HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 11 matching records:

Displaying record number 53978

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HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location ( C consensus)
Epitope QATQDVKNW Epitope Alignment
QATQDVKNW epitope logo
Subtype C
Species (MHC/HLA) human(B*53:01)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 57777

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HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag(308-316)
Epitope QATQDVKNW Epitope Alignment
QATQDVKNW epitope logo
Epitope Name QW9
Subtype C
Species (MHC/HLA) human(B*57, B*58:01)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Relative replication capacity assay
Keywords responses in children, rate of progression

Notes

References

Prado2010 Julia G. Prado, Andrew Prendergast, Christina Thobakgale, Claudia Molina, Gareth Tudor-Williams, Thumbi Ndung'u, Bruce D. Walker, and Philip Goulder. Replicative Capacity of Human Immunodeficiency Virus Type 1 Transmitted from Mother to Child Is Associated with Pediatric Disease Progression Rate. J. Virol., 84(1):492-502, Jan 2010. PubMed ID: 19828603. Show all entries for this paper.


Displaying record number 61622

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HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location p24
Epitope QATQDVKNW Epitope Alignment
QATQDVKNW epitope logo
Show epitope variants
Epitope Name B*5801-QW9, B*57-QW9
Subtype C
Species (MHC/HLA) human(B*57, B*58:01)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords elite controllers

Notes

References

Koofhethile2016 Catherine K. Koofhethile, Zaza M. Ndhlovu, Christina Thobakgale-Tshabalala, Julia G. Prado, Nasreen Ismail, Zenele Mncube, Lungile Mkhize, Mary van der Stok, Nonhlanhla Yende, Bruce D. Walker, Philip J. R. Goulder, and Thumbi Ndung'u. CD8+ T Cell Breadth and Ex Vivo Virus Inhibition Capacity Distinguish between Viremic Controllers with and without Protective HLA Class I Alleles. J. Virol., 90(15):6818-6831, 1 Aug 2016. PubMed ID: 27194762. Show all entries for this paper.


Displaying record number 57686

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HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location  
Epitope QATQDVKNW Epitope Alignment
QATQDVKNW epitope logo
Epitope Name QW9
Subtype C
Species (MHC/HLA) human(B*57, B*58:01)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords immunodominance, characterizing CD8+ T cells

Notes

References

Mkhwanazi2010 Nompumelelo Mkhwanazi, Christina F. Thobakgale, Mary van der Stok, Shabashini Reddy, Zenele Mncube, Fundisiwe Chonco, Bruce D. Walker, Marcus Altfeld, Philip J. R. Goulder, and Thumbi Ndung'u. Immunodominant HIV-1-Specific HLA-B- and HLA-C-Restricted CD8+ T Cells Do Not Differ in Polyfunctionality. Virology, 405(2):483-491, 30 Sep 2010. PubMed ID: 20638093. Show all entries for this paper.


Displaying record number 53638

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HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location p24(308-316)
Epitope QATQDVKNW Epitope Alignment
QATQDVKNW epitope logo
Epitope Name QW9
Subtype C
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country Ethiopia
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords immunodominance, escape, variant cross-reactivity

Notes

References

Currier2005 Jeffrey R. Currier, Matthew E. Harris, Josephine H. Cox, Francine E. McCutchan, Deborah L. Birx, Shlomo Maayan, and Guido Ferrari. Immunodominance and Cross-Reactivity of B5703-Restricted CD8 T Lymphocytes from HIV Type 1 Subtype C-Infected Ethiopians. AIDS Res. Hum. Retroviruses, 21(3):239-245, Mar 2005. PubMed ID: 15795531. Show all entries for this paper.


Displaying record number 58690

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HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag(308-316)
Epitope QATQDVKNW Epitope Alignment
QATQDVKNW epitope logo
Show epitope variants
Epitope Name QW9
Subtype C
Species (MHC/HLA) human(B*57:02, B*57:03, B*58:01)
Immunogen HIV-1 infection
Country Botswana, South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords HLA associated polymorphism

Notes

References

Kloverpris2012 Henrik N. Kloverpris, Anette Stryhn, Mikkel Harndahl, Mary van der Stok, Rebecca P. Payne, Philippa C. Matthews, Fabian Chen, Lynn Riddell, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HLA-B*57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control. J. Virol., 86(2):919-929, Jan 2012. PubMed ID: 22090105. Show all entries for this paper.


