HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 6 matching records:

Displaying record number 58405

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HXB2 Location Nef(73-81)
DNA(9013..9039)
Nef Epitope Map
Author Location Nef
Epitope QVPLRPMTY Epitope Alignment
QVPLRPMTY epitope logo
Epitope Name Nef073
Subtype B, CRF02_AG
Species (MHC/HLA) human(A1)
Immunogen HIV-1 infection
Country Cote D'Ivoire, Denmark, Ghana, Guinea-Bissau, Mali, Senegal
Experimental methods Intracellular cytokine staining, Pentamer labeling
Keywords vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.

Vinner2011 Lasse Vinner, Birgitta Holmgren, Kristoffer J. Jensen, Joakim Esbjornsson, Marie Borggren, Julie L. Hentze, Ingrid Karlsson, Betina S. Andresen, Gregers J. Gram, Henrik Kloverpris, Peter Aaby, Zacarias José Da Silva, Eva-Maria Fenyö, and Anders Fomsgaard. Sequence Analysis of HIV-1 Isolates from Guinea-Bissau: Selection of Vaccine Epitopes Relevant in Both West African and European Countries. APMIS, 119(8):487-497, Aug 2011. PubMed ID: 21749448. Show all entries for this paper.


Displaying record number 61956

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HXB2 Location Nef(73-81)
DNA(9013..9039)
Nef Epitope Map
Author Location Nef(73-)
Epitope QVPLRPMTY Epitope Alignment
QVPLRPMTY epitope logo
Epitope Name QY9
Subtype A3, B, C, CRF02_AG
Species (MHC/HLA) human(A*80:01)
Immunogen HIV-1 infection
Patient MHC/HLA 1213: A*30:01, A*30:02, B*07:02, B*58:01
Country Denmark, Guinea-Bissau
Experimental methods HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords binding affinity, vaccine antigen design

Notes

References

Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.


Displaying record number 59004

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HXB2 Location Nef(73-81)
DNA(9013..9039)
Nef Epitope Map
Author Location Nef(73-)
Epitope QVPLRPMTY Epitope Alignment
QVPLRPMTY epitope logo
Epitope Name Nef73
Subtype A
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA P2: A*68:02, A*74:01, B*35:01, B*53:01; P15: A*23:01, A*31:01, B*35:01, B*41:02; P21: A*02:02, A*23:01, B*14:01, B*35:01
Country Guinea-Bissau
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses, vaccine antigen design, therapeutic vaccine, chronic infection

Vaccine Details

Vaccine type peptide
Vaccine strain A clade
Adjuvant CAF01

Notes

References

Roman2013 Victor Raúl Gómez Román, Kristoffer Jarlov Jensen, Sanne Skov Jensen, Christian Leo-Hansen, Sanne Jespersen, David da Silva Té, Candida Medina Rodrigues, Christoph Mikkel Janitzek, Lasse Vinner, Terese Lea Katzenstein, Peter Andersen, Ingrid Kromann, Lars Vibe Andreasen, Ingrid Karlsson, and Anders Fomsgaard. Therapeutic Vaccination Using Cationic Liposome-Adjuvanted HIV Type 1 Peptides Representing HLA-Supertype-Restricted Subdominant T Cell Epitopes: Safety, Immunogenicity, and Feasibility in Guinea-Bissau. AIDS Res Hum Retroviruses, 29(11):1504-1512, Nov 2013. PubMed ID: 23634822. Show all entries for this paper.


Displaying record number 59126

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HXB2 Location Nef(73-81)
DNA(9013..9039)
Nef Epitope Map
Author Location Nef(73-81 NL4.3)
Epitope QVPLRPMTY Epitope Alignment
QVPLRPMTY epitope logo
Epitope Name QY9
Subtype B
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infected monocyte-derived
Country United States
Experimental methods Chromium-release assay, Other
Keywords epitope processing, dendritic cells

Notes

References

Dinter2014 Jens Dinter, Pauline Gourdain, Nicole Y. Lai, Ellen Duong, Edith Bracho-Sanchez, Marijana Rucevic, Paul H. Liebesny, Yang Xu, Mariko Shimada, Musie Ghebremichael, Daniel G. Kavanagh, and Sylvie Le Gall. Different Antigen-Processing Activities in Dendritic Cells, Macrophages, and Monocytes Lead to Uneven Production of HIV Epitopes and Affect CTL Recognition. J. Immunol., 193(9):4322-4334, 1 Nov 2014. PubMed ID: 25230751. Show all entries for this paper.


Displaying record number 56481

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HXB2 Location Nef(73-81)
DNA(9013..9039)
Nef Epitope Map
Author Location Nef
Epitope QVPLRPMTY Epitope Alignment
QVPLRPMTY epitope logo
Subtype C
Species (MHC/HLA) human(B*35:01)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords viral fitness and reversion, HLA associated polymorphism

Notes

References

Matthews2008 Philippa C. Matthews, Andrew Prendergast, Alasdair Leslie, Hayley Crawford, Rebecca Payne, Christine Rousseau, Morgane Rolland, Isobella Honeyborne, Jonathan Carlson, Carl Kadie, Christian Brander, Karen Bishop, Nonkululeko Mlotshwa, James I. Mullins, Hoosen Coovadia, Thumbi Ndung'u, Bruce D. Walker, David Heckerman, and Philip J. R. Goulder. Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point. J. Virol., 82(17):8548-8559, Sep 2008. PubMed ID: 18596105. Show all entries for this paper.


Displaying record number 57494

Download this epitope record as JSON.

HXB2 Location Nef(73-81)
DNA(9013..9039)
Nef Epitope Map
Author Location Nef(73-81)
Epitope QVPLRPMTY Epitope Alignment
QVPLRPMTY epitope logo
Show epitope variants
Epitope Name QY9
Subtype B, C, D
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Finland, Sweden, Uganda
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords variant cross-reactivity

Notes

References

Hoof2010 Ilka Hoof, Carina L. Pérez, Marcus Buggert, Rasmus K. L. Gustafsson, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Interdisciplinary Analysis of HIV-Specific CD8+ T Cell Responses against Variant Epitopes Reveals Restricted TCR Promiscuity. J Immunol, 184(9):5383-5391, 1 May 2010. PubMed ID: 20363973. Show all entries for this paper.


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