HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 20 matching records:

Displaying record number 137

HXB2 Location Gag(145-155)
p24(13-23)
DNA(1222..1254)
Gag Epitope Map
Author Location p24(145-155 LAI)
Epitope QAISPRTLNAW Epitope Alignment
QAISPRTLNAW epitope logo
Subtype B
Species (MHC/HLA) human(A25)
Immunogen  
Experimental methods  
Keywords  

References

KuranePerCom I. Kurane and K. West. Personal communication, 1998. Show all entries for this paper.


Displaying record number 52735

HXB2 Location Gag(145-155)
p24(13-23)
DNA(1222..1254)
Gag Epitope Map
Author Location Gag(145-155 IIIB)
Epitope QAISPRTLNAW Epitope Alignment
QAISPRTLNAW epitope logo
Subtype B
Species (MHC/HLA) human(A25)
Immunogen HIV-1 infection
Experimental methods Chromium-release assay
Keywords  

Notes

References

Kurane2003 Ichiro Kurane, Kim West, Carmelita U. Tuazon, Weilan Zeng, and Francis A. Ennis. Definition of Two New Epitopes on Human Immunodeficiency Virus Type 1 Gag Protein Recognized by Human CD8+ Cytotoxic T Lymphocyte Clones. J. Clin. Virol., 27(1):38-43, May 2003. PubMed ID: 12727527. Show all entries for this paper.


Displaying record number 55189

HXB2 Location Gag(145-155)
p24(13-23)
DNA(1222..1254)
Gag Epitope Map
Author Location  
Epitope QAISPRTLNAW Epitope Alignment
QAISPRTLNAW epitope logo
Species (MHC/HLA) human(A25)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supertype, HLA cross-presentation, optimal epitope

Notes

References

Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.


Displaying record number 57843

HXB2 Location Gag(145-155)
p24(13-23)
DNA(1222..1254)
Gag Epitope Map
Author Location  
Epitope QAISPRTLNAW Epitope Alignment
QAISPRTLNAW epitope logo
Epitope Name QW11
Subtype B
Species (MHC/HLA) human(A25, B57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, TCR binding
Keywords rate of progression, TCR usage, optimal epitope

Notes

References

Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.


Displaying record number 59187

HXB2 Location Gag(145-155)
p24(13-23)
DNA(1222..1254)
Gag Epitope Map
Author Location p24(13-23 NL4.3)
Epitope QAISPRTLNAW Epitope Alignment
QAISPRTLNAW epitope logo
Epitope Name QW11, 2-ISW9
Subtype B
Species (MHC/HLA) human(A*25)
Immunogen HIV-1 infection
Experimental methods In vitro proteasome digestion, Other
Keywords epitope processing

Notes

References

Kourjian2014 Georgio Kourjian, Yang Xu, Ijah Mondesire-Crump, Mariko Shimada, Pauline Gourdain, and Sylvie Le Gall. Sequence-Specific Alterations of Epitope Production by HIV Protease Inhibitors. J. Immunol., 192(8):3496-3506, 15 Apr 2014. PubMed ID: 24616479. Show all entries for this paper.


Displaying record number 62108

HXB2 Location Gag(145-155)
p24(13-23)
Gag Epitope Map
Author Location p24(145-155 NL4-3)
Epitope QAISPRTLNAW Epitope Alignment
QAISPRTLNAW epitope logo
Epitope Name QW11
Species (MHC/HLA) human(A*25)
Immunogen computer prediction
Experimental methods Other, Relative replication capacity assay
Keywords vaccine antigen design, viral fitness and reversion

Notes

References

Ferguson2013a Andrew L. Ferguson, Jaclyn K. Mann, Saleha Omarjee, Thumbi Ndung'u, Bruce D Walker, and Arup K. Chakraborty. Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design. Immunity, 38(3):606-617, 21 Mar 2013. PubMed ID: 23521886. Show all entries for this paper.


Displaying record number 60051

HXB2 Location Gag(145-155)
p24(13-23)
DNA(1222..1254)
Gag Epitope Map
Author Location Gag(145-155)
Epitope QAISPRTLNAW Epitope Alignment
QAISPRTLNAW epitope logo
Epitope Name QW11
Species (MHC/HLA) human(A*25)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 56365

HXB2 Location Gag(145-155)
p24(13-23)
DNA(1222..1254)
Gag Epitope Map
Author Location p24(145-155)
Epitope QAISPRTLNAW Epitope Alignment
QAISPRTLNAW epitope logo
Epitope Name QW11
Subtype B
Species (MHC/HLA) human(A*25)
Immunogen HIV-1 infection
Country United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 59081

HXB2 Location Gag(145-155)
p24(13-23)
DNA(1222..1254)
Gag Epitope Map
Author Location p24(13-23)
Epitope QAISPRTLNAW Epitope Alignment
QAISPRTLNAW epitope logo
Subtype B
Species (MHC/HLA) human(A*2501)
Immunogen HIV-1 infection
Patient MHC/HLA PIC1362: A*0201, A*2501, B*1801, B*5101, Cw*0102, Cw*1203
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords viral fitness and reversion

Notes

References

Liu2007a Yi Liu, John McNevin, Hong Zhao, Denis M. Tebit, Ryan M. Troyer, Matthew McSweyn, Ananta K. Ghosh, Daniel Shriner, Eric J. Arts, M. Juliana McElrath, and James I. Mullins. Evolution of Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitopes: Fitness-Balanced Escape. J. Virol., 81(22):12179-12188, Nov 2007. PubMed ID: 17728222. Show all entries for this paper.


