HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 52 matching records:

Displaying record number 60056

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag(308-316)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name QW9
Species (MHC/HLA) human(B*3501, B*3508)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 1319

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location p24( NL43)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name QW9
Species (MHC/HLA) human(B53)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords epitope processing, dendritic cells

Notes

References

Buseyne2001 F. Buseyne, S. Le Gall, C. Boccaccio, J. P. Abastado, J. D. Lifson, L. O. Arthur, Y. Riviere, J. M. Heard, and O. Schwartz. MHC-I-restricted presentation of HIV-1 virion antigens without viral replication. Nat. Med., 7(3):344-9, Mar 2001. PubMed ID: 11231634. Show all entries for this paper.


Displaying record number 57109

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag(176-184 consensus)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name QW9
Subtype B
Species (MHC/HLA) human(B53)
Immunogen HIV-1 infection
Patient MHC/HLA A*6801, A*6802, B*5101, B*5301, Cw*0401, Cw*1502
Country Spain
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Dalmau2009 Judith Dalmau, Maria Carmen Puertas, Marta Azuara, Ana Mariño, Nicole Frahm, Beatriz Mothe, Nuria Izquierdo-Useros, Maria José Buzón, Roger Paredes, Lourdes Matas, Todd M. Allen, Christian Brander, Carlos Rodrigo, Bonaventura Clotet, and Javier Martinez-Picado. Contribution of Immunological and Virological Factors to Extremely Severe Primary HIV Type 1 Infection. Clin. Infect. Dis., 48(2):229-238, 15 Jan 2009. PubMed ID: 19093810. Show all entries for this paper.


Displaying record number 342

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location p24(308-316 LAI)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Subtype B
Species (MHC/HLA) human(B53)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Buseyne1997 F. Buseyne, S. Stevanovic, H. Rammensee, and Y. Riviere. Characterization of an HIV-1 p24 Gag Epitope Recognized by a CD8+ Cytotoxic T Cell Clone. Immunol. Lett., 55(3):145-149, 1997. PubMed ID: 9161880. Show all entries for this paper.


Displaying record number 54377

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location p24
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name B53-QW9(p24)
Species (MHC/HLA) human(B53)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 55045

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location  
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Species (MHC/HLA) human(B53, B57, Cw4)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, immunodominance, optimal epitope

Notes

References

Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.


Displaying record number 55208

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location  
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Species (MHC/HLA) human(B53, B57, Cw4)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supertype, HLA cross-presentation, optimal epitope

Notes

References

Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.


Displaying record number 52923

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag(304-321 B con)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name QW9
Subtype B
Species (MHC/HLA) human(B53, B58)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords variant cross-reactivity

Notes

References

Draenert2004b R. Draenert, C. L. Verrill, Y. Tang, T. M. Allen, A. G. Wurcel, M. Boczanowski, A. Lechner, A. Y. Kim, T. Suscovich, N. V. Brown, M. M. Addo, and B. D. Walker. Persistent Recognition of Autologous Virus by High-Avidity CD8 T Cells in Chronic, Progressive Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(2):630-641, Jan 2004. PubMed ID: 14694094. Show all entries for this paper.


Displaying record number 57838

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location p24
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name QW9
Subtype B
Species (MHC/HLA) human(B53, B58)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, TCR binding
Keywords rate of progression, TCR usage, optimal epitope

Notes

References

Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.


Displaying record number 53714

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag(308-316)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name QAS
Species (MHC/HLA) human(B*5801, B53)
Immunogen HIV-1 infection
Country Gambia
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords HLA cross-presentation, characterizing CD8+ T cells, HIV-2

Notes

References

Gillespie2005a Geraldine M. A. Gillespie, Susana Pinheiro, Mohammad Sayeid-Al-Jamee, Abraham Alabi, Steve Kaye, Sehu Sabally, Ramu Sarge-Njie, Harr Njai, Ken Joof, Assan Jaye, Hilton Whittle, Sarah Rowland-Jones, and Lucy Dorrell. CD8+ T Cell Responses to Human Immunodeficiency Viruses Type 2 (HIV-2) and Type 1 (HIV-1) Gag Proteins are Distinguishable by Magnitude and Breadth but not Cellular Phenotype. Eur. J. Immunol., 35(5):1445-1453, May 2005. PubMed ID: 15832290. Show all entries for this paper.


