HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 26 matching records:

Displaying record number 56593

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24(254-262)
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Epitope Name PY9
Subtype C
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Country South Africa, Zambia
Experimental methods  
Keywords viral fitness and reversion, HLA associated polymorphism

Notes

References

Goepfert2008 Paul A. Goepfert, Wendy Lumm, Paul Farmer, Philippa Matthews, Andrew Prendergast, Jonathan M. Carlson, Cynthia A. Derdeyn, Jianming Tang, Richard A. Kaslow, Anju Bansal, Karina Yusim, David Heckerman, Joseph Mulenga, Susan Allen, Philip J. R. Goulder, and Eric Hunter. Transmission of HIV-1 Gag Immune Escape Mutations Is Associated with Reduced Viral Load in Linked Recipients. J. Exp. Med., 205(5):1009-1017, 12 May 2008. PubMed ID: 18426987. Show all entries for this paper.


Displaying record number 241

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24(260-268 LAI)
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

McMichael1994 A. J. McMichael and B. D. Walker. Cytotoxic T Lymphocytes Epitopes: Implications for HIV Vaccine. AIDS, 8S:S155-S173, 1994. Comprehensive review summarizing CTL epitopes that have known HLA type and are fine mapped to indicate epitope boundaries. Anchor residues are indicated when known for different HLA restricted epitopes. Includes a summary of the published literature, as well as much work that was in press or submitted for publication. Show all entries for this paper.


Displaying record number 244

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Species (MHC/HLA) human(B35)
Immunogen  
Experimental methods  
Keywords  

Notes

References

RowlandJones1995 S. L. Rowland-Jones, J. Sutton, K. Ariyoshi, T. Dong, F. Gotch, S. McAdam, D. Whitby, S. Sabally, A. Gallimore, T. Corrah, M. Takiguchi, T. Schultz, A. McMichael, and H. Whittle. HIV-Specific Cytotoxic T Cells in HIV-Exposed but Uninfected Gambian Women. Nat. Med., 1:59-64, 1995. Four HIV-1 and -2 cross-reactive epitopes that are presented to CTL from HIV-infected Gambians by HLA-35 were identified. These peptides could elicit HIV-specific CTLs from 3 of 6 repeatedly exposed but seronegative sex workers who carry the HLA-B35 allele. Most CTL derived from HIV-2 positive donors also recognized the HIV-2 peptide and the analogous HIV-1 peptide. PubMed ID: 7584954. Show all entries for this paper.

Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.


Displaying record number 1384

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24(260-268)
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Epitope Name PPI
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Oxenius2000b A. Oxenius, D. A. Price, P. J. Easterbrook, C. A. O'Callaghan, A. D. Kelleher, J. A. Whelan, G. Sontag, A. K. Sewell, and R. E. Phillips. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proc. Natl. Acad. Sci. U.S.A., 97(7):3382-7, 28 Mar 2000. URL: http://www.pnas.org/cgi/content/full/97/7/3382. PubMed ID: 10737796. Show all entries for this paper.


Displaying record number 1455

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24(122-130)
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.


Displaying record number 1563

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24(254-262 SF2)
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 1685

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24(260-268)
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS), immunodominance

Notes

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 53033

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24(260-268)
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords characterizing CD8+ T cells

Notes

References

Kleen2004 Thomas O. Kleen, Robert Asaad, Samuel J. Landry, Bernhard O. Boehm, and Magdalena Tary-Lehmann. Tc1 Effector Diversity Shows Dissociated Expression of Granzyme B and Interferon-gamma in HIV Infection. AIDS, 18(3):383-392, 20 Feb 2004. PubMed ID: 15090789. Show all entries for this paper.


Displaying record number 238

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24(260-268 LAI)
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 or HIV-2 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS), HIV-2

Notes

References

RowlandJones1995 S. L. Rowland-Jones, J. Sutton, K. Ariyoshi, T. Dong, F. Gotch, S. McAdam, D. Whitby, S. Sabally, A. Gallimore, T. Corrah, M. Takiguchi, T. Schultz, A. McMichael, and H. Whittle. HIV-Specific Cytotoxic T Cells in HIV-Exposed but Uninfected Gambian Women. Nat. Med., 1:59-64, 1995. Four HIV-1 and -2 cross-reactive epitopes that are presented to CTL from HIV-infected Gambians by HLA-35 were identified. These peptides could elicit HIV-specific CTLs from 3 of 6 repeatedly exposed but seronegative sex workers who carry the HLA-B35 allele. Most CTL derived from HIV-2 positive donors also recognized the HIV-2 peptide and the analogous HIV-1 peptide. PubMed ID: 7584954. Show all entries for this paper.


