HIV molecular immunology database
Found 22 matching records:
Download this epitope record as JSON.
HXB2 Location | Gag(145-155) p24(13-23) DNA(1222..1254) |
Gag Epitope Map |
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Author Location | p24(145-155) | |
Epitope |
QAISPRTLNAW
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Epitope Alignment
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Show epitope variants | ||
Epitope Name | QW11 | |
Subtype | B | |
Species (MHC/HLA) | human(A*25) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | PIC1362: A*02:01, A*25:01, B*18:01, B*51:01, C*01:02, C*12:03; PIC1349: A*02, A*25, B*58, B*62, C*04, C*07; PIC1052: A*25, A*30, B*07, B*35, C*04, C*07; PIC1483: A*01:01, A*25:01, B*38:01, B*39:01, C*12:03, C*12:03 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | acute/early infection, mutation acquisition, viral fitness and reversion, viral replication |
Troyer2009 Ryan M. Troyer, John McNevin, Yi Liu, Shao Chong Zhang, Randall W. Krizan, Awet Abraha, Denis M. Tebit, Hong Zhao, Santiago Avila, Michael A. Lobritz, M. Juliana McElrath, Sylvie Le Gall, James I. Mullins, and Eric J. Arts. Variable Fitness Impact of HIV-1 Escape Mutations to Cytotoxic T Lymphocyte (CTL) Response. PLoS Pathog., 5(4):e1000365, Apr 2009. PubMed ID: 19343217. Show all entries for this paper.
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HXB2 Location | Gag(145-155) p24(13-23) DNA(1222..1254) |
Gag Epitope Map |
---|---|---|
Author Location | p24(13-23 NL4.3) | |
Epitope |
QAISPRTLNAW
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Epitope Alignment
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Epitope Name | QW11, 2-ISW9 | |
Subtype | B | |
Species (MHC/HLA) | human(A*25) | |
Immunogen | HIV-1 infection | |
Experimental methods | In vitro proteasome digestion, Other | |
Keywords | epitope processing |
Kourjian2014 Georgio Kourjian, Yang Xu, Ijah Mondesire-Crump, Mariko Shimada, Pauline Gourdain, and Sylvie Le Gall. Sequence-Specific Alterations of Epitope Production by HIV Protease Inhibitors. J. Immunol., 192(8):3496-3506, 15 Apr 2014. PubMed ID: 24616479. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(145-155) p24(13-23) DNA(1222..1254) |
Gag Epitope Map |
---|---|---|
Author Location | p24(145-155) | |
Epitope |
QAISPRTLNAW
|
Epitope Alignment
|
Epitope Name | QW11 | |
Subtype | B | |
Species (MHC/HLA) | human(A*25) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | ||
Keywords | HLA associated polymorphism |
Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(145-155) p24(13-23) DNA(1222..1254) |
Gag Epitope Map |
---|---|---|
Author Location | p24(145-155 NL4-3) | |
Epitope |
QAISPRTLNAW
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Epitope Alignment
|
Epitope Name | QW11 | |
Species (MHC/HLA) | human(A*25) | |
Immunogen | computer prediction | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | vaccine antigen design, viral fitness and reversion |
Ferguson2013a Andrew L. Ferguson, Jaclyn K. Mann, Saleha Omarjee, Thumbi Ndung'u, Bruce D Walker, and Arup K. Chakraborty. Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design. Immunity, 38(3):606-617, 21 Mar 2013. PubMed ID: 23521886. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(145-155) p24(13-23) DNA(1222..1254) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(145-155) | |
Epitope |
QAISPRTLNAW
|
Epitope Alignment
|
Epitope Name | QW11 | |
Species (MHC/HLA) | human(A*25) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(145-155) p24(13-23) DNA(1222..1254) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(145-155 IIIB) | |
Epitope |
QAISPRTLNAW
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Epitope Alignment
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Subtype | B | |
Species (MHC/HLA) | human(A25) | |
Immunogen | HIV-1 infection | |
Experimental methods | Chromium-release assay | |
Keywords |
Kurane2003 Ichiro Kurane, Kim West, Carmelita U. Tuazon, Weilan Zeng, and Francis A. Ennis. Definition of Two New Epitopes on Human Immunodeficiency Virus Type 1 Gag Protein Recognized by Human CD8+ Cytotoxic T Lymphocyte Clones. J. Clin. Virol., 27(1):38-43, May 2003. PubMed ID: 12727527. Show all entries for this paper.
