HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 10 matching records:

Displaying record number 60609

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HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24(122-130)
Epitope PPIPVGEIY Epitope Alignment
PPIPVGEIY epitope logo
Show epitope variants
Epitope Name PY-9
Subtype B
Species (MHC/HLA) human(B*35, B*35:01, B*35:02, B*53)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tenzer2014 Stefan Tenzer, Hayley Crawford, Phillip Pymm, Robert Gifford, Vattipally B. Sreenu, Mirjana Weimershaus, Tulio de Oliveira, Anne Burgevin, Jan Gerstoft, Nadja Akkad, Daniel Lunn, Lars Fugger, John Bell, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification. Cell Rep., 7(2):448-463, 24 Apr 2014. PubMed ID: 24726370. Show all entries for this paper.


Displaying record number 242

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HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24( subtype B)
Epitope PPIPVGEIY Epitope Alignment
PPIPVGEIY epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons

Notes

References

Rowland-Jones1998 S. L. Rowland-Jones, T. Dong, K. R. Fowke, J. Kimani, P. Krausa, H. Newell, T. Blanchard, K. Ariyoshi, J. Oyugi, E. Ngugi, J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi. J. Clin. Invest., 102(9):1758-65, 1 Nov 1998. PubMed ID: 9802890. Show all entries for this paper.


Displaying record number 243

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HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location  
Epitope PPIPVGEIY Epitope Alignment
PPIPVGEIY epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords acute/early infection

Notes

References

Wilson2000 J. D. Wilson, G. S. Ogg, R. L. Allen, C. Davis, S. Shaunak, J. Downie, W. Dyer, C. Workman, S. Sullivan, A. J. McMichael, and S. L. Rowland-Jones. Direct Visualization of HIV-1-Specific Cytotoxic T Lymphocytes During Primary Infection. AIDS, 14:225-233, 2000. PubMed ID: 10716497. Show all entries for this paper.


Displaying record number 52422

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HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24
Epitope PPIPVGEIY Epitope Alignment
PPIPVGEIY epitope logo
Subtype A, B, C, D
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection, vaccine
Experimental methods  
Keywords subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain A clade
Vaccine component p17 Gag, p24 Gag

Notes

References

Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.

Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.


Displaying record number 53043

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HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location Gag
Epitope PPIPVGEIY Epitope Alignment
PPIPVGEIY epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Koning2004 Fransje A. Koning, Christine A. Jansen, Jos Dekker, Richard A. Kaslow, Nicole Dukers, Debbie van Baarle, Maria Prins, and Hanneke Schuitemaker. Correlates of Resistance to HIV-1 Infection in Homosexual Men with High-Risk Sexual Behaviour. AIDS, 18(8):1117-1126, 21 May 2004. PubMed ID: 15166527. Show all entries for this paper.


Displaying record number 53677

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HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24
Epitope PPIPVGEIY Epitope Alignment
PPIPVGEIY epitope logo
Subtype B, D
Species (MHC/HLA) human(B35, B53)
Immunogen HIV-1 infection
Patient MHC/HLA A23, A24, B35, B58, Cw4, Cw7; M11814: A*23, A*24, B*35, B*58, C*04, C*07
Country Democratic Republic of the Congo
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons

Notes

References

Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.


Displaying record number 57479

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HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location Gag(254-262)
Epitope PPIPVGEIY Epitope Alignment
PPIPVGEIY epitope logo
Epitope Name PY9
Subtype B
Species (MHC/HLA) human(B*35:01)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Cytokine production, Flow cytometric T-cell cytokine assay, HLA binding
Keywords computational epitope prediction

Notes

References

Westrop2009 Samantha J. Westrop, Nathali Grageda, and Nesrina Imami. Novel Approach to Recognition of Predicted HIV-1 Gag B3501-Restricted CD8 T-Cell Epitopes by HLA-B3501+ Patients: Confirmation by Quantitative ELISpot Analyses and Characterisation Using Multimers. J. Immunol. Methods, 341(1-2):76-85, 28 Feb 2009. PubMed ID: 19056394. Show all entries for this paper.


Displaying record number 60680

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HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24(254-262)
Epitope PPIPVGEIY Epitope Alignment
PPIPVGEIY epitope logo
Subtype B
Species (MHC/HLA) human(B*35:01)
Immunogen HIV-1 infection
Patient MHC/HLA S2: ; S3:
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords dendritic cells, assay or method development, memory cells

Notes

References

Smith2016 Kellie N. Smith, Robbie B. Mailliard, Paolo A. Piazza, Will Fischer, Bette T. Korber, Ronald J. Fecek, Deena Ratner, Phalguni Gupta, James I. Mullins, and Charles R. Rinaldo. Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV-1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells. MBio, 7(3), 31 May 2016. PubMed ID: 27247230. Show all entries for this paper.


Displaying record number 52963

Download this epitope record as JSON.

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location Gag(254-262)
Epitope PPIPVGEIY Epitope Alignment
PPIPVGEIY epitope logo
Subtype B
Species (MHC/HLA) human(B7 supertype)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Proliferation
Keywords vaccine-induced immune responses, variant cross-reactivity

Vaccine Details

Vaccine type lipopeptide
Vaccine strain B clade LAI
Vaccine component Env, Gag, Nef
Adjuvant QS21

Notes

References

Gahery-Segard2003 Hanne Gahéry-Ségard, Gilles Pialoux, Suzanne Figueiredo, Céline Igéa, Mathieu Surenaud, Jessintha Gaston, Helene Gras-Masse, Jean-Paul Lévy, and Jean-Gérard Guillet. Long-Term Specific Immune Responses Induced in Humans by a Human Immunodeficiency Virus Type 1 Lipopeptide Vaccine: Characterization of CD8+-T-Cell Epitopes Recognized. J. Virol., 77(20):11220-11231, Oct 2003. PubMed ID: 14512570. Show all entries for this paper.


Displaying record number 56011

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HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24
Epitope PPIPVGEIY Epitope Alignment
PPIPVGEIY epitope logo
Show epitope variants
Epitope Name PY9(p24)
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords variant cross-reactivity, chronic infection

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


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