HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 21 matching records:

Displaying record number 57407

HXB2 Location Nef(136-145)
DNA(9202..9231)
Nef Epitope Map
Author Location Nef(136-145)
Epitope PLTFGWCYKL Epitope Alignment
PLTFGWCYKL epitope logo
Epitope Name PL10
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection, in vitro stimulation or selection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords TCR usage, assay or method development

Notes

References

Balamurugan2010 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Rapid T Cell Receptor Delineation Reveals Clonal Expansion Limitation of the Magnitude of the HIV-1-Specific CD8+ T Cell Response. J. Immunol., 185(10):5935-5942, 15 Nov 2010. PubMed ID: 20944001. Show all entries for this paper.


Displaying record number 56713

HXB2 Location Nef(136-145)
DNA(9202..9231)
Nef Epitope Map
Author Location Nef(136-145 HIV-1 NL4-3.1)
Epitope PLTFGWCYKL Epitope Alignment
PLTFGWCYKL epitope logo
Epitope Name PL10
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen virus
Experimental methods CTL suppression of replication
Keywords  

Notes

References

Cruz2009 Justin De La Cruz, Ayub Ali, Hwee L Ng, and Otto O Yang. Disruption of an env Tyrosine-Dependent Sorting Signal Does Not Affect Susceptibility of HIV-1 to Cytotoxic T Lymphocytes. AIDS, 23(11):1449-1451, 17 Jul 2009. PubMed ID: 19564727. Show all entries for this paper.


Displaying record number 1771

HXB2 Location Nef(136-145)
DNA(9202..9231)
Nef Epitope Map
Author Location Nef(136-145)
Epitope PLTFGWCYKL Epitope Alignment
PLTFGWCYKL epitope logo
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, acute/early infection

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 53771

HXB2 Location Nef(136-145)
DNA(9202..9231)
Nef Epitope Map
Author Location Nef(136-145 HXB2)
Epitope PLTFGWCYKL Epitope Alignment
PLTFGWCYKL epitope logo
Show epitope variants
Subtype B, CRF01_AE
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Viet Nam
Experimental methods HLA binding
Keywords subtype comparisons, computational epitope prediction, variant cross-reactivity, vaccine antigen design

Notes

References

Lazaro2005 Estibaliz Lazaro, Ioannis Theodorou, Elisabeth Legrand, Patricia Recordon-Pinson, Sebastien Boucher, Corinne Capoulade, Thi Hoang Lan, Pham Van Hung, Patrice Debre, and Herve Fleury. Sequences of Clustered Epitopes in Gag and Nef Potentially Presented by Predominant Class I Human Leukocyte Antigen (HLA) Alleles A and B Expressed By Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients in Vietnam. AIDS Res. Hum. Retroviruses, 21(6):586-591, Jun 2005. PubMed ID: 15989466. Show all entries for this paper.


Displaying record number 1754

HXB2 Location Nef(136-145)
DNA(9202..9231)
Nef Epitope Map
Author Location Nef(135-144 93TH253 subtype CRF01)
Epitope PLTFGWCYKL Epitope Alignment
PLTFGWCYKL epitope logo
Show epitope variants
Subtype CRF01_AE
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

Bond2001 K. B. Bond, B. Sriwanthana, T. W. Hodge, A. S. De Groot, T. D. Mastro, N. L. Young, N. Promadej, J. D. Altman, K. Limpakarnjanarat, and J. M. McNicholl. An HLA-directed molecular and bioinformatics approach identifies new HLA-A11 HIV-1 subtype E cytotoxic T lymphocyte epitopes in HIV-1-infected Thais. AIDS Res. Hum. Retroviruses, 17(8):703-17, 20 May 2001. PubMed ID: 11429111. Show all entries for this paper.