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HXB2 Location | Gag(145-155) p24(13-23) DNA(1222..1254) |
Gag Epitope Map |
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Author Location | p24(145-155 LAI) | |
Epitope |
QAISPRTLNAW
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Epitope Alignment
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Subtype | B | |
Species (MHC/HLA) | human(A25) | |
Immunogen | ||
Experimental methods | ||
Keywords |
KuranePerCom I. Kurane and K. West. Personal communication, 1998. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(145-155) p24(13-23) DNA(1222..1254) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
QAISPRTLNAW
|
Epitope Alignment
|
Species (MHC/HLA) | human(A25) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | supertype, HLA cross-presentation, optimal epitope |
Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(145-155) p24(13-23) DNA(1222..1254) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
QAISPRTLNAW
|
Epitope Alignment
|
Epitope Name | QW11 | |
Subtype | B | |
Species (MHC/HLA) | human(A25, B57) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, TCR binding | |
Keywords | rate of progression, TCR usage, optimal epitope |
Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(145-155) p24(13-23) DNA(1222..1254) |
Gag Epitope Map |
---|---|---|
Author Location | p24(13-23) | |
Epitope |
QAISPRTLNAW
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*25:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 94153: A*25:01, A*68:01, B*14:02, B*44:02, C*05:01, C*08:02 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection |
Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(145-155) p24(13-23) DNA(1222..1254) |
Gag Epitope Map |
---|---|---|
Author Location | p24(145-155 LAI) | |
Epitope |
QAISPRTLNAW
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*25:01) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(145-155) p24(13-23) DNA(1222..1254) |
Gag Epitope Map |
---|---|---|
Author Location | p24(13-23 HXB2) | |
Epitope |
QAISPRTLNAW
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | QW11 | |
Subtype | B | |
Species (MHC/HLA) | human(A*25:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | PIC1362: A*02:01, A*25:01, B*18:01, B*51:01, C*01:02, C*12:03 | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | escape, mutation acquisition, optimal epitope |
Liu2006 Yi Liu, John McNevin, Jianhong Cao, Hong Zhao, Indira Genowati, Kim Wong, Sherry McLaughlin, Matthew D. McSweyn, Kurt Diem, Claire E. Stevens, Janine Maenza, Hongxia He, David C. Nickle, Daniel Shriner, Sarah E. Holte, Ann C. Collier, Lawrence Corey, M. Juliana McElrath, and James I. Mullins. Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection. J. Virol., 80(19):9519-9529, Oct 2006. PubMed ID: 16973556. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(145-155) p24(13-23) DNA(1222..1254) |
Gag Epitope Map |
---|---|---|
Author Location | p24(13-23) | |
Epitope |
QAISPRTLNAW
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | QW11 | |
Subtype | B | |
Species (MHC/HLA) | human(A*25:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | PIC1362: A*02:01, A*25:01, B*18:01, B*51:01, C*01:02, C*12:03 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | escape, acute/early infection |
Liu2011a Yi Liu, John P. McNevin, Sarah Holte, M. Juliana McElrath, and James I. Mullins. Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection. PLoS One, 6(1):e15639, 2011. PubMed ID: 21283794. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(145-155) p24(13-23) DNA(1222..1254) |
Gag Epitope Map |
---|---|---|
Author Location | p24(13-23) | |
Epitope |
QAISPRTLNAW
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*25:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | PIC1362: A*02:01, A*25:01, B*18:01, B*51:01, C*01:02, C*12:03 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | viral fitness and reversion |
Liu2007a Yi Liu, John McNevin, Hong Zhao, Denis M. Tebit, Ryan M. Troyer, Matthew McSweyn, Ananta K. Ghosh, Daniel Shriner, Eric J. Arts, M. Juliana McElrath, and James I. Mullins. Evolution of Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitopes: Fitness-Balanced Escape. J. Virol., 81(22):12179-12188, Nov 2007. PubMed ID: 17728222. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(145-155) p24(13-23) DNA(1222..1254) |
Gag Epitope Map |
---|---|---|
Author Location | p24(13-23) | |
Epitope |
QAISPRTLNAW
|
Epitope Alignment
|
Epitope Name | QW11 | |
Subtype | B, C | |
Species (MHC/HLA) | human(A*25:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Tenzer2014 Stefan Tenzer, Hayley Crawford, Phillip Pymm, Robert Gifford, Vattipally B. Sreenu, Mirjana Weimershaus, Tulio de Oliveira, Anne Burgevin, Jan Gerstoft, Nadja Akkad, Daniel Lunn, Lars Fugger, John Bell, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification. Cell Rep., 7(2):448-463, 24 Apr 2014. PubMed ID: 24726370. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(145-155) p24(13-23) DNA(1222..1254) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(145-155) | |
Epitope |
QAISPRTLNAW
|
Epitope Alignment
|
Epitope Name | QW11 | |
Species (MHC/HLA) | human(B*35:01, B*35:08) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(145-155) p24(13-23) DNA(1222..1254) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(145-155) | |
Epitope |
QAISPRTLNAW
|
Epitope Alignment
|
Epitope Name | QW11 | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(145-155) p24(13-23) DNA(1222..1254) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(145-155) | |
Epitope |
QAISPRTLNAW
|
Epitope Alignment
|
Epitope Name | QW11 | |
Species (MHC/HLA) | human(B*58:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(145-155) p24(13-23) DNA(1222..1254) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(145-155) | |
Epitope |
QAISPRTLNAW
|
Epitope Alignment
|
Epitope Name | QW11 | |
Species (MHC/HLA) | human(C*06) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(145-155) p24(13-23) DNA(1222..1254) |
Gag Epitope Map |
---|---|---|
Author Location | p24(145-155) | |
Epitope |
QAISPRTLNAW
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | engineered | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | assay or method development, protective allele |
Du2017 Yushen Du, Tian-Hao Zhang, Lei Dai, Xiaojuan Zheng, Aleksandr M. Gorin, John Oishi, Ting-Ting Wu, Janice M. Yoshizawa, Xinmin Li, Otto O. Yang, Otoniel Martinez-Maza, Roger Detels, and Ren Sun. Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes. mBio, 8(6), 28 Nov 2017. PubMed ID: 29184023. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(145-155) p24(13-23) DNA(1222..1254) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
QAISPRTLNAW
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection, vaccine | |
Patient MHC/HLA | 014A-001: A*02:02, A*80:01, B*18:01, B*53:01; 014A-005: A*25:01, A*30:02, B*07:02, B*18:01, C*07:02, C*12:03 | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | vaccine-induced immune responses, acute/early infection |
Vaccine type | canarypox prime with gp120 boost |
---|---|
Vaccine strain | B clade LAI, B clade MN |
Vaccine component | Gag-Pol, gp120, gp41 |
Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(145-155) p24(13-23) DNA(1222..1254) |
Gag Epitope Map |
---|---|---|
Author Location | p24(145-155) | |
Epitope |
QAISPRTLNAW
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | immunodominance |
Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.