC/HLA) | human(A*11:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, TCR binding | |
Keywords | assay or method development, novel epitope |
Yaciuk2014 Jane C. Yaciuk, Matthew Skaley, Wilfried Bardet, Fredda Schafer, Danijela Mojsilovic, Steven Cate, Christopher J. Stewart, Curtis McMurtrey, Kenneth W. Jackson, Rico Buchli, Alex Olvera, Samandhy Cedeño, Montserrat Plana, Beatriz Mothe, Christian Brander, John T. West, and William H. Hildebrand. Direct Interrogation of Viral Peptides Presented by the Class I HLA of HIV-Infected T Cells. J. Virol., 88(22):12992-13004, Nov 2014. PubMed ID: 25165114. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | Nef73 | |
Subtype | B | |
Species (MHC/HLA) | human(A*11:01) | |
Immunogen | HIV-1 infection | |
Country | Japan | |
Experimental methods | CD8 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining, Relative replication capacity assay, Tetramer binding | |
Keywords | rate of progression, immunodominance |
Koizumi2010 Hirokazu Koizumi, Masao Hashimoto, Mamoru Fujiwara, Hayato Murakoshi, Takayuki Chikata, Mohamed Ali Borghan, Atsuko Hachiya, Yuka Kawashima, Hiroshi Takata, Takamasa Ueno, Shinichi Oka, and Masafumi Takiguchi. Different In Vivo Effects of HIV-1 Immunodominant Epitope-Specific Cytotoxic T Lymphocytes on Selection of Escape Mutant Viruses. J. Virol., 84(11):5508-5519, Jun 2010. PubMed ID: 20335254. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Subtype | B, CRF01_AE | |
Species (MHC/HLA) | (A*11:01) | |
Immunogen | ||
Country | Thailand | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS), immunodominance, structure |
Li2004 Lenong Li and Marlene Bouvier. Structures of HLA-A*1101 Complexed with Immunodominant Nonamer and Decamer HIV-1 Epitopes Clearly Reveal the Presence of a Middle, Secondary Anchor Residue. J. Immunol., 172(10):6175-6184, 15 May 2004. PubMed ID: 15128805. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | QK10 | |
Subtype | B | |
Species (MHC/HLA) | human(A*11:01) | |
Immunogen | HIV-1 infection | |
Country | China | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Tetramer binding | |
Keywords | HAART, ART, responses in children, dendritic cells |
Zhang2006 Zheng Zhang, Qing-xia Zhao, Jun-liang Fu, Jin-xia Yao, Yun He, Lei Jin, and Fu-sheng Wang. Characteristics of HIV-1-Specific CD8 T-Cell Responses and Their Role in Loss of Viremia in Children Chronically Infected with HIV-1 Undergoing Highly Active Antiretroviral Therapy. Chin. Med. J., 119(23):1949-1957, 5 Dec 2006. PubMed ID: 17199938. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | ( LAI) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*11:01) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
BuseynePerCom1999 F. Buseyne. Personal communication, 1999. Show all entries for this paper.
