HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 15 matching records:

Displaying record number 56753

Download this epitope record as JSON.

HXB2 Location Pol(424-432)
RT(269-277)
DNA(3354..3380)
Pol Epitope Map
Author Location RT
Epitope QIYAGIKVK Epitope Alignment
QIYAGIKVK epitope logo
Show epitope variants
Subtype CRF02_AG
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Patient MHC/HLA MM12: A*03, A*68, B*07, B*44, C*07, C*07
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Other, Peptide titration, Tetramer binding
Keywords dynamics, escape, acute/early infection, optimal epitope

Notes

References

Turnbull2009 Emma L. Turnbull, MaiLee Wong, Shuyi Wang, Xiping Wei, Nicola A. Jones, Karen E. Conrod, Diana Aldam, Jo Turner, Pierre Pellegrino, Brandon F. Keele, Ian Williams, George M. Shaw, and Persephone Borrow. Kinetics of Expansion of Epitope-Specific T Cell Responses During primary HIV-1 Infection. J. Immunol., 182(11):7131-7145, 1 Jun 2009. PubMed ID: 19454710. Show all entries for this paper.


Displaying record number 60064

Download this epitope record as JSON.

HXB2 Location Pol(424-432)
RT(269-277)
DNA(3354..3380)
Pol Epitope Map
Author Location Pol(424-432)
Epitope QIYAGIKVK Epitope Alignment
QIYAGIKVK epitope logo
Epitope Name QVK9
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60986

Download this epitope record as JSON.

HXB2 Location Pol(424-432)
RT(269-277)
DNA(3354..3380)
Pol Epitope Map
Author Location RT(269-277)
Epitope QIYAGIKVK Epitope Alignment
QIYAGIKVK epitope logo
Subtype B
Species (MHC/HLA) human(A*03, A*11:01)
Immunogen HIV-1 infection
Patient MHC/HLA 51314: A*03:01, A*11:01, B*35:03, B*53:01, C*04:01, C*04:01
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 61165

Download this epitope record as JSON.

HXB2 Location Pol(424-432)
RT(269-277)
DNA(3354..3380)
Pol Epitope Map
Author Location Pol(424-432)
Epitope QIYAGIKVK Epitope Alignment
QIYAGIKVK epitope logo
Show epitope variants
Epitope Name QK9
Subtype B
Species (MHC/HLA) human(A*03:01)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords acute/early infection, variant cross-reactivity

Notes

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61133

Download this epitope record as JSON.

HXB2 Location Pol(424-432)
RT(269-277)
DNA(3354..3380)
Pol Epitope Map
Author Location Pol
Epitope QIYAGIKVK Epitope Alignment
QIYAGIKVK epitope logo
Show epitope variants
Epitope Name QK9
Subtype C
Species (MHC/HLA) human(A*03:01)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining, Other
Keywords escape, mutation acquisition, HLA associated polymorphism

Notes

References

Carlson2016 Jonathan M. Carlson, Victor Y. Du, Nico Pfeifer, Anju Bansal, Vincent Y. F. Tan, Karen Power, Chanson J. Brumme, Anat Kreimer, Charles E. DeZiel, Nicolo Fusi, Malinda Schaefer, Mark A. Brockman, Jill Gilmour, Matt A. Price, William Kilembe, Richard Haubrich, Mina John, Simon Mallal, Roger Shapiro, John Frater, P. Richard Harrigan, Thumbi Ndung'u, Susan Allen, David Heckerman, John Sidney, Todd M. Allen, Philip J. R. Goulder, Zabrina L. Brumme, Eric Hunter, and Paul A. Goepfert. Impact of Pre-Adapted HIV Transmission. Nat. Med., 22(6):606-613, Jun 2016. PubMed ID: 27183217. Show all entries for this paper.


Displaying record number 59294

Download this epitope record as JSON.

HXB2 Location Pol(424-432)
RT(269-277)
DNA(3354..3380)
Pol Epitope Map
Author Location RT
Epitope QIYAGIKVK Epitope Alignment
QIYAGIKVK epitope logo
Epitope Name QVK9
Species (MHC/HLA) human(A*11)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression

Notes

References

Streeck2014 Hendrik Streeck, Richard Lu, Noor Beckwith, Mark Milazzo, Michelle Liu, Jean-Pierre Routy, Susan Little, Heiko Jessen, Anthony D. Kelleher, Frederick Hecht, Rafick-Pierre Sekaly, Galit Alter, David Heckerman, Mary Carrington, Eric S. Rosenberg, and Marcus Altfeld. Emergence of Individual HIV-Specific CD8 T Cell Responses during Primary HIV-1 Infection Can Determine Long-Term Disease Outcome. J. Virol., 88(21):12793-12801, Nov 2014. PubMed ID: 25165102. Show all entries for this paper.