Displaying record number 61216

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HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag
Epitope QATQDVKNW Epitope Alignment
QATQDVKNW epitope logo
Show epitope variants
Epitope Name QW9
Subtype B
Species (MHC/HLA) human(B*57:02, B*57:03, B*58:01)
Immunogen HIV-1 infection
Experimental methods Other
Keywords review, escape, HLA associated polymorphism

Notes

References

Kloverpris2015a Henrik N. Kløverpris, Alasdair Leslie, and Philip Goulder. Role of HLA Adaptation in HIV Evolution. Front. Immunol., 6:665, 18 Jan 2016. PubMed ID: 26834742. Show all entries for this paper.


Displaying record number 61677

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HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag(308-316)
Epitope QATQDVKNW Epitope Alignment
QATQDVKNW epitope logo
Show epitope variants
Epitope Name Gag-QW9
Subtype C
Species (MHC/HLA) human(B*58:01)
Immunogen HIV-1 infection
Country Botswana, South Africa, United Kingdom, Zimbabwe
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HLA associated polymorphism

Notes

References

Carlson2012 Jonathan M. Carlson, Jennifer Listgarten, Nico Pfeifer, Vincent Tan, Carl Kadie, Bruce D. Walker, Thumbi Ndung'u, Roger Shapiro, John Frater, Zabrina L. Brumme, Philip J. R. Goulder, and David Heckerman. Widespread Impact of HLA Restriction on Immune Control and Escape Pathways of HIV-1. J. Virol., 86(9):5230-5243, May 2012. PubMed ID: 22379086. Show all entries for this paper.


Displaying record number 56475

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HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location p24
Epitope QATQDVKNW Epitope Alignment
QATQDVKNW epitope logo
Subtype C
Species (MHC/HLA) human(B*58:01)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords viral fitness and reversion, HLA associated polymorphism

Notes

References

Matthews2008 Philippa C. Matthews, Andrew Prendergast, Alasdair Leslie, Hayley Crawford, Rebecca Payne, Christine Rousseau, Morgane Rolland, Isobella Honeyborne, Jonathan Carlson, Carl Kadie, Christian Brander, Karen Bishop, Nonkululeko Mlotshwa, James I. Mullins, Hoosen Coovadia, Thumbi Ndung'u, Bruce D. Walker, David Heckerman, and Philip J. R. Goulder. Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point. J. Virol., 82(17):8548-8559, Sep 2008. PubMed ID: 18596105. Show all entries for this paper.


Displaying record number 56596

Download this epitope record as JSON.

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location p24(308-316)
Epitope QATQDVKNW Epitope Alignment
QATQDVKNW epitope logo
Epitope Name QW9
Subtype C
Species (MHC/HLA) human(B*58:01)
Immunogen HIV-1 infection
Country South Africa, Zambia
Experimental methods  
Keywords viral fitness and reversion, HLA associated polymorphism

Notes

References

Goepfert2008 Paul A. Goepfert, Wendy Lumm, Paul Farmer, Philippa Matthews, Andrew Prendergast, Jonathan M. Carlson, Cynthia A. Derdeyn, Jianming Tang, Richard A. Kaslow, Anju Bansal, Karina Yusim, David Heckerman, Joseph Mulenga, Susan Allen, Philip J. R. Goulder, and Eric Hunter. Transmission of HIV-1 Gag Immune Escape Mutations Is Associated with Reduced Viral Load in Linked Recipients. J. Exp. Med., 205(5):1009-1017, 12 May 2008. PubMed ID: 18426987. Show all entries for this paper.


Displaying record number 53337

Download this epitope record as JSON.

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location ( C consensus)
Epitope QATQDVKNW Epitope Alignment
QATQDVKNW epitope logo
Subtype C
Species (MHC/HLA) human(B*58:01)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords characterizing CD8+ T cells

Notes

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.


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