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Lubaki1997 N. M. Lubaki, S. C. Ray, B. Dhruva, T. C. Quinn, R. F. Siliciano, and R. C. Bollinger. Characterization of a Polyclonal Cytolytic T Lymphocyte Response to Human Immunodeficiency Virus in Persons without Clinical Progression. J. Infect. Dis., 6:1360-1367, 1997. Five individuals were studied who survived HIV infection in good health for over 5 years. A broad polyclonal response was found to multiple proteins. PubMed ID: 9180175. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82 LAI) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B | |
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | epitope processing, escape |
Chassin1999 D. Chassin, M. Andrieu, W. Cohen, B. Culmann-Penciolelli, M. Ostankovitch, D. Hanau, and J. G. Guillet. Dendritic Cells Transfected with the nef Genes of HIV-1 Primary Isolates Specifically Activate Cytotoxic T Lymphocytes from Seropositive Subjects. Eur. J. Immunol., 29:196-202, 1999. PubMed ID: 9933101. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | subtype comparisons |
Durali1998 D. Durali, J. Morvan, F. Letourneur, D. Schmitt, N. Guegan, M. Dalod, S. Saragosti, D. Sicard, J. P. Levy, and E. Gomard. Cross-Reactions between the Cytotoxic T-Lymphocyte Responses of Human Immunodeficiency Virus-Infected African and European Patients. J. Virol., 72:3547-3553, 1998. PubMed ID: 9557634. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82 LAI) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 003: A*02, A*03, B*07, B*51; 023: A*02, A*03, B*07, B*51 | |
Experimental methods | ||
Keywords | review, escape |
Goulder1997 P. J. Goulder, A. K. Sewell, D. G. Lalloo, D. A. Price, J. A. Whelan, J. Evans, G. P. Taylor, G. Luzzi, P. Giangrande, R. E. Phillips, and A. J. McMichael. Patterns of Immunodominance in HIV-1-Specific Cytotoxic T Lymphocyte Responses in Two Human Histocompatibility Leukocyte Antigens (HLA)-Identical Siblings with HLA-A*0201 Are Influenced by Epitope Mutation. J. Exp. Med., 8:1423-1433, 1997. Primary human immunodeficiency virus (HIV) infection is controlled principally by HIV-specific cytotoxic T lymphocytes (CTL) to a steady- state level of virus load, which strongly influences the ultimate rate of progression to disease. Epitope selection by CTL may be an important determinant of the degree of immune control over the virus. This report describes the CTL responses of two HLA-identical hemophiliac brothers who were exposed to identical batches of Factor VIII and became seropositive within 10 wk of one another. Both have HLA-A*0201. The CTL responses of the two siblings were very dissimilar, one donor making strong responses to two epitopes within p17 Gag (HLA-A*0201-restricted SLYNTVATL and HLA-A3-restricted RLRPGGKKK). The sibling responded to neither epitope, but made strong responses to two epitopes presented by HLA-B7. This was not the result of differences in presentation of the epitopes. However, mutations in both immunodominant epitopes of the p17 Gag responder were seen in proviral sequences of the nonresponder. We then documented the CTL responses to two HLA-A*0201-restricted epitopes, in Gag (SLYNTVATL) and Pol (ILKEPVHGV) in 22 other HIV-infected donors with HLA-A*0201. The majority (71\%) generated responses to the Gag epitope. In the 29\% of donors failing to respond to the Gag epitope in standard assays, there was evidence of low frequency memory CTL responses using peptide stimulation of PBMC, and most of these donors also showed mutations in or around the Gag epitope. PubMed ID: 9126923. Show all entries for this paper.
Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | N1 | |
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, escape |
Samri2000 A. Samri, G. Haas, J. Duntze, J. M. Bouley, V. Calvez, C. Katlama, and B. Autran. Immunogenicity of mutations induced by nucleoside reverse transcriptase inhibitors for human immunodeficiency virus type 1-specific cytotoxic T cells. J. Virol., 74(19):9306-12, Oct 2000. URL: http://jvi.asm.org/cgi/content/full/74/19/9306. PubMed ID: 10982378. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef( SF2) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Altfeld2000 M. A. Altfeld, A. Trocha, R. L. Eldridge, E. S. Rosenberg, M. N. Phillips, M. M. Addo, R. P. Sekaly, S. A. Kalams, S. A. Burchett, K. McIntosh, B. D. Walker, and P. J. Goulder. Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay. J. Virol., 74:8541, 2000. PubMed ID: 10954555. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | A3-QK10 | |
Subtype | B | |
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A3, B7, Cw7 | |
Experimental methods | ||
Keywords | dynamics, supervised treatment interruptions (STI), acute/early infection |
Yu2002b Xu G. Yu, Marylyn M. Addo, Eric S. Rosenberg, William R. Rodriguez, Paul K. Lee, Cecily A. Fitzpatrick, Mary N. Johnston, Daryld. Strick, Philip J. R. Goulder, Bruce D. Walker, and Marcus Altfeld. Consistent Patterns in the Development and Immunodominance of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T-Cell Responses Following Acute HIV-1 Infection. J. Virol., 76(17):8690-8701, Sep 2002. PubMed ID: 12163589. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A3, B44, B64, Bw4, Bw6 | |
Experimental methods | ||
Keywords | HAART, ART |
Appay2002 Victor Appay, Pokrath Hansasuta, Julian Sutton, Rachel D. Schrier, Joseph K. Wong, Manohar Furtado, Diane V. Havlir, Steven M. Wolinsky, Andrew J. McMichael, Douglas D. Richman, Sarah L. Rowland-Jones, and Celsa A. Spina. Persistent HIV-1-Specific Cellular Responses Despite Prolonged Therapeutic Viral Suppression. AIDS, 16(2):161-170, 25 Jan 2002. PubMed ID: 11807299. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A1, A3, B14, B7, C*07:02, C*08:02 | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | binding affinity, acute/early infection, early-expressed proteins |
Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A3, A32, B15, B51, C*03, Cw6, DQ7, DR4, DR8 | |
Country | Netherlands | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, escape |
Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Country | Netherlands | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | HIV exposed persistently seronegative (HEPS) |
Koning2004 Fransje A. Koning, Christine A. Jansen, Jos Dekker, Richard A. Kaslow, Nicole Dukers, Debbie van Baarle, Maria Prins, and Hanneke Schuitemaker. Correlates of Resistance to HIV-1 Infection in Homosexual Men with High-Risk Sexual Behaviour. AIDS, 18(8):1117-1126, 21 May 2004. PubMed ID: 15166527. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | ( B consensus) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | QK10 | |
Subtype | B | |
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A3, B14, B60, Cw3, Cw7; A1, A3, B14, B8, Cw7, Cw8 | |
Experimental methods | Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | assay or method development, memory cells, characterizing CD8+ T cells |
Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A2, A3, B44, B7 | |
Country | United States | |
Experimental methods | Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | HAART, ART, escape, variant cross-reactivity |
Casazza2005a Joseph P. Casazza, Michael R. Betts, Brenna J. Hill, Jason M. Brenchley, David A. Price, Daniel C. Douek, and Richard A. Koup. Immunologic Pressure within Class I-Restricted Cognate Human Immunodeficiency Virus Epitopes during Highly Active Antiretroviral Therapy. J. Virol., 79(6):3653-3663, Mar 2005. PubMed ID: 15731259. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | C | |
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*03:01, A*74:01, B*15:10, B*35:01, C*04:01; A*03:01, A*68, B*07:02, B*15:10, C*04:01, C*07:02 | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | responses in children, mother-to-infant transmission, escape, acute/early infection |
Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | A3-QK10(Nef) | |
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A3) | |
Immunogen | HIV-1 infection, vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | vaccine-induced immune responses, characterizing CD8+ T cells |
Vaccine type | canarypox, canarypox prime with recombinant protein boost |