Displaying record number 53674

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location p24
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Show epitope variants
Subtype B, D
Species (MHC/HLA) human(B53, Cw4)
Immunogen HIV-1 infection
Patient MHC/HLA A23, A24, B35, B58, Cw4, Cw7; A23, A34, B44, B53, Cw4, Cw6
Country Democratic Republic of the Congo
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, variant cross-reactivity

Notes

References

Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.


Displaying record number 58434

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag(308-316)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Subtype A1
Species (MHC/HLA) human(B*5301)
Immunogen HIV-1 infection
Country Kenya
Experimental methods Other
Keywords assay or method development

Notes

References

Liang2011 Binhua Liang, Ma Luo, Joel Scott-Herridge, Christina Semeniuk, Mark Mendoza, Rupert Capina, Brent Sheardown, Hezhao Ji, Joshua Kimani, Blake T. Ball, Gary Van Domselaar, Morag Graham, Shane Tyler, Steven J. M. Jones, and Francis A. Plummer. A Comparison of Parallel Pyrosequencing and Sanger Clone-Based Sequencing and Its Impact on the Characterization of the Genetic Diversity of HIV-1. PLoS One, 6(10):e26745, 2011. PubMed ID: 22039546. Show all entries for this paper.


Displaying record number 1151

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location p24(308-316 LAI)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Subtype B
Species (MHC/HLA) human(B*5301)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 1980

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location p24(176-184)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name Gag-QW9; p24-QW9
Subtype B
Species (MHC/HLA) human(B*5301, B*57)
Immunogen HIV-1 infection
Patient MHC/HLA 01RCH59: A*0201, A*3201, B*4002, B*5301, Cw*0202, Cw*0401
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords HAART, ART

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 57602

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location p24
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name QW9
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, genital and mucosal immunity

Notes

References

Ferre2010 April L. Ferre, Donna Lemongello, Peter W. Hunt, Megan M. Morris, Juan Carlos Garcia, Richard B. Pollard, Hal F. Yee, Jr., Jeffrey N. Martin, Steven G. Deeks, and Barbara L. Shacklett. Immunodominant HIV-Specific CD8+ T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers. J. Virol., 84(19):10354-10365, Oct 2010. PubMed ID: 20668079. Show all entries for this paper.


Displaying record number 55608

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name QW9
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction

Notes

References

Schellens2008 Ingrid M. M. Schellens, Can Kesmir, Frank Miedema, Debbie van Baarle, and José A. M. Borghans. An Unanticipated Lack of Consensus Cytotoxic T Lymphocyte Epitopes in HIV-1 Databases: The Contribution of Prediction Programs. AIDS, 22(1):33-37, 2 Jan 2008. PubMed ID: 18090389. Show all entries for this paper.


Displaying record number 1298

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag( SF2)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name QW9
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords acute/early infection

Notes

References

Goulder2001 P. J. Goulder, M. M. Addo, M. A. Altfeld, E. S. Rosenberg, Y. Tang, U. Govender, N. Mngqundaniso, K. Annamalai, T. U. Vogel, M. Hammond, M. Bunce, H. M. Coovadia, and B. D. Walker. Rapid Definition of Five Novel HLA-A*3002-Restricted Human Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Epitopes by Elispot and Intracellular Cytokine Staining Assays. J. Virol., 75(3):1339-1347, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1339. PubMed ID: 11152507. Show all entries for this paper.


Displaying record number 57979

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location p24(176-184)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name QW9
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords immunodominance, elite controllers

Notes

References

Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.


Displaying record number 54879

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location  
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, characterizing CD8+ T cells

Vaccine Details

Vaccine type canarypox, canarypox prime with recombinant protein boost
Vaccine strain B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen
Vaccine component Gag, gp120, gp41, Nef, Pol, Protease

Notes

References

Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.


Displaying record number 53492

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name QW9
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 53652

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location  
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Species (MHC/HLA) human(B*5801, B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords responses in children, mother-to-infant transmission

Notes

References

Feeney2005a Margaret E. Feeney, Yanhua Tang, Katja Pfafferott, Kathleen A. Roosevelt, Rika Draenert, Alicja Trocha, Xu G. Yu, Cori Verrill, Todd Allen, Corey Moore, Simon Mallal, Sandra Burchett, Kenneth McIntosh, Stephen I. Pelton, M. Anne St. John, Rohan Hazra, Paul Klenerman, Marcus Altfeld, Bruce D. Walker, and Philip J. R. Goulder. HIV-1 Viral Escape in Infancy Followed by Emergence of a Variant-Specific CTL Response. J. Immunol., 174(12):7524-7530, 15 Jun 2005. PubMed ID: 15944251. Show all entries for this paper.