Displaying record number 1985

HXB2 Location Nef(136-145)
DNA(9202..9231)
Nef Epitope Map
Author Location Nef
Epitope PLTFGWCYKL Epitope Alignment
PLTFGWCYKL epitope logo
Epitope Name Nef-PL10
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 1075

HXB2 Location Nef(136-145)
DNA(9202..9231)
Nef Epitope Map
Author Location Nef(136-145)
Epitope PLTFGWCYKL Epitope Alignment
PLTFGWCYKL epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords binding affinity, dendritic cells, Th1

Notes

References

Wilson1999b C. C. Wilson, W. C. Olson, T. Tuting, C. R. Rinaldo, M. T. Lotze, and W. J. Storkus. HIV-1-Specific CTL Responses Primed In Vitro by Blood-Derived Dendritic Cells and Th1-Biasing Cytokines. J. Immunol., 162:3070-3078, 1999. PubMed ID: 10072560. Show all entries for this paper.


Displaying record number 1107

HXB2 Location Nef(136-145)
DNA(9202..9231)
Nef Epitope Map
Author Location Nef(136-145 LAI)
Epitope PLTFGWCYKL Epitope Alignment
PLTFGWCYKL epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 1827

HXB2 Location Nef(136-145)
DNA(9202..9231)
Nef Epitope Map
Author Location Nef(136-145 LAI)
Epitope PLTFGWCYKL Epitope Alignment
PLTFGWCYKL epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords epitope processing

Notes

References

LucchiariHartz2000 M. Lucchiari-Hartz, P. M. van Endert, G. Lauvau, R. Maier, A. Meyerhans, D. Mann, K. Eichmann, and G. Niedermann. Cytotoxic T lymphocyte epitopes of HIV-1 Nef: Generation of multiple definitive major histocompatibility complex class I ligands by proteasomes. J. Exp. Med., 191(2):239-52, 17 Jan 2000. URL: http://www.jem.org/cgi/content/full/191/2/239. PubMed ID: 10637269. Show all entries for this paper.


Displaying record number 53018

HXB2 Location Nef(136-145)
DNA(9202..9231)
Nef Epitope Map
Author Location Nef(136-145)
Epitope PLTFGWCYKL Epitope Alignment
PLTFGWCYKL epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords Th1, characterizing CD8+ T cells

Notes

References

Kleen2004 Thomas O. Kleen, Robert Asaad, Samuel J. Landry, Bernhard O. Boehm, and Magdalena Tary-Lehmann. Tc1 Effector Diversity Shows Dissociated Expression of Granzyme B and Interferon-gamma in HIV Infection. AIDS, 18(3):383-392, 20 Feb 2004. PubMed ID: 15090789. Show all entries for this paper.


Displaying record number 54227

HXB2 Location Nef(136-145)
DNA(9202..9231)
Nef Epitope Map
Author Location Nef
Epitope PLTFGWCYKL Epitope Alignment
PLTFGWCYKL epitope logo
Epitope Name A2-PL11(Nef)
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 52942

HXB2 Location Nef(136-145)
DNA(9202..9231)
Nef Epitope Map
Author Location Nef(136-145)
Epitope PLTFGWCYKL Epitope Alignment
PLTFGWCYKL epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Proliferation
Keywords vaccine-induced immune responses, variant cross-reactivity

Vaccine Details

Vaccine type lipopeptide
Vaccine strain B clade LAI
Vaccine component Env, Gag, Nef
Adjuvant QS21

Notes

References

Gahery-Segard2003 Hanne Gahéry-Ségard, Gilles Pialoux, Suzanne Figueiredo, Céline Igéa, Mathieu Surenaud, Jessintha Gaston, Helene Gras-Masse, Jean-Paul Lévy, and Jean-Gérard Guillet. Long-Term Specific Immune Responses Induced in Humans by a Human Immunodeficiency Virus Type 1 Lipopeptide Vaccine: Characterization of CD8+-T-Cell Epitopes Recognized. J. Virol., 77(20):11220-11231, Oct 2003. PubMed ID: 14512570. Show all entries for this paper.