---|---|
Vaccine strain | B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen |
Vaccine component | Gag, gp120, gp41, Nef, Pol, Protease |
Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | QK10 | |
Species (MHC/HLA) | human(A*33) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | QK10 | |
Species (MHC/HLA) | human(A*34) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(94-103) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human(A3 supertype) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | supertype, rate of progression |
Propato2001 A. Propato, E. Schiaffella, E. Vicenzi, V. Francavilla, L. Baloni, M. Paroli, L. Finocchi, N. Tanigaki, S. Ghezzi, R. Ferrara, R. Chesnut, B. Livingston, A. Sette, R. Paganelli, F. Aiuti, G. Poli, and V. Barnaba. Spreading of HIV-specific CD8+ T-cell repertoire in long-term nonprogressors and its role in the control of viral load and disease activity. Hum. Immunol., 62(6):561-76, Jun 2001. PubMed ID: 11390031. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | QK10 | |
Species (MHC/HLA) | human(A*66) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*08) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | computational epitope prediction, HLA associated polymorphism |
Almeida2011 Coral-Ann M. Almeida, Corine Bronke, Steven G. Roberts, Elizabeth McKinnon, Niamh M. Keane, Abha Chopra, Carl Kadie, Jonathan Carlson, David W. Haas, Sharon A. Riddler, Richard Haubrich, David Heckerman, Simon Mallal, and Mina John. Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts to Inflate CD8 T Cell Responses against Nef and HLA-Adapted Variant Epitopes. J. Immunol., 187(5):2502-2513, 1 Sep 2011. PubMed ID: 21821798. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82 LAI) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B27) | |
Immunogen | ||
Experimental methods | ||
Keywords |
CulmannPerCom B. Culmann. Personal communication, 1998. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | QK10 | |
Species (MHC/HLA) | human(B*35:02, B*35:03, B*53:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | QK10 | |
Species (MHC/HLA) | human(B8) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Proliferation, Tetramer binding | |
Keywords | immunodominance, acute/early infection, characterizing CD8+ T cells |
Lichterfeld2004 Mathias Lichterfeld, Daniel E. Kaufmann, Xu G. Yu, Stanley K. Mui, Marylyn M. Addo, Mary N. Johnston, Daniel Cohen, Gregory K. Robbins, Eunice Pae, Galit Alter, Alysse Wurcel, David Stone, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. Loss of HIV-1-Specific CD8+ T Cell Proliferation after Acute HIV-1 Infection and Restoration by Vaccine-Induced HIV-1-Specific CD4+ T Cells. J. Exp. Med., 200(6):701-12, Sep 20 2004. PubMed ID: 15381726. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other | |
Keywords | binding affinity, acute/early infection |
Lichterfeld2007 Mathias Lichterfeld, Xu G. Yu, Stanley K. Mui, Katie L. Williams, Alicja Trocha, Mark A. Brockman, Rachel L. Allgaier, Michael T. Waring, Tomohiko Koibuchi, Mary N. Johnston, Daniel Cohen, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. Selective Depletion of High-Avidity Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T Cells after Early HIV-1 Infection. J. Virol., 81(8):4199-4214, Apr 2007. PubMed ID: 17287271. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Garcia1997 S. Garcia, M. Fevrier, G. Dadaglio, H. Lecoeur, Y. Riviere, and M.-L. Gougeon. Potential Deleterious Effect of Anti-Viral Cytotoxic Lymphocyte through the CD95 (FAS/APO-1)-Mediated Pathway during Chronic HIV Infection. Immunol. Lett., 57:53-58, 1997. PubMed ID: 9232425. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(73-82) DNA(9013..9042) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(73-82) | |
Epitope |
QVPLRPMTYK
|
Epitope Alignment
|
Epitope Name | QK10 | |
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | AC1: A*02:01, A*30:01, B*37:01, B*38:01, C*06:02, C*12:03; VP1: A*02:01, A*03:01, B*41:01, B*52:01, C*03:03, C*17:01 | |
Country | United States | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | NK cells, transmission pair |
Walker-Sperling2017 Victoria E. Walker-Sperling, Christopher W. Pohlmeyer, Rebecca T. Veenhuis, Megan May, Krystle A. Luna, Allison R. Kirkpatrick, Oliver Laeyendecker, Andrea L. Cox, Mary Carrington, Justin R. Bailey, Roberto C. Arduino, and Joel N. Blankson. Factors Associated with the Control of Viral Replication and Virologic Breakthrough in a Recently Infected HIV-1 Controller. EBioMedicine, 16:141-149, Feb 2017. PubMed ID: 28159573. Show all entries for this paper.