Displaying record number 58745

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag( NL4-3)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Show epitope variants
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords elite controllers

Notes

References

Buckheit2012 Robert W. Buckheit, III, Tracy G. Allen, Angela Alme, Maria Salgado, Karen A. O'Connell, Sarah Huculak, Oluwaseun Falade-Nwulia, Thomas M. Williams, Joel E. Gallant, Robert F. Siliciano, and Joel N. Blankson. Host Factors Dictate Control of Viral Replication in Two HIV-1 Controller/Chronic Progressor Transmission Pairs. Nat Commun, 3:716, 2012. PubMed ID: 22395607. Show all entries for this paper.


Displaying record number 53125

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location p24(176-184)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Spain
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.


Displaying record number 54379

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name QW9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape

Notes

References

Bailey2006 Justin R. Bailey, Thomas M. Williams, Robert F. Siliciano, and Joel N. Blankson. Maintenance of Viral Suppression in HIV-1-Infected HLA-B*57+ Elite Suppressors Despite CTL Escape Mutations. J. Exp. Med., 203(5):1357-1369, 15 May 2006. PubMed ID: 16682496. Show all entries for this paper.


Displaying record number 54819

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location p24(176-184)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name QW10
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Kenya, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords TCR usage, structure, characterizing CD8+ T cells

Notes

References

Gillespie2006 Geraldine M. A. Gillespie, Guillaume Stewart-Jones, Jaya Rengasamy, Tara Beattie, Job J. Bwayo, Francis A. Plummer, Rupert Kaul, Andrew J. McMichael, Philippa Easterbrook, Tao Dong, E. Yvonne Jones, and Sarah L. Rowland-Jones. Strong TCR Conservation and Altered T Cell Cross-Reactivity Characterize a B*57-Restricted Immune Response in HIV-1 Infection. J. Immunol., 177(6):3893-3902, 15 Sep 2006. PubMed ID: 16951352. Show all entries for this paper.


Displaying record number 57246

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location p24
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name QW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Barbados, Haiti, Jamaica
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords mother-to-infant transmission, elite controllers

Notes

References

Schneidewind2009 Arne Schneidewind, Yanhua Tang, Mark A. Brockman, Elizabeth G. Ryland, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, M. Anne St. John, Joseph A. Conrad, Spyros A. Kalams, Francine Noel, Todd M. Allen, Celia D. Christie, and Margaret E. Feeney. Maternal Transmission of Human Immunodeficiency Virus Escape Mutations Subverts HLA-B57 Immunodominance but Facilitates Viral Control in the Haploidentical Infant. J. Virol., 83(17):8616-8627, Sep 2009. PubMed ID: 19515764. Show all entries for this paper.


Displaying record number 57403

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag(308-316)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name QW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection, in vitro stimulation or selection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords TCR usage, assay or method development

Notes

References

Balamurugan2010 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Rapid T Cell Receptor Delineation Reveals Clonal Expansion Limitation of the Magnitude of the HIV-1-Specific CD8+ T Cell Response. J. Immunol., 185(10):5935-5942, 15 Nov 2010. PubMed ID: 20944001. Show all entries for this paper.


Displaying record number 57413

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag(308-316)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Show epitope variants
Epitope Name QW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods  
Keywords escape, acute/early infection

Notes

References

Durand2010 Christine M. Durand, Karen A. O'Connell, Linda G. Apuzzo, Susan J. Langan, Hejab Imteyaz, Aima A. Ahonkhai, Christina M. Ceccato, Thomas M. Williams, Joseph B. Margolick, and Joel N. Blankson. HIV-1 Gag Evolution in Recently Infected Human Leukocyte Antigen-B*57 Patients with Low-Level Viremia. AIDS, 24(15):2405-2408, 24 Sep 2010. PubMed ID: 20671542. Show all entries for this paper.