Displaying record number 240

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24(260-268 LAI)
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Subtype B
Species (MHC/HLA) human(B35)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords  

Notes

References

Lalvani1997 A. Lalvani, T. Dong, G. Ogg, A. A. Patham, H. Newell, A. V. Hill, A. J. McMichael, and S. Rowland-Jones. Optimization of a Peptide-Based Protocol Employing IL-7 for In Vitro Restimulation of Human Cytotoxic T Lymphocyte Precursors. J. Immunol. Methods, 210:65-77, 1997. PubMed ID: 9502585. Show all entries for this paper.


Displaying record number 57129

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location Gag(254-262)
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Species (MHC/HLA) (B*35)
Immunogen HIV-1 infection
Experimental methods Intracellular cytokine staining, Relative replication capacity assay
Keywords escape, HLA associated polymorphism

Notes

References

Kawashima2009 Yuka Kawashima, Katja Pfafferott, John Frater, Philippa Matthews, Rebecca Payne, Marylyn Addo, Hiroyuki Gatanaga, Mamoru Fujiwara, Atsuko Hachiya, Hirokazu Koizumi, Nozomi Kuse, Shinichi Oka, Anna Duda, Andrew Prendergast, Hayley Crawford, Alasdair Leslie, Zabrina Brumme, Chanson Brumme, Todd Allen, Christian Brander, Richard Kaslow, James Tang, Eric Hunter, Susan Allen, Joseph Mulenga, Songee Branch, Tim Roach, Mina John, Simon Mallal, Anthony Ogwu, Roger Shapiro, Julia G. Prado, Sarah Fidler, Jonathan Weber, Oliver G. Pybus, Paul Klenerman, Thumbi Ndung'u, Rodney Phillips, David Heckerman, P. Richard Harrigan, Bruce D. Walker, Masafumi Takiguchi, and Philip Goulder. Adaptation of HIV-1 to Human Leukocyte Antigen Class I. Nature, 458(7238):641-645, 2 Apr 2009. PubMed ID: 19242411. Show all entries for this paper.


Displaying record number 58532

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24(122-130)
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Subtype B
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Country Canada
Experimental methods Other
Keywords characterizing CD8+ T cells, elite controllers

Notes

References

Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.


Displaying record number 56336

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location Gag
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Subtype B, C
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Country Canada, South Africa
Experimental methods  
Keywords escape

Notes

References

Carlson2008 Jonathan M. Carlson, Zabrina L. Brumme, Christine M. Rousseau, Chanson J. Brumme, Philippa Matthews, Carl Kadie, James I. Mullins, Bruce D. Walker, P. Richard Harrigan, Philip J. R. Goulder, and David Heckerman. Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag. PLoS Comput Biol, 4(11):e1000225, Nov 2008. PubMed ID: 19023406. Show all entries for this paper.


Displaying record number 53110

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24(122-130)
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.


Displaying record number 53927

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location ( C consensus)
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Subtype C
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 56373

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24(254-262)
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Epitope Name PY9
Subtype B
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 55687

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location Gag
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Subtype A, CRF02_AG
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection, HIV-1 or HIV-2 infection
Country Gambia
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords subtype comparisons, variant cross-reactivity, HIV-2

Notes

References

Ondondo2008 Beatrice O. Ondondo, Sarah L. Rowland-Jones, Lucy Dorrell, Kevin Peterson, Matthew Cotten, Hilton Whittle, and Assan Jaye. Comprehensive Analysis of HIV Gag-Specific IFN-gamma Response in HIV-1- and HIV-2-Infected Asymptomatic Patients from a Clinical Cohort in The Gambia. Eur. J. Immunol., 38(12):3549-3560, Dec 2008. PubMed ID: 19016530. Show all entries for this paper.


