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Displaying record number 54211

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HXB2 Location	Rev(70-78) DNA(8510..8536)	Rev Epitope Map
Author Location	Rev(70-78)
Epitope	PVPFQLPPL	Epitope Alignment
		Show epitope variants
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Patient MHC/HLA	A2, B13, B41
Country	France
Experimental methods	Other
Keywords	computational epitope prediction, escape, acute/early infection, mutation acquisition

Notes

• A longitudinal study from primary infection to 5 years postinfection was conducted to determine Tat and Rev gene evolution. 2/4 patients showed Tat gene evolution. It was found that though Tat evolved by mostly nonsynonymous, non-random sequence changes, there was no increase in transactivating capacity or size of Tat protein. Sequence evolution occurred mostly in predicted epitopes that are MHC I restricted.
• Tat and Rev seem to evolve due to CTL pressure later in infection, after seroconversion, and possibly during viral replication.
• The previously described epitope PVPFQLPPL, had a variant PVPlQLPPL in the fourth position.

References

Guillon2006 C. Guillon, K. Stankovic, Y. Ataman-Önal, F. Biron, and B. Verrier. Evidence for CTL-Mediated Selection of Tat and Rev Mutants after the Onset of the Asymptomatic Period during HIV Type 1 Infection. AIDS Res. Hum. Retroviruses, 22(12):1283-1292, Dec 2006. PubMed ID: 17209772. Show all entries for this paper.