Displaying record number 57417

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location  
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Show epitope variants
Epitope Name QW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization
Keywords elite controllers

Notes

References

Tang2010 Yanhua Tang, Sihong Huang, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, Elizabeth G. Ryland, M. Anne St. John, Rohan Hazra, Celia D. C. Christie, and Margaret E. Feeney. Correlates of Spontaneous Viral Control among Long-Term Survivors of Perinatal HIV-1 Infection Expressing Human Leukocyte Antigen-B57. AIDS, 24(10):1425-1435, 19 Jun 2010. PubMed ID: 20539088. Show all entries for this paper.


Displaying record number 58284

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location  
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Show epitope variants
Epitope Name QW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Keywords variant cross-reactivity, characterizing CD8+ T cells

Notes

References

Conrad2011 Joseph A. Conrad, Ramesh K. Ramalingam, Rita M. Smith, Louise Barnett, Shelly L. Lorey, Jie Wei, Brenna C. Simons, Shanmugalakshmi Sadagopal, Dirk Meyer-Olson, and Spyros A. Kalams. Dominant Clonotypes within HIV-Specific T Cell Responses Are Programmed Death-1 High and CD127 Low and Display Reduced Variant Cross-Reactivity. J. Immunol., 186(12):6871-6885, 15 Jun 2011. PubMed ID: 21562156. Show all entries for this paper.


Displaying record number 58771

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag(308-316)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name Gag-QW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Australia, Canada, United States
Experimental methods Chromium-release assay
Keywords class I down-regulation by Nef

Notes

References

Chen2012 Diana Y. Chen, Arumugam Balamurugan, Hwee L. Ng, William G. Cumberland, and Otto O. Yang. Epitope Targeting and Viral Inoculum Are Determinants of Nef-Mediated Immune Evasion of HIV-1 from Cytotoxic T Lymphocytes. Blood, 120(1):100-111, 5 Jul 2012. PubMed ID: 22613796. Show all entries for this paper.


Displaying record number 58804

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location  
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name B*57-QW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods Other, Tetramer binding
Keywords HAART, ART

Notes

References

Conrad2012 Joseph A. Conrad, Ramesh K. Ramalingam, Coley B. Duncan, Rita M. Smith, Jie Wei, Louise Barnett, Brenna C. Simons, Shelly L. Lorey, and Spyros A. Kalams. Antiretroviral Therapy Reduces the Magnitude and T Cell Receptor Repertoire Diversity of HIV-Specific T Cell Responses without Changing T Cell Clonotype Dominance. J. Virol., 86(8):4213-4221, Apr 2012. PubMed ID: 22258246. Show all entries for this paper.


Displaying record number 59146

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location p24
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name QW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords elite controllers

Notes

References

Jessen2014 Heiko Jessen, Todd M. Allen, and Hendrik Streeck. How a Single Patient Influenced HIV Research — 15-Year Follow-Up. N. Engl. J. Med., 370(7):682-683, 13 Feb 2014. PubMed ID: 24521131. Show all entries for this paper.


Displaying record number 60055

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag(308-316)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name QW9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 61564

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location p24
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name B57-QW9(p24)
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Patient MHC/HLA AC-108: A*02, B*57, B*61, Cw*03, Cw*06
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords acute/early infection, protective allele

Notes

References

Altfeld2003a Marcus Altfeld, Marylyn M. Addo, Eric S. Rosenberg, Frederick M. Hecht, Paul K. Lee, Martin Vogel, Xu G. Yu, Rika Draenert, Mary N. Johnston, Daryld Strick, Todd M. Allen, Margaret E. Feeney, James O. Kahn, Rafick P. Sekaly, Jay A. Levy, Jürgen K. Rockstroh, Philip J. Goulder, and Bruce D. Walker. Influence of HLA-B57 on Clinical Presentation and Viral Control during Acute HIV-1 Infection. AIDS, 17(18):2581-2591, 5 Dec 2003. PubMed ID: 14685052. Show all entries for this paper.


Displaying record number 56723

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag(308-316)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name QW10
Subtype B
Species (MHC/HLA) human(B*57, B*5801)
Immunogen HIV-1 infection
Patient MHC/HLA B*57; B*27, B*5801
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, autologous responses, elite controllers

Notes

References

OConnell2010 Karen A. O'Connell, Timothy P. Brennan, Justin R. Bailey, Stuart C. Ray, Robert F. Siliciano, and Joel N. Blankson. Control of HIV-1 in Elite Suppressors Despite Ongoing Replication and Evolution in Plasma Virus. J. Virol., 84(14):7018-7028, Jul 2010. PubMed ID: 20444904. Show all entries for this paper.


