Search CTL/CD8+ T-Cell Epitope Database

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Displaying record number 783

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HXB2 Location	gp160(376-384) gp120(376-384) DNA(7350..7376)	gp160 Epitope Map
Author Location	gp120(376-384 IIIB)
Epitope	PNCGGEFFY	Epitope Alignment
		Show epitope variants
Species (MHC/HLA)	human(A29)
Immunogen	HIV-1 infection
Experimental methods
Keywords	responses in children, mother-to-infant transmission, escape

Notes

• This study describes maternal CTL responses in the context of mother-to-infant transmission.
• Detection of CTL escape mutants in the mother was associated with transmission, but the CTL-susceptible forms of the virus tended to be found in infected infants.
• PNCRGEFFY was an escape variant.

References

Wilson1999a C. C. Wilson, R. C. Brown, B. T. Korber, B. M. Wilkes, D. J. Ruhl, D. Sakamoto, K. Kunstman, K. Luzuriaga, I. C. Hanson, S. M. Widmayer, A. Wiznia, S. Clapp, A. J. Ammann, R. A. Koup, S. M. Wolinsky, and B. D. Walker. Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: The Ariel Project for the Prevention of Transmission of HIV from Mother to Infant. J. Virol., 73:3975-3985, 1999. PubMed ID: 10196293. Show all entries for this paper.