Displaying record number 52116

HXB2 Location Nef(136-145)
DNA(9202..9231)
Nef Epitope Map
Author Location Nef(136-145 BRU)
Epitope PLTFGWCYKL Epitope Alignment
PLTFGWCYKL epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, epitope processing

Notes

References

Choppin2001 Jeannine Choppin, William Cohen, Albert Bianco, Jean-Paul Briand, Francine Connan, Marc Dalod, and Jean-Gérard Guillet. Characteristics of HIV-1 Nef Regions Containing Multiple CD8+ T Cell Epitopes: Wealth of HLA-Binding Motifs and Sensitivity to Proteasome Degradation. J. Immunol., 166(10):6164-6169, 15 May 2001. PubMed ID: 11342637. Show all entries for this paper.


Displaying record number 53575

HXB2 Location Nef(136-145)
DNA(9202..9231)
Nef Epitope Map
Author Location Nef(136-145)
Epitope PLTFGWCYKL Epitope Alignment
PLTFGWCYKL epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords acute/early infection, optimal epitope

Notes

References

Altfeld2005a Marcus Altfeld, Todd M. Allen, Elizabeth T. Kalife, Nicole Frahm, Marylyn M. Addo, Bianca R. Mothe, Almas Rathod, Laura L. Reyor, Jason Harlow, Xu G. Yu, Beth Perkins, Loren K. Robinson, John Sidney, Galit Alter, Mathias Lichterfeld, Alessandro Sette, Eric S. Rosenberg, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. The Majority of Currently Circulating Human Immunodeficiency Virus Type 1 Clade B Viruses Fail To Prime Cytotoxic T-Lymphocyte Responses against an Otherwise Immunodominant HLA-A2-Restricted Epitope: Implications for Vaccine Design. J. Virol., 79(8):5000-5005, Apr 2005. PubMed ID: 15795285. Show all entries for this paper.


Displaying record number 60046

HXB2 Location Nef(136-145)
DNA(9202..9231)
Nef Epitope Map
Author Location Nef(136-145)
Epitope PLTFGWCYKL Epitope Alignment
PLTFGWCYKL epitope logo
Epitope Name PL10
Species (MHC/HLA) human(A*32)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60049

HXB2 Location Nef(136-145)
DNA(9202..9231)
Nef Epitope Map
Author Location Nef(136-145)
Epitope PLTFGWCYKL Epitope Alignment
PLTFGWCYKL epitope logo
Epitope Name PL10
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60045

HXB2 Location Nef(136-145)
DNA(9202..9231)
Nef Epitope Map
Author Location Nef(136-145)
Epitope PLTFGWCYKL Epitope Alignment
PLTFGWCYKL epitope logo
Epitope Name PL10
Species (MHC/HLA) human(B*18)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60043

HXB2 Location Nef(136-145)
DNA(9202..9231)
Nef Epitope Map
Author Location Nef(136-145)
Epitope PLTFGWCYKL Epitope Alignment
PLTFGWCYKL epitope logo
Epitope Name PL10
Species (MHC/HLA) human(B*3502, B*3503, B*5301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60047

HXB2 Location Nef(136-145)
DNA(9202..9231)
Nef Epitope Map
Author Location Nef(136-145)
Epitope PLTFGWCYKL Epitope Alignment
PLTFGWCYKL epitope logo
Epitope Name PL10
Species (MHC/HLA) human(B*49)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60048

HXB2 Location Nef(136-145)
DNA(9202..9231)
Nef Epitope Map
Author Location Nef(136-145)
Epitope PLTFGWCYKL Epitope Alignment
PLTFGWCYKL epitope logo
Epitope Name PL10
Species (MHC/HLA) human(B*5801)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60044

HXB2 Location Nef(136-145)
DNA(9202..9231)
Nef Epitope Map
Author Location Nef(136-145)
Epitope PLTFGWCYKL Epitope Alignment
PLTFGWCYKL epitope logo
Epitope Name PL10
Species (MHC/HLA) human(C*14)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


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