Displaying record number 1152

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location p24(311-319 LAI)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 52084

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location  
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, immunodominance

Notes

References

Migueles2001 Stephen A. Migueles and Mark Connors. Frequency and Function of HIV-Specific CD8(+) T Cells. Immunol. Lett., 79(1-2):141-150, 1 Nov 2001. PubMed ID: 11595301. Show all entries for this paper.


Displaying record number 55003

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location p24(176-184)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name QAS
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, TCR usage, variant cross-reactivity, characterizing CD8+ T cells

Notes

References

Turnbull2006 Emma L. Turnbull, A. Ross Lopes, Nicola A. Jones, David Cornforth, Phillipa Newton, Diana Aldam, Pierre Pellegrino, Jo Turner, Ian Williams, Craig M. Wilson, Paul A. Goepfert, Mala K. Maini, and Persephone Borrow. HIV-1 Epitope-Specific CD8+ T Cell Responses Strongly Associated with Delayed Disease Progression Cross-Recognize Epitope Variants Efficiently. J. Immunol., 176(10):6130-6146, 15 May 2006. PubMed ID: 16670322. Show all entries for this paper.


Displaying record number 58841

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag(240-249)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Show epitope variants
Epitope Name QW9
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Patient MHC/HLA A*0101, A*0301, B*2705, B*5701; A*0101, A*2402, B*4002, B*5701; A*2402, A*3201, B*4002, B*5701; A*0101, A*0201, B*5101, B*5701; A*0101, A*0101, B*0801, B*5701; A*0301, A*2402, B*3501, B*5701
Country United States
Experimental methods Flow cytometric T-cell cytokine assay
Keywords rate of progression

Notes

References

Norstrom2012 Melissa M. Norström, Marcus Buggert, Johanna Tauriainen, Wendy Hartogensis, Mattia C. Prosperi, Mark A. Wallet, Frederick M. Hecht, Marco Salemi, and Annika C. Karlsson. Combination of Immune and Viral Factors Distinguishes Low-Risk Versus High-Risk HIV-1 Disease Progression in HLA-B*5701 Subjects. J. Virol., 86(18):9802-9816, Sep 2012. PubMed ID: 22761389. Show all entries for this paper.


Displaying record number 62173

HXB2 Location Gag(308-316)
p24(176-184)
Gag Epitope Map
Author Location Gag
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name QW9
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods HLA binding
Keywords binding affinity, NK cells

Notes

References

Martin2018 Maureen P. Martin, Vivek Naranbhai, Patrick R. Shea, Ying Qi, Veron Ramsuran, Nicolas Vince, Xiaojiang Gao, Rasmi Thomas, Zabrina L. Brumme, Jonathan M. Carlson, Steven M. Wolinsky, James J. Goedert, Bruce D. Walker, Florencia P. Segal, Steven G. Deeks, David W. Haas, Stephen A. Migueles, Mark Connors, Nelson Michael, Jacques Fellay, Emma Gostick, Sian Llewellyn-Lacey, David A. Price, Bernard A. Lafont, Phillip Pymm, Philippa M. Saunders, Jacqueline Widjaja, Shu Cheng Wong, Julian P. Vivian, Jamie Rossjohn, Andrew G. Brooks, and Mary Carrington. Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1. J Clin Invest, 128(5):1903-1912 doi, May 2018. PubMed ID: 29461980 Show all entries for this paper.


Displaying record number 59209

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag(308-316)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Show epitope variants
Epitope Name QW9
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Patient MHC/HLA P1: B*5701; P2: B*5701; P3: B*5701
Country United States
Experimental methods Other
Keywords elite controllers

Notes

References

Buggert2014 Marcus Buggert, Melissa M. Norström, Marco Salemi, Frederick M. Hecht, and Annika C. Karlsson. Functional Avidity and IL-2/Perforin Production Is Linked to the Emergence of Mutations within HLA-B*5701-Restricted Epitopes and HIV-1 Disease Progression. J. Immunol., 192(10):4685-4696, 15 May 2014. PubMed ID: 24740510. Show all entries for this paper.


