HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 6 matching records:

Displaying record number 61960

HXB2 Location Nef(107-115)
DNA(9115..9141)
Nef Epitope Map
Author Location Nef(107-)
Epitope QEILDLWVY Epitope Alignment
QEILDLWVY epitope logo
Epitope Name QY9
Subtype A3 (CRF02_AG+C), B
Species (MHC/HLA) human(B*1801, B*4402)
Immunogen HIV-1 infection
Patient MHC/HLA 1108: ; 1115: A*0201, A*6801, B*5001, B*5801
Country Denmark, Guinea-Bissau
Experimental methods HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords binding affinity, vaccine antigen design

Notes

References

Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.


Displaying record number 58422

HXB2 Location Nef(107-115)
DNA(9115..9141)
Nef Epitope Map
Author Location Nef
Epitope QEILDLWVY Epitope Alignment
QEILDLWVY epitope logo
Epitope Name Nef107
Subtype B, CRF02_AG
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Country Cote D'Ivoire, Denmark, Ghana, Guinea-Bissau, Mali, Senegal
Experimental methods Intracellular cytokine staining, Pentamer labeling
Keywords vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.

Vinner2011 Lasse Vinner, Birgitta Holmgren, Kristoffer J. Jensen, Joakim Esbjornsson, Marie Borggren, Julie L. Hentze, Ingrid Karlsson, Betina S. Andresen, Gregers J. Gram, Henrik Kloverpris, Peter Aaby, Zacarias José Da Silva, Eva-Maria Fenyö, and Anders Fomsgaard. Sequence Analysis of HIV-1 Isolates from Guinea-Bissau: Selection of Vaccine Epitopes Relevant in Both West African and European Countries. APMIS, 119(8):487-497, Aug 2011. PubMed ID: 21749448. Show all entries for this paper.


Displaying record number 59008

HXB2 Location Nef(107-115)
DNA(9115..9141)
Nef Epitope Map
Author Location Nef(592-)
Epitope QEILDLWVY Epitope Alignment
QEILDLWVY epitope logo
Epitope Name Nef107
Subtype A
Species (MHC/HLA) human(B*44)
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA P5: A*2601, A*3303, B*0801, B*4403; P17: A*0201, A*6801, B*5001, B*5801
Country Guinea-Bissau
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type peptide
Vaccine strain A clade
Adjuvant CAF01

Notes

References

Roman2013 Victor Raúl Gómez Román, Kristoffer Jarlov Jensen, Sanne Skov Jensen, Christian Leo-Hansen, Sanne Jespersen, David da Silva Té, Candida Medina Rodrigues, Christoph Mikkel Janitzek, Lasse Vinner, Terese Lea Katzenstein, Peter Andersen, Ingrid Kromann, Lars Vibe Andreasen, Ingrid Karlsson, and Anders Fomsgaard. Therapeutic Vaccination Using Cationic Liposome-Adjuvanted HIV Type 1 Peptides Representing HLA-Supertype-Restricted Subdominant T Cell Epitopes: Safety, Immunogenicity, and Feasibility in Guinea-Bissau. AIDS Res Hum Retroviruses, 29(11):1504-1512, Nov 2013. PubMed ID: 23634822. Show all entries for this paper.


Displaying record number 61767

HXB2 Location Nef(107-115)
DNA(9115..9141)
Nef Epitope Map
Author Location Nef(107-115)
Epitope QEILDLWVY Epitope Alignment
QEILDLWVY epitope logo
Epitope Name QY9
Species (MHC/HLA) human(B*4402, B*4403)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 55481

HXB2 Location Nef(107-115)
DNA(9115..9141)
Nef Epitope Map
Author Location Nef
Epitope QEILDLWVY Epitope Alignment
QEILDLWVY epitope logo
Subtype A1, B, C, CRF01_AE
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, computational epitope prediction, vaccine antigen design, HLA associated polymorphism

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.


Displaying record number 57496

HXB2 Location Nef(107-115)
DNA(9115..9141)
Nef Epitope Map
Author Location Nef(107-115)
Epitope QEILDLWVY Epitope Alignment
QEILDLWVY epitope logo
Show epitope variants
Epitope Name QY9
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords variant cross-reactivity

Notes

References

Hoof2010 Ilka Hoof, Carina L. Pérez, Marcus Buggert, Rasmus K. L. Gustafsson, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Interdisciplinary Analysis of HIV-Specific CD8+ T Cell Responses against Variant Epitopes Reveals Restricted TCR Promiscuity. J Immunol, 184(9):5383-5391, 1 May 2010. PubMed ID: 20363973. Show all entries for this paper.


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