Displaying record number 60065

Download this epitope record as JSON.

HXB2 Location Pol(424-432)
RT(269-277)
DNA(3354..3380)
Pol Epitope Map
Author Location Pol(424-432)
Epitope QIYAGIKVK Epitope Alignment
QIYAGIKVK epitope logo
Epitope Name QVK9
Species (MHC/HLA) human(A*11)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 53480

Download this epitope record as JSON.

HXB2 Location Pol(424-432)
RT(269-277)
DNA(3354..3380)
Pol Epitope Map
Author Location Pol(425-433)
Epitope QIYAGIKVK Epitope Alignment
QIYAGIKVK epitope logo
Epitope Name QK9
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A2, B18, B44, C*12, Cw5
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords  

Notes

References

Allen2005 Todd M. Allen, Xu G. Yu, Elizabeth T. Kalife, Laura L. Reyor, Mathias Lichterfeld, Mina John, Michael Cheng, Rachel L. Allgaier, Stanley Mui, Nicole Frahm, Galit Alter, Nancy V. Brown, Mary N. Johnston, Eric S. Rosenberg, Simon A. Mallal, Christian Brander, Bruce D. Walker, and Marcus Altfeld. De Novo Generation of Escape Variant-Specific CD8+ T-Cell Responses Following Cytotoxic T-Lymphocyte Escape in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(20):12952-12960, Oct 2005. PubMed ID: 16188997. Show all entries for this paper.


Displaying record number 55926

Download this epitope record as JSON.

HXB2 Location Pol(424-432)
RT(269-277)
DNA(3354..3380)
Pol Epitope Map
Author Location RT
Epitope QIYAGIKVK Epitope Alignment
QIYAGIKVK epitope logo
Epitope Name QK9(RT)
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords chronic infection

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 53559

Download this epitope record as JSON.

HXB2 Location Pol(424-432)
RT(269-277)
DNA(3354..3380)
Pol Epitope Map
Author Location Pol(425-433)
Epitope QIYAGIKVK Epitope Alignment
QIYAGIKVK epitope logo
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A2, B18, B44, C*12, Cw5
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 53351

Download this epitope record as JSON.

HXB2 Location Pol(424-432)
RT(269-277)
DNA(3354..3380)
Pol Epitope Map
Author Location ( B consensus)
Epitope QIYAGIKVK Epitope Alignment
QIYAGIKVK epitope logo
Epitope Name QVK9
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A2, B18, B44, C*12, Cw5
Country United States
Experimental methods Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords assay or method development, memory cells, characterizing CD8+ T cells

Notes

References

Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.


Displaying record number 52100

Download this epitope record as JSON.

HXB2 Location Pol(424-432)
RT(269-277)
DNA(3354..3380)
Pol Epitope Map
Author Location Pol(424-432)
Epitope QIYAGIKVK Epitope Alignment
QIYAGIKVK epitope logo
Show epitope variants
Subtype B, CRF01_AE
Species (MHC/HLA) human(A*11:01)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, subtype comparisons

Notes

References

Fukada2002 Katsuhiko Fukada, Hiroko Tomiyama, Chantapong Wasi, Tomoko Matsuda, Shigeru Kusagawa, Hironori Sato, Shinichi Oka, Yutaka Takebe, and Masafumi Takiguchi. Cytotoxic T-cell Recognition of HIV-1 Cross-Clade and Clade-Specific Epitopes in HIV-1-Infected Thai and Japanese Patients. AIDS, 16(5):701-711, 29 Mar 2002. PubMed ID: 11964526. Show all entries for this paper.


Displaying record number 52821

Download this epitope record as JSON.

HXB2 Location Pol(424-432)
RT(269-277)
DNA(3354..3380)
Pol Epitope Map
Author Location RT(269-277)
Epitope QIYAGIKVK Epitope Alignment
QIYAGIKVK epitope logo
Show epitope variants
Epitope Name A3-QR9 Pol
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supervised treatment interruptions (STI), escape, early treatment, superinfection

Notes

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.


Displaying record number 60066

Download this epitope record as JSON.

HXB2 Location Pol(424-432)
RT(269-277)
DNA(3354..3380)
Pol Epitope Map
Author Location Pol(424-432)
Epitope QIYAGIKVK Epitope Alignment
QIYAGIKVK epitope logo
Epitope Name QVK9
Species (MHC/HLA) human(B*54)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60063

Download this epitope record as JSON.

HXB2 Location Pol(424-432)
RT(269-277)
DNA(3354..3380)
Pol Epitope Map
Author Location Pol(424-432)
Epitope QIYAGIKVK Epitope Alignment
QIYAGIKVK epitope logo
Epitope Name QVK9
Species (MHC/HLA) human(C*14)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health