Displaying record number 52761

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag(308-316)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Show epitope variants
Epitope Name QW9
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords rate of progression, escape

Notes

References

Migueles2003 Stephen A. Migueles, Alisha C. Laborico, Hiromi Imamichi, W. Lesley Shupert, Cassandra Royce, Mary McLaughlin, Linda Ehler, Julia Metcalf, Shuying Liu, Claire W. Hallahan, and Mark Connors. The Differential Ability of HLA B*5701+ Long-Term Nonprogressors and Progressors to Restrict Human Immunodeficiency Virus Replication Is Not Caused by Loss of Recognition of Autologous Viral gag Sequences. J. Virol., 77(12):6889-6898, Jun 2003. PubMed ID: 12768008. Show all entries for this paper.


Displaying record number 52089

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location  
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, immunodominance

Notes

References

Migueles2001 Stephen A. Migueles and Mark Connors. Frequency and Function of HIV-Specific CD8(+) T Cells. Immunol. Lett., 79(1-2):141-150, 1 Nov 2001. PubMed ID: 11595301. Show all entries for this paper.


Displaying record number 341

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location p24(309-317 LAI)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Goulder1996 P. J. R. Goulder, M. Bunce, P. Krausa, K. McIntyre, S. Crowley, B. Morgan, A. Edwards, P. Giangrande, R. E. Phillips, and A. J. McMichael. Novel, Cross-Restricted, Conserved and Immunodominant Cytotoxic T Lymphocyte Epitopes in Slow HIV Type 1 Infection. AIDS Res. Hum. Retroviruses, 12:1691-1698, 1996. HLA-B*57 is over-represented in slow progressors. HLA*5801 is a closely related molecule, and while the defined anchor residues of HLA*5801 can be used to predict epitopes in HIV-1 proteins, the CTL from HLA-B*57 positive individuals have limited cross-presentation capacity with HLA*5801 targets. In this paper five new HLA-B*57 epitopes were defined. PubMed ID: 8959245. Show all entries for this paper.


Displaying record number 60980

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location p24(176-184)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Patient MHC/HLA 67200: A*0101, A*2401, B*0801, B*5701, Cw*0602, Cw*0701
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 58631

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag(308-316)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Species (MHC/HLA) human(B*5801)
Immunogen HIV-1 infection
Country Gambia
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 60057

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag(308-316)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name QW9
Species (MHC/HLA) human(B*5801)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 62002

HXB2 Location Gag(308-316)
p24(176-184)
Gag Epitope Map
Author Location Gag(308-316)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Epitope Name QW9
Species (MHC/HLA) human(B*5801)
Immunogen peptide-HLA interaction
Experimental methods Other
Keywords structure, protective allele

Notes

References

Li2017b Xiaolong Li, Pedro A. Lamothe, Bruce D. Walker, and Jia-Huai Wang. Crystal Structure of HLA-B*5801 with a TW10 HIV Gag Epitope Reveals a Novel Mode of Peptide Presentation. Cell. Mol. Immunol., 14(7):631-634, Jul 2017. PubMed ID: 28552904. Show all entries for this paper.


Displaying record number 1204

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location ( LAI)
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Subtype B
Species (MHC/HLA) human(Cw4)
Immunogen  
Experimental methods  
Keywords  

References

BuseynePerCom1999 F. Buseyne. Personal communication, 1999. Show all entries for this paper.


Displaying record number 53164

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords epitope processing, assay or method development, characterizing CD8+ T cells

Notes

References

Beattie2004 Tara Beattie, Rupert Kaul, Tim Rostron, Tao Dong, Philippa Easterbrook, Walter Jaoko, Joshua Kimani, Francis Plummer, Andrew McMichael, and Sarah Rowland-Jones. Screening for HIV-Specific T-Cell Responses Using Overlapping 15-Mer Peptide Pools or Optimized Epitopes. AIDS, 18(11):1595-1598, 23 Jul 2004. PubMed ID: 15238779. Show all entries for this paper.


Displaying record number 58040

HXB2 Location Gag(308-316)
p24(176-184)
DNA(1711..1737)
Gag Epitope Map
Author Location Gag
Epitope QASQEVKNW Epitope Alignment
QASQEVKNW epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Patient MHC/HLA A*3301, A*7401, B*5301, B*7801, Cw*0401, Cw*1601
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus type 5 (Ad5), DNA prime with Ad5 boost
Vaccine strain B clade IIIB, B clade JRFL, B clade CAM-1
Vaccine component Gag, Nef, Pol

Notes

References

Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Operated by Los Alamos National Security, LLC, for the U.S. Department of Energy's National Nuclear Security Administration
Copyright © 2006-2017 LANS LLC All rights reserved | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health