Displaying record number 60610

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24(122-130)
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Show epitope variants
Subtype C
Species (MHC/HLA) human(B*35, B*3501, B*3502, B*53)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tenzer2014 Stefan Tenzer, Hayley Crawford, Phillip Pymm, Robert Gifford, Vattipally B. Sreenu, Mirjana Weimershaus, Tulio de Oliveira, Anne Burgevin, Jan Gerstoft, Nadja Akkad, Daniel Lunn, Lars Fugger, John Bell, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification. Cell Rep., 7(2):448-463, 24 Apr 2014. PubMed ID: 24726370. Show all entries for this paper.


Displaying record number 2000

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Epitope Name Gag-PY9; p24-PY9
Subtype B
Species (MHC/HLA) human(B*35, B*5301)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 60977

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24(122-130)
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Subtype B
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Patient MHC/HLA 57604: A*0201, A*0201, B*1302, B*3501, Cw*0419, Cw*0602
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 239

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24(260-268 LAI)
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Subtype B
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 or HIV-2 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 56473

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location p24
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Subtype C
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HLA associated polymorphism

Notes

References

Matthews2008 Philippa C. Matthews, Andrew Prendergast, Alasdair Leslie, Hayley Crawford, Rebecca Payne, Christine Rousseau, Morgane Rolland, Isobella Honeyborne, Jonathan Carlson, Carl Kadie, Christian Brander, Karen Bishop, Nonkululeko Mlotshwa, James I. Mullins, Hoosen Coovadia, Thumbi Ndung'u, Bruce D. Walker, David Heckerman, and Philip J. R. Goulder. Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point. J. Virol., 82(17):8548-8559, Sep 2008. PubMed ID: 18596105. Show all entries for this paper.


Displaying record number 58428

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location Gag(254-262)
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Subtype C
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Country Kenya
Experimental methods Other
Keywords assay or method development

Notes

References

Liang2011 Binhua Liang, Ma Luo, Joel Scott-Herridge, Christina Semeniuk, Mark Mendoza, Rupert Capina, Brent Sheardown, Hezhao Ji, Joshua Kimani, Blake T. Ball, Gary Van Domselaar, Morag Graham, Shane Tyler, Steven J. M. Jones, and Francis A. Plummer. A Comparison of Parallel Pyrosequencing and Sanger Clone-Based Sequencing and Its Impact on the Characterization of the Genetic Diversity of HIV-1. PLoS One, 6(10):e26745, 2011. PubMed ID: 22039546. Show all entries for this paper.


Displaying record number 55107

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location Gag
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Epitope Name PY9
Subtype B
Species (MHC/HLA) human(B*3501, B*3502)
Immunogen HIV-1 infection
Country Australia, Canada, United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, escape, mutation acquisition, optimal epitope

Notes

References

Streeck2007a Hendrik Streeck, Mathias Lichterfeld, Galit Alter, Angela Meier, Nickolas Teigen, Bader Yassine-Diab, Harlyn K. Sidhu, Susan Little, Anthony Kelleher, Jean-Pierre Routy, Eric S. Rosenberg, Rafick-Pierre Sekaly, Bruce D. Walker, and Marcus Altfeld. Recognition of a Defined Region within p24 Gag by CD8+ T Cells during Primary Human Immunodeficiency Virus Type 1 Infection in Individuals Expressing Protective HLA Class I Alleles. J. Virol., 81(14):7725-7731, Jul 2007. PubMed ID: 17494064. Show all entries for this paper.


Displaying record number 57347

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location  
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Epitope Name PY9
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country United States
Experimental methods Other
Keywords dendritic cells

Notes

References

Huang2009a Jinghe Huang, James J. Goedert, Eric J. Sundberg, Thai Duong Hong Cung, Patrick S. Burke, Maureen P. Martin, Liliana Preiss, Jeffrey Lifson, Mathias Lichterfeld, Mary Carrington, and Xu G. Yu. HLA-B*35-Px-Mediated Acceleration of HIV-1 Infection by Increased Inhibitory Immunoregulatory Impulses. J. Exp. Med., 206(13):2959-2966, 21 Dec 2009. PubMed ID: 20008523. Show all entries for this paper.


Displaying record number 54929

HXB2 Location Gag(254-262)
p24(122-130)
DNA(1549..1575)
Gag Epitope Map
Author Location  
Epitope PPIPVGDIY Epitope Alignment
PPIPVGDIY epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA A2, A2; B35, B62
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type canarypox prime with gp160 boost
Vaccine strain B clade LAI, B clade MN
Vaccine component Gag-Pol, gp120, gp41

Notes

References

Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.


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