Displaying record number 138

HXB2 Location Gag(145-155)
p24(13-23)
DNA(1222..1254)
Gag Epitope Map
Author Location p24(145-155 LAI)
Epitope QAISPRTLNAW Epitope Alignment
QAISPRTLNAW epitope logo
Subtype B
Species (MHC/HLA) human(A*2501)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 54145

HXB2 Location Gag(145-155)
p24(13-23)
DNA(1222..1254)
Gag Epitope Map
Author Location p24(13-23 HXB2)
Epitope QAISPRTLNAW Epitope Alignment
QAISPRTLNAW epitope logo
Show epitope variants
Epitope Name QW11
Subtype B
Species (MHC/HLA) human(A*2501)
Immunogen HIV-1 infection
Patient MHC/HLA PIC1362: A*0201, A*2501, B*1801, B*5101, Cw*0102, Cw*1203
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, mutation acquisition, optimal epitope

Notes

References

Liu2006 Yi Liu, John McNevin, Jianhong Cao, Hong Zhao, Indira Genowati, Kim Wong, Sherry McLaughlin, Matthew D. McSweyn, Kurt Diem, Claire E. Stevens, Janine Maenza, Hongxia He, David C. Nickle, Daniel Shriner, Sarah E. Holte, Ann C. Collier, Lawrence Corey, M. Juliana McElrath, and James I. Mullins. Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection. J. Virol., 80(19):9519-9529, Oct 2006. PubMed ID: 16973556. Show all entries for this paper.


Displaying record number 58160

HXB2 Location Gag(145-155)
p24(13-23)
DNA(1222..1254)
Gag Epitope Map
Author Location p24(13-23)
Epitope QAISPRTLNAW Epitope Alignment
QAISPRTLNAW epitope logo
Show epitope variants
Epitope Name QW11
Subtype B
Species (MHC/HLA) human(A*2501)
Immunogen HIV-1 infection
Patient MHC/HLA PIC1362: A*0201, A*2501, B*1801, B*5101, Cw*0102, Cw*1203
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, acute/early infection

Notes

References

Liu2011a Yi Liu, John P. McNevin, Sarah Holte, M. Juliana McElrath, and James I. Mullins. Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection. PLoS One, 6(1):e15639, 2011. PubMed ID: 21283794. Show all entries for this paper.


Displaying record number 60626

HXB2 Location Gag(145-155)
p24(13-23)
DNA(1222..1254)
Gag Epitope Map
Author Location p24(13-23)
Epitope QAISPRTLNAW Epitope Alignment
QAISPRTLNAW epitope logo
Epitope Name QW11
Subtype B, C
Species (MHC/HLA) human(A*2501)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tenzer2014 Stefan Tenzer, Hayley Crawford, Phillip Pymm, Robert Gifford, Vattipally B. Sreenu, Mirjana Weimershaus, Tulio de Oliveira, Anne Burgevin, Jan Gerstoft, Nadja Akkad, Daniel Lunn, Lars Fugger, John Bell, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification. Cell Rep., 7(2):448-463, 24 Apr 2014. PubMed ID: 24726370. Show all entries for this paper.


Displaying record number 60978

HXB2 Location Gag(145-155)
p24(13-23)
DNA(1222..1254)
Gag Epitope Map
Author Location p24(13-23)
Epitope QAISPRTLNAW Epitope Alignment
QAISPRTLNAW epitope logo
Subtype B
Species (MHC/HLA) human(A*2501)
Immunogen HIV-1 infection
Patient MHC/HLA 94153: A*2501, A*6801, B*1402, B*4401, Cw*0501, Cw*0802
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 60052

HXB2 Location Gag(145-155)
p24(13-23)
DNA(1222..1254)
Gag Epitope Map
Author Location Gag(145-155)
Epitope QAISPRTLNAW Epitope Alignment
QAISPRTLNAW epitope logo
Epitope Name QW11
Species (MHC/HLA) human(B*3501, B*3508)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60050

HXB2 Location Gag(145-155)
p24(13-23)
DNA(1222..1254)
Gag Epitope Map
Author Location Gag(145-155)
Epitope QAISPRTLNAW Epitope Alignment
QAISPRTLNAW epitope logo
Epitope Name QW11
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60053

HXB2 Location Gag(145-155)
p24(13-23)
DNA(1222..1254)
Gag Epitope Map
Author Location Gag(145-155)
Epitope QAISPRTLNAW Epitope Alignment
QAISPRTLNAW epitope logo
Epitope Name QW11
Species (MHC/HLA) human(B*5801)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60054

HXB2 Location Gag(145-155)
p24(13-23)
DNA(1222..1254)
Gag Epitope Map
Author Location Gag(145-155)
Epitope QAISPRTLNAW Epitope Alignment
QAISPRTLNAW epitope logo
Epitope Name QW11
Species (MHC/HLA) human(C*06)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54919

HXB2 Location Gag(145-155)
p24(13-23)
DNA(1222..1254)
Gag Epitope Map
Author Location  
Epitope QAISPRTLNAW Epitope Alignment
QAISPRTLNAW epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA A*0202, A*8001; B*1801, B*5301
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type canarypox prime with gp120 boost
Vaccine strain B clade LAI, B clade MN
Vaccine component Gag-Pol, gp120, gp41

Notes

References

Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.


Displaying record number 136

HXB2 Location Gag(145-155)
p24(13-23)
DNA(1222..1254)
Gag Epitope Map
Author Location p24(145-155)
Epitope QAISPRTLNAW Epitope Alignment
QAISPRTLNAW epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance

Notes

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.


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